Hindrance of the Proteolytic Activity of Neutrophil-Derived Serine Proteases by Serine Protease Inhibitors as a Management of Cardiovascular Diseases and Chronic Inflammation

Elastase and Exacerbation of Neutrophil Innate Immunity are Involved in Multi‐Visceral Manifestations of COVID‐19

(2021) Jean‐Louis Guéant et al.   ALLERGY

Elastase inhibitor agaphelin protects from acute ischemic stroke in mice by reducing thrombosis, blood–brain barrier damage, and inflammation

(2021) Jonas Leinweber et al.   BRAIN BEHAVIOR AND IMMUNITY

Neutrophil Elastase Deficiency Ameliorates Myocardial Injury Post Myocardial Infarction in Mice

(2021) Yukino Ogura et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Protease-antiprotease imbalance in patients with severe COVID-19

(2021) Farid Zerimech et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

The Potential for Lactoferrin to Reduce SARS-CoV-2 Induced Cytokine Storm

(2021) Michał Zimecki et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Neutrophil Elastase and Proteinase 3 Cleavage Sites Are Adjacent to the Polybasic Sequence within the Proteolytic Sensitive Activation Loop of the SARS-CoV-2 Spike Protein

(2021) Zhadyra Mustafa et al.   ACS Omega

SARS-CoV-2 mutation 614G creates an elastase cleavage site enhancing its spread in high AAT-deficient regions

(2021) Chandrika Bhattacharyya et al.   INFECTION GENETICS AND EVOLUTION

The Course of AαVal541 as a Proteinase 3 Specific Neo-Epitope after Alpha-1-Antitrypsin Augmentation in Severe Deficient Patients

(2021) Iris G. M. Schouten et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

How the coronavirus infects cells — and why Delta is so dangerous

(2021) Megan Scudellari   NATURE

Increased elastase sensitivity and decreased intramolecular interactions in the more transmissible 501Y.V1 and 501Y.V2 SARS-CoV-2 variants’ spike protein–an in silico analysis

(2021) Suman Pokhrel et al.   PLoS One

Human proteinase 3 resistance to inhibition extends to alpha‐2 macroglobulin

(2020) Koffi N’Guessan et al.   FEBS Journal

Potent and Broad but not Unselective Cleavage of Cytokines and Chemokines by Human Neutrophil Elastase and Proteinase 3

(2020) Zhirong Fu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Novel Coronavirus from Patients with Pneumonia in China, 2019

(2020) Na Zhu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Anti-inflammatory and anti-cancer activities of frankincense: Targets, treatments and toxicities

(2020) Thomas Efferth et al.   SEMINARS IN CANCER BIOLOGY

Cathepsin G—Not Only Inflammation: The Immune Protease Can Regulate Normal Physiological Processes

(2020) Tatyana S. Zamolodchikova et al.   Frontiers in Immunology

Autopsy Findings and Venous Thromboembolism in Patients With COVID-19

(2020) Dominic Wichmann et al.   ANNALS OF INTERNAL MEDICINE

Nafamostat Mesylate Blocks Activation of SARS-CoV-2: New Treatment Option for COVID-19

(2020) Markus Hoffmann et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

New Insights into the Systemic Effects of Oral Lactoferrin: Transcriptome Profiling

(2020) Marian L Kruzel et al.   Biochemistry and Cell Biology

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor

(2020) Xiangyu Chen et al.   Cellular & Molecular Immunology

Inhibitors of the renin–angiotensin system and SARS-CoV-2 infection

(2020) Thorsten Kessler et al.   HERZ

The versatile heparin in COVID‐19

(2020) Jecko Thachil   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells

(2020) Markus Hoffmann et al.   MOLECULAR CELL

Controversies of renin–angiotensin system inhibition during the COVID-19 pandemic

(2020) Andrew M. South et al.   Nature Reviews Nephrology

Renin–Angiotensin–Aldosterone System Inhibitors in Patients with Covid-19

(2020) Muthiah Vaduganathan et al.   NEW ENGLAND JOURNAL OF MEDICINE

A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV

(2020) Meng Yuan et al.   SCIENCE

Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV

(2020) Xiuyuan Ou et al.   Nature Communications

TMPRSS2 and COVID-19: Serendipity or Opportunity for Intervention?

(2020) Konrad H. Stopsack et al.   Cancer Discovery

Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients

(2020) Jing Liu et al.   EBioMedicine

Pharmacological Therapeutics Targeting RNA-Dependent RNA Polymerase, Proteinase and Spike Protein: From Mechanistic Studies to Clinical Trials for COVID-19

(2020) Jiansheng Huang et al.   Journal of Clinical Medicine

Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19

(2020) Yuan Huang et al.   ACTA PHARMACOLOGICA SINICA

Cellular Mechanisms of NETosis

(2020) Hawa Racine Thiam et al.   Annual Review of Cell and Developmental Biology

Lack of type 1 diabetes involvement in SARS-COV-2 population: Only a particular coincidence?

(2020) Dario Pitocco et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Is Acetylsalicylic Acid a Safe and Potentially Useful Choice for Adult Patients with COVID-19 ?

(2020) Vanessa Bianconi et al.   DRUGS

Lung Protection by Cathepsin C Inhibition: A New Hope for COVID-19 and ARDS?

(2020) Brice Korkmaz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure of Furin Protease Binding to SARS-CoV-2 Spike Glycoprotein and Implications for Potential Targets and Virulence

(2020) Naveen Vankadari   Journal of Physical Chemistry Letters

Candidate drugs against SARS-CoV-2 and COVID-19

(2020) Dwight L. McKee et al.   PHARMACOLOGICAL RESEARCH

A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm

(2020) Michael R Garvin et al.   eLife

Preliminary Experience With Low Molecular Weight Heparin Strategy in COVID-19 Patients

(2020) Pasquale Paolisso et al.   Frontiers in Pharmacology

Vascular occlusion by neutrophil extracellular traps in COVID-19

(2020) Moritz Leppkes et al.   EBioMedicine

Neutrophil extracellular traps in COVID-19

(2020) Yu Zuo et al.   JCI Insight

TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells

(2020) Dorothea Bestle et al.   Life Science Alliance

Cathepsin G and its Dichotomous Role in Modulating Levels of MHC Class I Molecules

(2020) Timo Burster et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Activity-Based Protein Profiling of Serine Proteases in Immune Cells

(2020) Jan Pascal Kahler et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

NETosis Occurs Independently of Neutrophil Serine Proteases

(2020) Paulina Kasperkiewicz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Emodin inhibiting neutrophil elastase‐induced epithelial‐mesenchymal transition through Notch1 signalling in alveolar epithelial cells

(2020) Linshui Zhou et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Neutrophil elastase inhibitor (sivelestat) may be a promising therapeutic option for management of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID‐19

(2020) Adeleh Sahebnasagh et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

Proteins associated with neutrophil degranulation are upregulated in nasopharyngeal swabs from SARS-CoV-2 patients

(2020) Emel Akgun et al.   PLoS One

Alpha‐1‐antitrypsin : A possible host protective factor against Covid‐19

(2020) Mariana Braccialli Loyola et al.   REVIEWS IN MEDICAL VIROLOGY

Deep vein thrombosis in SARS-CoV-2 pneumonia-affected patients within standard care units: Exploring a submerged portion of the iceberg

(2020) Francesca Pizzolo et al.   THROMBOSIS RESEARCH

Beneficial non-anticoagulant mechanisms underlying heparin treatment of COVID-19 patients

(2020) Baranca Buijsers et al.   EBioMedicine

Membranous Nephropathy with Proteinase 3-ANCA-associated Vasculitis Successfully Treated with Rituximab

(2020) Shun Yoshida et al.   INTERNAL MEDICINE

Use of Nasoil® via intranasal to control the harmful effects of Covid-19

(2020) Carlos Eduardo Cuevas-Barragan et al.   MICROBIAL PATHOGENESIS

COVID-19 associated coagulopathy: Thrombosis, hemorrhage and mortality rates with an escalated-dose thromboprophylaxis strategy

(2020) Molly M. Daughety et al.   THROMBOSIS RESEARCH

The effect of anticoagulation on clinical outcomes in novel Coronavirus (COVID-19) pneumonia in a U.S. cohort

(2020) Lei Lynn et al.   THROMBOSIS RESEARCH

Alpha-1 Antitrypsin for COVID-19 Treatment: Dual Role in Antiviral Infection and Anti-Inflammation

(2020) Chengliang Yang et al.   Frontiers in Pharmacology

Role of Low-Molecular-Weight Heparin in Hospitalized Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Pneumonia: A Prospective Observational Study

(2020) Marco Falcone et al.   Open Forum Infectious Diseases

Neutrophil serine protease 4 is required for mast cell-dependent vascular leakage

(2020) Andrew P. AhYoung et al.   Communications Biology

Acute respiratory distress syndrome

(2019) Michael A. Matthay et al.   Nature Reviews Disease Primers

059. The Reversible Dipeptidyl Peptidase 1 Inhibitor, INS1007, Decreases Surface Proteinase 3 Expression and Neutrophil Serine Protease Activities in Human Neutrophils

(2019) Jimin Zhang et al.   RHEUMATOLOGY

Safety and efficacy of the human neutrophil elastase inhibitor BAY 85-8501 for the treatment of non-cystic fibrosis bronchiectasis: a randomized controlled trial

(2019) Henrik Watz et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Proteinase 3 phosphonic inhibitors

(2019) Renata Grzywa et al.   BIOCHIMIE

Neutrophil Elastase Damages the Pulmonary Endothelial Glycocalyx in Lipopolysaccharide-Induced Experimental Endotoxemia

(2019) Kodai Suzuki et al.   AMERICAN JOURNAL OF PATHOLOGY

Increased proteinase 3 and neutrophil elastase plasma concentrations are associated with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes

(2019) Andreea-Manuela Mirea et al.   MOLECULAR MEDICINE

Structure-based design and in vivo anti-arthritic activity evaluation of a potent dipeptidyl cyclopropyl nitrile inhibitor of cathepsin C

(2019) Brice Korkmaz et al.   BIOCHEMICAL PHARMACOLOGY

Cathepsin G Inhibition by Serpinb1 and Serpinb6 Prevents Programmed Necrosis in Neutrophils and Monocytes and Reduces GSDMD-Driven Inflammation

(2019) Sabrina Sofia Burgener et al.   Cell Reports

Role of Neutrophil Extracellular Traps and Vesicles in Regulating Vascular Endothelial Permeability

(2019) Yonggang Ma et al.   Frontiers in Immunology

Cow Milk Lactoferrin Possesses Several Catalytic Activities

(2019) Svetlana E. Soboleva et al.   Biomolecules

Peptidomimetic inhibitors targeting the membrane-binding site of the neutrophil proteinase 3

(2019) Ksenia Maximova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Single dose escalation studies with inhaled POL6014, a potent novel selective reversible inhibitor of human neutrophil elastase, in healthy volunteers and subjects with cystic fibrosis

(2019) P. Barth et al.   Journal of Cystic Fibrosis

Intracardiac administration of neutrophil protease cathepsin G activates noncanonical inflammasome pathway and promotes inflammation and pathological remodeling in non-injured heart

(2019) Sonni-Ali Miller et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Neutrophil proteases degrade autoepitopes of NET‐associated proteins

(2019) C. M. Bont et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Neutrophil elastase contributes to the pathological vascular permeability characteristic of diabetic retinopathy

(2019) Haitao Liu et al.   DIABETOLOGIA

The N125S polymorphism in the cathepsin G gene (rs45567233) is associated with susceptibility to osteomyelitis in a Spanish population

(2019) Laura Pérez-Is et al.   PLoS One

Neutrophil Elastase Inhibition Ameliorates Endotoxin-Induced Myocardial Injury Accompanying Degradation of Cardiac Capillary Glycocalyx

(2019) Tetsuya Fukuta et al.   SHOCK

Prevention of Pulmonary Edema after Minimally Invasive Cardiac Surgery with Mini-Thoracotomy Using Neutrophil Elastase Inhibitor

(2018) Satoshi Yamashiro et al.   Annals of Thoracic and Cardiovascular Surgery

Neutrophil Extracellular Traps Induce Endothelial Cell Activation and Tissue Factor Production Through Interleukin-1α and Cathepsin G

(2018) Eduardo J. Folco et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Lung tissue destruction by proteinase 3 and cathepsin G mediated elastin degradation is elevated in chronic obstructive pulmonary disease

(2018) Natasja Stæhr Gudmann et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Extended cleavage specificity of human neutrophil cathepsin G: A low activity protease with dual chymase and tryptase-type specificities

(2018) Michael Thorpe et al.   PLoS One

Functional Proteomic Profiling of Secreted Serine Proteases in Health and Inflammatory Bowel Disease

(2018) Alexandre Denadai-Souza et al.   Scientific Reports

Aggregated neutrophil extracellular traps resolve inflammation by proteolysis of cytokines and chemokines and protection from antiproteases

(2018) Jonas Hahn et al.   FASEB JOURNAL

Proteases and Their Inhibitors in Chronic Obstructive Pulmonary Disease

(2018) Tapan Dey et al.   Journal of Clinical Medicine

Highly Selective Cleavage of Cytokines and Chemokines by the Human Mast Cell Chymase and Neutrophil Cathepsin G

(2017) Zhirong Fu et al.   JOURNAL OF IMMUNOLOGY

Proteinase 3: the odd one out that became an autoantigen

(2017) Katherine R. Martin et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Design of Potent and Selective Cathepsin G Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold

(2017) Joakim E. Swedberg et al.   JOURNAL OF MEDICINAL CHEMISTRY

Vasoactive properties of antihypertensive lactoferrin-derived peptides in resistance vessels: Effects in small mesenteric arteries from SHR rats

(2017) Aurora García-Tejedor et al.   LIFE SCIENCES

Lactoferrin in a Context of Inflammation-Induced Pathology

(2017) Marian L. Kruzel et al.   Frontiers in Immunology

Lactoferrin, a Pleiotropic Protein in Health and Disease

(2016) Sylvain Mayeur et al.   ANTIOXIDANTS & REDOX SIGNALING

Cathepsin G Controls Arterial But Not Venular Myeloid Cell RecruitmentClinical Perspective

(2016) Almudena Ortega-Gomez et al.   CIRCULATION

A small molecule neutrophil elastase inhibitor, KRP-109, inhibits cystic fibrosis mucin degradation

(2016) Shashi Chillappagari et al.   Journal of Cystic Fibrosis

Identification of the Fusion Peptide-Containing Region in Betacoronavirus Spike Glycoproteins

(2016) Xiuyuan Ou et al.   JOURNAL OF VIROLOGY

Neutrophil Elastase-mediated proteolysis activates the anti-inflammatory cytokine IL-36 Receptor antagonist

(2016) Tom Macleod et al.   Scientific Reports

Lactoferrin Suppresses Neutrophil Extracellular Traps Release in Inflammation

(2016) Koshu Okubo et al.   EBioMedicine

Lactoferrin Is an Allosteric Enhancer of the Proteolytic Activity of Cathepsin G

(2016) Steffen Eipper et al.   PLoS One

Up-regulation of Cathepsin G in the Development of Chronic Postsurgical Pain

(2015) Xiaodong Liu et al.   ANESTHESIOLOGY

Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases

(2015) Franz von Nussbaum et al.   ChemMedChem

Neutrophil Elastase Promotes Interleukin-1β Secretion from Human Coronary Endothelium

(2015) Mabruka Alfaidi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unopposed Cathepsin G, Neutrophil Elastase, and Proteinase 3 Cause Severe Lung Damage and Emphysema

(2014) Nicolas Guyot et al.   AMERICAN JOURNAL OF PATHOLOGY

Cathepsin G degradation of phospholipid transfer protein (PLTP) augments pulmonary inflammation

(2014) Anthony Brehm et al.   FASEB JOURNAL

Proteinase 3–dependent caspase-3 cleavage modulates neutrophil death and inflammation

(2014) Fabien Loison et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanism of Neutrophil Dysfunction: Neutrophil Serine Proteases Cleave and Inactivate the C5a Receptor

(2014) C. W. van den Berg et al.   JOURNAL OF IMMUNOLOGY

Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein

(2014) Jean Kaoru Millet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of Neutrophil Serine Protease 4 Reveal an Unusual Mechanism of Substrate Recognition by a Trypsin-Fold Protease

(2014) S. Jack Lin et al.   STRUCTURE

Proteolytic activation of the SARS-coronavirus spike protein: Cutting enzymes at the cutting edge of antiviral research

(2013) Graham Simmons et al.   ANTIVIRAL RESEARCH

Inhibitors of cathepsin G: a patent review (2005 to present)

(2013) Paulina Kosikowska et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

TMPRSS2 Activates the Human Coronavirus 229E for Cathepsin-Independent Host Cell Entry and Is Expressed in Viral Target Cells in the Respiratory Epithelium

(2013) S. Bertram et al.   JOURNAL OF VIROLOGY

Risk Factors for Bronchiectasis in Children with Cystic Fibrosis

(2013) Peter D. Sly et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cathepsin G-Dependent Modulation of Platelet Thrombus Formation In Vivo by Blood Neutrophils

(2013) Nauder Faraday et al.   PLoS One

Sunflower Trypsin Inhibitor 1 as a Molecular Scaffold for Drug Discovery

(2012) Adam Lesner et al.   CURRENT PHARMACEUTICAL DESIGN

NSP4, an elastase-related protease in human neutrophils with arginine specificity

(2012) N. C. Perera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Boswellia serrata

(2011) Mona Abdel-Tawab et al.   CLINICAL PHARMACOKINETICS

Loss of expression of neutrophil proteinase-3: a factor contributing to thrombotic risk in paroxysmal nocturnal hemoglobinuria

(2011) A. M. Jankowska et al.   HAEMATOLOGICA

Interaction of Serine Proteases from Polymorphonuclear Leucocytes with the Cell Surface and Heparin

(2011) Jana Fleddermann et al.   INFLAMMATION

Targeting COPD: advances on low-molecular-weight inhibitors of human neutrophil elastase

(2011) Susana D. Lucas et al.   MEDICINAL RESEARCH REVIEWS

Regulation of Cathepsin G Reduces the Activation of Proinsulin-Reactive T Cells from Type 1 Diabetes Patients

(2011) Fang Zou et al.   PLoS One

Inhaled neutrophil elastase inhibitor reduces oleic acid-induced acute lung injury in rats

(2011) Wei Tao et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Rituximab in relapsing or refractory ANCA-associated vasculitis: a case series of 16 patients

(2011) M Wendt et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

How Immune Peptidases Change Specificity: Cathepsin G Gained Tryptic Function but Lost Efficiency during Primate Evolution

(2010) W. W. Raymond et al.   JOURNAL OF IMMUNOLOGY

Efficient Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein by the Transmembrane Protease TMPRSS2

(2010) S. Matsuyama et al.   JOURNAL OF VIROLOGY

Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases

(2010) Steffen Massberg et al.   NATURE MEDICINE

Neutrophil Elastase, Proteinase 3, and Cathepsin G as Therapeutic Targets in Human Diseases

(2010) B. Korkmaz et al.   PHARMACOLOGICAL REVIEWS

In vitro effects of human neutrophil cathepsin G on thrombin generation: Both acceleration and decreased potential

(2010) Thomas Lecompte et al.   THROMBOSIS AND HAEMOSTASIS

Contribution of neutrophil elastase to the lysis of obliterative thrombi in the context of their platelet and fibrin content

(2010) Gyöngyi Rábai et al.   THROMBOSIS RESEARCH

Dual Inhibition of Cathepsin G and Chymase Is Effective in Animal Models of Pulmonary Inflammation

(2009) Bruce E. Maryanoff et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Introduction of non-natural amino acid residues into the substrate-specific P1 position of trypsin inhibitor SFTI-1 yields potent chymotrypsin and cathepsin G inhibitors

(2009) Anna Łęgowska et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Neutrophil elastase inhibitor (sivelestat) reduces the Levels of inflammatory mediators by inhibiting NF-kB

(2009) S. Hagiwara et al.   INFLAMMATION RESEARCH

Serine proteases

(2009) Enrico Di Cera   IUBMB LIFE

Identification of Human Cathepsin G As a Functional Target of Boswellic Acids from the Anti-Inflammatory Remedy Frankincense

(2009) L. Tausch et al.   JOURNAL OF IMMUNOLOGY

Activation of the SARS coronavirus spike protein via sequential proteolytic cleavage at two distinct sites

(2009) S. Belouzard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SIVELESTAT (SELECTIVE NEUTROPHIL ELASTASE INHIBITOR) IMPROVES THE MORTALITY RATE OF SEPSIS ASSOCIATED WITH BOTH ACUTE RESPIRATORY DISTRESS SYNDROME AND DISSEMINATED INTRAVASCULAR COAGULATION PATIENTS

(2009) Mineji Hayakawa et al.   SHOCK

Lactoferrin Inhibits Platelet Production from Human Megakaryocytes in Vitro

(2008) Kuniko Matsumura-Takeda et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

The Membrane Proteinase 3 Expression on Neutrophils Was Downregulated After Treatment With Infliximab in Patients With Rheumatoid Arthritis

(2008) Takeshi Matsumoto et al.   CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS

Neutrophil elastase, proteinase 3 and cathepsin G: Physicochemical properties, activity and physiopathological functions

(2007) Brice Korkmaz et al.   BIOCHIMIE

Neutrophil serine proteases fine-tune the inflammatory response

(2007) C PHAM   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY