Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases

α-1-Antitrypsin variants and the proteinase/antiproteinase imbalance in chronic obstructive pulmonary disease

(2015) Nicola J. Sinden et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Best of Both Worlds: Combining Pharma Data and State of the Art Modeling Technology To Improve in Silico pKa Prediction

(2014) Robert Fraczkiewicz et al.   Journal of Chemical Information and Modeling

Sulfoximines: A Neglected Opportunity in Medicinal Chemistry

(2013) Ulrich Lücking   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Setting expectations in molecular optimizations: Strengths and limitations of commonly used composite parameters

(2013) Michael D. Shultz   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Jaguar: A high-performance quantum chemistry software program with strengths in life and materials sciences

(2013) Art D. Bochevarov et al.   INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY

Phase II study of a neutrophil elastase inhibitor (AZD9668) in patients with bronchiectasis

(2013) Robert Stockley et al.   RESPIRATORY MEDICINE

A Randomised, Placebo-Controlled, Dose-Finding Study Of AZD9668, An Oral Inhibitor of Neutrophil Elastase, in Patients with Chronic Obstructive Pulmonary Disease Treated with Tiotropium

(2012) Claus Vogelmeier et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Efficacy, safety and effect on biomarkers of AZD9668 in cystic fibrosis

(2012) J. Stuart Elborn et al.   EUROPEAN RESPIRATORY JOURNAL

Neutrophil elastase inhibitors: recent advances in the development of mechanism-based and nonelectrophilic inhibitors

(2012) Peter Sjö   Future Medicinal Chemistry

Unexpected Active-Site Flexibility in the Structure of Human Neutrophil Elastase in Complex with a New Dihydropyrimidone Inhibitor

(2011) Guido Hansen et al.   JOURNAL OF MOLECULAR BIOLOGY

Targeting COPD: advances on low-molecular-weight inhibitors of human neutrophil elastase

(2011) Susana D. Lucas et al.   MEDICINAL RESEARCH REVIEWS

AZD9668, a neutrophil elastase inhibitor, plus ongoing budesonide/formoterol in patients with COPD

(2011) Piotr Kuna et al.   RESPIRATORY MEDICINE

Neutrophil Elastase, Proteinase 3, and Cathepsin G as Therapeutic Targets in Human Diseases

(2010) B. Korkmaz et al.   PHARMACOLOGICAL REVIEWS