Acetylation of MORC2 by NAT10 regulates cell-cycle checkpoint control and resistance to DNA-damaging chemotherapy and radiotherapy in breast cancer

MORC2 regulates C/EBPα-mediated cell differentiation via sumoylation

(2019) Jia Liu et al.   CELL DEATH AND DIFFERENTIATION

Characterization of molecular mechanisms underlying the axonal Charcot-Marie-Tooth neuropathy caused by MORC2 mutations

(2019) Paula Sancho et al.   HUMAN MOLECULAR GENETICS

MORC2 regulates DNA damage response through a PARP1-dependent pathway

(2019) Lin Zhang et al.   NUCLEIC ACIDS RESEARCH

PARP1 regulates DNA damage-induced nucleolar-nucleoplasmic shuttling of WRN and XRCC1 in a toxicant and protein-specific manner

(2019) Sebastian Veith et al.   Scientific Reports

RNF144A functions as a tumor suppressor in breast cancer through ubiquitin ligase activity-dependent regulation of stability and oncogenic functions of HSPA2

(2019) Yin-Long Yang et al.   CELL DEATH AND DIFFERENTIATION

FBXO22 possesses both pro-tumorigenic and anti-metastatic roles in breast cancer progression

(2018) Rui Sun et al.   CANCER RESEARCH

Epigenetic restriction of Hippo signaling by MORC2 underlies stemness of hepatocellular carcinoma cells

(2018) Tao Wang et al.   CELL DEATH AND DIFFERENTIATION

MORC Domain Definition and Evolutionary Analysis of the MORC Gene Family in Green Plants

(2018) Wei Dong et al.   Genome Biology and Evolution

Aberrant high expression level of MORC2 is a common character in multiple cancers

(2018) Qian-shan Ding et al.   HUMAN PATHOLOGY

Inhibition of the acetyltransferase NAT10 normalizes progeric and aging cells by rebalancing the Transportin-1 nuclear import pathway

(2018) Delphine Larrieu et al.   Science Signaling

Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms

(2018) Christopher H. Douse et al.   Nature Communications

Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis

(2018) Fu-Long Li et al.   Nature Communications

Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome

(2018) Gabriel Balmus et al.   Nature Communications

Inhibition of the acetyltransferase NAT10 normalizes progeric and aging cells by rebalancing the Transportin-1 nuclear import pathway

(2018) Delphine Larrieu et al.   Science Signaling

Deacetylation of NAT10 by Sirt1 promotes the transition from rRNA biogenesis to autophagy upon energy stress

(2018) Xiaofeng Liu et al.   NUCLEIC ACIDS RESEARCH

MORC2 promotes development of an aggressive colorectal cancer phenotype through inhibition of NDRG1

(2018) Jiao Liu et al.   CANCER SCIENCE

Acetylation of Cytidine in mRNA Promotes Translation Efficiency

(2018) Daniel Arango et al.   CELL

Functions and mechanisms of non-histone protein acetylation

(2018) Takeo Narita et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

dbPTM in 2019: exploring disease association and cross-talk of post-translational modifications

(2018) Kai-Yao Huang et al.   NUCLEIC ACIDS RESEARCH

Clinical and mutational spectrum of Charcot-Marie-Tooth disease type 2Z caused by MORC2 variants in Japan

(2017) M. Ando et al.   EUROPEAN JOURNAL OF NEUROLOGY

PLMD: An updated data resource of protein lysine modifications

(2017) Haodong Xu et al.   Journal of Genetics and Genomics

Hyperactivation of HUSH complex function by Charcot–Marie–Tooth disease mutation in MORC2

(2017) Iva A Tchasovnikarova et al.   NATURE GENETICS

Therapeutic targeting of p53: all mutants are equal, but some mutants are more equal than others

(2017) Kanaga Sabapathy et al.   Nature Reviews Clinical Oncology

The essential kinase ATR: ensuring faithful duplication of a challenging genome

(2017) Joshua C. Saldivar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression

(2017) Juan Liu et al.   Nature Communications

MORC2mutations cause axonal Charcot-Marie-Tooth disease with pyramidal signs

(2016) Obaid M. Albulym et al.   ANNALS OF NEUROLOGY

NAT10 regulates p53 activation through acetylating p53 at K120 and ubiquitinating Mdm2

(2016) Xiaofeng Liu et al.   EMBO REPORTS

Family-wide Characterization of Histone Binding Abilities of Human CW Domain-containing Proteins

(2016) Yanli Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acetylation Reader Proteins: Linking Acetylation Signaling to Genome Maintenance and Cancer

(2016) Fade Gong et al.   PLoS Genetics

Mutations in theMORC2gene cause axonal Charcot–Marie–Tooth disease

(2015) Teresa Sevilla et al.   BRAIN

Spatiotemporal regulation of posttranslational modifications in the DNA damage response

(2015) N. P. Dantuma et al.   EMBO JOURNAL

Quantitative Proteomic Atlas of Ubiquitination and Acetylation in the DNA Damage Response

(2015) Andrew E.H. Elia et al.   MOLECULAR CELL

Acetylation site specificities of lysine deacetylase inhibitors in human cells

(2015) Christian Schölz et al.   NATURE BIOTECHNOLOGY

Yeast Kre33 and human NAT10 are conserved 18S rRNA cytosine acetyltransferases that modify tRNAs assisted by the adaptor Tan1/THUMPD1

(2015) Sunny Sharma et al.   NUCLEIC ACIDS RESEARCH

Identification of 33 candidate oncogenes by screening for base-specific mutations

(2014) S Tuupanen et al.   BRITISH JOURNAL OF CANCER

Human NAT10 Is an ATP-dependent RNA Acetyltransferase Responsible forN4-Acetylcytidine Formation in 18 S Ribosomal RNA (rRNA)

(2014) Satoshi Ito et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The growing landscape of lysine acetylation links metabolism and cell signalling

(2014) Chunaram Choudhary et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PhosphoSitePlus, 2014: mutations, PTMs and recalibrations

(2014) Peter V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

A novel function of HER2/Neu in the activation of G2/M checkpoint in response to γ-irradiation

(2014) Y Yan et al.   ONCOGENE

Chemical Inhibition of NAT10 Corrects Defects of Laminopathic Cells

(2014) D. Larrieu et al.   SCIENCE

Cytosolic functions of MORC2 in lipogenesis and adipogenesis

(2013) Beatriz Sánchez-Solana et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mechanisms and Functions of ATP-Dependent Chromatin-Remodeling Enzymes

(2013) Geeta J. Narlikar et al.   CELL

The MORC family

(2013) Da-Qiang Li et al.   Epigenetics

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

A Role for SIRT2-Dependent Histone H3K18 Deacetylation in Bacterial Infection

(2013) H. A. Eskandarian et al.   SCIENCE

Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response

(2012) Petra Beli et al.   MOLECULAR CELL

Sirtuins as regulators of metabolism and healthspan

(2012) Riekelt H. Houtkooper et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ASEB: a web server for KAT-specific acetylation site prediction

(2012) L. Wang et al.   NUCLEIC ACIDS RESEARCH

MORC2 Signaling Integrates Phosphorylation-Dependent, ATPase-Coupled Chromatin Remodeling during the DNA Damage Response

(2012) Da-Qiang Li et al.   Cell Reports

The CW domain, a new histone recognition module in chromatin proteins

(2011) Verena Hoppmann et al.   EMBO JOURNAL

In Silico Analysis of Kinase Expression Identifies WEE1 as a Gatekeeper against Mitotic Catastrophe in Glioblastoma

(2010) Shahryar E. Mir et al.   CANCER CELL

Protein phosphatase 1γ is responsible for dephosphorylation of histone H3 at Thr 11 after DNA damage

(2010) Midori Shimada et al.   EMBO REPORTS

Structural Insight into the Zinc Finger CW Domain as a Histone Modification Reader

(2010) Fahu He et al.   STRUCTURE

NAT10, a nucleolar protein, localizes to the midbody and regulates cytokinesis and acetylation of microtubules

(2009) Qi Shen et al.   EXPERIMENTAL CELL RESEARCH

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

MutL homologs in restriction-modification systems and the origin of eukaryotic MORC ATPases

(2008) Lakshminarayan M Iyer et al.   Biology Direct

Chk1 Is a Histone H3 Threonine 11 Kinase that Regulates DNA Damage-Induced Transcriptional Repression

(2008) Midori Shimada et al.   CELL

DNA Damage Detection and Repair Pathways--Recent Advances with Inhibitors of Checkpoint Kinases in Cancer Therapy

(2008) S. Ashwell et al.   CLINICAL CANCER RESEARCH

The SIRT2 Deacetylase Regulates Autoacetylation of p300

(2008) Joshua C. Black et al.   MOLECULAR CELL

Regulation of DNA repair throughout the cell cycle

(2008) Dana Branzei et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY