The role of stromal cancer-associated fibroblasts in pancreatic cancer

Cancer-Associated Fibroblasts in Pancreatic Cancer Are Reprogrammed by Tumor-Induced Alterations in Genomic DNA Methylation

(2016) Qian Xiao et al.   CANCER RESEARCH

TGF-β-induced stromal CYR61 promotes resistance to gemcitabine in pancreatic ductal adenocarcinoma through downregulation of the nucleoside transporters hENT1 and hCNT3

(2016) Rachel A. Hesler et al.   CARCINOGENESIS

Phase Ib Study of PEGylated Recombinant Human Hyaluronidase and Gemcitabine in Patients with Advanced Pancreatic Cancer

(2016) S. R. Hingorani et al.   CLINICAL CANCER RESEARCH

ETS-Transcription Factor ETV1 Regulates Stromal Expansion and Metastasis in Pancreatic Cancer

(2016) Steffen Heeg et al.   GASTROENTEROLOGY

Loss of P53 Function Activates JAK2–STAT3 Signaling to Promote Pancreatic Tumor Growth, Stroma Modification, and Gemcitabine Resistance in Mice and Is Associated With Patient Survival

(2016) Sonja M. Wörmann et al.   GASTROENTEROLOGY

Cancer-associated fibroblasts promote the progression of endometrial cancer via the SDF-1/CXCR4 axis

(2016) Fei Teng et al.   Journal of Hematology & Oncology

Autologous cytokine-induced killer cell transfusion increases overall survival in advanced pancreatic cancer

(2016) Zibing Wang et al.   Journal of Hematology & Oncology

Anti-stromal treatment together with chemotherapy targets multiple signalling pathways in pancreatic adenocarcinoma

(2016) Elisabete F Carapuça et al.   JOURNAL OF PATHOLOGY

Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

(2016) Cristovão M. Sousa et al.   NATURE

Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis

(2016) Sebastian R. Nielsen et al.   NATURE CELL BIOLOGY

Tumor-infiltrating monocytes/macrophages promote tumor invasion and migration by upregulating S100A8 and S100A9 expression in cancer cells

(2016) S Y Lim et al.   ONCOGENE

Metastatic progression is associated with dynamic changes in the local microenvironment

(2016) Nicole M. Aiello et al.   Nature Communications

GM-CSF Mediates Mesenchymal-Epithelial Cross-talk in Pancreatic Cancer

(2016) M. Waghray et al.   Cancer Discovery

The Unfolded Protein Response Plays a Predominant Homeostatic Role in Response to Mitochondrial Stress in Pancreatic Stellate Cells

(2016) Hsin-Yuan Su et al.   PLoS One

Vascular and ductal elastotic changes in pancreatic cancer

(2015) Eleftheria Lakiotaki et al.   APMIS

Fibroblast activation protein-α-expressing fibroblasts promote the progression of pancreatic ductal adenocarcinoma

(2015) Tomoya Kawase et al.   BMC GASTROENTEROLOGY

A novel epigenetic mechanism regulating hyaluronan production in pancreatic cancer cells

(2015) Shiro Kohi et al.   CLINICAL & EXPERIMENTAL METASTASIS

Palladin expression is a conserved characteristic of the desmoplastic tumor microenvironment and contributes to altered gene expression

(2015) Austin R. Cannon et al.   Cytoskeleton

Gemcitabine-releasing mesenchymal stromal cells inhibit in vitro proliferation of human pancreatic carcinoma cells

(2015) Arianna Bonomi et al.   CYTOTHERAPY

Pharmacological targeting of the protein synthesis mTOR/4E-BP1 pathway in cancer-associated fibroblasts abrogates pancreatic tumour chemoresistance

(2015) C. Duluc et al.   EMBO Molecular Medicine

Randomized, Double-Blind, Phase II Study of Ruxolitinib or Placebo in Combination With Capecitabine in Patients With Metastatic Pancreatic Cancer for Whom Therapy With Gemcitabine Has Failed

(2015) Herbert I. Hurwitz et al.   JOURNAL OF CLINICAL ONCOLOGY

Advances in the management of gastrointestinal cancers—an upcoming role of immune checkpoint blockade

(2015) Gaurav Goel et al.   Journal of Hematology & Oncology

Novel approaches in the management of pancreatic ductal adenocarcinoma: potential promises for the future

(2015) Gaurav Goel et al.   Journal of Hematology & Oncology

Cancer stem cells in basic science and in translational oncology: can we translate into clinical application?

(2015) Axel Schulenburg et al.   Journal of Hematology & Oncology

CD146 attenuation in cancer-associated fibroblasts promotes pancreatic cancer progression

(2015) Biao Zheng et al.   MOLECULAR CARCINOGENESIS

Paracrine SDF-1α signaling mediates the effects of PSCs on GEM chemoresistance through an IL-6 autocrine loop in pancreatic cancer cells

(2015) Hui Zhang et al.   Oncotarget

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2014) Berna C. Özdemir et al.   CANCER CELL

Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma

(2014) Andrew D. Rhim et al.   CANCER CELL

Pilot Clinical Trial of Hedgehog Pathway Inhibitor GDC-0449 (Vismodegib) in Combination with Gemcitabine in Patients with Metastatic Pancreatic Adenocarcinoma

(2014) E. J. Kim et al.   CLINICAL CANCER RESEARCH

Colon cancer mesenchymal stem cells modulate the tumorigenicity of colon cancer through interleukin 6

(2013) Jen-Tsun Lin et al.   EXPERIMENTAL CELL RESEARCH

Modified FOLFIRINOX Regimen With Improved Safety and Maintained Efficacy in Pancreatic Adenocarcinoma

(2013) Hemchandra Mahaseth et al.   PANCREAS

Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma

(2012) Paolo P. Provenzano et al.   CANCER CELL

Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer

(2012) Michael A Jacobetz et al.   GUT

How fibrosis influences imaging and surgical decisions in pancreatic cancer

(2012) Mert Erkan et al.   Frontiers in Physiology

FAP-overexpressing fibroblasts produce an extracellular matrix that enhances invasive velocity and directionality of pancreatic cancer cells

(2011) Hyung-Ok Lee et al.   BMC CANCER

Retinoic Acid–Induced Pancreatic Stellate Cell Quiescence Reduces Paracrine Wnt–β-Catenin Signaling to Slow Tumor Progression

(2011) Fieke E.M. Froeling et al.   GASTROENTEROLOGY

Human ovarian carcinoma–associated mesenchymal stem cells regulate cancer stem cells and tumorigenesis via altered BMP production

(2011) Karen McLean et al.   JOURNAL OF CLINICAL INVESTIGATION

Gemcitabine Plusnab-Paclitaxel Is an Active Regimen in Patients With Advanced Pancreatic Cancer: A Phase I/II Trial

(2011) Daniel D. Von Hoff et al.   JOURNAL OF CLINICAL ONCOLOGY

Recruitment and Activation of Pancreatic Stellate Cells from the Bone Marrow in Pancreatic Cancer: A Model of Tumor-Host Interaction

(2011) Christopher J. Scarlett et al.   PLoS One

Pancreatic Stellate Cells Increase the Invasion of Human Pancreatic Cancer Cells through the Stromal Cell-Derived Factor-1/CXCR4 Axis

(2010) Zhenjun Gao et al.   PANCREATOLOGY

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

(2009) K. P. Olive et al.   SCIENCE

Carcinoma-Associated Fibroblast-Like Differentiation of Human Mesenchymal Stem Cells

(2008) P. J. Mishra et al.   CANCER RESEARCH

Sonic Hedgehog Promotes Desmoplasia in Pancreatic Cancer

(2008) J. M. Bailey et al.   CLINICAL CANCER RESEARCH

The Activated Stroma Index Is a Novel and Independent Prognostic Marker in Pancreatic Ductal Adenocarcinoma

(2008) Mert Erkan et al.   Clinical Gastroenterology and Hepatology

CXCL8/IL-8 and CXCL12/SDF-1α co-operatively promote invasiveness and angiogenesis in pancreatic cancer

(2008) Yoichi Matsuo et al.   INTERNATIONAL JOURNAL OF CANCER

A paracrine requirement for hedgehog signalling in cancer

(2008) Robert L. Yauch et al.   NATURE