Interleukin-1β-induced pancreatitis promotes pancreatic ductal adenocarcinoma via B lymphocyte–mediated immune suppression

Tumor Cell–Derived IL1β Promotes Desmoplasia and Immune Suppression in Pancreatic Cancer

(2020) Shipra Das et al.   CANCER RESEARCH

BTK signaling drives CD1dhiCD5+ regulatory B-cell differentiation to promote pancreatic carcinogenesis

(2019) Shipra Das et al.   ONCOGENE

Two Birds with One Stone: Therapeutic Targeting of IL1α Signaling Pathways in Pancreatic Ductal Adenocarcinoma and the Cancer-Associated Fibroblasts

(2019) Jianhua Ling et al.   Cancer Discovery

Elevated numbers of PD-L1 expressing B cells are associated with the development of AIDS-NHL

(2019) Marta Epeldegui et al.   Scientific Reports

Checkpoint inhibitors in pancreatic cancer

(2019) Andreas Henriksen et al.   CANCER TREATMENT REVIEWS

β2 Adrenergic-Neurotrophin Feedforward Loop Promotes Pancreatic Cancer

(2018) Bernhard W. Renz et al.   CANCER CELL

Tumor–Stroma IL1β-IRAK4 Feedforward Circuitry Drives Tumor Fibrosis, Chemoresistance, and Poor Prognosis in Pancreatic Cancer

(2018) Daoxiang Zhang et al.   CANCER RESEARCH

Interleukin 35 Expression Correlates With Microvessel Density in Pancreatic Ductal Adenocarcinoma, Recruits Monocytes, and Promotes Growth and Angiogenesis of Xenograft Tumors in Mice

(2018) Chongbiao Huang et al.   GASTROENTEROLOGY

Cholinergic Signaling via Muscarinic Receptors Directly and Indirectly Suppresses Pancreatic Tumorigenesis and Cancer Stemness

(2018) Bernhard W Renz et al.   Cancer Discovery

IL-1-induced JAK/STAT signaling is antagonized by TGF-beta to shape CAF heterogeneity in pancreatic ductal adenocarcinoma

(2018) Giulia Biffi et al.   Cancer Discovery

Pancreatic cancer

(2016) Terumi Kamisawa et al.   LANCET

IL1 Receptor Antagonist Inhibits Pancreatic Cancer Growth by Abrogating NF- B Activation

(2015) Z. Zhuang et al.   CLINICAL CANCER RESEARCH

Myeloid regulatory cells in tumor spreading and metastasis

(2015) Anton A. Keskinov et al.   IMMUNOBIOLOGY

Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy

(2015) Shabnam Shalapour et al.   NATURE

PD-L1hi B cells are critical regulators of humoral immunity

(2015) Adnan R. Khan et al.   Nature Communications

IL35-Producing B Cells Promote the Development of Pancreatic Neoplasia

(2015) Y. Pylayeva-Gupta et al.   Cancer Discovery

Bruton Tyrosine Kinase-Dependent Immune Cell Cross-talk Drives Pancreas Cancer

(2015) A. J. Gunderson et al.   Cancer Discovery

Hif1a Deletion Reveals Pro-Neoplastic Function of B Cells in Pancreatic Neoplasia

(2015) K. E. Lee et al.   Cancer Discovery

Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States

(2014) L. Rahib et al.   CANCER RESEARCH

Unique versus redundant functions of IL-1α and IL-1β in the tumor microenvironment

(2014) Elena Voronov   Frontiers in Immunology

Serum levels of IL-6 and IL-1β can predict the efficacy of gemcitabine in patients with advanced pancreatic cancer

(2013) S Mitsunaga et al.   BRITISH JOURNAL OF CANCER

Interleukin-6 Is Required for Pancreatic Cancer Progression by Promoting MAPK Signaling Activation and Oxidative Stress Resistance

(2013) Y. Zhang et al.   CANCER RESEARCH

B Cells Promote Tumor Progression via STAT3 Regulated-Angiogenesis

(2013) Chunmei Yang et al.   PLoS One

Disputed Paternity: The Uncertain Ancestry of Pancreatic Ductal Neoplasia

(2012) Anirban Maitra et al.   CANCER CELL

IL-1β promotes stemness and invasiveness of colon cancer cells through Zeb1 activation

(2012) Yijing Li et al.   Molecular Cancer

Pancreatic cancer in chronic pancreatitis; aetiology, incidence, and early detection

(2010) Sara Raimondi et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

B-cell-derived lymphotoxin promotes castration-resistant prostate cancer

(2010) Massimo Ammirante et al.   NATURE

Pancreatitis and pancreatic cancer in two large pooled case–control studies

(2009) Paige M. Bracci et al.   CANCER CAUSES & CONTROL

Ras Activity in Acinar Cells Links Chronic Pancreatitis and Pancreatic Cancer

(2009) Craig D. Logsdon et al.   Clinical Gastroenterology and Hepatology

Pancreatic Ductal Morphogenesis and the Pdx1 Homeodomain Transcription Factor

(2009) Melanie P. Wescott et al.   MOLECULAR BIOLOGY OF THE CELL

Overexpression of Interleukin-1β Induces Gastric Inflammation and Cancer and Mobilizes Myeloid-Derived Suppressor Cells in Mice

(2008) Shuiping Tu et al.   CANCER CELL

Overexpression of Interleukin-1β in the Murine Pancreas Results in Chronic Pancreatitis

(2008) Frederic Marrache et al.   GASTROENTEROLOGY

Opposing effects of fibrosarcoma cell-derived IL-1α and IL-1β on immune response induction

(2008) Rachid Marhaba et al.   INTERNATIONAL JOURNAL OF CANCER

Mononuclear cell-derived interleukin-1 beta confers chemoresistance in pancreatic cancer cells by upregulation of cyclooxygenase-2

(2008) Eliane Angst et al.   SURGERY