The diversity, plasticity, and adaptability of cap-dependent translation initiation and the associated machinery

Biochemical and Structural Insights into the eukaryotic translation initiation factor eIF4E

(2019) Laurent Volpon et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

A threonyl-tRNA synthetase-mediated translation initiation machinery

(2019) Seung Jae Jeong et al.   Nature Communications

Nuclear eIF4E Stimulates 3′-End Cleavage of Target RNAs

(2019) Margaret Rose Davis et al.   Cell Reports

Structural studies of the eIF4E–VPg complex reveal a direct competition for capped RNA: Implications for translation

(2019) Luciana Coutinho de Oliveira et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insights into Structural and Mechanistic Features of Viral IRES Elements

(2018) Encarnacion Martinez-Salas et al.   Frontiers in Microbiology

Chemical shift assignment of the viral protein genome-linked (VPg) from potato virus Y

(2018) Luciana Coutinho de Oliveira et al.   Biomolecular NMR Assignments

A Rev–CBP80–eIF4AI complex drives Gag synthesis from the HIV-1 unspliced mRNA

(2018) Daniela Toro-Ascuy et al.   NUCLEIC ACIDS RESEARCH

A widespread alternate form of cap-dependent mRNA translation initiation

(2018) Columba de la Parra et al.   Nature Communications

Differential Requirement for Translation Initiation Factor Pathways during Ecdysone-Dependent Neuronal Remodeling in Drosophila

(2018) Sandra Rode et al.   Cell Reports

Spatial Organization of Single mRNPs at Different Stages of the Gene Expression Pathway

(2018) Srivathsan Adivarahan et al.   MOLECULAR CELL

Revisiting the Closed-Loop Model and the Nature of mRNA 5′–3′ Communication

(2018) Quentin Vicens et al.   MOLECULAR CELL

Targeting EIF4E signaling with ribavirin in infant acute lymphoblastic leukemia

(2018) Karen A. Urtishak et al.   ONCOGENE

The Role of the Eukaryotic Translation Initiation Factor 4E (eIF4E) in Neuropsychiatric Disorders

(2018) Inês S. Amorim et al.   Frontiers in Genetics

The Impact of Post-transcriptional Control: Better Living Through RNA Regulons

(2018) Biljana Culjkovic-Kraljacic et al.   Frontiers in Genetics

Phase I study of induction chemotherapy with afatinib, ribavirin, and weekly carboplatin and paclitaxel for stage IVA/IVB human papillomavirus-associated oropharyngeal squamous cell cancer

(2017) Lara A. Dunn et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Cellular cap-binding protein, eIF4E, promotes picornavirus genome restructuring and translation

(2017) Brian C. Avanzino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A biochemical framework for eIF4E-dependent mRNA export and nuclear recycling of the export machinery

(2017) Laurent Volpon et al.   RNA

Ribosomal Chamber Music: Toward an Understanding of IRES Mechanisms

(2017) Hiroshi Yamamoto et al.   TRENDS IN BIOCHEMICAL SCIENCES

eIF4E Resistance: Natural Variation Should Guide Gene Editing

(2017) Anna Bastet et al.   TRENDS IN PLANT SCIENCE

The eukaryotic translation initiation factor eIF4E harnesses hyaluronan production to drive its malignant activity

(2017) Hiba Ahmad Zahreddine et al.   eLife

Toward the mechanism of eIF4F-mediated ribosomal attachment to mammalian capped mRNAs

(2016) Parimal Kumar et al.   GENES & DEVELOPMENT

A Specialized Mechanism of Translation Mediated by FXR1a-Associated MicroRNP in Cellular Quiescence

(2016) Syed I.A. Bukhari et al.   MOLECULAR CELL

The Structures of eIF4E-eIF4G Complexes Reveal an Extended Interface to Regulate Translation Initiation

(2016) Stefan Grüner et al.   MOLECULAR CELL

eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation

(2016) Amy S. Y. Lee et al.   NATURE

Importin 8 mediates m7G cap-sensitive nuclear import of the eukaryotic translation initiation factor eIF4E

(2016) Laurent Volpon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systematic discovery of cap-independent translation sequences in human and viral genomes

(2016) Shira Weingarten-Gabbay et al.   SCIENCE

Combinatorial targeting of nuclear export and translation of RNA inhibits aggressive B-cell lymphomas

(2015) B. Culjkovic-Kraljacic et al.   BLOOD

Genetic and Pharmacologic Inhibition of eIF4E Reduces Breast Cancer Cell Migration, Invasion, and Metastasis

(2015) F. Pettersson et al.   CANCER RESEARCH

Differential Requirements for eIF4E Dose in Normal Development and Cancer

(2015) Morgan L. Truitt et al.   CELL

Mechanism, factors, and physiological role of nonsense-mediated mRNA decay

(2015) Tobias Fatscher et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Structure of mammalian eIF3 in the context of the 43S preinitiation complex

(2015) Amedee des Georges et al.   NATURE

LOOP IIId of the HCV IRES is essential for the structural rearrangement of the 40S-HCV IRES complex

(2015) Jenniffer Angulo et al.   NUCLEIC ACIDS RESEARCH

Cryo-EM structure of Hepatitis C virus IRES bound to the human ribosome at 3.9-Å resolution

(2015) Nick Quade et al.   Nature Communications

Tumor suppression by small molecule inhibitors of translation initiation

(2015) Limo Chen et al.   Oncotarget

The Scanning Mechanism of Eukaryotic Translation Initiation

(2014) Alan G. Hinnebusch   Annual Review of Biochemistry

The diverse roles of the eIF4A family: you are the company you keep

(2014) Wei-Ting Lu et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Cancer Cells Exploit eIF4E2-Directed Synthesis of Hypoxia Response Proteins to Drive Tumor Progression

(2014) J. Uniacke et al.   CANCER RESEARCH

A phase I trial of ribavirin and low-dose cytarabine for the treatment of relapsed and refractory acute myeloid leukemia with elevated eIF4E

(2014) S. Assouline et al.   HAEMATOLOGICA

The eukaryotic translation initiation factor eIF4E in the nucleus: taking the road less traveled

(2014) Michael J. Osborne et al.   IMMUNOLOGICAL REVIEWS

The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation

(2014) Hiba Ahmad Zahreddine et al.   NATURE

Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch

(2014) Alaji Bah et al.   NATURE

eIF4AIII enhances translation of nuclear cap-binding complex-bound mRNAs by promoting disruption of secondary structures in 5'UTR

(2014) J. Choe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinetic pathway of 40S ribosomal subunit recruitment to hepatitis C virus internal ribosome entry site

(2014) Gabriele Fuchs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Base pairing between hepatitis C virus RNA and 18S rRNA is required for IRES-dependent translation initiation in vivo

(2014) D. Matsuda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mRNP granules

(2014) J Ross Buchan   RNA Biology

MNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven mRNA translation in DLBCL

(2014) Ari L. Landon et al.   Nature Communications

3′ Cap-Independent Translation Enhancers of Plant Viruses

(2013) Anne E. Simon et al.   Annual Review of Microbiology

Conformational changes induced in the eukaryotic translation initiation factor eIF4E by a clinically relevant inhibitor, ribavirin triphosphate

(2013) Laurent Volpon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Proteins of the human 40S ribosomal subunit involved in hepatitis C IRES Binding as revealed from fluorescent labeling

(2013) A. A. Malygin et al.   BIOCHEMISTRY-MOSCOW

Cap-Translation Inhibitor, 4EGI-1, Restores Sensitivity to ABT-737 Apoptosis through Cap-Dependent and -Independent Mechanisms in Chronic Lymphocytic Leukemia

(2013) S. Willimott et al.   CLINICAL CANCER RESEARCH

The Oncogene eIF4E: Using Biochemical Insights to Target Cancer

(2013) Martin Carroll et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Nonsense-mediated mRNA decay occurs during eIF4F-dependent translation in human cells

(2013) Sébastien Durand et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

eIF4E-bound mRNPs are substrates for nonsense-mediated mRNA decay in mammalian cells

(2013) Simone C Rufener et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human inducible nitric oxide synthase (iNOS) expression depends on chromosome region maintenance 1 (CRM1)- and eukaryotic translation initiation factor 4E (elF4E)-mediated nucleocytoplasmic mRNA transport

(2013) Franziska Bollmann et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Human eIF4E promotes mRNA restructuring by stimulating eIF4A helicase activity

(2013) K. Feoktistova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

eIF4E3 acts as a tumor suppressor by utilizing an atypical mode of methyl-7-guanosine cap recognition

(2013) M. J. Osborne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aiding and abetting cancer: mRNA export and the nuclear pore

(2013) Biljana Culjkovic-Kraljacic et al.   TRENDS IN CELL BIOLOGY

The Current Status of Vertebrate Cellular mRNA IRESs

(2013) R. J. Jackson   Cold Spring Harbor Perspectives in Biology

Site-Specific Cleavage of the Host Poly(A) Binding Protein by the Encephalomyocarditis Virus 3C Proteinase Stimulates Viral Replication

(2012) M. Kobayashi et al.   JOURNAL OF VIROLOGY

A Novel 4EHP-GIGYF2 Translational Repressor Complex Is Essential for Mammalian Development

(2012) M. Morita et al.   MOLECULAR AND CELLULAR BIOLOGY

HCV IRES manipulates the ribosome to promote the switch from translation initiation to elongation

(2012) Megan E Filbin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Oncogene eIF4E Reprograms the Nuclear Pore Complex to Promote mRNA Export and Oncogenic Transformation

(2012) Biljana Culjkovic-Kraljacic et al.   Cell Reports

Thriving under Stress: Selective Translation of HIV-1 Structural Protein mRNA during Vpr-Mediated Impairment of eIF4E Translation Activity

(2012) Amit Sharma et al.   PLoS Pathogens

The eukaryotic translation initiation factor 4E (eIF4E) and HuR RNA operons collaboratively regulate the expression of survival and proliferative genes

(2011) Ivan Topisirovic et al.   CELL CYCLE

Ribavirin Treatment Effects on Breast Cancers Overexpressing eIF4E, a Biomarker with Prognostic Specificity for Luminal B-Type Breast Cancer

(2011) F. Pettersson et al.   CLINICAL CANCER RESEARCH

A Phase 1 Dose Escalation, Pharmacokinetic, and Pharmacodynamic Evaluation of eIF-4E Antisense Oligonucleotide LY2275796 in Patients with Advanced Cancer

(2011) D. S. Hong et al.   CLINICAL CANCER RESEARCH

Structural Insights into the Allosteric Effects of 4EBP1 on the Eukaryotic Translation Initiation Factor eIF4E

(2011) Nadeem Siddiqui et al.   JOURNAL OF MOLECULAR BIOLOGY

Inhibition of eIF4E with ribavirin cooperates with common chemotherapies in primary acute myeloid leukemia specimens

(2011) B C Kraljacic et al.   LEUKEMIA

Yeast mRNA cap-binding protein Cbc1/Sto1 is necessary for the rapid reprogramming of translation after hyperosmotic shock

(2011) Elena Garre et al.   MOLECULAR BIOLOGY OF THE CELL

Cap-Assisted Internal Initiation of Translation of Histone H4

(2011) Franck Martin et al.   MOLECULAR CELL

mRNA helicases: the tacticians of translational control

(2011) Armen Parsyan et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural basis for nematode eIF4E binding an m 2,2,7 G-Cap and its implications for translation initiation

(2011) Weizhi Liu et al.   NUCLEIC ACIDS RESEARCH

The Cap-Binding Translation Initiation Factor, eIF4E, Binds a Pseudoknot in a Viral Cap-Independent Translation Element

(2011) Zhaohui Wang et al.   STRUCTURE

The Pioneer Round of Translation: Features and Functions

(2010) Lynne E. Maquat et al.   CELL

Alternative Ways to Think about Cellular Internal Ribosome Entry

(2010) Wendy V. Gilbert   JOURNAL OF BIOLOGICAL CHEMISTRY

Noncytotoxic Inhibition of Viral Infection through eIF4F-Independent Suppression of Translation by 4EGi-1

(2010) R. McMahon et al.   JOURNAL OF VIROLOGY

Trimethylguanosine capping selectively promotes expression of Rev-dependent HIV-1 RNAs

(2010) V. S. R. K. Yedavalli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural characterization of the Z RING-eIF4E complex reveals a distinct mode of control for eIF4E

(2010) L. Volpon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): a proof-of-principle clinical trial with ribavirin

(2009) S. Assouline et al.   BLOOD

Topology and Regulation of the Human eIF4A/4G/4H Helicase Complex in Translation Initiation

(2009) Assen Marintchev et al.   CELL

Hepatitis C Virus Blocks Interferon Effector Function by Inducing Protein Kinase R Phosphorylation

(2009) Urtzi Garaigorta et al.   Cell Host & Microbe

Molecular dissection of the eukaryotic initiation factor 4E (eIF4E) export-competent RNP

(2009) Ivan Topisirovic et al.   EMBO JOURNAL

Structure of a Viral Cap-independent Translation Element That Functions via High Affinity Binding to the eIF4E Subunit of eIF4F

(2009) Zhaohui Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Host and Viral Translational Mechanisms during Cricket Paralysis Virus Infection

(2009) J. L. Garrey et al.   JOURNAL OF VIROLOGY

Direct functional interaction of initiation factor eIF4G with type 1 internal ribosomal entry sites

(2009) S. de Breyne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding and Targeting the Eukaryotic Translation Initiation Factor eIF4E in Head and Neck Cancer

(2009) Biljana Culjkovic et al.   Journal of Oncology

eIF4GI links nutrient sensing by mTOR to cell proliferation and inhibition of autophagy

(2008) Francisco Ramírez-Valle et al.   JOURNAL OF CELL BIOLOGY

The eIF4E RNA regulon promotes the Akt signaling pathway

(2008) Biljana Culjkovic et al.   JOURNAL OF CELL BIOLOGY

Crystal Structure of the RRM Domain of Poly(A)-Specific Ribonuclease Reveals a Novel m7G-Cap-Binding Mode

(2008) Thomas Monecke et al.   JOURNAL OF MOLECULAR BIOLOGY

Mutational Analysis of Plant Cap-Binding Protein eIF4E Reveals Key Amino Acids Involved in Biochemical Functions and Potyvirus Infection

(2008) S. German-Retana et al.   JOURNAL OF VIROLOGY

DAP5 Promotes Cap-Independent Translation of Bcl-2 and CDK1 to Facilitate Cell Survival during Mitosis

(2008) Lea Marash et al.   MOLECULAR CELL

The RRM domain of poly(A)-specific ribonuclease has a noncanonical binding site for mRNA cap analog recognition

(2008) Takashi Nagata et al.   NUCLEIC ACIDS RESEARCH