Lysine Acetylation, Cancer Hallmarks and Emerging Onco-Therapeutic Opportunities

MutSα mismatch repair protein stability is governed by subunit interaction, acetylation, and ubiquitination

(2021) Tim Arlow et al.   G3-Genes Genomes Genetics

Acetylation-dependent glutamate receptor GluR signalosome formation for STAT3 activation in both transcriptional and metabolism regulation

(2021) Xiang-Rong Li et al.   Cell Death Discovery

Lamin B1 acetylation slows the G1 to S cell cycle transition through inhibition of DNA repair

(2021) Laura A Murray-Nerger et al.   NUCLEIC ACIDS RESEARCH

Computational Analysis Indicates That PARP1 Acts as a Histone Deacetylases Interactor Sharing Common Lysine Residues for Acetylation, Ubiquitination, and SUMOylation in Alzheimer’s and Parkinson’s Disease

(2021) Rohan Gupta et al.   ACS Omega

Coenzyme A levels influence protein acetylation, CoAlation and 4′-phosphopantetheinylation: Expanding the impact of a metabolic nexus molecule

(2021) Yi Yu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Nuclear-translocation of ACLY induced by obesity-related factors enhances pyrimidine metabolism through regulating histone acetylation in endometrial cancer

(2021) Miao Dai et al.   CANCER LETTERS

The Influence of Cold Atmospheric Pressure Plasma-Treated Media on the Cell Viability, Motility, and Induction of Apoptosis in Human Non-Metastatic (MCF7) and Metastatic (MDA-MB-231) Breast Cancer Cell Lines

(2021) Dominik Terefinko et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role of mono‑ADP‑ribosylation histone modification (Review)

(2021) Jing-Jing Zha et al.   Experimental and Therapeutic Medicine

Acetylation of KLF5 maintains EMT and tumorigenicity to cause chemoresistant bone metastasis in prostate cancer

(2021) Baotong Zhang et al.   Nature Communications

Lysine 53 Acetylation of Cytochrome c in Prostate Cancer: Warburg Metabolism and Evasion of Apoptosis

(2021) Viktoriia Bazylianska et al.   Cells

The Biological Significance of Targeting Acetylation-Mediated Gene Regulation for Designing New Mechanistic Tools and Potential Therapeutics

(2021) Chenise O’Garro et al.   Biomolecules

Protein Acetylation at the Interface of Genetics, Epigenetics and Environment in Cancer

(2021) Mio Harachi et al.   Metabolites

Epithelial-to-Mesenchymal Transition Enhances Cancer Cell Sensitivity to Cytotoxic Effects of Cold Atmospheric Plasmas in Breast and Bladder Cancer Systems

(2021) Peiyu Wang et al.   Cancers

Effect of Cold Atmospheric Plasma on Epigenetic Changes, DNA Damage, and Possibilities for Its Use in Synergistic Cancer Therapy

(2021) Dušan Braný et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Romidepsin (FK228), An Histone Deacetylase Inhibitor, and its Analogues in Cancer Chemotherapy.

(2020) Eftiola Pojani et al.   CURRENT MEDICINAL CHEMISTRY

Acetylation of MORC2 by NAT10 regulates cell-cycle checkpoint control and resistance to DNA-damaging chemotherapy and radiotherapy in breast cancer

(2020) Hong-Yi Liu et al.   NUCLEIC ACIDS RESEARCH

Stabilization of FASN by ACAT1-mediated GNPAT acetylation promotes lipid metabolism and hepatocarcinogenesis

(2020) Li Gu et al.   ONCOGENE

Synergistic Radiosensitization by Gold Nanoparticles and the Histone Deacetylase Inhibitor SAHA in 2D and 3D Cancer Cell Cultures

(2020) Nóra Igaz et al.   Nanomaterials

Belinostat in Relapsed/Refractory T-Cell Large Granular Lymphocyte Leukemia

(2020) Christina Poh et al.   ACTA HAEMATOLOGICA

The DNA sensor cGAS is decorated by acetylation and phosphorylation modifications in the context of immune signaling

(2020) Bokai Song et al.   MOLECULAR & CELLULAR PROTEOMICS

ZNRD1 and Its Antisense Long Noncoding RNA ZNRD1-AS1 Are Oppositely Regulated by Cold Atmospheric Plasma in Breast Cancer Cells

(2020) Hyeon Woo Kim et al.   Oxidative Medicine and Cellular Longevity

Pyruvate Kinase M2 Promotes the Activation of Dendritic Cells by Enhancing IL-12p35 Expression

(2020) Xin Jin et al.   Cell Reports

System-Wide Analysis of Protein Acetylation and Ubiquitination Reveals a Diversified Regulation in Human Cancer Cells

(2020) Hiroko Kozuka-Hata et al.   Biomolecules

Protein acetylation in mitochondria plays critical functions in the pathogenesis of fatty liver disease

(2020) Zhang Le-tian et al.   BMC GENOMICS

18F-Fluoroestradiol (18F-FES)-PET imaging in a Phase II trial of vorinostat to restore endocrine sensitivity in ER+/HER2- metastatic breast cancer

(2020) Lanell M Peterson et al.   JOURNAL OF NUCLEAR MEDICINE

Dynamic RNA acetylation revealed by quantitative cross-evolutionary mapping

(2020) Aldema Sas-Chen et al.   NATURE

Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy

(2020) Yang Gao et al.   NATURE CELL BIOLOGY

Protein N-Terminal Acetylation: Structural Basis, Mechanism, Versatility, and Regulation

(2020) Sunbin Deng et al.   TRENDS IN BIOCHEMICAL SCIENCES

Controlling stem cell fate using cold atmospheric plasma

(2020) Fei Tan et al.   Stem Cell Research & Therapy

Schedule-Dependent Synergy Between the Histone Deacetylase Inhibitor Belinostat and the Dihydrofolate Reductase Inhibitor Pralatrexate in T-and B-cell Lymphoma Cells in vitro

(2020) Godefridus J. Peters et al.   Frontiers in Cell and Developmental Biology

miR-15a-5p inhibits metastasis and lipid metabolism by suppressing histone acetylation in lung cancer

(2020) Yinyun Ni et al.   FREE RADICAL BIOLOGY AND MEDICINE

A novel miRNA inhibits metastasis of prostate cancer via decreasing CREBBP-mediated histone acetylation

(2020) Fubo Wang et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Lysine acetylation of NKG2D ligand Rae-1 stabilizes the protein and sensitizes tumor cells to NKG2D immune surveillance

(2020) Jiemiao Hu et al.   CANCER LETTERS

Evodiamine Augments NLRP3 Inflammasome Activation and Anti-bacterial Responses Through Inducing α-Tubulin Acetylation

(2019) Chen-Guang Li et al.   Frontiers in Pharmacology

Histone Acetylation of Immune Regulatory Genes in Human Placenta in Association with Maternal Intake of Olive Oil and Fish Consumption

(2019) Nathalie Acevedo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effects of α-tubulin acetylation on microtubule structure and stability

(2019) Lisa Eshun-Wilson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dissecting the role of H3K27 acetylation and methylation in PRC2 mediated control of cellular identity

(2019) Elisa Lavarone et al.   Nature Communications

BRD4 promotes gastric cancer progression and metastasis through acetylation-dependent stabilization of Snail

(2019) Zhong-yi Qin et al.   CANCER RESEARCH

A ZEB1/p53 signaling axis in stromal fibroblasts promotes mammary epithelial tumours

(2019) Rong Fu et al.   Nature Communications

NAD-Biosynthetic and Consuming Enzymes as Central Players of Metabolic Regulation of Innate and Adaptive Immune Responses in Cancer

(2019) Valentina Audrito et al.   Frontiers in Immunology

Class I HDAC inhibitors enhance YB ‐1 acetylation and oxidative stress to block sarcoma metastasis

(2019) Amal M El‐Naggar et al.   EMBO REPORTS

Dynamic Regulation of ME1 Phosphorylation and Acetylation Affects Lipid Metabolism and Colorectal Tumorigenesis

(2019) Yahui Zhu et al.   MOLECULAR CELL

Cold atmospheric plasma inhibits the growth of osteosarcoma cells by inducing apoptosis, independent of the device used

(2019) Lyubomir Haralambiev et al.   Oncology Letters

Poly (ADP‑ribosylation) of HMGB1 facilitates its acetylation and promotes HMGB1 translocation‑associated chemotherapy‑induced autophagy in leukaemia cells

(2019) Yunyao Li et al.   Oncology Letters

Cold Atmospheric Plasma and Plasma-Activated Medium Trigger RONS-Based Tumor Cell Apoptosis

(2019) Georg Bauer et al.   Scientific Reports

Numerical modelling of the effects of cold atmospheric plasma on mitochondrial redox homeostasis and energy metabolism

(2019) Tomoyuki Murakami   Scientific Reports

Cold Atmospheric Plasma-Treated PBS Eliminates Immunosuppressive Pancreatic Stellate Cells and Induces Immunogenic Cell Death of Pancreatic Cancer Cells

(2019) Jinthe Van Loenhout et al.   Cancers

Aza-PBHA, a potent histone deacetylase inhibitor, inhibits human gastric-cancer cell migration via PKCα-mediated AHR-HDAC interactions

(2019) Chi-Hao Tsai et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Non-thermal atmospheric pressure plasma induces epigenetic modifications that activate the expression of various cytokines and growth factors in human mesoderm-derived stem cells

(2019) Jeongyeon Park et al.   FREE RADICAL BIOLOGY AND MEDICINE

Toll-like Receptor Signaling Rewires Macrophage Metabolism and Promotes Histone Acetylation via ATP-Citrate Lyase

(2019) Mario A. Lauterbach et al.   IMMUNITY

Lovastatin‐mediated MCF‐7 cancer cell death involves LKB1‐AMPK‐p38MAPK‐p53‐survivin signalling cascade

(2019) Shiu‐Wen Huang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Inhibition of Endothelial NOTCH1 Signaling Attenuates Inflammation by Reducing Cytokine-Mediated Histone Acetylation at Inflammatory EnhancersHighlights

(2018) Lars la Cour Poulsen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Lysine Acetylation Goes Global: From Epigenetics to Metabolism and Therapeutics

(2018) Ibraheem Ali et al.   CHEMICAL REVIEWS

Cold atmospheric plasma conveys selectivity on triple negative breast cancer cells both in vitro and in vivo

(2018) Liangjian Xiang et al.   FREE RADICAL BIOLOGY AND MEDICINE

c-Myc regulates the CDK1/cyclin B1 dependent‑G2/M cell cycle progression by histone H4 acetylation in Raji cells

(2018) Yan Yang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Cross-talk between chromatin acetylation and SUMOylation of tripartite motif–containing protein 24 (TRIM24) impacts cell adhesion

(2018) Srikanth Appikonda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ZMYND8 acetylation mediates HIF-dependent breast cancer progression and metastasis

(2018) Yan Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Acetylation blocks DNA damage–induced chromatin ADP-ribosylation

(2018) Glen Liszczak et al.   Nature Chemical Biology

Histone H1 acetylation at lysine 85 regulates chromatin condensation and genome stability upon DNA damage

(2018) Yinglu Li et al.   NUCLEIC ACIDS RESEARCH

Sinomenine Induces G1-Phase Cell Cycle Arrest and Apoptosis in Malignant Glioma Cells Via Downregulation of Sirtuin 1 and Induction of p53 Acetylation

(2018) Xiaoyan He et al.   TECHNOLOGY IN CANCER RESEARCH & TREATMENT

The Emerging Role of Gas Plasma in Oncotherapy

(2018) Xiaofeng Dai et al.   TRENDS IN BIOTECHNOLOGY

ChIP-seq analysis reveals alteration of H3K4 trimethylation occupancy in cancer-related genes by cold atmospheric plasma

(2018) Seungyeon Lee et al.   FREE RADICAL BIOLOGY AND MEDICINE

TIP60-dependent acetylation of the SPZ1-TWIST complex promotes epithelial–mesenchymal transition and metastasis in liver cancer

(2018) Li-Ting Wang et al.   ONCOGENE

Entinostat finds a path: A new study elucidates effects of the histone deacetylase inhibitor on the immune system

(2018) Ira Surolia et al.   CANCER

Acetylation of Cytidine in mRNA Promotes Translation Efficiency

(2018) Daniel Arango et al.   CELL

Vorinostat and Simvastatin have synergistic effects on triple-negative breast cancer cells via abrogating Rab7 prenylation

(2017) Xinhui Kou et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Differential protein acetylation assists import of excess SOD2 into mitochondria and mediates SOD2 aggregation associated with cardiac hypertrophy in the murine SOD2-tg heart

(2017) Liwen Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Acetylation of PCNA Sliding Surface by Eco1 Promotes Genome Stability through Homologous Recombination

(2017) Pierre Billon et al.   MOLECULAR CELL

Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation

(2017) Ka Lung Cheung et al.   MOLECULAR CELL

Histone deacetylase inhibitors stimulate the susceptibility of A549 cells to a plasma-activated medium treatment

(2016) Tetsuo Adachi et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Histone deacetylase inhibitor induces cell apoptosis and cycle arrest in lung cancer cells via mitochondrial injury and p53 up-acetylation

(2016) Lianmin Bao et al.   CELL BIOLOGY AND TOXICOLOGY

Acidosis Drives the Reprogramming of Fatty Acid Metabolism in Cancer Cells through Changes in Mitochondrial and Histone Acetylation

(2016) Cyril Corbet et al.   Cell Metabolism

Metabolic regulation of immune responses: therapeutic opportunities

(2016) Nadine Assmann et al.   JOURNAL OF CLINICAL INVESTIGATION

The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation

(2016) Karine Jacquet et al.   MOLECULAR CELL

Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain

(2016) Yuanyuan Li et al.   MOLECULAR CELL

Acetylation-regulated interaction between p53 and SET reveals a widespread regulatory mode

(2016) Donglai Wang et al.   NATURE

Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss

(2016) Tara E. Tracy et al.   NEURON

Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism

(2016) M. Peng et al.   SCIENCE

Clinical pharmacokinetics of panobinostat, a novel histone deacetylase (HDAC) inhibitor: review and perspectives

(2016) Nuggehally R. Srinivas   XENOBIOTICA

CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas

(2016) Yanwen Jiang et al.   Cancer Discovery

Epigenetic silencing of miR-19a-3p by cold atmospheric plasma contributes to proliferation inhibition of the MCF-7 breast cancer cell

(2016) Seungyeon Lee et al.   Scientific Reports

Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation

(2016) Eoin McDonnell et al.   Cell Reports

Genome Stability Requires p53

(2016) Christine M. Eischen   Cold Spring Harbor Perspectives in Medicine

Acetylation Reader Proteins: Linking Acetylation Signaling to Genome Maintenance and Cancer

(2016) Fade Gong et al.   PLoS Genetics

Romidepsin-associated cardiac toxicity and ECG changes: A case report and review of the literature

(2016) Zachary T Rivers et al.   JOURNAL OF ONCOLOGY PHARMACY PRACTICE

STAT3 Undergoes Acetylation-dependent Mitochondrial Translocation to Regulate Pyruvate Metabolism

(2016) Yan S. Xu et al.   Scientific Reports

Non-thermal plasma treatment altered gene expression profiling in non-small-cell lung cancer A549 cells

(2015) Jue Hou et al.   BMC GENOMICS

Role of Histone Acetylation in Cell Cycle Regulation

(2015) Miglena Koprinarova et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination

(2015) Fade Gong et al.   GENES & DEVELOPMENT

KATs in cancer: functions and therapies

(2015) A Farria et al.   ONCOGENE

GITR subverts Foxp3+ Tregs to boost Th9 immunity through regulation of histone acetylation

(2015) Xiang Xiao et al.   Nature Communications

Differential Epigenetic Effects of Atmospheric Cold Plasma on MCF-7 and MDA-MB-231 Breast Cancer Cells

(2015) Sung-Bin Park et al.   PLoS One

Acetylation of Werner syndrome protein (WRN): relationships with DNA damage, DNA replication and DNA metabolic activities

(2014) Enerlyn Lozada et al.   BIOGERONTOLOGY

Tyr Phosphorylation of PDP1 Toggles Recruitment between ACAT1 and SIRT3 to Regulate the Pyruvate Dehydrogenase Complex

(2014) Jun Fan et al.   MOLECULAR CELL

HDAC6 Deacetylates and Ubiquitinates MSH2 to Maintain Proper Levels of MutSα

(2014) Mu Zhang et al.   MOLECULAR CELL

50 years of protein acetylation: from gene regulation to epigenetics, metabolism and beyond

(2014) Eric Verdin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Acetylation of RNA Polymerase II Regulates Growth-Factor-Induced Gene Transcription in Mammalian Cells

(2013) Sebastian Schröder et al.   MOLECULAR CELL

SIRT6 Recruits SNF2H to DNA Break Sites, Preventing Genomic Instability through Chromatin Remodeling

(2013) Debra Toiber et al.   MOLECULAR CELL

Mammalian DNA repair: HATs and HDACs make their mark through histone acetylation

(2013) Fade Gong et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

The bromodomain protein Brd4 insulates chromatin from DNA damage signalling

(2013) Scott R. Floyd et al.   NATURE

Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination

(2013) Jiangbo Tang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Reversible Histone H3 Acetylation Cooperates with Mismatch Repair and Replicative Polymerases in Maintaining Genome Stability

(2013) Lyudmila Y. Kadyrova et al.   PLoS Genetics

Acetyl-CoA Carboxylase Regulates Global Histone Acetylation

(2012) Luciano Galdieri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-wide screen of human bromodomain-containing proteins identifies Cecr2 as a novel DNA damage response protein

(2012) Seul-Ki Lee et al.   MOLECULES AND CELLS

Modification of RelA by O-linked N-acetylglucosamine links glucose metabolism to NF- B acetylation and transcription

(2012) D. F. Allison et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization

(2011) Lydia W.S. Finley et al.   CANCER CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes

(2011) Marcus Bantscheff et al.   NATURE BIOTECHNOLOGY

Histone acetylation by CBP and p300 at double-strand break sites facilitates SWI/SNF chromatin remodeling and the recruitment of non-homologous end joining factors

(2011) H Ogiwara et al.   ONCOGENE

Proliferating cell nuclear antigen (PCNA): a key factor in DNA replication and cell cycle regulation

(2010) Wojciech Strzalka et al.   ANNALS OF BOTANY

The Tale of Protein Lysine Acetylation in the Cytoplasm

(2010) Karin Sadoul et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining

(2010) Kyle M Miller et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

PARP1 ADP-ribosylates lysine residues of the core histone tails

(2010) Simon Messner et al.   NUCLEIC ACIDS RESEARCH

Human SIRT6 Promotes DNA End Resection Through CtIP Deacetylation

(2010) Abderrahmane Kaidi et al.   SCIENCE

Regulation of Cellular Metabolism by Protein Lysine Acetylation

(2010) S. Zhao et al.   SCIENCE

p53 post-translational modification: deregulated in tumorigenesis

(2010) Chao Dai et al.   TRENDS IN MOLECULAR MEDICINE

Molecular and biologic characterization and drug sensitivity of pan-histone deacetylase inhibitor-resistant acute myeloid leukemia cells

(2008) W. Fiskus et al.   BLOOD

Identification of lysines 36 and 37 of PARP-2 as targets for acetylation and auto-ADP-ribosylation

(2008) Sandra S. Haenni et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Acetylation of mitogen-activated protein kinase phosphatase-1 inhibits Toll-like receptor signaling

(2008) Wangsen Cao et al.   JOURNAL OF EXPERIMENTAL MEDICINE