The PDAC Extracellular Matrix: A Review of the ECM Protein Composition, Tumor Cell Interaction, and Therapeutic Strategies

Cancer Statistics, 2021

(2021) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Inhibition of Hedgehog signaling alters fibroblast composition in pancreatic cancer

(2021) Nina G Steele et al.   CLINICAL CANCER RESEARCH

Predicting postoperative peritoneal metastasis in gastric cancer with serosal invasion using a collagen nomogram

(2021) Dexin Chen et al.   Nature Communications

Pancreatic cancer is suppressed by fibroblast-derived collagen I

(2021) Chris D. Madsen   CANCER CELL

Suppression of pancreatic ductal adenocarcinoma growth and metastasis by fibrillar collagens produced selectively by tumor cells

(2021) Chenxi Tian et al.   Nature Communications

An Integrated Meta-Analysis of Secretome and Proteome Identify Potential Biomarkers of Pancreatic Ductal Adenocarcinoma

(2020) Grasieli de Oliveira et al.   Cancers

Clinical development of therapies targeting TGFβ: current knowledge and future perspectives.

(2020) D. Ciardiello et al.   ANNALS OF ONCOLOGY

First-in-Human Study of AT13148, a Dual ROCK-AKT Inhibitor in Patients with Solid Tumors

(2020) Robert McLeod et al.   CLINICAL CANCER RESEARCH

Pancreatic ductal adenocarcinoma progression is restrained by stromal matrix

(2020) Honglin Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Randomized Phase III Trial of Pegvorhyaluronidase Alfa With Nab-Paclitaxel Plus Gemcitabine for Patients With Hyaluronan-High Metastatic Pancreatic Adenocarcinoma

(2020) Eric Van Cutsem et al.   JOURNAL OF CLINICAL ONCOLOGY

Three distinct stroma types in human pancreatic cancer identified by image analysis of fibroblast subpopulations and collagen

(2020) Yurina Ogawa et al.   CLINICAL CANCER RESEARCH

The vitamin D analogue calcipotriol promotes an anti-tumorigenic phenotype of human pancreatic CAFs but reduces T cell mediated immunity

(2020) Laia Gorchs et al.   Scientific Reports

The Role of the ECM in Lung Cancer Dormancy and Outgrowth

(2020) Amelia L. Parker et al.   Frontiers in Oncology

Molecular subtypes of pancreatic cancer

(2019) Eric A. Collisson et al.   Nature Reviews Gastroenterology & Hepatology

Phase IB/II Randomized Study of FOLFIRINOX Plus Pegylated Recombinant Human Hyaluronidase Versus FOLFIRINOX Alone in Patients With Metastatic Pancreatic Adenocarcinoma: SWOG S1313

(2019) Ramesh K. Ramanathan et al.   JOURNAL OF CLINICAL ONCOLOGY

Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer

(2019) Matteo Ligorio et al.   CELL

Maintenance Olaparib for Germline BRCA-Mutated Metastatic Pancreatic Cancer

(2019) Talia Golan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts

(2019) Ela Elyada et al.   Cancer Discovery

The role of collagen in cancer: from bench to bedside

(2019) Shuaishuai Xu et al.   Journal of Translational Medicine

Proteomic analyses of ECM during pancreatic ductal adenocarcinoma progression reveal different contributions by tumor and stromal cells

(2019) Chenxi Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phase 2 study of vismodegib, a hedgehog inhibitor, combined with gemcitabine and nab-paclitaxel in patients with untreated metastatic pancreatic adenocarcinoma

(2019) Ana De Jesus-Acosta et al.   BRITISH JOURNAL OF CANCER

Epithelial to mesenchymal plasticity and differential response to therapies in pancreatic ductal adenocarcinoma

(2019) Rebecca L. Porter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Collagen fragments quantified in serum as measures of desmoplasia associate with survival outcome in patients with advanced pancreatic cancer

(2019) Nicholas Willumsen et al.   Scientific Reports

Rho Kinase Inhibition by AT13148 Blocks Pancreatic Ductal Adenocarinoma Invasion and Tumor Growth

(2018) Nicola Rath et al.   CANCER RESEARCH

Parallel Accumulation of Tumor Hyaluronan, Collagen and Other Drivers of Tumor Progression

(2018) Xiaoming Li et al.   CLINICAL CANCER RESEARCH

Extracellular matrix composition modulates PDAC parenchymal and stem cell plasticity and behavior through the secretome

(2018) Giulia Biondani et al.   FEBS Journal

Targeting galectin-1 inhibits pancreatic cancer progression by modulating tumor–stroma crosstalk

(2018) Carlos A. Orozco et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stromal biology and therapy in pancreatic cancer: ready for clinical translation?

(2018) Albrecht Neesse et al.   GUT

The Role of Tumor Microenvironment in Chemoresistance: 3D Extracellular Matrices as Accomplices

(2018) Dimakatso Senthebane et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Extracellular Matrix and Pancreatic Cancer: A Complex Relationship

(2018) Maximilian Weniger et al.   Cancers

Antifibrotic Therapy Disrupts Stromal Barriers and Modulates the Immune Landscape in Pancreatic Ductal Adenocarcinoma

(2018) Kianna Y. Elahi-Gedwillo et al.   CANCER RESEARCH

Mutual Expression of ALDH1A1, LOX, and Collagens in Ovarian Cancer Cell Lines as Combined CSCs- and ECM-Related Models of Drug Resistance Development

(2018) Karolina Sterzyńska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanisms of Matrix-Induced Chemoresistance of Breast Cancer Cells—Deciphering Novel Potential Targets for a Cell Sensitization

(2018) Bastian Jakubzig et al.   Cancers

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

(2017) Daniel Öhlund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis

(2017) Claire Vennin et al.   Science Translational Medicine

Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions

(2017) Orianne Olivares et al.   Nature Communications

Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer

(2017) Julienne L. Carstens et al.   Nature Communications

Galectin-3, a Druggable Vulnerability for KRAS-Addicted Cancers

(2017) Laetitia Seguin et al.   Cancer Discovery

Ellagic acid inhibits the proliferation of human pancreatic carcinoma PANC-1 cells in vitro and in vivo

(2017) Hao Cheng et al.   Oncotarget

TGF-β in pancreatic cancer initiation and progression: two sides of the same coin

(2017) Wei Shen et al.   Cell and Bioscience

Matrix stiffness induces epithelial–mesenchymal transition and promotes chemoresistance in pancreatic cancer cells

(2017) A J Rice et al.   Oncogenesis

Inhibition of ROCK1 kinase modulates both tumor cells and stromal fibroblasts in pancreatic cancer

(2017) Clifford J. Whatcott et al.   PLoS One

Vitamin D and Myofibroblasts in Fibrosis and Cancer: At Cross-purposes with TGF-β/SMAD Signaling

(2016) SHRAGA SHANY et al.   ANTICANCER RESEARCH

YAP1 and TAZ Control Pancreatic Cancer Initiation in Mice by Direct Up-regulation of JAK–STAT3 Signaling

(2016) Ralph Gruber et al.   GASTROENTEROLOGY

The integrin adhesome network at a glance

(2016) Edward R. Horton et al.   JOURNAL OF CELL SCIENCE

Locally Advanced, Unresectable Pancreatic Cancer: American Society of Clinical Oncology Clinical Practice Guideline

(2016) Edward P. Balaban et al.   JOURNAL OF CLINICAL ONCOLOGY

Diffusion-weighted and dynamic contrast-enhanced MRI of pancreatic adenocarcinoma xenografts: associations with tumor differentiation and collagen content

(2016) Catherine S. Wegner et al.   Journal of Translational Medicine

Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors

(2016) Shawn M Davidson et al.   NATURE MEDICINE

Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression

(2016) Hanane Laklai et al.   NATURE MEDICINE

A Phase I Study of FOLFIRINOX Plus IPI-926, a Hedgehog Pathway Inhibitor, for Advanced Pancreatic Adenocarcinoma

(2016) Andrew H. Ko et al.   PANCREAS

Glycoproteins and glycoproteomics in pancreatic cancer

(2016) Sheng Pan et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Collagen type V promotes the malignant phenotype of pancreatic ductal adenocarcinoma

(2015) Sonja Berchtold et al.   CANCER LETTERS

Human Pancreatic Cancer Tumors Are Nutrient Poor and Tumor Cells Actively Scavenge Extracellular Protein

(2015) J. J. Kamphorst et al.   CANCER RESEARCH

RUNX3 Controls a Metastatic Switch in Pancreatic Ductal Adenocarcinoma

(2015) Martin C. Whittle et al.   CELL

Tissue Transglutaminase Mediated Tumor-Stroma Interaction Promotes Pancreatic Cancer Progression

(2015) J. Lee et al.   CLINICAL CANCER RESEARCH

Desmoplasia in Primary Tumors and Metastatic Lesions of Pancreatic Cancer

(2015) C. J. Whatcott et al.   CLINICAL CANCER RESEARCH

Randomized Phase Ib/II Study of Gemcitabine Plus Placebo or Vismodegib, a Hedgehog Pathway Inhibitor, in Patients With Metastatic Pancreatic Cancer

(2015) Daniel V.T. Catenacci et al.   JOURNAL OF CLINICAL ONCOLOGY

Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassembly

(2015) Edward R. Horton et al.   NATURE CELL BIOLOGY

Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma

(2015) Richard A Moffitt et al.   NATURE GENETICS

Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors

(2015) Anneleen Daemen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endothelial destabilization by angiopoietin-2 via integrin β1 activation

(2015) Laura Hakanpaa et al.   Nature Communications

Stromal-derived factor-1α/CXCL12-CXCR4 chemotactic pathway promotes perineural invasion in pancreatic cancer

(2015) Qinhong Xu et al.   Oncotarget

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2014) Berna C. Özdemir et al.   CANCER CELL

Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma

(2014) Andrew D. Rhim et al.   CANCER CELL

Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States

(2014) L. Rahib et al.   CANCER RESEARCH

Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy

(2014) Mara H. Sherman et al.   CELL

Sonic Hedgehog Paracrine Signaling Activates Stromal Cells to Promote Perineural Invasion in Pancreatic Cancer

(2014) X. Li et al.   CLINICAL CANCER RESEARCH

Pilot Clinical Trial of Hedgehog Pathway Inhibitor GDC-0449 (Vismodegib) in Combination with Gemcitabine in Patients with Metastatic Pancreatic Adenocarcinoma

(2014) E. J. Kim et al.   CLINICAL CANCER RESEARCH

The extracellular matrix modulates the hallmarks of cancer

(2014) M. W. Pickup et al.   EMBO REPORTS

Cellular contractility and extracellular matrix stiffness regulate matrix metalloproteinase activity in pancreatic cancer cells

(2014) Amanda Haage et al.   FASEB JOURNAL

Quantitative Glycoproteomics Analysis Reveals Changes in N-Glycosylation Level Associated with Pancreatic Ductal Adenocarcinoma

(2014) Sheng Pan et al.   JOURNAL OF PROTEOME RESEARCH

Proteins associated with pancreatic cancer survival in patients with resectable pancreatic ductal adenocarcinoma

(2014) Ru Chen et al.   LABORATORY INVESTIGATION

Mechanotransduction and extracellular matrix homeostasis

(2014) Jay D. Humphrey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Biology of YAP/TAZ: Hippo Signaling and Beyond

(2014) Stefano Piccolo et al.   PHYSIOLOGICAL REVIEWS

Stromal response to Hedgehog signaling restrains pancreatic cancer progression

(2014) J. J. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular composition and function of integrin-based collagen glues—Introducing COLINBRIs

(2013) Cédric Zeltz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Type IV collagen stimulates pancreatic cancer cell proliferation, migration, and inhibits apoptosis through an autocrine loop

(2013) Daniel Öhlund et al.   BMC CANCER

Neuropilin-2 Promotes Extravasation and Metastasis by Interacting with Endothelial  5 Integrin

(2013) Y. Cao et al.   CANCER RESEARCH

LOX-Mediated Collagen Crosslinking Is Responsible for Fibrosis-Enhanced Metastasis

(2013) T. R. Cox et al.   CANCER RESEARCH

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

(2013) Cosimo Commisso et al.   NATURE

Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine

(2013) Daniel D. Von Hoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels

(2013) Vikash P. Chauhan et al.   Nature Communications

Discoidin domain receptor tyrosine kinases: new players in cancer progression

(2012) Rajeshwari R. Valiathan et al.   CANCER AND METASTASIS REVIEWS

Stromal galectin-1 expression is associated with long-term survival in resectable pancreatic ductal adenocarcinoma

(2012) Ru Chen et al.   CANCER BIOLOGY & THERAPY

Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma

(2012) Paolo P. Provenzano et al.   CANCER CELL

Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer

(2012) Michael A Jacobetz et al.   GUT

Pancreatic stellate cells: a starring role in normal and diseased pancreas

(2012) Minoti V. Apte et al.   Frontiers in Physiology

Knockdown of the β1 integrin subunit reduces primary tumor growth and inhibits pancreatic cancer metastasis

(2011) John J. Grzesiak et al.   INTERNATIONAL JOURNAL OF CANCER

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer

(2011) Thierry Conroy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dynamic interplay between the collagen scaffold and tumor evolution

(2010) Mikala Egeblad et al.   CURRENT OPINION IN CELL BIOLOGY

Enzymatic Depletion of Tumor Hyaluronan Induces Antitumor Responses in Preclinical Animal Models

(2010) C. B. Thompson et al.   MOLECULAR CANCER THERAPEUTICS

Type IV collagen is a tumour stroma-derived biomarker for pancreas cancer

(2009) D Öhlund et al.   BRITISH JOURNAL OF CANCER

Basement membranes and human disease

(2009) Tom Van Agtmael et al.   CELL AND TISSUE RESEARCH

Desmoplasia of Pancreatic Ductal Adenocarcinoma

(2009) Stephen Pandol et al.   Clinical Gastroenterology and Hepatology

Lack of host SPARC enhances vascular function and tumor spread in an orthotopic murine model of pancreatic carcinoma

(2009) S. A. Arnold et al.   Disease Models & Mechanisms

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

(2009) K. P. Olive et al.   SCIENCE

Sonic Hedgehog Promotes Desmoplasia in Pancreatic Cancer

(2008) J. M. Bailey et al.   CLINICAL CANCER RESEARCH

Traction stress in focal adhesions correlates biphasically with actin retrograde flow speed

(2008) Margaret L. Gardel et al.   JOURNAL OF CELL BIOLOGY

Vitamin D reduces the expression of collagen and key profibrotic factors by inducing an antifibrotic phenotype in mesenchymal multipotent cells

(2008) Jorge N Artaza et al.   JOURNAL OF ENDOCRINOLOGY

IFATS Collection: Combinatorial Peptides Identify α5β1 Integrin as a Receptor for the Matricellular Protein SPARC on Adipose Stromal Cells

(2008) Jing Nie et al.   STEM CELLS