Highly Selective Cleavage of Cytokines and Chemokines by the Human Mast Cell Chymase and Neutrophil Cathepsin G

IGF-1 degradation by mouse mast cell protease 4 promotes cell death and adverse cardiac remodeling days after a myocardial infarction

(2016) Thor Tejada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mast cells and IgE in defense against venoms: Possible “good side” of allergy?

(2016) Stephen J. Galli et al.   ALLERGOLOGY INTERNATIONAL

Eotaxin-3 (CCL26) exerts innate host defense activities that are modulated by mast cell proteases

(2015) A. Gela et al.   ALLERGY

Mediators of Chronic Pruritus in Atopic Dermatitis: Getting the Itch Out?

(2015) Nicholas K. Mollanazar et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Interleukin-15, a Master Piece in the Immunological Jigsaw of Celiac Disease

(2015) Bertrand Meresse et al.   DIGESTIVE DISEASES

The Shared and Contrasting Roles of IL2 and IL15 in the Life and Death of Normal and Neoplastic Lymphocytes: Implications for Cancer Therapy

(2015) T. A. Waldmann   Cancer Immunology Research

Mast Cells as Regulators of T Cell Responses

(2015) Silvia Bulfone-Paus et al.   Frontiers in Immunology

Central domain of IL-33 is cleaved by mast cell proteases for potent activation of group-2 innate lymphoid cells

(2014) E. Lefrancais et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Granule proteases of hematopoietic cells, a family of versatile inflammatory mediators – an update on their cleavage specificity, in vivo substrates, and evolution

(2013) Lars Hellman et al.   BIOLOGICAL CHEMISTRY

Mast Cell Chymase Degrades the Alarmins Heat Shock Protein 70, Biglycan, HMGB1, and Interleukin-33 (IL-33) and Limits Danger-induced Inflammation

(2013) Ananya Roy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Biology of IL-15: Implications for Cancer Therapy and the Treatment of Autoimmune Disorders

(2013) Thomas A. Waldmann   JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS

Spreading Depression Triggers Headache by Activating Neuronal Panx1 Channels

(2013) H. Karatas et al.   SCIENCE

The Chymase Mouse Mast Cell Protease 4 Degrades TNF, Limits Inflammation, and Promotes Survival in a Model of Sepsis

(2012) Adrian M. Piliponsky et al.   AMERICAN JOURNAL OF PATHOLOGY

Mast cells limit extracellular levels of IL-13 via a serglycin proteoglycan-serine protease axis

(2012) Ida Waern et al.   BIOLOGICAL CHEMISTRY

Extended cleavage specificity of the mast cell chymase from the crab-eating macaque (Macaca fascicularis): an interesting animal model for the analysis of the function of the human mast cell chymase

(2012) M. Thorpe et al.   INTERNATIONAL IMMUNOLOGY

Mast cell chymase modulates IL-33 levels and controls allergic sensitization in dust-mite induced airway inflammation

(2012) I Waern et al.   Mucosal Immunology

Discriminating between the activities of human cathepsin G and chymase using fluorogenic substrates

(2011) Brice Korkmaz et al.   FEBS Journal

The role of interleukin-15 in inflammation and immune responses to infection: implications for its therapeutic use

(2011) Pin-Yu Perera et al.   MICROBES AND INFECTION

Potency variation of small-molecule chymase inhibitors across species

(2010) Jukka Kervinen et al.   BIOCHEMICAL PHARMACOLOGY

Mast cell proteases: multifaceted regulators of inflammatory disease

(2010) G. Pejler et al.   BLOOD

Arg143 and Lys192 of the human mast cell chymase mediate the preference for acidic amino acids in position P2′ of substrates

(2010) Mattias K. Andersson et al.   FEBS Journal

How Immune Peptidases Change Specificity: Cathepsin G Gained Tryptic Function but Lost Efficiency during Primate Evolution

(2010) W. W. Raymond et al.   JOURNAL OF IMMUNOLOGY

The extended substrate specificity of the human mast cell chymase reveals a serine protease with well-defined substrate recognition profile

(2008) M. K. Andersson et al.   INTERNATIONAL IMMUNOLOGY

Role of neutrophil proteinase 3 and mast cell chymase in chemerin proteolytic regulation

(2008) Aude Guillabert et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neutrophil elastase, proteinase 3 and cathepsin G: Physicochemical properties, activity and physiopathological functions

(2007) Brice Korkmaz et al.   BIOCHIMIE

The extended cleavage specificity of the rodent β-chymases rMCP-1 and mMCP-4 reveal major functional similarities to the human mast cell chymase

(2007) Mattias K. Andersson et al.   MOLECULAR IMMUNOLOGY