Article
Oncology
Qian Xie, Huiling Guo, Peirong He, Huan Deng, Yanjun Gao, Ningning Dong, Wenbo Niu, Tiancai Liu, Ming Li, Suihai Wang, Yingsong Wu, Ji-Liang Li
Summary: High expression of Tspan5 is significantly associated with clinicopathological features and poor survival in HCC patients, promoting cell migration and tumour metastasis. Mechanistically, Tspan5 enhances ADAM10 enzymatic activity, activates Notch signaling, and induces epithelial-mesenchymal transition in tumour cells. These findings highlight the pivotal role of Tspan5 in regulating Notch signaling, EMT, and tumour metastasis in HCC.
MOLECULAR ONCOLOGY
(2021)
Article
Cell Biology
Ellen K. Janke, Silke B. Chalmers, Sarah J. Roberts-Thomson, Gregory R. Monteith
Summary: Epithelial-mesenchymal transition (EMT) is a critical step in cancer progression and is associated with the remodeling of calcium (Ca2+) signaling pathways. This review explores the complex interplay between Ca2+ signaling and EMT, highlighting the potential therapeutic opportunities in regulating EMT through Ca2+ signaling. However, the complexity of these pathways presents challenges in manipulating Ca2+ signaling for therapeutic intervention in cancer.
Review
Pharmacology & Pharmacy
Sara Lovisa
Summary: EMT, a process crucial in wound healing, fibrosis, and cancer, has gained significant attention from researchers since its discovery in the seventies. Despite advances in understanding its functional role, targeting EMT in fibrotic diseases remains a challenge at an early stage of development.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Sarthak Sahoo, Sonali Priyadarshini Nayak, Kishore Hari, Prithu Purkait, Susmita Mandal, Akash Kishore, Herbert Levine, Mohit Kumar Jolly
Summary: Recent research shows that cells with hybrid epithelial/mesenchymal characteristics can have high levels of PD-L1, important for immune evasion, without needing to fully undergo epithelial-mesenchymal transition. This cellular state in breast cancer is associated with resistance to anti-estrogen therapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Integrative & Complementary Medicine
Xiao Li, Wei Liu, Chong Geng, Tingting Li, Yanni Li, Yaoyu Guo, Chunhui Wang
Summary: This study demonstrated that Ginsenoside Rg3 could effectively inhibit colon cancer cell invasion and metastasis by suppressing the Notch-Hes1-EMT signaling pathway.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Article
Immunology
Sajad Karampoor, Khashayar Hesamizadeh, Faezeh Maleki, Mohammad Farahmand, Hamid Zahednasab, Rasoul Mirzaei, Helene Banoun, Farhad Zamani, Marzieh Hajibaba, Alireza Tabibzadeh, Behnaz Bouzari, Mohammad-Navid Bastani, Azadeh Laali, Hossein Keyvani
Summary: The study suggests that NE, IL-6, and IL-8 levels are significantly elevated in COVID-19 patients, with ICU patients showing higher levels than non-ICU patients. Deceased patients also had significantly higher levels of NE, IL-6, and IL-8 compared to recovered patients.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Lili Liang, Andreas M. Kaufmann
Summary: Cancer stem cells (CSCs) have been identified and characterized in both hematopoietic and solid tumors. They possess unique properties, including slow proliferation, self-renewal, differentiation, and the ability to undergo epithelial-mesenchymal transition (EMT) and its reverse process. CSCs play a crucial role in tumor growth, therapy resistance, and cancer metastasis. Strategies targeting CSCs are being developed for novel anti-metastasis treatments, aiming to improve therapeutic efficiency and prognosis with fewer side effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Joanna Kozak, Alicja Forma, Marcin Czeczelewski, Pawel Kozyra, Elzbieta Sitarz, Elzbieta Radzikowska-Buchner, Monika Sitarz, Jacek Baj
Summary: Epithelial-mesenchymal transition (EMT) is a key process in the development of gastric cancer, affecting patient outcomes. There is an urgent need for research on pharmacological agents targeting EMT to prevent progression and potential metastasis of gastric cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Anastasios Goulioumis, Kostis Gyftopoulos
Summary: Epithelial-to-mesenchymal transition (EMT) is a molecular phenomenon that occurs in epithelial neoplasms, such as laryngeal carcinoma. EMT leads to the loss of epithelial traits and acquisition of mesenchymal traits by tumor cells, enhancing their migratory capacity. EMT is mediated by complex molecular pathways and involves various changes, including loss of adhesion, cytoskeleton remodeling, evasion of apoptosis and immune surveillance, upregulation of metalloproteinases, etc. Partial EMT models have been accepted to explain the cell plasticity associated with invasion and metastasis of tumors.
Review
Oncology
Tuan Luu
Summary: Pancreatic cancer, known for its high mortality and insensitivity to existing therapies, has attracted increasing scholarly attention for its progression mechanisms, particularly the role of epithelial-mesenchymal transition (EMT) in cancer genesis and metastasis. Recent discoveries on EMT-regulating factors in pancreatic cancer have shed light on the relationship between EMT and this cancer type, marking a key advancement in research on EMT in pancreatic cancer.
FRONTIERS IN ONCOLOGY
(2021)
Review
Pharmacology & Pharmacy
Zhi Xiong Chong, Swee Keong Yeap, Wan Yong Ho
Summary: Osteosarcoma, a prevalent primary bone tumor, has high metastatic potential and poor prognosis. MiRNAs play crucial roles in regulating the EMT process in osteosarcoma, which may offer insights for prognostic and therapeutic strategies.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Oncology
Ying Feng, Fuyin Le, Puyuan Tian, Yanying Zhong, Fuliang Zhan, Genhua Huang, Hui Hu, Tingtao Chen, Buzhen Tan
Summary: The study found that tripterygium glycosides (GTW) can inhibit the proliferation, invasion, and migration of epithelial ovarian cancer cells by suppressing the EMT pathway. Animal experiments demonstrated that GTW can reduce tumor burden, prolong lifespan, and down-regulate levels of tumor markers by regulating the EMT pathway. The results suggest that GTW could be a potential adjuvant therapeutic agent for chemo-resistant epithelial ovarian cancer.
Article
Engineering, Biomedical
Adrian Cervero-Varona, Angelo Canciello, Alessia Peserico, Arlette Alina Haidar Montes, Maria Rita Citeroni, Annunziata Mauro, Valentina Russo, Samanta Moffa, Serena Pilato, Stefano Di Giacomo, Beatrice Dufrusine, Enrico Dainese, Antonella Fontana, Barbara Barboni
Summary: The use of biomaterials in immune regenerative strategies for unresolved pathologies is gaining attention in tissue engineering. Graphene oxide (GO) has been proposed as an immune-mimetic material for stem cell-based regenerative therapies, influencing stem cell behavior and immune response. Amniotic epithelial stem cells (AECs) are also of interest due to their plasticity and immunomodulatory paracrine activities, and the effects of GO on AECs are explored in this study. GO-coating induced and accelerated the Epithelial-Mesenchymal Transition (EMT) in AECs, leading to changes in cytokine secretion and enhanced activation of macrophages. Adhesion of AECs on GO-functionalized surfaces could create a tailored microenvironment for the regenerative process.
MATERIALS TODAY BIO
(2023)
Article
Biochemistry & Molecular Biology
Yuan Zhang, Aurore Devocelle, Christophe Desterke, Lucas Eduardo Botelho de Souza, Eva Hadadi, Herve Acloque, Adlen Foudi, Yao Xiang, Annabelle Ballesta, Yunhua Chang, Julien Giron-Michel
Summary: The study demonstrates that BMAL1 plays a crucial role in maintaining the balance between epithelial and mesenchymal properties of CRC cell lines, influencing their capacities for adhesion, migration, invasion, and chemoresistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Dilihumaer Tuluhong, Tao Chen, Jingjie Wang, Huijuan Zeng, Hanjun Li, Wangmu Dunzhu, Qiurong Li, Shaohua Wang
Summary: This study revealed that FZD2 is abundantly expressed in breast cancer tissues, and high levels of FZD2 are significantly correlated with poor prognosis. Silencing of FZD2 suppresses cell growth, migration, and invasion in breast cancer. FZD2 promotes TGF-beta 1-induced EMT process by activating the Notch signaling pathway.
CANCER CELL INTERNATIONAL
(2021)