Protein Acetylation at the Interface of Genetics, Epigenetics and Environment in Cancer

Codependency of Metabolism and Epigenetics Drives Cancer Progression: A Review

(2020) Kenta Masui et al.   ACTA HISTOCHEMICA ET CYTOCHEMICA

The GATOR2–mTORC2 axis mediates Sestrin2-induced AKT Ser/Thr kinase activation

(2020) Allison Ho Kowalsky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of HDACs in normal and malignant hematopoiesis

(2020) Pan Wang et al.   Molecular Cancer

mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis

(2020) C. Martinez Calejman et al.   Nature Communications

mTOR complex 2 is an integrator of cancer metabolism and epigenetics

(2020) Kenta Masui et al.   CANCER LETTERS

Dual Regulation of Histone Methylation by mTOR Complexes Controls Glioblastoma Tumor Cell Growth via EZH2 and SAM

(2020) Mio Harachi et al.   MOLECULAR CANCER RESEARCH

HDAC10 Regulates Cancer Stem-like Cell Properties in KRAS-driven Lung Adenocarcinoma

(2020) Yixuan Li et al.   CANCER RESEARCH

Dual screen for efficacy and toxicity identifies HDAC inhibitor with distinctive activity spectrum for BAP1-mutant uveal melanoma

(2020) Jeffim N Kuznetsoff et al.   MOLECULAR CANCER RESEARCH

SIRT3, a metabolic target linked to ataxia-telangiectasia mutated (ATM) gene deficiency in diffuse large B-cell lymphoma

(2020) Kavita Bhalla et al.   Scientific Reports

The HDAC Inhibitor, SAHA, Combined with Cisplatin Synergistically Induces Apoptosis in Alpha-fetoprotein-producing Hepatoid Adenocarcinoma Cells

(2019) Myat Tin Htwe Kyaw et al.   ACTA HISTOCHEMICA ET CYTOCHEMICA

HDAC3 deficiency promotes liver cancer through a defect in H3K9ac/H3K9me3 transition

(2019) Hongjie Ji et al.   CANCER RESEARCH

NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodelling

(2019) Sudhir Chowdhry et al.   NATURE

Effects of α-tubulin acetylation on microtubule structure and stability

(2019) Lisa Eshun-Wilson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prolonged hypoxia decreases nuclear pyruvate dehydrogenase complex and regulates the gene expression

(2019) Kayoko Eguchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

HDAC11 Deficiency or Inhibition Disrupts Oncogene-Induced Stress Hematopoiesis in Myeloproliferative Neoplasms

(2019) Lanzhu Yue et al.   BLOOD

A complex interplay between SAM synthetase and the epigenetic regulator SIN3 controls metabolism and transcription

(2019) Mengying Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTORC2 links growth factor signaling with epigenetic regulation of iron metabolism in glioblastoma

(2019) Kenta Masui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MYST1/KAT8 contributes to tumor progression by activating EGFR signaling in glioblastoma cells

(2019) Zhen Dong et al.   Cancer Medicine

Disruption of Acetyl-Lysine Turnover in Muscle Mitochondria Promotes Insulin Resistance and Redox Stress without Overt Respiratory Dysfunction

(2019) Ashley S. Williams et al.   Cell Metabolism

The HDAC Inhibitor, SAHA, Prevents Colonic Inflammation by Suppressing Pro-inflammatory Cytokines and Chemokines in DSS-induced Colitis

(2018) Mohmand Noor Ali et al.   ACTA HISTOCHEMICA ET CYTOCHEMICA

BRD4 Inhibition Is Synthetic Lethal with PARP Inhibitors through the Induction of Homologous Recombination Deficiency

(2018) Chaoyang Sun et al.   CANCER CELL

Bivalent Chromatin Domains in Glioblastoma Reveal a Subtype-Specific Signature of Glioma Stem Cells

(2018) Amelia Weber Hall et al.   CANCER RESEARCH

Mammalian target of rapamycin complex 2 (mTORC2) controls glycolytic gene expression by regulating Histone H3 Lysine 56 acetylation

(2018) Raghavendra Vadla et al.   CELL CYCLE

Metabolism in pluripotency: Both driver and passenger?

(2018) Perrine Dahan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TOR complex 2 in fission yeast is required for chromatin-mediated gene silencing and assembly of heterochromatic domains at subtelomeres

(2018) Adiel Cohen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sirtuin5 contributes to colorectal carcinogenesis by enhancing glutaminolysis in a deglutarylation-dependent manner

(2018) Yun-Qian Wang et al.   Nature Communications

RNAs interact with BRD4 to promote enhanced chromatin engagement and transcription activation

(2018) Homa Rahnamoun et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

BRD4 amplification facilitates an oncogenic gene expression program in high-grade serous ovarian cancer and confers sensitivity to BET inhibitors

(2018) Garrett W. Rhyasen et al.   PLoS One

mTOR Complexes as a Nutrient Sensor for Driving Cancer Progression

(2018) Mio Harachi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

BRD4 and Cancer: going beyond transcriptional regulation

(2018) Benedetta Donati et al.   Molecular Cancer

Nuclear E-Cadherin Acetylation Promotes Colorectal Tumorigenesis via Enhancing β-Catenin Activity

(2018) Yongxu Zhao et al.   MOLECULAR CANCER RESEARCH

The many lives of KATs — detectors, integrators and modulators of the cellular environment

(2018) Bilal N. Sheikh et al.   NATURE REVIEWS GENETICS

Histone deacetylase 3 is associated with gastric cancer cell growth via the miR-454-mediated targeting of CHD5

(2017) Guangru Xu et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Sirtuin 2 mutations in human cancers impair its function in genome maintenance

(2017) PamelaSara E. Head et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysine acetylation and cancer: A proteomics perspective

(2017) Jeovanis Gil et al.   Journal of Proteomics

Hdac7 promotes lung tumorigenesis by inhibiting Stat3 activation

(2017) Yubin Lei et al.   Molecular Cancer

ARID1A-mutated ovarian cancers depend on HDAC6 activity

(2017) Benjamin G. Bitler et al.   NATURE CELL BIOLOGY

Specific blockade of Rictor-mTOR association inhibits mTORC2 activity and is cytotoxic in glioblastoma

(2017) Angelica Benavides-Serrato et al.   PLoS One

Role of novel histone modifications in cancer

(2017) Muthu K. Shanmugam et al.   Oncotarget

Non-enzymatic N -acetylation of Lysine Residues by AcetylCoA Often Occurs via a Proximal S -acetylated Thiol Intermediate Sensitive to Glyoxalase II

(2017) Andrew M. James et al.   Cell Reports

The Role of Mitochondrial Non-Enzymatic Protein Acylation in Ageing

(2017) Shin Yee Hong et al.   PLoS One

Proteome-wide acetylation dynamics in human cells

(2017) Yekaterina Kori et al.   Scientific Reports

mTORC2 activity in brain cancer: Extracellular nutrients are required to maintain oncogenic signaling

(2016) Kenta Masui et al.   BIOESSAYS

The 3D Genome as Moderator of Chromosomal Communication

(2016) Job Dekker et al.   CELL

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

The multifaceted role of lysine acetylation in cancer: prognostic biomarker and therapeutic target

(2016) Marta Di Martile et al.   Oncotarget

Exploitation of EP300 and CREBBP Lysine Acetyltransferases by Cancer

(2016) Narsis Attar et al.   Cold Spring Harbor Perspectives in Medicine

HDACs and HDAC Inhibitors in Cancer Development and Therapy

(2016) Yixuan Li et al.   Cold Spring Harbor Perspectives in Medicine

Molecular Basis for Histone Acetyltransferase Regulation by Binding Partners, Associated Domains, and Autoacetylation

(2015) Cheryl E. McCullough et al.   ACS Chemical Biology

Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress

(2015) Zachary T. Schug et al.   CANCER CELL

Phase I trial of valproic acid and lenalidomide in patients with advanced cancer

(2015) Mehmet Asim Bilen et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

The complex role of SIRT6 in carcinogenesis

(2015) Batia Lerrer et al.   CARCINOGENESIS

Acetyl Coenzyme A: A Central Metabolite and Second Messenger

(2015) Federico Pietrocola et al.   Cell Metabolism

Histone deacetylases: structural determinants of inhibitor selectivity

(2015) Carmina Micelli et al.   DRUG DISCOVERY TODAY

Panobinostat: a novel pan-deacetylase inhibitor for the treatment of relapsed or relapsed and refractory multiple myeloma

(2015) Paul G Richardson et al.   Expert Review of Anticancer Therapy

The oncogenic BRD4-NUT chromatin regulator drives aberrant transcription within large topological domains

(2015) Artyom A. Alekseyenko et al.   GENES & DEVELOPMENT

Elp3 drives Wnt-dependent tumor initiation and regeneration in the intestine

(2015) Aurélie Ladang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth

(2015) Jiajun Zhu et al.   NATURE

Metabolic pathways promoting cancer cell survival and growth

(2015) Lindsey K. Boroughs et al.   NATURE CELL BIOLOGY

KATs in cancer: functions and therapies

(2015) A Farria et al.   ONCOGENE

Glucose-dependent acetylation of Rictor promotes targeted cancer therapy resistance

(2015) Kenta Masui et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SIRT7 inactivation reverses metastatic phenotypes in epithelial and mesenchymal tumors

(2015) Shivani Malik et al.   Scientific Reports

Role of transcription factor acetylation in the regulation of metabolic homeostasis

(2015) Joo-Man Park et al.   Protein & Cell

A Nuclear Pyruvate Dehydrogenase Complex Is Important for the Generation of Acetyl-CoA and Histone Acetylation

(2014) Gopinath Sutendra et al.   CELL

Mitochondrial protein acetylation regulates metabolism

(2014) Kristin A. Anderson et al.   Essays in Biochemistry

Deficient Import of Acetyl-CoA into the ER Lumen Causes Neurodegeneration and Propensity to Infections, Inflammation, and Cancer

(2014) Y. Peng et al.   JOURNAL OF NEUROSCIENCE

The Mechanisms behind the Therapeutic Activity of BET Bromodomain Inhibition

(2014) Junwei Shi et al.   MOLECULAR CELL

Erasers of Histone Acetylation: The Histone Deacetylase Enzymes

(2014) E. Seto et al.   Cold Spring Harbor Perspectives in Biology

Rational design and validation of a Tip60 histone acetyltransferase inhibitor

(2014) Chunxia Gao et al.   Scientific Reports

Hbo1 Is a Cyclin E/CDK2 Substrate That Enriches Breast Cancer Stem-like Cells

(2013) M. T. Duong et al.   CANCER RESEARCH

PFI-1, a Highly Selective Protein Interaction Inhibitor, Targeting BET Bromodomains

(2013) S. Picaud et al.   CANCER RESEARCH

BRD4 Sustains Melanoma Proliferation and Represents a New Target for Epigenetic Therapy

(2013) M. F. Segura et al.   CANCER RESEARCH

A tale of two approaches: complementary mechanisms of cytotoxic and targeted therapy resistance may inform next-generation cancer treatments

(2013) K. Masui et al.   CARCINOGENESIS

Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

(2013) Jakob Lovén et al.   CELL

Influence of Metabolism on Epigenetics and Disease

(2013) William G. Kaelin et al.   CELL

mTOR Complex 2 Controls Glycolytic Metabolism in Glioblastoma through FoxO Acetylation and Upregulation of c-Myc

(2013) Kenta Masui et al.   Cell Metabolism

Interplay between chromatin-modifying enzymes controls colon cancer progression through Wnt signaling

(2013) Martine Chevillard-Briet et al.   HUMAN MOLECULAR GENETICS

Crosstalk between mTOR complexes

(2013) Jianling Xie et al.   NATURE CELL BIOLOGY

A Histone Acetyltransferase p300 Inhibitor C646 Induces Cell Cycle Arrest and Apoptosis Selectively in AML1-ETO-Positive AML Cells

(2013) Xiao-ning Gao et al.   PLoS One

Clinical and Experimental Applications of Sodium Phenylbutyrate

(2013) Tommaso Iannitti et al.   Drugs in research & development

Selective Small Molecule Targeting β-Catenin Function Discovered by In Vivo Chemical Genetic Screen

(2013) Jijun Hao et al.   Cell Reports

Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma

(2012) Dominik Sturm et al.   CANCER CELL

Arylsulfonamide KCN1 Inhibits In Vivo Glioma Growth and Interferes with HIF Signaling by Disrupting HIF-1  Interaction with Cofactors p300/CBP

(2012) S. Yin et al.   CLINICAL CANCER RESEARCH

SIRT1, Is It a Tumor Promoter or Tumor Suppressor?

(2012) Chu-Xia Deng   International Journal of Biological Sciences

Proteomic Assessment Shows That Many Endoplasmic Reticulum (ER)-resident Proteins Are Targeted by Nϵ-Lysine Acetylation in the Lumen of the Organelle and Predicts Broad Biological Impact

(2012) Mariana Pehar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Combination therapy for hepatocellular carcinoma: Additive preclinical efficacy of the HDAC inhibitor panobinostat with sorafenib

(2012) Anja Lachenmayer et al.   JOURNAL OF HEPATOLOGY

Calorie Restriction and SIRT3 Trigger Global Reprogramming of the Mitochondrial Protein Acetylome

(2012) Alexander S. Hebert et al.   MOLECULAR CELL

Histone-modifying enzymes: regulators of developmental decisions and drivers of human disease

(2012) Jill S Butler et al.   Epigenomics

HDAC inhibitors and decitabine are highly synergistic and associated with unique gene-expression and epigenetic profiles in models of DLBCL

(2011) M. Kalac et al.   BLOOD

SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization

(2011) Lydia W.S. Finley et al.   CANCER CELL

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

(2011) Jake E. Delmore et al.   CELL

Class IIa Histone Deacetylases Are Hormone-Activated Regulators of FOXO and Mammalian Glucose Homeostasis

(2011) Maria M. Mihaylova et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

CPTH6, a Thiazole Derivative, Induces Histone Hypoacetylation and Apoptosis in Human Leukemia Cells

(2011) D. Trisciuoglio et al.   CLINICAL CANCER RESEARCH

Entinostat for treatment of solid tumors and hematologic malignancies

(2011) Jeffrey Knipstein et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Multiple Site Acetylation of Rictor Stimulates Mammalian Target of Rapamycin Complex 2 (mTORC2)-dependent Phosphorylation of Akt Protein

(2011) Emily J. Glidden et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mocetinostat for relapsed classical Hodgkin's lymphoma: an open-label, single-arm, phase 2 trial

(2011) Anas Younes et al.   LANCET ONCOLOGY

HDAC5 and HDAC9 in Medulloblastoma: Novel Markers for Risk Stratification and Role in Tumor Cell Growth

(2010) T. Milde et al.   CLINICAL CANCER RESEARCH

Macrocyclic Histone Deacetylase Inhibitors

(2010) Sandra C. Mwakwari et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

The Role of HDAC6 in Cancer

(2010) Grace I. Aldana-Masangkay et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

The Tale of Protein Lysine Acetylation in the Cytoplasm

(2010) Karin Sadoul et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Physical and Functional HAT/HDAC Interplay Regulates Protein Acetylation Balance

(2010) Alessia Peserico et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Selective inhibition of BET bromodomains

(2010) Panagis Filippakopoulos et al.   NATURE

Histone H3K27ac separates active from poised enhancers and predicts developmental state

(2010) M. P. Creyghton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The major  -tubulin K40 acetyltransferase  TAT1 promotes rapid ciliogenesis and efficient mechanosensation

(2010) T. Shida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Cellular Metabolism by Protein Lysine Acetylation

(2010) S. Zhao et al.   SCIENCE

DNMT1 Stability Is Regulated by Proteins Coordinating Deubiquitination and Acetylation-Driven Ubiquitination

(2010) Z. Du et al.   Science Signaling

Genome-wide Mapping of HATs and HDACs Reveals Distinct Functions in Active and Inactive Genes

(2009) Zhibin Wang et al.   CELL

Cytotoxicity Mediated by Histone Deacetylase Inhibitors in Cancer Cells: Mechanisms and Potential Clinical Implications

(2009) D. S. Schrump   CLINICAL CANCER RESEARCH

Hypoxia-inducible factor-1α blocks differentiation of malignant gliomas

(2009) Huimin Lu et al.   FEBS Journal

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

(2009) K. E. Wellen et al.   SCIENCE

ATP Citrate Lyase: Activation and Therapeutic Implications in Non-Small Cell Lung Cancer

(2008) T. Migita et al.   CANCER RESEARCH

An Inactivating Mutation in HDAC2 Leads to Dysregulation of Apoptosis Mediated by APAF1

(2008) Christin L. Hanigan et al.   GASTROENTEROLOGY

Acetylation of non-histone proteins modulates cellular signalling at multiple levels

(2008) Stephanie Spange et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Two Endoplasmic Reticulum (ER)/ER Golgi Intermediate Compartment-based Lysine Acetyltransferases Post-translationally Regulate BACE1 Levels

(2008) Mi Hee Ko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Histone Acetyltransferase Inhibitor Modulating Gcn5 Network: Cyclopentylidene-[4-(4′-chlorophenyl)thiazol-2-yl)hydrazone

(2008) Franco Chimenti et al.   JOURNAL OF MEDICINAL CHEMISTRY

Combinatorial patterns of histone acetylations and methylations in the human genome

(2008) Zhibin Wang et al.   NATURE GENETICS