Tumor Microenvironment in Pancreatic Intraepithelial Neoplasia

Cancer Statistics, 2021

(2021) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Inhibition of Hedgehog signaling alters fibroblast composition in pancreatic cancer

(2021) Nina G Steele et al.   CLINICAL CANCER RESEARCH

Type I collagen deletion in αSMA+ myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer

(2021) Yang Chen et al.   CANCER CELL

A Guide to the Composition and Functions of the Extracellular Matrix

(2021) Nikos K. Karamanos et al.   FEBS Journal

Intraduktale Pankreasneoplasien

(2021) Irene Esposito et al.   PATHOLOGE

Mesenchymal Lineage Heterogeneity Underlies Non-Redundant Functions of Pancreatic Cancer-Associated Fibroblasts

(2021) Erin J Helms et al.   Cancer Discovery

Complement factor B regulates cellular senescence and is associated with poor prognosis in pancreatic cancer

(2021) Reiri Shimazaki et al.   CELLULAR ONCOLOGY

Expression and Role of Heparan Sulfated Proteoglycans in Pancreatic Cancer

(2021) Simone Furini et al.   Frontiers in Oncology

ANGPTL4 accelerates KRASG12D-Induced acinar to ductal metaplasia and pancreatic carcinogenesis

(2021) Hong Hua Yan et al.   CANCER LETTERS

The PDAC Extracellular Matrix: A Review of the ECM Protein Composition, Tumor Cell Interaction, and Therapeutic Strategies

(2021) Vincent M. Perez et al.   Frontiers in Oncology

Tumor Cell–Derived IL1β Promotes Desmoplasia and Immune Suppression in Pancreatic Cancer

(2020) Shipra Das et al.   CANCER RESEARCH

Cancer‐associated fibroblasts that restrain cancer progression (rCAFs): hypotheses and perspectives

(2020) Yuki Miyai et al.   CANCER SCIENCE

Tumour innervation and neurosignalling in prostate cancer

(2020) Brayden March et al.   Nature Reviews Urology

Oncogenic Kras driven metabolic reprogramming in pancreas cancer cells utilizes cytokines from the tumor microenvironment

(2020) Prasenjit Dey et al.   Cancer Discovery

Deciphering the Crosstalk Between Myeloid-Derived Suppressor Cells and Regulatory T Cells in Pancreatic Ductal Adenocarcinoma

(2020) Carole Siret et al.   Frontiers in Immunology

Tumor-Associated Macrophages: Recent Insights and Therapies

(2020) Jiawei Zhou et al.   Frontiers in Oncology

Pancreatic ductal adenocarcinoma: Treatment hurdles, tumor microenvironment and immunotherapy

(2020) Panagiotis Sarantis et al.   World Journal of Gastrointestinal Oncology

Fibroblasts from distinct pancreatic pathologies exhibit disease-specific properties

(2020) Lawrence N Barrera et al.   CANCER RESEARCH

Interleukin-1β-induced pancreatitis promotes pancreatic ductal adenocarcinoma via B lymphocyte–mediated immune suppression

(2020) Ryota Takahashi et al.   GUT

Acidic fibroblast growth factor underlies microenvironmental regulation of MYC in pancreatic cancer

(2020) Sohinee Bhattacharyya et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The tumour microenvironment in pancreatic cancer — clinical challenges and opportunities

(2020) Won Jin Ho et al.   Nature Reviews Clinical Oncology

Pancreatic cancer stroma: an update on therapeutic targeting strategies

(2020) Abdel N. Hosein et al.   Nature Reviews Gastroenterology & Hepatology

Tenascin C in the Tumor-Nerve Microenvironment Enhances Perineural Invasion and Correlates With Locoregional Recurrence in Pancreatic Ductal Adenocarcinoma

(2020) Satoru Furuhashi et al.   PANCREAS

Microenvironmental Determinants of Pancreatic Cancer

(2020) Elisabeth Hessmann et al.   PHYSIOLOGICAL REVIEWS

CD200 promotes immunosuppression in the pancreatic tumor microenvironment

(2020) Fouad Choueiry et al.   Journal for ImmunoTherapy of Cancer

The Immune Microenvironment in Pancreatic Cancer

(2020) Magdalena Huber et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Heparan Sulfate Proteoglycans Can Promote Opposite Effects on Adhesion and Directional Migration of Different Cancer Cells

(2020) Lorenzo Depau et al.   JOURNAL OF MEDICINAL CHEMISTRY

BTK signaling drives CD1dhiCD5+ regulatory B-cell differentiation to promote pancreatic carcinogenesis

(2019) Shipra Das et al.   ONCOGENE

Stromal fibronectin expression in patients with resected pancreatic ductal adenocarcinoma

(2019) Dingyuan Hu et al.   World Journal of Surgical Oncology

Reduction of intrapancreatic neural density in cancer tissue predicts poorer outcome in pancreatic ductal carcinoma

(2019) Toshimitsu Iwasaki et al.   CANCER SCIENCE

Pomalidomide Alters Pancreatic Macrophage Populations to Generate an Immune-Responsive Environment at Precancerous and Cancerous Lesions

(2019) Ligia I. Bastea et al.   CANCER RESEARCH

Transforming Growth Factor-β Signaling in Immunity and Cancer

(2019) Eduard Batlle et al.   IMMUNITY

Exosomal Tenascin-c induces proliferation and invasion of pancreatic cancer cells by WNT signaling

(2019) Songying Qian et al.   OncoTargets and Therapy

The Tumor Microenvironment Innately Modulates Cancer Progression

(2019) Dominique C. Hinshaw et al.   CANCER RESEARCH

Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts

(2019) Ela Elyada et al.   Cancer Discovery

Proteomic analyses of ECM during pancreatic ductal adenocarcinoma progression reveal different contributions by tumor and stromal cells

(2019) Chenxi Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunosuppression by monocytic myeloid-derived suppressor cells in patients with pancreatic ductal carcinoma is orchestrated by STAT3

(2019) Rosalinda Trovato et al.   Journal for ImmunoTherapy of Cancer

CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan

(2019) Claire Vennin et al.   Nature Communications

Single-cell RNA sequencing reveals stromal evolution into LRRC15+ myofibroblasts as a determinant of patient response to cancer immunotherapy

(2019) Claudia X Dominguez et al.   Cancer Discovery

Immunoevolution of mouse pancreatic organoid isografts from preinvasive to metastatic disease

(2019) Dea Filippini et al.   Scientific Reports

Myeloid-Derived Suppressor Cells and Pancreatic Cancer: Implications in Novel Therapeutic Approaches

(2019) Anita Thyagarajan et al.   Cancers

Novel targets identified by integrated cancer-stromal interactome analysis of pancreatic adenocarcinoma

(2019) Yukihiko Hiroshima et al.   CANCER LETTERS

When worlds collide: Th17 and Treg cells in cancer and autoimmunity

(2018) Hannah M. Knochelmann et al.   Cellular & Molecular Immunology

MicroRNAs 15A and 16–1 Activate Signaling Pathways That Mediate Chemotaxis of Immune Regulatory B cells to Colorectal Tumors

(2018) Ronghua Liu et al.   GASTROENTEROLOGY

Expression of annexin�II and stromal tenascin�C promotes epithelial to mesenchymal transition and correlates with distant metastasis in pancreatic cancer

(2018) Naoko Yoneura et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Expression of neuropeptide Y and its receptors Y1 and Y2 in pancreatic intraepithelial neoplasia and invasive pancreatic cancer in a transgenic mouse model and human samples of pancreatic cancer

(2018) Jens Waldmann et al.   JOURNAL OF SURGICAL RESEARCH

Stromal heterogeneity in pancreatic cancer and chronic pancreatitis

(2018) Lena Haeberle et al.   PANCREATOLOGY

The Pancreatic Cancer Microbiome Promotes Oncogenesis by Induction of Innate and Adaptive Immune Suppression

(2018) Smruti Pushalkar et al.   Cancer Discovery

Glypican-1 is enriched in circulating-exosomes in pancreatic cancer and correlates with tumor burden

(2018) Adam E. Frampton et al.   Oncotarget

Immune Evasion in Pancreatic Cancer: From Mechanisms to Therapy

(2018) Neus Martinez-Bosch et al.   Cancers

Stromal biology and therapy in pancreatic cancer: ready for clinical translation?

(2018) Albrecht Neesse et al.   GUT

The Paradoxical Web of Pancreatic Cancer Tumor Microenvironment

(2018) Kelly J. Lafaro et al.   AMERICAN JOURNAL OF PATHOLOGY

Stromal protein βig-h3 reprogrammes tumour microenvironment in pancreatic cancer

(2018) Delphine Goehrig et al.   GUT

Tenascin C, Fibronectin, and Tumor-Stroma Ratio in Pancreatic Ductal Adenocarcinoma

(2018) Joni Leppänen et al.   PANCREAS

IL-1-induced JAK/STAT signaling is antagonized by TGF-beta to shape CAF heterogeneity in pancreatic ductal adenocarcinoma

(2018) Giulia Biffi et al.   Cancer Discovery

Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility

(2018) Amanpreet Kaur et al.   Cancer Discovery

Regulatory B cells in inflammatory diseases and tumor

(2018) Xiaoyu Cai et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Targeting both tumour-associated CXCR2+neutrophils and CCR2+macrophages disrupts myeloid recruitment and improves chemotherapeutic responses in pancreatic ductal adenocarcinoma

(2017) Timothy M Nywening et al.   GUT

Tissue-Resident Macrophages in Pancreatic Ductal Adenocarcinoma Originate from Embryonic Hematopoiesis and Promote Tumor Progression

(2017) Yu Zhu et al.   IMMUNITY

α1-antitrypsin promotes lung adenocarcinoma metastasis through upregulating fibronectin expression

(2017) Yan Li et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

(2017) Daniel Öhlund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The role of stromal cancer-associated fibroblasts in pancreatic cancer

(2017) Dagny von Ahrens et al.   Journal of Hematology & Oncology

Cancer-associated fibroblasts enhance pancreatic cancer cell invasion by remodeling the metabolic conversion mechanism

(2017) Tao Shan et al.   ONCOLOGY REPORTS

Adrenergic nerves activate an angio-metabolic switch in prostate cancer

(2017) Ali H. Zahalka et al.   SCIENCE

Blockade of surface-bound TGF-β on regulatory T cells abrogates suppression of effector T cell function in the tumor microenvironment

(2017) Sadna Budhu et al.   Science Signaling

Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions

(2017) Orianne Olivares et al.   Nature Communications

Tenascin-C induces migration and invasion through JNK/c-Jun signalling in pancreatic cancer

(2017) Jun Cai et al.   Oncotarget

The Presence of Interleukin-13 at Pancreatic ADM/PanIN Lesions Alters Macrophage Populations and Mediates Pancreatic Tumorigenesis

(2017) Geou-Yarh Liou et al.   Cell Reports

Blockade of surface-bound TGF-β on regulatory T cells abrogates suppression of effector T cell function in the tumor microenvironment

(2017) Sadna Budhu et al.   Science Signaling

Myeloid-Derived Suppressor Cells

(2017) Dmitry I. Gabrilovich   Cancer Immunology Research

Elevated glypican-1 expression is associated with an unfavorable prognosis in pancreatic ductal adenocarcinoma

(2017) Haizhen Lu et al.   Cancer Medicine

Stromal Modulators of TGF-β in Cancer

(2017) Brunella Costanza et al.   Journal of Clinical Medicine

More deaths from pancreatic cancer than breast cancer in the EU by 2017

(2016) J. Ferlay et al.   ACTA ONCOLOGICA

Extracellular matrix structure

(2016) Achilleas D. Theocharis et al.   ADVANCED DRUG DELIVERY REVIEWS

Worse outcome in breast cancer with higher tumor-infiltrating FOXP3+ Tregs : a systematic review and meta-analysis

(2016) Jiafeng Shou et al.   BMC CANCER

Matrix control of pancreatic cancer: New insights into fibronectin signaling

(2016) Mary Topalovski et al.   CANCER LETTERS

Oncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation

(2016) Christopher J. Tape et al.   CELL

Parasympathetic neurogenesis is strongly associated with tumor budding and correlates with an adverse prognosis in pancreatic ductal adenocarcinoma

(2016) Lingfu Zhang et al.   Chinese Journal of Cancer Research

Genetic Diversity of Pancreatic Ductal Adenocarcinoma and Opportunities for Precision Medicine

(2016) Erik S. Knudsen et al.   GASTROENTEROLOGY

Loss of P53 Function Activates JAK2–STAT3 Signaling to Promote Pancreatic Tumor Growth, Stroma Modification, and Gemcitabine Resistance in Mice and Is Associated With Patient Survival

(2016) Sonja M. Wörmann et al.   GASTROENTEROLOGY

Pharmacological macrophage inhibition decreases metastasis formation in a genetic model of pancreatic cancer

(2016) Heidi Griesmann et al.   GUT

Tenascin-C at a glance

(2016) Kim S. Midwood et al.   JOURNAL OF CELL SCIENCE

RelA regulates CXCL1/CXCR2-dependent oncogene-induced senescence in murine Kras-driven pancreatic carcinogenesis

(2016) Marina Lesina et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: a single-centre, open-label, dose-finding, non-randomised, phase 1b trial

(2016) Timothy M Nywening et al.   LANCET ONCOLOGY

Periostin action in bone

(2016) Nicolas Bonnet et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Genomic analyses identify molecular subtypes of pancreatic cancer

(2016) Peter Bailey et al.   NATURE

Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression

(2016) Hanane Laklai et al.   NATURE MEDICINE

Ablation of sensory neurons in a genetic model of pancreatic ductal adenocarcinoma slows initiation and progression of cancer

(2016) Jami L. Saloman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of microenvironmental periostin in pancreatic cancer progression

(2016) Yang Liu et al.   Oncotarget

Pancreatic stellate cell secreted IL-6 stimulates STAT3 dependent invasiveness of pancreatic intraepithelial neoplasia and cancer cells

(2016) Nagaraj S. Nagathihalli et al.   Oncotarget

Innate Immune Recognition of Cancer

(2015) Seng-Ryong Woo et al.   Annual Review of Immunology

Collagen type V promotes the malignant phenotype of pancreatic ductal adenocarcinoma

(2015) Sonja Berchtold et al.   CANCER LETTERS

IL17 Functions through the Novel REG3 -JAK2-STAT3 Inflammatory Pathway to Promote the Transition from Chronic Pancreatitis to Pancreatic Cancer

(2015) C. Loncle et al.   CANCER RESEARCH

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

Desmoplasia in Primary Tumors and Metastatic Lesions of Pancreatic Cancer

(2015) C. J. Whatcott et al.   CLINICAL CANCER RESEARCH

Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer

(2015) Nagaraj S. Nagathihalli et al.   GASTROENTEROLOGY

Stromal biology and therapy in pancreatic cancer: a changing paradigm

(2015) Albrecht Neesse et al.   GUT

Regulatory B Cells: Origin, Phenotype, and Function

(2015) Elizabeth C. Rosser et al.   IMMUNITY

Glypican-1 identifies cancer exosomes and detects early pancreatic cancer

(2015) Sonia A. Melo et al.   NATURE

Neural plasticity in pancreatitis and pancreatic cancer

(2015) Ihsan Ekin Demir et al.   Nature Reviews Gastroenterology & Hepatology

Role of pancreatic stellate cells and periostin in pancreatic cancer progression

(2015) Yang Liu et al.   TUMOR BIOLOGY

IL35-Producing B Cells Promote the Development of Pancreatic Neoplasia

(2015) Y. Pylayeva-Gupta et al.   Cancer Discovery

Activated T cells sustain myeloid-derived suppressor cell-mediated immune suppression

(2015) Laura Pinton et al.   Oncotarget

Clinicopathological Significance of CDKN2A Promoter Hypermethylation Frequency with Pancreatic Cancer

(2015) Bo Tang et al.   Scientific Reports

Heterogeneity in the Differentiation and Function of CD8+ T Cells

(2014) Hans-Willi Mittrücker et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Th17 and regulatory T cell balance in autoimmune and inflammatory diseases

(2014) Mélissa Noack et al.   AUTOIMMUNITY REVIEWS

Oncogenic Kras Activates a Hematopoietic-to-Epithelial IL-17 Signaling Axis in Preinvasive Pancreatic Neoplasia

(2014) Florencia McAllister et al.   CANCER CELL

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2014) Berna C. Özdemir et al.   CANCER CELL

Patients with pancreatic adenocarcinoma exhibit elevated levels of myeloid-derived suppressor cells upon progression of disease

(2014) Joseph Markowitz et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States

(2014) L. Rahib et al.   CANCER RESEARCH

A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice

(2014) Bridget P. Keenan et al.   GASTROENTEROLOGY

Dynamic Treg interactions with intratumoral APCs promote local CTL dysfunction

(2014) Christian A. Bauer et al.   JOURNAL OF CLINICAL INVESTIGATION

Disruption of CCR5-Dependent Homing of Regulatory T Cells Inhibits Tumor Growth in a Murine Model of Pancreatic Cancer

(2014) M. C. B. Tan et al.   JOURNAL OF IMMUNOLOGY

Fibrogenesis in pancreatic cancer is a dynamic process regulated by macrophage–stellate cell interaction

(2014) Chanjuan Shi et al.   LABORATORY INVESTIGATION

Tenascins in stem cell niches

(2014) Ruth Chiquet-Ehrismann et al.   MATRIX BIOLOGY

IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases

(2014) Ping Shen et al.   NATURE

Interleukin-35 induces regulatory B cells that suppress autoimmune disease

(2014) Ren-Xi Wang et al.   NATURE MEDICINE

Drugging the p53 pathway: understanding the route to clinical efficacy

(2014) Kian Hoe Khoo et al.   NATURE REVIEWS DRUG DISCOVERY

Regulatory B cells—IL-35 and IL-21 regulate the regulators

(2014) Thomas F. Tedder et al.   Nature Reviews Rheumatology

An Increased Abundance of Tumor-Infiltrating Regulatory T Cells Is Correlated with the Progression and Prognosis of Pancreatic Ductal Adenocarcinoma

(2014) Yichen Tang et al.   PLoS One

Evolutionary aspects of cancer resistance

(2014) George Klein   SEMINARS IN CANCER BIOLOGY

Intraductal neoplasms of the pancreas

(2014) Günter Klöppel et al.   SEMINARS IN DIAGNOSTIC PATHOLOGY

Cyr61 promotes growth of pancreatic carcinoma via nuclear exclusion of p27

(2014) Weidong Shi et al.   TUMOR BIOLOGY

Pathology of pancreatic ductal adenocarcinoma: Facts, challenges and future developments

(2014) Irene Esposito   WORLD JOURNAL OF GASTROENTEROLOGY

Mutant KRAS–Induced Expression of ICAM-1 in Pancreatic Acinar Cells Causes Attraction of Macrophages to Expedite the Formation of Precancerous Lesions

(2014) Geou-Yarh Liou et al.   Cancer Discovery

CXC and CC Chemokines as Angiogenic Modulators in Nonhaematological Tumors

(2014) Matteo Santoni et al.   Biomed Research International

Expression of urocortin in pancreatic ductal adenocarcinoma and pancreatic intraepithelial neoplasia

(2013) Ming-Fang Cheng et al.   APMIS

Precancerous lesions of the pancreas

(2013) Giuseppe Zamboni et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Type IV collagen stimulates pancreatic cancer cell proliferation, migration, and inhibits apoptosis through an autocrine loop

(2013) Daniel Öhlund et al.   BMC CANCER

SnapShot: Pancreatic Cancer

(2013) Haiyong Han et al.   CANCER CELL

Ex vivo analysis of pancreatic cancer-infiltrating T lymphocytes reveals that ENO-specific Tregs accumulate in tumor tissue and inhibit Th1/Th17 effector cell functions

(2013) Amedeo Amedei et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

High-Fat, High-Calorie Diet Promotes Early Pancreatic Neoplasia in the Conditional KrasG12D Mouse Model

(2013) D. W. Dawson et al.   Cancer Prevention Research

PanIN-Specific Regulation of Wnt Signaling by HIF2  during Early Pancreatic Tumorigenesis

(2013) A. Criscimanna et al.   CANCER RESEARCH

Pancreatic Cancer-Associated Stellate Cells Promote Differentiation of Myeloid-Derived Suppressor Cells in a STAT3-Dependent Manner

(2013) T. A. Mace et al.   CANCER RESEARCH

Integrin  v 3 and Fibronectin Upregulate Slug in Cancer Cells to Promote Clot Invasion and Metastasis

(2013) L. M. Knowles et al.   CANCER RESEARCH

Extracellular matrix signaling in morphogenesis and repair

(2013) Kelly C Clause et al.   CURRENT OPINION IN BIOTECHNOLOGY

Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-κB and MMPs

(2013) Geou-Yarh Liou et al.   JOURNAL OF CELL BIOLOGY

Collagen XV Inhibits Epithelial to Mesenchymal Transition in Pancreatic Adenocarcinoma Cells

(2013) Anthony G. Clementz et al.   PLoS One

The plasticity of human Treg and Th17 cells and its role in autoimmunity

(2013) Markus Kleinewietfeld et al.   SEMINARS IN IMMUNOLOGY

IL-10-producing regulatory B cells (B10 cells) in autoimmune disease

(2013) Ioannis Kalampokis et al.   ARTHRITIS RESEARCH & THERAPY

Carcinoma-Associated Fibroblasts Are a Promising Therapeutic Target

(2013) Shinsaku Togo et al.   Cancers

Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma

(2012) Paolo P. Provenzano et al.   CANCER CELL

Tumor-Derived Granulocyte-Macrophage Colony-Stimulating Factor Regulates Myeloid Inflammation and T Cell Immunity in Pancreatic Cancer

(2012) Lauren J. Bayne et al.   CANCER CELL

Oncogenic Kras-Induced GM-CSF Production Promotes the Development of Pancreatic Neoplasia

(2012) Yuliya Pylayeva-Gupta et al.   CANCER CELL

Pathologie und Klassifikation intraduktaler papillär muzinöser Neoplasien des Pankreas

(2012) A.M. Schlitter et al.   CHIRURG

The Pancreas Cancer Microenvironment

(2012) C. Feig et al.   CLINICAL CANCER RESEARCH

Presence of Somatic Mutations in Most Early-Stage Pancreatic Intraepithelial Neoplasia

(2012) Mitsuro Kanda et al.   GASTROENTEROLOGY

The Receptor for Advanced Glycation End Products Promotes Pancreatic Carcinogenesis and Accumulation of Myeloid-Derived Suppressor Cells

(2012) P. J. Vernon et al.   JOURNAL OF IMMUNOLOGY

Secretomic Analysis Identifies Alpha-1 Antitrypsin (A1AT) as a Required Protein in Cancer Cell Migration, Invasion, and Pericellular Fibronectin Assembly for Facilitating Lung Colonization of Lung Adenocarcinoma Cells

(2012) Ying-Hua Chang et al.   MOLECULAR & CELLULAR PROTEOMICS

Cancer-Associated Fibroblasts Drive the Progression of Metastasis through both Paracrine and Mechanical Pressure on Cancer Tissue

(2012) G. S. Karagiannis et al.   MOLECULAR CANCER RESEARCH

RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis

(2012) Min Yu et al.   NATURE

The role of stroma in pancreatic cancer: diagnostic and therapeutic implications

(2012) Mert Erkan et al.   Nature Reviews Gastroenterology & Hepatology

The multiple facets of periostin in bone metabolism

(2012) B. Merle et al.   OSTEOPOROSIS INTERNATIONAL

Neue Einblicke in die Entstehung des Pankreaskarzinoms

(2012) I. Esposito et al.   PATHOLOGE

Potential plasticity of T regulatory cells in pancreatic carcinoma in relation to disease progression and outcome

(2012) BARBARA VIZIO et al.   Experimental and Therapeutic Medicine

Elevated myeloid-derived suppressor cells in pancreatic, esophageal and gastric cancer are an independent prognostic factor and are associated with significant elevation of the Th2 cytokine interleukin-13

(2011) Rachel F. Gabitass et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Tumor-Evoked Regulatory B Cells Promote Breast Cancer Metastasis by Converting Resting CD4+ T Cells to T-Regulatory Cells

(2011) P. B. Olkhanud et al.   CANCER RESEARCH

The meaning of p16ink4aexpression in tumors

(2011) Agnieszka K. Witkiewicz et al.   CELL CYCLE

StellaTUM: current consensus and discussion on pancreatic stellate cell research

(2011) Mert Erkan et al.   GUT

Distribution and Clinical Significance of Th17 Cells in the Tumor Microenvironment and Peripheral Blood of Pancreatic Cancer Patients

(2011) Songbing He et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Integrin  5 1 facilitates cancer cell invasion through enhanced contractile forces

(2011) C. T. Mierke et al.   JOURNAL OF CELL SCIENCE

Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: a double-blind randomised phase 3 study

(2011) Hedy L Kindler et al.   LANCET ONCOLOGY

Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression

(2011) Mina J Bissell et al.   NATURE MEDICINE

Periostin, a matrix specific protein, is associated with proliferation and invasion of pancreatic cancer

(2011) Yuan   ONCOLOGY REPORTS

Analysis of the Human Pancreatic Stellate Cell Secreted Proteome

(2011) Angela Y. Wehr et al.   PANCREAS

Tenascin-C Enhances Pancreatic Cancer Cell Growth and Motility and Affects Cell Adhesion through Activation of the Integrin Pathway

(2011) Igor Paron et al.   PLoS One

Imaging guided trials of the angiogenesis inhibitor sunitinib in mouse models predict efficacy in pancreatic neuroendocrine but not ductal carcinoma

(2011) P. Olson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanical compression drives cancer cells toward invasive phenotype

(2011) J. M. Tse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Periostin shows increased evolutionary plasticity in its alternatively spliced region

(2010) Sebastian Hoersch et al.   BMC EVOLUTIONARY BIOLOGY

Stromal biology and therapy in pancreatic cancer

(2010) A. Neesse et al.   GUT

Interaction between Periostin and BMP-1 Promotes Proteolytic Activation of Lysyl Oxidase

(2010) Takumi Maruhashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The extracellular matrix at a glance

(2010) C. Frantz et al.   JOURNAL OF CELL SCIENCE

Gemcitabine Plus Bevacizumab Compared With Gemcitabine Plus Placebo in Patients With Advanced Pancreatic Cancer: Phase III Trial of the Cancer and Leukemia Group B (CALGB 80303)

(2010) Hedy Lee Kindler et al.   JOURNAL OF CLINICAL ONCOLOGY

Transcriptional Regulation of the Endogenous Danger Signal Tenascin-C: A Novel Autocrine Loop in Inflammation

(2010) Fui G. Goh et al.   JOURNAL OF IMMUNOLOGY

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

(2010) Subhra K Biswas et al.   NATURE IMMUNOLOGY

The Collagen Family

(2010) S. Ricard-Blum   Cold Spring Harbor Perspectives in Biology

Periostin mediates vascular smooth muscle cell migration through the integrins ανβ3 and ανβ5 and focal adhesion kinase (FAK) pathway

(2009) Guohong Li et al.   ATHEROSCLEROSIS

Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments

(2009) I. Kryczek et al.   BLOOD

Type IV collagen is a tumour stroma-derived biomarker for pancreas cancer

(2009) D Öhlund et al.   BRITISH JOURNAL OF CANCER

Modeling Inducible Human Tissue Neoplasia Identifies an Extracellular Matrix Interaction Network Involved in Cancer Progression

(2009) Jason A. Reuter et al.   CANCER CELL

Basement membranes and human disease

(2009) Tom Van Agtmael et al.   CELL AND TISSUE RESEARCH

Increase in frequency of myeloid-derived suppressor cells in mice with spontaneous pancreatic carcinoma

(2009) Fei Zhao et al.   IMMUNOLOGY

Incorporation of Tenascin-C into the Extracellular Matrix by Periostin Underlies an Extracellular Meshwork Architecture

(2009) Isao Kii et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

 9 Integrin and Its Ligands Constitute Critical Joint Microenvironments for Development of Autoimmune Arthritis

(2009) M. Kanayama et al.   JOURNAL OF IMMUNOLOGY

Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease

(2009) Kim Midwood et al.   NATURE MEDICINE

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

(2009) K. P. Olive et al.   SCIENCE

Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin–cyclophosphamide chemotherapy

(2008) C. Marcela Diaz-Montero et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Pancreatic Stellate Cells: Partners in Crime with Pancreatic Cancer Cells

(2008) A. Vonlaufen et al.   CANCER RESEARCH

Cancer-Associated Stromal Fibroblasts Promote Pancreatic Tumor Progression

(2008) R. F. Hwang et al.   CANCER RESEARCH

RNF13: a novel RING-type ubiquitin ligase over-expressed in pancreatic cancer

(2008) Qiang Zhang et al.   CELL RESEARCH

Neuropilin-2-Mediated Tumor Growth and Angiogenesis in Pancreatic Adenocarcinoma

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