The nuclear cap-binding complex as choreographer of gene transcription and pre-mRNA processing

The role of Mediator and Little Elongation Complex in transcription termination

(2020) Hidehisa Takahashi et al.   Nature Communications

Structure and mechanism of the RNA polymerase II transcription machinery

(2020) Allison C. Schier et al.   GENES & DEVELOPMENT

NELF Regulates a Promoter-Proximal Step Distinct from RNA Pol II Pause-Release

(2020) Yuki Aoi et al.   MOLECULAR CELL

A Collection of Pre-mRNA Splicing Mutants in Arabidopsis thaliana

(2020) Tatsuo Kanno et al.   G3-Genes Genomes Genetics

Paip2 cooperates with Cbp80 at an active promoter and participates in RNA Polymerase II phosphorylation in Drosophila

(2019) Zaur M. Kachaev et al.   FEBS LETTERS

Promoter-proximal pausing of RNA polymerase II: a nexus of gene regulation

(2019) Leighton Core et al.   GENES & DEVELOPMENT

Genetic abnormalities and pathophysiology of MDS

(2019) Naoko Hosono   International Journal of Clinical Oncology

Quality and quantity control of gene expression by nonsense-mediated mRNA decay

(2019) Tatsuaki Kurosaki et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

CDK12 controls G1/S progression by regulating RNAPII processivity at core DNA replication genes

(2019) Anil Paul Chirackal Manavalan et al.   EMBO REPORTS

A Complex of U1 snRNP with Cleavage and Polyadenylation Factors Controls Telescripting, Regulating mRNA Transcription in Human Cells

(2019) Byung Ran So et al.   MOLECULAR CELL

Nascent RNA and the Coordination of Splicing with Transcription

(2019) Karla M. Neugebauer   Cold Spring Harbor Perspectives in Biology

The Intrinsically Disordered C-Terminal Domain Triggers Nucleolar Localization and Function Switch of PARN in Response to DNA Damage

(2019) Duan et al.   Cells

The capping enzyme facilitates promoter escape and assembly of a follow-on preinitiation complex for reinitiation

(2019) Rina Fujiwara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exon-Mediated Activation of Transcription Starts

(2019) Ana Fiszbein et al.   CELL

A unified allosteric/torpedo mechanism for transcriptional termination on human protein-coding genes

(2019) Joshua D. Eaton et al.   GENES & DEVELOPMENT

Arabidopsis Serrate Coordinates Histone Methyltransferases ATXR5/6 and RNA Processing Factor RDR6 to Regulate Transposon Expression

(2018) Zeyang Ma et al.   DEVELOPMENTAL CELL

Transcriptional coactivator PGC-1α contains a novel CBP80-binding motif that orchestrates efficient target gene expression

(2018) Hana Cho et al.   GENES & DEVELOPMENT

Cdc48/VCP Promotes Chromosome Morphogenesis by Releasing Condensin from Self-Entrapment in Chromatin

(2018) Yogitha Thattikota et al.   MOLECULAR CELL

Eukaryotic core promoters and the functional basis of transcription initiation

(2018) Vanja Haberle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural analysis of human ARS2 as a platform for co-transcriptional RNA sorting

(2018) Wiebke Manuela Schulze et al.   Nature Communications

Cdk9 regulates a promoter-proximal checkpoint to modulate RNA polymerase II elongation rate in fission yeast

(2018) Gregory T. Booth et al.   Nature Communications

Structural and biochemical analysis of a NOT1 MIF4G-like domain of the CCR4-NOT complex

(2018) Tobias Raisch et al.   JOURNAL OF STRUCTURAL BIOLOGY

The U1 snRNP subunit LUC7 modulates plant development and stress responses via regulation of alternative splicing

(2018) Marcella de Francisco Amorim et al.   PLANT CELL

RNA G-quadruplex secondary structure promotes alternative splicing via the RNA-binding protein hnRNPF

(2017) Huilin Huang et al.   GENES & DEVELOPMENT

ARS2 is a general suppressor of pervasive transcription

(2017) Claudia Iasillo et al.   NUCLEIC ACIDS RESEARCH

The conserved AU dinucleotide at the 5′ end of nascent U1 snRNA is optimized for the interaction with nuclear cap-binding-complex

(2017) Chung-Shu Yeh et al.   NUCLEIC ACIDS RESEARCH

Cleavage and polyadenylation: Ending the message expands gene regulation

(2017) Jonathan Neve et al.   RNA Biology

Structural basis for mutually exclusive co-transcriptional nuclear cap-binding complexes with either NELF-E or ARS2

(2017) Wiebke Manuela Schulze et al.   Nature Communications

Mutually Exclusive CBC-Containing Complexes Contribute to RNA Fate

(2017) Simone Giacometti et al.   Cell Reports

Regulation of expression of human RNA polymerase II-transcribed snRNA genes

(2017) Joana Guiro et al.   Open Biology

The role of TREX in gene expression and disease

(2016) C. G. Heath et al.   BIOCHEMICAL JOURNAL

The mRNA cap-binding protein Cbc1 is required for high and timely expression of genes by promoting the accumulation of gene-specific activators at promoters

(2016) Tianlu Li et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Divergence of a conserved elongation factor and transcription regulation in budding and fission yeast

(2016) Gregory T. Booth et al.   GENOME RESEARCH

Enhancer of Rudimentary Cooperates with Conserved RNA-Processing Factors to Promote Meiotic mRNA Decay and Facultative Heterochromatin Assembly

(2016) Tomoyasu Sugiyama et al.   MOLECULAR CELL

Comprehensive Identification of RNA-Binding Domains in Human Cells

(2016) Alfredo Castello et al.   MOLECULAR CELL

Identification of a Nuclear Exosome Decay Pathway for Processed Transcripts

(2016) Nicola Meola et al.   MOLECULAR CELL

Transcriptomic comparison ofDrosophilasnRNP biogenesis mutants reveals mutant-specific changes in pre-mRNA processing: implications for spinal muscular atrophy

(2016) Eric L. Garcia et al.   RNA

Mutagenesis of ARS2 Domains To Assess Possible Roles in Cell Cycle Progression and MicroRNA and Replication-Dependent Histone mRNA Biogenesis

(2015) Connor O'Sullivan et al.   MOLECULAR AND CELLULAR BIOLOGY

SRSF1-Regulated Alternative Splicing in Breast Cancer

(2015) Olga Anczuków et al.   MOLECULAR CELL

Molecular Basis of Transcription-Coupled Pre-mRNA Capping

(2015) Fuensanta W. Martinez-Rucobo et al.   MOLECULAR CELL

Transcription termination and the control of the transcriptome: why, where and how to stop

(2015) Odil Porrua et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A positioned +1 nucleosome enhances promoter-proximal pausing

(2015) Silvia Jimeno-González et al.   NUCLEIC ACIDS RESEARCH

mRNA export through an additional cap-binding complex consisting of NCBP1 and NCBP3

(2015) Anna Gebhardt et al.   Nature Communications

Human Telomerase RNA Processing and Quality Control

(2015) Chi-Kang Tseng et al.   Cell Reports

H2B ubiquitylation modulates spliceosome assembly and function in budding yeast

(2014) Lucas Hérissant et al.   BIOLOGY OF THE CELL

A Splicing-Dependent Transcriptional Checkpoint Associated with Prespliceosome Formation

(2014) Keerthi T. Chathoth et al.   MOLECULAR CELL

Nucleosomes Are Context-Specific, H2A.Z-Modulated Barriers to RNA Polymerase

(2014) Christopher M. Weber et al.   MOLECULAR CELL

Coupling mRNA processing with transcription in time and space

(2014) David L. Bentley   NATURE REVIEWS GENETICS

Good cap/bad cap: how the cap-binding complex determines RNA fate

(2014) Michaela Müller-McNicoll et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mass spectrometry-based relative quantification of proteins in precatalytic and catalytically active spliceosomes by metabolic labeling (SILAC), chemical labeling (iTRAQ), and label-free spectral count

(2014) C. Schmidt et al.   RNA

Biological and clinical significance of epigenetic silencing of MARVELD1 gene in lung cancer

(2014) Ming Shi et al.   Scientific Reports

Binding properties and dynamic localization of an alternative isoform of the cap-binding complex subunit CBP20

(2014) Marta Pabis et al.   Nucleus

Cap-binding complex (CBC)

(2013) Thomas Gonatopoulos-Pournatzis et al.   BIOCHEMICAL JOURNAL

A Novel Role for Cet1p mRNA 5′-Triphosphatase in Promoter Proximal Accumulation of RNA Polymerase II in Saccharomyces cerevisiase

(2013) Shweta Lahudkar et al.   GENETICS

MARVELD1 regulates integrin β1-mediated cell adhesion and actin organization via inhibiting its pre-mRNA processing

(2013) Shan Wang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Cap Completion and C-Terminal Repeat Domain Kinase Recruitment Underlie the Initiation-Elongation Transition of RNA Polymerase II

(2013) M. Lidschreiber et al.   MOLECULAR AND CELLULAR BIOLOGY

CBC–ARS2 stimulates 3′-end maturation of multiple RNA families and favors cap-proximal processing

(2013) Marie Hallais et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The human cap-binding complex is functionally connected to the nuclear RNA exosome

(2013) Peter Refsing Andersen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural and functional analysis of the three MIF4G domains of nonsense-mediated decay factor UPF2

(2013) Marcello Clerici et al.   NUCLEIC ACIDS RESEARCH

The SERRATE protein is involved in alternative splicing in Arabidopsis thaliana

(2013) K. D. Raczynska et al.   NUCLEIC ACIDS RESEARCH

MARVELD1 Inhibits Nonsense-Mediated RNA Decay by Repressing Serine Phosphorylation of UPF1

(2013) Jianran Hu et al.   PLoS One

3'-End processing of histone pre-mRNAs in Drosophila: U7 snRNP is associated with FLASH and polyadenylation factors

(2013) I. Sabath et al.   RNA

The nuclear cap-binding complex interacts with the U4/U6{middle dot}U5 tri-snRNP and promotes spliceosome assembly in mammalian cells

(2013) M. Pabis et al.   RNA

HINT: High-quality protein interactomes and their applications in understanding human disease

(2012) Jishnu Das et al.   BMC Systems Biology

The Yeast Cap Binding Complex Modulates Transcription Factor Recruitment and Establishes Proper Histone H3K36 Trimethylation during Active Transcription

(2012) M. A. Hossain et al.   MOLECULAR AND CELLULAR BIOLOGY

A Complex Containing the CPSF73 Endonuclease and Other Polyadenylation Factors Associates with U7 snRNP and Is Recruited to Histone Pre-mRNA for 3'-End Processing

(2012) X.-C. Yang et al.   MOLECULAR AND CELLULAR BIOLOGY

Ars2 Promotes Proper Replication-Dependent Histone mRNA 3′ End Formation

(2012) Joshua J. Gruber et al.   MOLECULAR CELL

The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts

(2012) Alexander G. Baltz et al.   MOLECULAR CELL

Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans

(2012) Karen Adelman et al.   NATURE REVIEWS GENETICS

RNA Polymerase II Pausing Downstream of Core Histone Genes Is Different from Genes Producing Polyadenylated Transcripts

(2012) Krishanpal Anamika et al.   PLoS One

Genetic interactions of hypomorphic mutations in the m7G cap-binding pocket of yeast nuclear cap binding complex: An essential role for Cbc2 in meiosis via splicing of MER3 pre-mRNA

(2012) Z. R. Qiu et al.   RNA

hnRNP C Tetramer Measures RNA Length to Classify RNA Polymerase II Transcripts for Export

(2012) A. McCloskey et al.   SCIENCE

First Exon Length Controls Active Chromatin Signatures and Transcription

(2012) Nicole I. Bieberstein et al.   Cell Reports

Transcriptional Regulation inSaccharomyces cerevisiae: Transcription Factor Regulation and Function, Mechanisms of Initiation, and Roles of Activators and Coactivators

(2011) Steven Hahn et al.   GENETICS

Cap-binding Protein Complex Links Pre-mRNA Capping to Transcription Elongation and Alternative Splicing through Positive Transcription Elongation Factor b (P-TEFb)

(2011) Tina Lenasi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction Profiling Identifies the Human Nuclear Exosome Targeting Complex

(2011) Michal Lubas et al.   MOLECULAR CELL

The FRIGIDA Complex Activates Transcription ofFLC, a Strong Flowering Repressor inArabidopsis, by Recruiting Chromatin Modification Factors

(2011) Kyuha Choi et al.   PLANT CELL

The structure of human Cleavage Factor Imhints at functions beyond UGUA-specific RNA binding

(2011) Qin Yang et al.   RNA Biology

Nuclear deadenylation/polyadenylation factors regulate 3′ processing in response to DNA damage

(2010) Murat A Cevher et al.   EMBO JOURNAL

CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1

(2010) B. Bartkowiak et al.   GENES & DEVELOPMENT

The mRNA cap-binding complex stimulates the formation of pre-initiation complex at the promoter via its interaction with Mot1p in vivo

(2010) Shweta Lahudkar et al.   NUCLEIC ACIDS RESEARCH

RPL30 regulation of splicing reveals distinct roles for Cbp80 in U1 and U2 snRNP cotranscriptional recruitment

(2010) M. Bragulat et al.   RNA

Spliceosome Structure and Function

(2010) C. L. Will et al.   Cold Spring Harbor Perspectives in Biology

Topology and Regulation of the Human eIF4A/4G/4H Helicase Complex in Translation Initiation

(2009) Assen Marintchev et al.   CELL

Involvement of the nuclear cap-binding protein complex in alternative splicing in Arabidopsis thaliana

(2009) Katarzyna Dorota Raczynska et al.   NUCLEIC ACIDS RESEARCH

FRIGIDA Delays Flowering in Arabidopsis via a Cotranscriptional Mechanism Involving Direct Interaction with the Nuclear Cap-Binding Complex

(2009) N. Geraldo et al.   PLANT PHYSIOLOGY

7SK snRNP/P-TEFb couples transcription elongation with alternative splicing and is essential for vertebrate development

(2009) M. Barboric et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cotranscriptional Splicing Potentiates the mRNA Production from a Subset of Estradiol-Stimulated Genes

(2008) D. Bittencourt et al.   MOLECULAR AND CELLULAR BIOLOGY

A 5′ Splice Site Enhances the Recruitment of Basal Transcription Initiation Factors In Vivo

(2008) Christian Kroun Damgaard et al.   MOLECULAR CELL

Nucleosome organization in the Drosophila genome

(2008) Travis N. Mavrich et al.   NATURE

Metabolism and regulation of canonical histone mRNAs: life without a poly(A) tail

(2008) William F. Marzluff et al.   NATURE REVIEWS GENETICS

Dual roles of the nuclear cap-binding complex and SERRATE in pre-mRNA splicing and microRNA processing in Arabidopsis thaliana

(2008) S. Laubinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA