The Cap-Binding Complex CBC and the Eukaryotic Translation Factor eIF4E: Co-Conspirators in Cap-Dependent RNA Maturation and Translation

Translation initiation in cancer at a glance

(2021) Rachael C. L. Smith et al.   JOURNAL OF CELL SCIENCE

Cytoplasmic cleavage of IMPA1 3′ UTR is necessary for maintaining axon integrity

(2021) Catia Andreassi et al.   Cell Reports

To cap it all off, again: dynamic capping and recapping of coding and non-coding RNAs to control transcript fate and biological activity

(2021) KLB Borden et al.   CELL CYCLE

Translation mediated by the nuclear cap-binding complex is confined to the perinuclear region via a CTIF–DDX19B interaction

(2021) Yeonkyoung Park et al.   NUCLEIC ACIDS RESEARCH

Revealing molecular pathways for cancer cell fitness through a genetic screen of the cancer translatome

(2021) Duygu Kuzuoglu-Ozturk et al.   Cell Reports

Alternative polyadenylation: An enigma of transcript length variation in health and disease

(2021) Neeraja K. Mohanan et al.   Wiley Interdisciplinary Reviews-RNA

Emerging Roles for 3′ UTRs in Neurons

(2020) Bongmin Bae et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The diversity, plasticity, and adaptability of cap-dependent translation initiation and the associated machinery

(2020) Katherine L.B. Borden et al.   RNA Biology

The nuclear cap-binding complex as choreographer of gene transcription and pre-mRNA processing

(2020) Xavier Rambout et al.   GENES & DEVELOPMENT

NCBP3 positively impacts mRNA biogenesis

(2020) Yuhui Dou et al.   NUCLEIC ACIDS RESEARCH

The eukaryotic translation initiation factor eIF4E elevates steady-state m7G capping of coding and noncoding transcripts

(2020) Biljana Culjkovic-Kraljacic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NCBP3: A Multifaceted Adaptive Regulator of Gene Expression

(2020) Xavier Rambout et al.   TRENDS IN BIOCHEMICAL SCIENCES

Polyadenylation and nuclear export of mRNAs

(2019) Murray Stewart   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear eIF4E Stimulates 3′-End Cleavage of Target RNAs

(2019) Margaret Rose Davis et al.   Cell Reports

Eukaryotic initiation factor 4E (eIF4E): A recap of the cap‐binding protein

(2019) Asiya Batool et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Staufen1 and UPF1 exert opposite actions on the replacement of the nuclear cap-binding complex by eIF4E at the 5′ end of mRNAs

(2019) Kwon Jeong et al.   NUCLEIC ACIDS RESEARCH

CPSF3 is a promising prognostic biomarker and predicts recurrence of non‑small cell lung cancer

(2019) Yue Ning et al.   Oncology Letters

NCBP1 promotes the development of lung adenocarcinoma through up‐regulation of CUL4B

(2019) Huijun Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

A Complex of U1 snRNP with Cleavage and Polyadenylation Factors Controls Telescripting, Regulating mRNA Transcription in Human Cells

(2019) Byung Ran So et al.   MOLECULAR CELL

Quantifying the RNA cap epitranscriptome reveals novel caps in cellular and viral RNA

(2019) Jin Wang et al.   NUCLEIC ACIDS RESEARCH

JTE-607, a multiple cytokine production inhibitor, targets CPSF3 and inhibits pre-mRNA processing

(2019) Junya Kakegawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structural studies of the eIF4E–VPg complex reveal a direct competition for capped RNA: Implications for translation

(2019) Luciana Coutinho de Oliveira et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing’s sarcoma

(2019) Nathan T. Ross et al.   Nature Chemical Biology

RNA regulons in cancer and inflammation

(2018) Laura Simone Bisogno et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Signaling Pathways Involved in the Regulation of mRNA Translation

(2018) Philippe P. Roux et al.   MOLECULAR AND CELLULAR BIOLOGY

Translation Elongation and Recoding in Eukaryotes

(2018) Thomas E. Dever et al.   Cold Spring Harbor Perspectives in Biology

Alternative-splicing defects in cancer: Splicing regulators and their downstream targets, guiding the way to novel cancer therapeutics

(2018) Laura M. Urbanski et al.   Wiley Interdisciplinary Reviews-RNA

A Rev–CBP80–eIF4AI complex drives Gag synthesis from the HIV-1 unspliced mRNA

(2018) Daniela Toro-Ascuy et al.   NUCLEIC ACIDS RESEARCH

A widespread alternate form of cap-dependent mRNA translation initiation

(2018) Columba de la Parra et al.   Nature Communications

mRNA cap regulation in mammalian cell function and fate

(2018) Alison Galloway et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Targeting EIF4E signaling with ribavirin in infant acute lymphoblastic leukemia

(2018) Karen A. Urtishak et al.   ONCOGENE

RNA G-quadruplex secondary structure promotes alternative splicing via the RNA-binding protein hnRNPF

(2017) Huilin Huang et al.   GENES & DEVELOPMENT

Phase I study of induction chemotherapy with afatinib, ribavirin, and weekly carboplatin and paclitaxel for stage IVA/IVB human papillomavirus-associated oropharyngeal squamous cell cancer

(2017) Lara A. Dunn et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

4EGI-1 represses cap-dependent translation and regulates genome-wide translation in malignant pleural mesothelioma

(2017) Arpita De et al.   INVESTIGATIONAL NEW DRUGS

RNA guanine-7 methyltransferase catalyzes the methylation of cytoplasmically recapped RNAs

(2017) Jackson B. Trotman et al.   NUCLEIC ACIDS RESEARCH

ALYREF mainly binds to the 5′ and the 3′ regions of the mRNA in vivo

(2017) Min Shi et al.   NUCLEIC ACIDS RESEARCH

A biochemical framework for eIF4E-dependent mRNA export and nuclear recycling of the export machinery

(2017) Laurent Volpon et al.   RNA

Structural basis for mutually exclusive co-transcriptional nuclear cap-binding complexes with either NELF-E or ARS2

(2017) Wiebke Manuela Schulze et al.   Nature Communications

Post-transcriptional 3´-UTR cleavage of mRNA transcripts generates thousands of stable uncapped autonomous RNA fragments

(2017) Yuval Malka et al.   Nature Communications

The eukaryotic translation initiation factor eIF4E harnesses hyaluronan production to drive its malignant activity

(2017) Hiba Ahmad Zahreddine et al.   eLife

La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs

(2017) Roni M Lahr et al.   eLife

Targeting the mTOR Pathway in Leukemia

(2016) Shira Dinner et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Migration and epithelial-to-mesenchymal transition of lung cancer can be targeted via translation initiation factors eIF4E and eIF4GI

(2016) Oshrat Attar-Schneider et al.   LABORATORY INVESTIGATION

Elevated Translation Initiation Factor eIF4E Is an Attractive Therapeutic Target in Multiple Myeloma

(2016) S. Li et al.   MOLECULAR CANCER THERAPEUTICS

CDK1-Cyclin B1 Activates RNMT, Coordinating mRNA Cap Methylation with G1 Phase Transcription

(2016) Michael Aregger et al.   MOLECULAR CELL

eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation

(2016) Amy S. Y. Lee et al.   NATURE

Alternative polyadenylation of mRNA precursors

(2016) Bin Tian et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Importin 8 mediates m7G cap-sensitive nuclear import of the eukaryotic translation initiation factor eIF4E

(2016) Laurent Volpon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

eIF4E promotes tumorigenesis and modulates chemosensitivity to cisplatin in esophageal squamous cell carcinoma

(2016) Ting Liu et al.   Oncotarget

A Transcript-Specific eIF3 Complex Mediates Global Translational Control of Energy Metabolism

(2016) Meera Shah et al.   Cell Reports

mRNA Cap Methylation in Pluripotency and Differentiation

(2016) Laura Grasso et al.   Cell Reports

New insights into decapping enzymes and selective mRNA decay

(2016) Ewa Grudzien-Nogalska et al.   Wiley Interdisciplinary Reviews-RNA

Modulating splicing with small molecular inhibitors of the spliceosome

(2016) Kerstin A. Effenberger et al.   Wiley Interdisciplinary Reviews-RNA

Combinatorial targeting of nuclear export and translation of RNA inhibits aggressive B-cell lymphomas

(2015) B. Culjkovic-Kraljacic et al.   BLOOD

Genetic and Pharmacologic Inhibition of eIF4E Reduces Breast Cancer Cell Migration, Invasion, and Metastasis

(2015) F. Pettersson et al.   CANCER RESEARCH

Differential Requirements for eIF4E Dose in Normal Development and Cancer

(2015) Morgan L. Truitt et al.   CELL

Detained introns are a novel, widespread class of post-transcriptionally spliced introns

(2015) Paul L. Boutz et al.   GENES & DEVELOPMENT

Mutagenesis of ARS2 Domains To Assess Possible Roles in Cell Cycle Progression and MicroRNA and Replication-Dependent Histone mRNA Biogenesis

(2015) Connor O'Sullivan et al.   MOLECULAR AND CELLULAR BIOLOGY

SRSF1-Regulated Alternative Splicing in Breast Cancer

(2015) Olga Anczuków et al.   MOLECULAR CELL

mRNA export through an additional cap-binding complex consisting of NCBP1 and NCBP3

(2015) Anna Gebhardt et al.   Nature Communications

eIF4E and eIF4GI have distinct and differential imprints on multiple myeloma's proteome and signaling

(2015) Oshrat Attar-Schneider et al.   Oncotarget

4EGI-1 targets breast cancer stem cells by selective inhibition of translation that persists in CSC maintenance, proliferation and metastasis

(2015) Tingfang Yi et al.   Oncotarget

The Scanning Mechanism of Eukaryotic Translation Initiation

(2014) Alan G. Hinnebusch   Annual Review of Biochemistry

Cancer Cells Exploit eIF4E2-Directed Synthesis of Hypoxia Response Proteins to Drive Tumor Progression

(2014) J. Uniacke et al.   CANCER RESEARCH

A phase I trial of ribavirin and low-dose cytarabine for the treatment of relapsed and refractory acute myeloid leukemia with elevated eIF4E

(2014) S. Assouline et al.   HAEMATOLOGICA

Multiple myeloma proteostasis can be targeted via translation initiation factor eIF4E

(2014) VICTORIA ZISMANOV et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation

(2014) Hiba Ahmad Zahreddine et al.   NATURE

eIF4AIII enhances translation of nuclear cap-binding complex-bound mRNAs by promoting disruption of secondary structures in 5'UTR

(2014) J. Choe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Implications of polyadenylation in health and disease

(2014) Ana Curinha et al.   Nucleus

Conformational changes induced in the eukaryotic translation initiation factor eIF4E by a clinically relevant inhibitor, ribavirin triphosphate

(2013) Laurent Volpon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cap-binding complex (CBC)

(2013) Thomas Gonatopoulos-Pournatzis et al.   BIOCHEMICAL JOURNAL

The Oncogene eIF4E: Using Biochemical Insights to Target Cancer

(2013) Martin Carroll et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

CBC–ARS2 stimulates 3′-end maturation of multiple RNA families and favors cap-proximal processing

(2013) Marie Hallais et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

eIF4E-bound mRNPs are substrates for nonsense-mediated mRNA decay in mammalian cells

(2013) Simone C Rufener et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The nuclear cap-binding complex interacts with the U4/U6{middle dot}U5 tri-snRNP and promotes spliceosome assembly in mammalian cells

(2013) M. Pabis et al.   RNA

Aiding and abetting cancer: mRNA export and the nuclear pore

(2013) Biljana Culjkovic-Kraljacic et al.   TRENDS IN CELL BIOLOGY

Postage for the messenger: designating routes for nuclear mRNA export

(2013) Barbara J. Natalizio et al.   TRENDS IN CELL BIOLOGY

Means to an end: mechanisms of alternative polyadenylation of messenger RNA precursors

(2013) Andreas R. Gruber et al.   Wiley Interdisciplinary Reviews-RNA

Ars2 Promotes Proper Replication-Dependent Histone mRNA 3′ End Formation

(2012) Joshua J. Gruber et al.   MOLECULAR CELL

Rapid degradation of replication-dependent histone mRNAs largely occurs on mRNAs bound by nuclear cap-binding proteins 80 and 20

(2012) Junho Choe et al.   NUCLEIC ACIDS RESEARCH

Post-transcriptional spliceosomes are retained in nuclear speckles until splicing completion

(2012) Cyrille Girard et al.   Nature Communications

The Oncogene eIF4E Reprograms the Nuclear Pore Complex to Promote mRNA Export and Oncogenic Transformation

(2012) Biljana Culjkovic-Kraljacic et al.   Cell Reports

Identification of Cytoplasmic Capping Targets Reveals a Role for Cap Homeostasis in Translation and mRNA Stability

(2012) Chandrama Mukherjee et al.   Cell Reports

Thriving under Stress: Selective Translation of HIV-1 Structural Protein mRNA during Vpr-Mediated Impairment of eIF4E Translation Activity

(2012) Amit Sharma et al.   PLoS Pathogens

The significant other: splicing by the minor spliceosome

(2012) Janne J. Turunen et al.   Wiley Interdisciplinary Reviews-RNA

The Development of Novel Therapies for the Treatment of Acute Myeloid Leukemia (AML)

(2012) Sarit Assouline et al.   Cancers

mRNA export and the TREX complex

(2011) Jun Katahira   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Single-Molecule Imaging of Transcriptionally Coupled and Uncoupled Splicing

(2011) Diana Y. Vargas et al.   CELL

Ribavirin Treatment Effects on Breast Cancers Overexpressing eIF4E, a Biomarker with Prognostic Specificity for Luminal B-Type Breast Cancer

(2011) F. Pettersson et al.   CLINICAL CANCER RESEARCH

A Phase 1 Dose Escalation, Pharmacokinetic, and Pharmacodynamic Evaluation of eIF-4E Antisense Oligonucleotide LY2275796 in Patients with Advanced Cancer

(2011) D. S. Hong et al.   CLINICAL CANCER RESEARCH

Ending the message: poly(A) signals then and now

(2011) N. J. Proudfoot   GENES & DEVELOPMENT

Cap-binding Protein Complex Links Pre-mRNA Capping to Transcription Elongation and Alternative Splicing through Positive Transcription Elongation Factor b (P-TEFb)

(2011) Tina Lenasi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of eIF4E with ribavirin cooperates with common chemotherapies in primary acute myeloid leukemia specimens

(2011) B C Kraljacic et al.   LEUKEMIA

Yeast mRNA cap-binding protein Cbc1/Sto1 is necessary for the rapid reprogramming of translation after hyperosmotic shock

(2011) Elena Garre et al.   MOLECULAR BIOLOGY OF THE CELL

RAM/Fam103a1 Is Required for mRNA Cap Methylation

(2011) Thomas Gonatopoulos-Pournatzis et al.   MOLECULAR CELL

Structure of the guanylyltransferase domain of human mRNA capping enzyme

(2011) C. Chu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Pioneer Round of Translation: Features and Functions

(2010) Lynne E. Maquat et al.   CELL

ATP is required for interactions between UAP56 and two conserved mRNA export proteins, Aly and CIP29, to assemble the TREX complex

(2010) K. Dufu et al.   GENES & DEVELOPMENT

Intron retention facilitates splice variant diversity in calcium-activated big potassium channel populations

(2010) T. J. Bell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and functional analysis of the interaction between the nucleoporin Nup98 and the mRNA export factor Rae1

(2010) Y. Ren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and functional insights into eukaryotic mRNA decapping

(2010) Sharon H. M. Ling et al.   Wiley Interdisciplinary Reviews-RNA

Cap and cap-binding proteins in the control of gene expression

(2010) Ivan Topisirovic et al.   Wiley Interdisciplinary Reviews-RNA

Regulation of mRNA cap methylation

(2009) Victoria H. Cowling   BIOCHEMICAL JOURNAL

Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): a proof-of-principle clinical trial with ribavirin

(2009) S. Assouline et al.   BLOOD

The Spliceosome: Design Principles of a Dynamic RNP Machine

(2009) Markus C. Wahl et al.   CELL

Molecular dissection of the eukaryotic initiation factor 4E (eIF4E) export-competent RNP

(2009) Ivan Topisirovic et al.   EMBO JOURNAL

A new MIF4G domain-containing protein, CTIF, directs nuclear cap-binding protein CBP80/20-dependent translation

(2009) K. M. Kim et al.   GENES & DEVELOPMENT

Identification of a Cytoplasmic Complex That Adds a Cap onto 5'-Monophosphate RNA

(2009) Y. Otsuka et al.   MOLECULAR AND CELLULAR BIOLOGY

Enhanced mRNA cap methylation increases Cyclin D1 expression and promotes cell transformation

(2009) V H Cowling   ONCOGENE

Co-transcriptional splicing of constitutive and alternative exons

(2009) A. Pandya-Jones et al.   RNA

Re-capping the message

(2009) Daniel R. Schoenberg et al.   TRENDS IN BIOCHEMICAL SCIENCES

Understanding and Targeting the Eukaryotic Translation Initiation Factor eIF4E in Head and Neck Cancer

(2009) Biljana Culjkovic et al.   Journal of Oncology

Apoptosis and Autophagy Induction in Mammalian Cells by Small Interfering RNA Knockdown of mRNA Capping Enzymes

(2008) C. Chu et al.   MOLECULAR AND CELLULAR BIOLOGY

Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing

(2008) Qun Pan et al.   NATURE GENETICS

Transcriptome-Wide Analysis of Uncapped mRNAs in Arabidopsis Reveals Regulation of mRNA Degradation

(2008) Y. Jiao et al.   PLANT CELL