Pharmacological Targeting of Endoplasmic Reticulum Stress in Pancreatic Beta Cells

Pharmacological Chaperones: A Therapeutic Approach for Diseases Caused by Destabilizing Missense Mutations

(2020) Ludovica Liguori et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

IRE1β negatively regulates IRE1α signaling in response to endoplasmic reticulum stress

(2020) Michael J. Grey et al.   JOURNAL OF CELL BIOLOGY

Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells

(2020) Nathaniel J. Hogrebe et al.   NATURE BIOTECHNOLOGY

Inadequate β-cell mass is essential for the pathogenesis of type 2 diabetes

(2020) Gordon C Weir et al.   Lancet Diabetes & Endocrinology

Sel1L-Hrd1 ER-associated degradation maintains β cell identity via TGF-β signaling

(2020) Neha Shrestha et al.   JOURNAL OF CLINICAL INVESTIGATION

Generation of pancreatic β cells from CD177+ anterior definitive endoderm

(2020) Pallavi U. Mahaddalkar et al.   NATURE BIOTECHNOLOGY

Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure

(2020) Décio L. Eizirik et al.   Nature Reviews Endocrinology

Endoplasmic Reticulum Protein Quality Control in β Cells

(2020) Neha Shrestha et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Protection from β-cell apoptosis by inhibition of TGF-β/Smad3 signaling

(2020) Ji-Hyeon Lee et al.   Cell Death & Disease

Dysfunction of Persisting β Cells Is a Key Feature of Early Type 2 Diabetes Pathogenesis

(2020) Christian M. Cohrs et al.   Cell Reports

Identification of an Anti-diabetic, Orally Available Small Molecule that Regulates TXNIP Expression and Glucagon Action

(2020) Lance A. Thielen et al.   Cell Metabolism

Modeling Type 1 Diabetes In Vitro Using Human Pluripotent Stem Cells

(2020) Nayara C. Leite et al.   Cell Reports

Endoplasmic Reticulum Associated Degradation (ERAD) Has a Critical Role in Supporting Glucose-Stimulated Insulin Secretion in Pancreatic β-Cells

(2019) Yabing Hu et al.   DIABETES

Specific PERK inhibitors enhanced glucose-stimulated insulin secretion in a mouse model of type 2 diabetes

(2019) Min Joo Kim et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Chaperoning Endoplasmic Reticulum–Associated Degradation (ERAD) and Protein Conformational Diseases

(2019) Patrick G. Needham et al.   Cold Spring Harbor Perspectives in Biology

The Unfolded Protein Response: Detecting and Responding to Fluctuations in the Protein-Folding Capacity of the Endoplasmic Reticulum

(2019) G. Elif Karagöz et al.   Cold Spring Harbor Perspectives in Biology

Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis

(2019) Erik A. Blackwood et al.   Nature Communications

A Map of Human Type 1 Diabetes Progression by Imaging Mass Cytometry

(2019) Nicolas Damond et al.   Cell Metabolism

β-Cell Fate in Human Insulin Resistance and Type 2 Diabetes: A Perspective on Islet Plasticity

(2019) Teresa Mezza et al.   DIABETES

Charting cellular identity during human in vitro β-cell differentiation

(2019) Adrian Veres et al.   NATURE

Pharmacologic Approaches for Adapting Proteostasis in the Secretory Pathway to Ameliorate Protein Conformational Diseases

(2019) Jeffery W. Kelly   Cold Spring Harbor Perspectives in Biology

An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes

(2019) Kevan C. Herold et al.   NEW ENGLAND JOURNAL OF MEDICINE

Proinsulin misfolding is an early event in the progression to type 2 diabetes

(2019) Anoop Arunagiri et al.   eLife

Alterations in Beta Cell Identity in Type 1 and Type 2 Diabetes

(2019) Abu Saleh Md Moin et al.   Current Diabetes Reports

Endoplasmic reticulum stress, degeneration of pancreatic islet β-cells, and therapeutic modulation of the unfolded protein response in diabetes

(2019) Rajarshi Ghosh et al.   Molecular Metabolism

Atf6α impacts cell number by influencing survival, death and proliferation

(2019) Rohit B. Sharma et al.   Molecular Metabolism

β-Cell Maturation and Identity in Health and Disease

(2019) Salinno et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pharmacological chaperones of ATP-sensitive potassium channels: Mechanistic insight from cryoEM structures

(2019) Gregory M. Martin et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Misfolded proinsulin in the endoplasmic reticulum during development of beta cell failure in diabetes

(2018) Anoop Arunagiri et al.   Annals of the New York Academy of Sciences

Estrogens Promote Misfolded Proinsulin Degradation to Protect Insulin Production and Delay Diabetes

(2018) Beibei Xu et al.   Cell Reports

Biosynthesis, structure, and folding of the insulin precursor protein

(2018) Ming Liu et al.   DIABETES OBESITY & METABOLISM

Pancreas regeneration

(2018) Qiao Zhou et al.   NATURE

Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins

(2018) Ryan Paxman et al.   eLife

Low Level Insulin Content Within Abundant Non-Beta Islet Endocrine Cells in Long-Standing Type 1 Diabetes

(2018) Carol J. Lam et al.   DIABETES

Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes

(2018) Emily K. Sims et al.   DIABETES CARE

Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes

(2018) Diego Balboa et al.   eLife

Guanabenz Sensitizes Pancreatic β Cells to Lipotoxic Endoplasmic Reticulum Stress and Apoptosis

(2017) Baroj Abdulkarim et al.   ENDOCRINOLOGY

Attenuation of PERK enhances glucose-stimulated insulin secretion in islets

(2017) Min Joo Kim et al.   JOURNAL OF ENDOCRINOLOGY

Mechanisms of β-cell dedifferentiation in diabetes: recent findings and future research directions

(2017) Mohammed Bensellam et al.   JOURNAL OF ENDOCRINOLOGY

Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3

(2017) Stefan Schoebel et al.   NATURE

Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells

(2017) Miriam Cnop et al.   Molecular Metabolism

Structural and Functional Analysis of the Allosteric Inhibition of IRE1α with ATP-Competitive Ligands

(2016) Hannah C. Feldman et al.   ACS Chemical Biology

Autoubiquitination of the Hrd1 Ligase Triggers Protein Retrotranslocation in ERAD

(2016) Ryan D. Baldridge et al.   CELL

Reduced Insulin Production Relieves Endoplasmic Reticulum Stress and Induces β Cell Proliferation

(2016) Marta Szabat et al.   Cell Metabolism

Pancreatic β-Cells Express the Fetal Islet Hormone Gastrin in Rodent and Human Diabetes

(2016) Tehila Dahan et al.   DIABETES

Phase 3 Trial of Transplantation of Human Islets in Type 1 Diabetes Complicated by Severe Hypoglycemia

(2016) Bernhard J. Hering et al.   DIABETES CARE

Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes

(2016) Francesca Cinti et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Direct and essential function for Hrd3 in ER-associated degradation

(2016) Nidhi Vashistha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proinsulin and heat shock protein 90 as biomarkers of beta-cell stress in the early period after onset of type 1 diabetes

(2016) Renecia A. Watkins et al.   Translational Research

ER stress and the decline and fall of pancreatic beta cells in type 1 diabetes

(2016) Flora Brozzi et al.   UPSALA JOURNAL OF MEDICAL SCIENCES

Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch

(2016) Ciara M Gallagher et al.   eLife

Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation

(2016) Lars Plate et al.   eLife

Tauroursodeoxycholic acid reduces ER stress by regulating of Akt-dependent cellular prion protein

(2016) Yeo Min Yoon et al.   Scientific Reports

Cytokines induce endoplasmic reticulum stress in human, rat and mouse beta cells via different mechanisms

(2015) Flora Brozzi et al.   DIABETOLOGIA

The E3 ligase synoviolin controls body weight and mitochondrial biogenesis through negative regulation of PGC-1 

(2015) H. Fujita et al.   EMBO JOURNAL

ATF6β regulates the Wfs1 gene and has a cell survival role in the ER stress response in pancreatic β-cells

(2015) Tanya Odisho et al.   EXPERIMENTAL CELL RESEARCH

Insulin demand regulates β cell number via the unfolded protein response

(2015) Rohit B. Sharma et al.   JOURNAL OF CLINICAL INVESTIGATION

Modulation of human IAPP fibrillation: cosolutes, crowders and chaperones

(2015) Mimi Gao et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Allosteric Inhibition of the IRE1α RNase Preserves Cell Viability and Function during Endoplasmic Reticulum Stress

(2014) Rajarshi Ghosh et al.   CELL

Pancreatic β Cell Dedifferentiation in Diabetes and Redifferentiation following Insulin Therapy

(2014) Zhiyu Wang et al.   Cell Metabolism

Inefficient Translocation of Preproinsulin Contributes to Pancreatic β Cell Failure and Late-onset Diabetes

(2014) Huan Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival

(2014) Shengyi Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unfolded Protein Response in Cancer: IRE1α Inhibition by Selective Kinase Ligands Does Not Impair Tumor Cell Viability

(2014) Paul E. Harrington et al.   ACS Medicinal Chemistry Letters

Reversible changes in pancreatic islet structure and function produced by elevated blood glucose

(2014) Melissa F. Brereton et al.   Nature Communications

Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway

(2014) Barak Blum et al.   eLife

Are we overestimating the loss of beta cells in type 2 diabetes?

(2013) Lorella Marselli et al.   DIABETOLOGIA

UPR Signal Activation by Luminal Sensor Domains

(2013) Marta Carrara et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Restoration of the Unfolded Protein Response in Pancreatic   Cells Protects Mice Against Type 1 Diabetes

(2013) F. Engin et al.   Science Translational Medicine

Oral Treatment Targeting the Unfolded Protein Response Prevents Neurodegeneration and Clinical Disease in Prion-Infected Mice

(2013) J. A. Moreno et al.   Science Translational Medicine

Endoplasmic Reticulum Stress and Type 2 Diabetes

(2012) Sung Hoon Back et al.   Annual Review of Biochemistry

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

Thioredoxin-Interacting Protein Mediates ER Stress-Induced β Cell Death through Initiation of the Inflammasome

(2012) Christine M. Oslowski et al.   Cell Metabolism

IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress

(2012) Alana G. Lerner et al.   Cell Metabolism

Failure of the Adaptive Unfolded Protein Response in Islets of Obese Mice Is Linked With Abnormalities in  -Cell Gene Expression and Progression to Diabetes

(2012) J. Y. Chan et al.   DIABETES

Islet  -Cell Endoplasmic Reticulum Stress Precedes the Onset of Type 1 Diabetes in the Nonobese Diabetic Mouse Model

(2012) S. A. Tersey et al.   DIABETES

Expression of endoplasmic reticulum stress markers in the islets of patients with type 1 diabetes

(2012) I. Marhfour et al.   DIABETOLOGIA

Discovery of 7-Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)

(2012) Jeffrey M. Axten et al.   JOURNAL OF MEDICINAL CHEMISTRY

Atf6α-null mice are glucose intolerant due to pancreatic β-cell failure on a high-fat diet but partially resistant to diet-induced insulin resistance

(2012) Masahiro Usui et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors

(2012) Likun Wang et al.   Nature Chemical Biology

Targeted estrogen delivery reverses the metabolic syndrome

(2012) Brian Finan et al.   NATURE MEDICINE

Protein Folding and Quality Control in the ER

(2011) K. Araki et al.   Cold Spring Harbor Perspectives in Biology

Deficiency of Suppressor Enhancer Lin12 1 Like (SEL1L) in Mice Leads to Systemic Endoplasmic Reticulum Stress and Embryonic Lethality

(2010) Adam B. Francisco et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates

(2009) Dan Han et al.   CELL

Chop deletion reduces oxidative stress, improves β cell function, and promotes cell survival in multiple mouse models of diabetes

(2008) Benbo Song et al.   JOURNAL OF CLINICAL INVESTIGATION

Tyrosine kinase inhibitors reverse type 1 diabetes in nonobese diabetic mice

(2008) C. Louvet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA