Lysine 53 Acetylation of Cytochrome c in Prostate Cancer: Warburg Metabolism and Evasion of Apoptosis

Cancer statistics, 2020

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Cytochrome c phosphorylation: Control of mitochondrial electron transport chain flux and apoptosis

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OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and increased succinate oxidation

(2020) Bernd Schöpf et al.   Nature Communications

Role of Mitochondrial Glycerol-3-Phosphate Dehydrogenase in Metabolic Adaptations of Prostate Cancer

(2020) Alena Pecinová et al.   Cells

Brain-Specific Serine-47 Modification of Cytochrome c Regulates Cytochrome c Oxidase Activity Attenuating ROS Production and Cell Death: Implications for Ischemia/Reperfusion Injury and Akt Signaling

(2020) Hasini A. Kalpage et al.   Cells

Metabolic regulation of prostate cancer heterogeneity and plasticity

(2020) Claudia Peitzsch et al.   SEMINARS IN CANCER BIOLOGY

Cytochrome c Deficiency Confers Apoptosome and Mitochondrial Dysfunction in African-American Men with Prostate Cancer

(2019) Rahul Kumar et al.   CANCER RESEARCH

A New Histone Deacetylase Inhibitor, MHY4381, Induces Apoptosis via Generation of Reactive Oxygen Species in Human Prostate Cancer Cells

(2019) Sachan Richa et al.   Biomolecules & Therapeutics

Serine-47 phosphorylation of cytochrome c in the mammalian brain regulates cytochrome c oxidase and caspase-3 activity

(2019) Hasini A. Kalpage et al.   FASEB JOURNAL

Regulation of Respiration and Apoptosis by Cytochrome c Threonine 58 Phosphorylation

(2019) Junmei Wan et al.   Scientific Reports

Hyper-acetylation contributes to the sensitivity of chemo-resistant prostate cancer cells to histone deacetylase inhibitor Trichostatin A

(2018) Qingqing Xu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Oxidative stress is tightly regulated by cytochromecphosphorylation and respirasome factors in mitochondria

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Tissue-specific regulation of cytochrome c by post-translational modifications: respiration, the mitochondrial membrane potential, ROS, and apoptosis

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Genetics and biology of prostate cancer

(2018) Guocan Wang et al.   GENES & DEVELOPMENT

Lysine acetylation in mitochondria: From inventory to function

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Structural basis of mitochondrial dysfunction in response to cytochromecphosphorylation at tyrosine 48

(2017) Blas Moreno-Beltrán et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tip60 is associated with resistance to X-ray irradiation in prostate cancer

(2017) Xin Xie et al.   FEBS Open Bio

The Metabolic Phenotype of Prostate Cancer

(2017) Eric Eidelman et al.   Frontiers in Oncology

Structural and functional characterization of phosphomimetic mutants of cytochrome c at threonine 28 and serine 47

(2016) Alejandra Guerra-Castellano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Phosphorylation of CytochromecThreonine 28 Regulates Electron Transport Chain Activity in Kidney

(2016) Gargi Mahapatra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms and Dynamics of Protein Acetylation in Mitochondria

(2016) Josue Baeza et al.   TRENDS IN BIOCHEMICAL SCIENCES

Bone marrow adipocytes promote the Warburg phenotype in metastatic prostate tumors via HIF-1α activation

(2016) Jonathan D. Diedrich et al.   Oncotarget

A near atomic structure of the active human apoptosome

(2016) Tat Cheung Cheng et al.   eLife

The Warburg effect in tumor progression: Mitochondrial oxidative metabolism as an anti-metastasis mechanism

(2015) Jianrong Lu et al.   CANCER LETTERS

New ways to boost molecular dynamics simulations

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Introduction to the molecular basis of cancer metabolism and the Warburg effect

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Mitochondrial oncobioenergetic index: A potential biomarker to predict progression from indolent to aggressive prostate cancer

(2015) Praveen K. Vayalil et al.   Oncotarget

Glycolysis is the primary bioenergetic pathway for cell motility and cytoskeletal remodeling in human prostate and breast cancer cells

(2015) Takumi Shiraishi et al.   Oncotarget

The mitochondrial lysine acetylome of Arabidopsis

(2014) Ann-Christine König et al.   MITOCHONDRION

The role of key residues in structure, function, and stability of cytochrome-c

(2013) Sobia Zaidi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Widespread and Enzyme-independentNϵ-Acetylation andNϵ-Succinylation of Proteins in the Chemical Conditions of the Mitochondrial Matrix

(2013) Gregory R. Wagner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytochrome c Is Tyrosine 97 Phosphorylated by Neuroprotective Insulin Treatment

(2013) Thomas H. Sanderson et al.   PLoS One

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

Data processing and analysis with theautoPROCtoolbox

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Comprehensive Structural Analysis of Mutant Nucleosomes Containing Lysine to Glutamine (KQ) Substitutions in the H3 and H4 Histone-Fold Domains

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Manganese superoxide dismutase, MnSOD and its mimics

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Hallmarks of Cancer: The Next Generation

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Tyrosine phosphorylation turns alkaline transition into a biologically relevant process and makes human cytochrome c behave as an anti-apoptotic switch

(2011) José M. García-Heredia et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

The multiple functions of cytochrome c and their regulation in life and death decisions of the mammalian cell: From respiration to apoptosis

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XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Phosphomimetic Substitution of CytochromecTyrosine 48 Decreases Respiration and Binding to Cardiolipin and Abolishes Ability to Trigger Downstream Caspase Activation

(2010) Petr Pecina et al.   BIOCHEMISTRY

Cytochrome c/cardiolipin relations in mitochondria: a kiss of death

(2009) Valerian E. Kagan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sensors and regulators of intracellular pH

(2009) Joseph R. Casey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Mammalian liver cytochrome c is tyrosine-48 phosphorylated in vivo, inhibiting mitochondrial respiration

(2008) Hong Yu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS