Reactive oxygen and nitrogen species generation, antioxidant defenses, and β-cell function: a critical role for amino acids

Glucokinase mediates coupling of glycolysis to mitochondrial metabolism but not to beta cell damage at high glucose exposure levels

(2011) H. Schmitt et al.   DIABETOLOGIA

Oleic Acid Modulates Metabolic Substrate Channeling during Glucose-Stimulated Insulin Secretion via NAD(P)H Oxidase

(2011) Laila R. B. Santos et al.   ENDOCRINOLOGY

Stimulus-inducedS-Nitrosylation of Syntaxin 4 Impacts Insulin Granule Exocytosis

(2011) Dean A. Wiseman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

l-Arginine is essential for pancreatic β-cell functional integrity, metabolism and defense from inflammatory challenge

(2011) Mauricio S Krause et al.   JOURNAL OF ENDOCRINOLOGY

Cytokine toxicity in insulin-producing cells is mediated by nitro-oxidative stress-induced hydroxyl radical formation in mitochondria

(2011) Ewa Gurgul-Convey et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Metabolite profiles and the risk of developing diabetes

(2011) Thomas J Wang et al.   NATURE MEDICINE

Alterations of NADPH Oxidase Activity in Rat Pancreatic Islets Induced by a High-Fat Diet

(2011) Maíra Mello Rezende Valle et al.   PANCREAS

Control of the Intracellular Redox State by Glucose Participates in the Insulin Secretion Mechanism

(2011) Eduardo Rebelato et al.   PLoS One

Effects of pharmacological inhibition of NADPH oxidase or iNOS on pro-inflammatory cytokine, palmitic acid or H2O2-induced mouse islet or clonal pancreatic β-cell dysfunction

(2010) Marta Michalska et al.   BIOSCIENCE REPORTS

Role of metabolically generated reactive oxygen species for lipotoxicity in pancreatic β-cells

(2010) W. Gehrmann et al.   DIABETES OBESITY & METABOLISM

Ablation of AMP-activated protein kinase α1 and α2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo

(2010) G. Sun et al.   DIABETOLOGIA

Suppression of NADPH oxidase 2 substantially restores glucose-induced dysfunction of pancreatic NIT-1 cells

(2010) Huiping Yuan et al.   FEBS Journal

Intracellular generation of superoxide by the phagocyte NADPH oxidase: How, where, and what for?

(2010) Johan Bylund et al.   FREE RADICAL BIOLOGY AND MEDICINE

NAD(P)H oxidase participates in the palmitate-induced superoxide production and insulin secretion by rat pancreatic islets

(2010) Maria Fernanda R. Graciano et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Oxidative stress and beta-cell dysfunction

(2010) Gisela Drews et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

α-Hydroxybutyrate Is an Early Biomarker of Insulin Resistance and Glucose Intolerance in a Nondiabetic Population

(2010) Walter E. Gall et al.   PLoS One

Usurping the mitochondrial supremacy: Extramitochondrial sources of reactive oxygen intermediates and their role in beta cell metabolism and insulin secretion

(2010) Joshua P. Gray et al.   TOXICOLOGY MECHANISMS AND METHODS

Pancreatic islet plasticity: Interspecies comparison of islet architecture and composition

(2010) Donald J. Steiner et al.   Islets

Spermidine Regulates Insulin Synthesis and Cytoplasmic Ca2+ in Mouse Beta-TC6 Insulinoma Cells

(2009) Masahiro Ohtani et al.   CELL STRUCTURE AND FUNCTION

Exercise and possible molecular mechanisms of protection from vascular disease and diabetes: the central role of ROS and nitric oxide

(2009) Philip Newsholme et al.   CLINICAL SCIENCE

Insights into the critical role of NADPH oxidase(s) in the normal and dysregulated pancreatic beta cell

(2009) P. Newsholme et al.   DIABETOLOGIA

High glucose inhibits glucose-6-phosphate dehydrogenase, leading to increased oxidative stress and β-cell apoptosis

(2009) Zhaoyun Zhang et al.   FASEB JOURNAL

AMP-activated Protein Kinase Attenuates Nitric Oxide-induced β-Cell Death

(2009) Gordon P. Meares et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective amino acid deficiency in patients with impaired glucose tolerance and type 2 diabetes

(2009) Bjoern A. Menge et al.   REGULATORY PEPTIDES

Imidazoline-induced amplification of glucose- and carbachol-stimulated insulin release includes a marked suppression of islet nitric oxide generation in the mouse

(2008) S. Meidute-Abaraviciene et al.   Acta Physiologica

Regulation of the susceptibility to oxidative stress by cysteine availability in pancreatic β-cells

(2008) Satoshi Numazawa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Oxidative stress: the vulnerable β-cell

(2008) Sigurd Lenzen   BIOCHEMICAL SOCIETY TRANSACTIONS

Type 1 diabetes: can exercise impair the autoimmune event? TheL-arginine/glutamine coupling hypothesis

(2008) Maurício da Silva Krause et al.   CELL BIOCHEMISTRY AND FUNCTION

Mitochondrial Reactive Oxygen Species Are Obligatory Signals for Glucose-Induced Insulin Secretion

(2008) C. Leloup et al.   DIABETES

Bioinformatics Analysis of Targeted Metabolomics—Uncovering Old and New Tales of Diabetic Mice under Medication

(2008) Elisabeth Altmaier et al.   ENDOCRINOLOGY

The role of antioxidants and antioxidant-related enzymes in protective responses to environmentally induced oxidative stress

(2008) Jorge Limón-Pacheco et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS