Targeting EIF4E signaling with ribavirin in infant acute lymphoblastic leukemia

Inhibition of eukaryotic translation initiation factor 4E is effective against chemo-resistance in colon and cervical cancer

(2018) Changlei Xi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A phase 1/2a trial of docetaxel plus ribavirin for reprogramming efficacy in patients with progressive metastatic castration resistant prostate cancer who have previously received docetaxel alone: DRREEM trial.

(2018) Takeo Kosaka et al.   JOURNAL OF CLINICAL ONCOLOGY

Autophagy suppression sensitizes glioma cells to IMP dehydrogenase inhibition-induced apoptotic death

(2017) Andjelka M. Isakovic et al.   EXPERIMENTAL CELL RESEARCH

Phase I study of induction chemotherapy with afatinib, ribavirin, and weekly carboplatin and paclitaxel for stage IVA/IVB human papillomavirus-associated oropharyngeal squamous cell cancer

(2017) Lara A. Dunn et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Trends in childhood leukemia incidence over two decades from 1992 to 2013

(2016) Jessica L. Barrington-Trimis et al.   INTERNATIONAL JOURNAL OF CANCER

Use of an anti-viral drug, Ribavirin, as an anti-glioblastoma therapeutic

(2016) F Volpin et al.   ONCOGENE

Importin 8 mediates m7G cap-sensitive nuclear import of the eukaryotic translation initiation factor eIF4E

(2016) Laurent Volpon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combinatorial targeting of nuclear export and translation of RNA inhibits aggressive B-cell lymphomas

(2015) B. Culjkovic-Kraljacic et al.   BLOOD

Genetic and Pharmacologic Inhibition of eIF4E Reduces Breast Cancer Cell Migration, Invasion, and Metastasis

(2015) F. Pettersson et al.   CANCER RESEARCH

Anti-tumor effect of ribavirin in combination with interferon-α on renal cell carcinoma cell lines in vitro

(2014) Lichen Teng et al.   Cancer Cell International

A phase I trial of ribavirin and low-dose cytarabine for the treatment of relapsed and refractory acute myeloid leukemia with elevated eIF4E

(2014) S. Assouline et al.   HAEMATOLOGICA

The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation

(2014) Hiba Ahmad Zahreddine et al.   NATURE

Intensified chemotherapy without SCT in infant ALL: Results from COG P9407 (Cohort 3)

(2014) ZoAnn E. Dreyer et al.   PEDIATRIC BLOOD & CANCER

Efficacy of ribavirin against malignant glioma cell lines

(2014) AKIYOSHI OGINO et al.   Oncology Letters

MNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven mRNA translation in DLBCL

(2014) Ari L. Landon et al.   Nature Communications

Conformational changes induced in the eukaryotic translation initiation factor eIF4E by a clinically relevant inhibitor, ribavirin triphosphate

(2013) Laurent Volpon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Potent obatoclax cytotoxicity and activation of triple death mode killing across infant acute lymphoblastic leukemia

(2013) K. A. Urtishak et al.   BLOOD

Designing Novel Therapies Against Sarcomas in the Era of Personalized Medicine and Economic Crisis

(2013) Maria Manara et al.   CURRENT PHARMACEUTICAL DESIGN

Drug Repurposing for Gastrointestinal Stromal Tumor

(2013) Z. Y. Pessetto et al.   MOLECULAR CANCER THERAPEUTICS

An evaluation of small-molecule p53 activators as chemoprotectants ameliorating adverse effects of anticancer drugs in normal cells

(2012) Ingeborg M.M. van Leeuwen et al.   CELL CYCLE

Improved Survival for Children and Adolescents With Acute Lymphoblastic Leukemia Between 1990 and 2005: A Report From the Children's Oncology Group

(2012) Stephen P. Hunger et al.   JOURNAL OF CLINICAL ONCOLOGY

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Gene expression profiles predictive of outcome and age in infant acute lymphoblastic leukemia: a Children's Oncology Group study

(2011) H. Kang et al.   BLOOD

Database identifies FDA-approved drugs with potential to be repurposed for treatment of orphan diseases

(2011) K. Xu et al.   BRIEFINGS IN BIOINFORMATICS

Ribavirin Treatment Effects on Breast Cancers Overexpressing eIF4E, a Biomarker with Prognostic Specificity for Luminal B-Type Breast Cancer

(2011) F. Pettersson et al.   CLINICAL CANCER RESEARCH

Interpretation of cellular proliferation data: Avoid the panglossian

(2011) Mario Roederer   CYTOMETRY PART A

In silico repositioning of approved drugs for rare and neglected diseases

(2011) Sean Ekins et al.   DRUG DISCOVERY TODAY

MicroRNA characterize genetic diversity and drug resistance in pediatric acute lymphoblastic leukemia

(2011) D. Schotte et al.   HAEMATOLOGICA

Vincristine pharmacodynamics and pharmacogenetics in children with cancer: A limited-sampling, population modelling approach

(2011) Andrew S Moore et al.   JOURNAL OF PAEDIATRICS AND CHILD HEALTH

Inhibition of eIF4E with ribavirin cooperates with common chemotherapies in primary acute myeloid leukemia specimens

(2011) B C Kraljacic et al.   LEUKEMIA

An improved technique for calculating relative response in cellular proliferation experiments

(2010) Mark E. Munson   CYTOMETRY PART A

The eIF2 Kinase GCN2 Is Essential for the Murine Immune System to Adapt to Amino Acid Deprivation by Asparaginase1–3

(2010) Piyawan Bunpo et al.   JOURNAL OF NUTRITION

Perspectives on inhibiting mTOR as a future treatment strategy for hematological malignancies

(2010) N Chapuis et al.   LEUKEMIA

Ribavirin as an anti-cancer therapy: acute myeloid leukemia and beyond?

(2010) Katherine L. B. Borden et al.   LEUKEMIA & LYMPHOMA

Gene expression profiling-based dissection of MLL translocated and MLL germline acute lymphoblastic leukemia in infants

(2009) R. W. Stam et al.   BLOOD

Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): a proof-of-principle clinical trial with ribavirin

(2009) S. Assouline et al.   BLOOD

c-Myc and eIF4F Constitute a Feedforward Loop That Regulates Cell Growth: Implications for Anticancer Therapy

(2009) C.-J. Lin et al.   CANCER RESEARCH

Two independent gene signatures in pediatric t(4;11) acute lymphoblastic leukemia patients

(2009) Luca Trentin et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

GCN2 Protein Kinase Is Required to Activate Amino Acid Deprivation Responses in Mice Treated with the Anti-cancer Agent l-Asparaginase

(2009) Piyawan Bunpo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of Nucleoside Transporters in the Erythrocyte Disposition and Oral Absorption of Ribavirin in the Wild-Type and Equilibrative Nucleoside Transporter 1(-/-) Mice

(2009) C. J. Endres et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Original Research: Intravenous Ribavirin—Review of the FDA's Emergency Investigational New Drug Database (1997–2008) and Literature Review

(2009) Andrea Riner et al.   POSTGRADUATE MEDICINE

Understanding and Targeting the Eukaryotic Translation Initiation Factor eIF4E in Head and Neck Cancer

(2009) Biljana Culjkovic et al.   Journal of Oncology

Ribavirin targets eIF4E dependent Akt survival signaling

(2008) Keith Tan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

HOXA9 is required for survival in human MLL-rearranged acute leukemias

(2008) J. Faber et al.   BLOOD

Abundant anti-apoptotic BCL-2 is a molecular target in leukaemias with t(4;11) translocation

(2008) Blaine W. Robinson et al.   BRITISH JOURNAL OF HAEMATOLOGY

Acute leukemia as a secondary malignancy in children and adolescents: Current findings and issues

(2008) Nobuko Hijiya et al.   CANCER

The eIF4E RNA regulon promotes the Akt signaling pathway

(2008) Biljana Culjkovic et al.   JOURNAL OF CELL BIOLOGY

Asparaginase May Influence Dexamethasone Pharmacokinetics in Acute Lymphoblastic Leukemia

(2008) Lei Yang et al.   JOURNAL OF CLINICAL ONCOLOGY

Stability of Eukaryotic Translation Initiation Factor 4E mRNA Is Regulated by HuR, and This Activity Is Dysregulated in Cancer

(2008) I. Topisirovic et al.   MOLECULAR AND CELLULAR BIOLOGY