Migration and epithelial-to-mesenchymal transition of lung cancer can be targeted via translation initiation factors eIF4E and eIF4GI

miR-125a-3p targets MTA1 to suppress NSCLC cell proliferation, migration, and invasion

(2015) Hong Zhang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Genetic and Pharmacologic Inhibition of eIF4E Reduces Breast Cancer Cell Migration, Invasion, and Metastasis

(2015) F. Pettersson et al.   CANCER RESEARCH

MicroRNA-29b attenuates non-small cell lung cancer metastasis by targeting matrix metalloproteinase 2 and PTEN

(2015) Hongyan Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Secretome of human bone marrow mesenchymal stem cells: an emerging player in lung cancer progression and mechanisms of translation initiation

(2015) Oshrat Attar-Schneider et al.   TUMOR BIOLOGY

eIF4E and eIF4GI have distinct and differential imprints on multiple myeloma's proteome and signaling

(2015) Oshrat Attar-Schneider et al.   Oncotarget

Transforming Growth Factor-β1 Induced Epithelial Mesenchymal Transition is blocked by a chemical antagonist of translation factor eIF4E

(2015) K. A. Smith et al.   Scientific Reports

Combined inhibition of Hsp90 and the proteasome affects NSCLC proteostasis and attenuates cell migration

(2014) Victoria Zismanov et al.   ANTI-CANCER DRUGS

Targeting eIF4GI translation initiation factor affords an attractive therapeutic strategy in multiple myeloma

(2014) Oshrat Attar-Schneider et al.   CELLULAR SIGNALLING

Transcriptome-wide studies uncover the diversity of modes of mRNA recruitment to eukaryotic ribosomes

(2014) Ivan N. Shatsky et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

miR-96 downregulates RECK to promote growth and motility of non-small cell lung cancer cells

(2014) Haizhou Guo et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3

(2014) N Robichaud et al.   ONCOGENE

Expression of microRNA-96 and its potential functions by targeting FOXO3 in non-small cell lung cancer

(2014) Juan Li et al.   TUMOR BIOLOGY

Regulation of MicroRNAs by Natural Agents: New Strategies in Cancer Therapies

(2014) Neoh Hun Phuah et al.   Biomed Research International

Expression of Notch-1 and its clinical significance in different histological subtypes of human lung adenocarcinoma

(2013) Jiayuan Huang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

miR-146a Inhibits Cell Growth, Cell Migration and Induces Apoptosis in Non-Small Cell Lung Cancer Cells

(2013) Gang Chen et al.   PLoS One

Enzymatic Synthesis of RNAs Capped with Nucleotide Analogues Reveals the Molecular Basis for Substrate Selectivity of RNA Capping Enzyme: Impacts on RNA Metabolism

(2013) Moheshwarnath Issur et al.   PLoS One

ER homeostasis and motility of NSCLC cell lines can be therapeutically targeted with combined Hsp90 and HDAC inhibitors

(2013) Victoria Zismanov et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Translational control in the stress adaptive response of cancer cells: a novel role for the heat shock protein TRAP1

(2013) D S Matassa et al.   Cell Death & Disease

Elevated expression of eukaryotic translation initiation factor 4E is associated with proliferation, invasion and acquired resistance to erlotinib in lung cancer

(2012) Yikun Li et al.   CANCER BIOLOGY & THERAPY

The translational landscape of mTOR signalling steers cancer initiation and metastasis

(2012) Andrew C. Hsieh et al.   NATURE

Mechanisms of Acquired Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors and New Therapeutic Perspectives in Non Small Cell Lung Cancer

(2011) Laura Bonanno et al.   CURRENT DRUG TARGETS

TGF-β Signaling in Breast Cancer Cell Invasion and Bone Metastasis

(2011) Yvette Drabsch et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Bevacizumab attenuates major signaling cascades and eIF4E translation initiation factor in multiple myeloma cells

(2011) Oshrat Attar-Schneider et al.   LABORATORY INVESTIGATION

The Role of Matrix Metalloproteinase 2 on the Survival of Patients with Non-Small Cell Lung Cancer: A Systematic Review with Meta-Analysis

(2010) Qian Qian et al.   CANCER INVESTIGATION

eIF4B controls survival and proliferation and is regulated by proto-oncogenic signaling pathways

(2010) David Shahbazian et al.   CELL CYCLE

Nontoxic Chemical Interdiction of the Epithelial-to-Mesenchymal Transition by Targeting Cap-Dependent Translation

(2009) Brahma Ghosh et al.   ACS Chemical Biology

Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): a proof-of-principle clinical trial with ribavirin

(2009) S. Assouline et al.   BLOOD

Tetraspanin-induced death of myeloma cell lines is autophagic and involves increased UPR signalling

(2009) V Zismanov et al.   BRITISH JOURNAL OF CANCER

Bone morphogenetic protein 7 induces mesenchymal-to-epithelial transition in melanoma cells, leading to inhibition of metastasis

(2009) Yi-Rang Na et al.   CANCER SCIENCE

Chemotherapy for lung cancer: the state of the art in 2009

(2009) Michaela J Higgins et al.   Expert Review of Anticancer Therapy

Translation of mRNAs from Vesicular Stomatitis Virus and Vaccinia Virus Is Differentially Blocked in Cells with Depletion of eIF4GI and/or eIF4GII

(2009) Ewelina Welnowska et al.   JOURNAL OF MOLECULAR BIOLOGY

Essential role for eIF4GI overexpression in the pathogenesis of inflammatory breast cancer

(2009) Deborah Silvera et al.   NATURE CELL BIOLOGY

Activating and resistance mutations of EGFR in non-small-cell lung cancer: role in clinical response to EGFR tyrosine kinase inhibitors

(2009) A F Gazdar   ONCOGENE

The helicase protein DHX29 promotes translation initiation, cell proliferation, and tumorigenesis

(2009) Armen Parsyan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ribavirin targets eIF4E dependent Akt survival signaling

(2008) Keith Tan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

c-Myc and eIF4F Are Components of a Feedforward Loop that Links Transcription and Translation

(2008) C.-J. Lin et al.   CANCER RESEARCH

eIF4GI links nutrient sensing by mTOR to cell proliferation and inhibition of autophagy

(2008) Francisco Ramírez-Valle et al.   JOURNAL OF CELL BIOLOGY

Requirement of RNA Binding of Mammalian Eukaryotic Translation Initiation Factor 4GI (eIF4GI) for Efficient Interaction of eIF4E with the mRNA Cap

(2008) A. Yanagiya et al.   MOLECULAR AND CELLULAR BIOLOGY

Transcriptional regulation of cell polarity in EMT and cancer

(2008) G Moreno-Bueno et al.   ONCOGENE

Activation of cap-independent translation by variant eukaryotic initiation factor 4G in vivo

(2008) C. Kaiser et al.   RNA