A nanofibrous encapsulation device for safe delivery of insulin-producing cells to treat type 1 diabetes

Gene-edited human stem cell–derived β cells from a patient with monogenic diabetes reverse preexisting diabetes in mice

(2020) Kristina G. Maxwell et al.   Science Translational Medicine

Hydrogels in Emerging Technologies for Type 1 Diabetes

(2020) Stephanie Fuchs et al.   CHEMICAL REVIEWS

Acquisition of Dynamic Function in Human Stem Cell-Derived β Cells

(2019) Leonardo Velazco-Cruz et al.   Stem Cell Reports

Macroencapsulated Human iPSC-Derived Pancreatic Progenitors Protect against STZ-Induced Hyperglycemia in Mice

(2019) Corinne Haller et al.   Stem Cell Reports

Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived β cells

(2019) Gopika G. Nair et al.   NATURE CELL BIOLOGY

Three-Dimensional Objects Consisting of Hierarchically Assembled Nanofibers with Controlled Alignments for Regenerative Medicine

(2019) Shixuan Chen et al.   NANO LETTERS

Navigating Two Roads to Glucose Normalization in Diabetes: Automated Insulin Delivery Devices and Cell Therapy

(2019) Esther Latres et al.   Cell Metabolism

Nanotechnology in cell replacement therapies for type 1 diabetes

(2019) Alexander U. Ernst et al.   ADVANCED DRUG DELIVERY REVIEWS

Engineering the Vasculature for Islet Transplantation

(2019) Daniel T. Bowers et al.   Acta Biomaterialia

Oxygenation strategies for encapsulated islet and beta cell transplants

(2019) Klearchos K. Papas et al.   ADVANCED DRUG DELIVERY REVIEWS

Zwitterionically modified alginates mitigate cellular overgrowth for cell encapsulation

(2019) Qingsheng Liu et al.   Nature Communications

Engineering transferrable microvascular meshes for subcutaneous islet transplantation

(2019) Wei Song et al.   Nature Communications

Paracrine Interactions within the Pancreatic Islet Determine the Glycemic Set Point

(2018) Rayner Rodriguez-Diaz et al.   Cell Metabolism

Pancreatic β Cell Regeneration as a Possible Therapy for Diabetes

(2018) Cristina Aguayo-Mazzucato et al.   Cell Metabolism

Impact of Oxygen on Pancreatic Islet Survival

(2018) Hirotake Komatsu et al.   PANCREAS

Functional Beta Cell Mass from Device-Encapsulated hESC-Derived Pancreatic Endoderm Achieving Metabolic Control

(2018) Thomas Robert et al.   Stem Cell Reports

Islet Encapsulation

(2018) Alexander Ulrich Ernst et al.   Journal of Materials Chemistry B

Increase Functional β-Cell Mass in Subcutaneous Alginate Capsules With Porcine Prenatal Islet Cells but Loss With Human Adult Islet Cells

(2018) Ines De Mesmaeker et al.   DIABETES

Islet encapsulation therapy — racing towards the finish line?

(2018) Tejal A. Desai et al.   Nature Reviews Endocrinology

Insulin Secretion Depends on Intra-islet Glucagon Signaling

(2018) Berit Svendsen et al.   Cell Reports

Designing a retrievable and scalable cell encapsulation device for potential treatment of type 1 diabetes

(2017) Duo An et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modular tissue engineering for the vascularization of subcutaneously transplanted pancreatic islets

(2017) Alexander E. Vlahos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9

(2017) Dong Niu et al.   SCIENCE

Transplantation of Human Pancreatic Endoderm Cells Reverses Diabetes Post Transplantation in a Prevascularized Subcutaneous Site

(2017) Andrew R. Pepper et al.   Stem Cell Reports

Vasculogenic hydrogel enhances islet survival, engraftment, and function in leading extrahepatic sites

(2017) Jessica D. Weaver et al.   Science Advances

Overcoming foreign-body reaction through nanotopography: Biocompatibility and immunoisolation properties of a nanofibrous membrane

(2016) Kai Wang et al.   BIOMATERIALS

National Institutes of Health–Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities

(2016) Camillo Ricordi et al.   DIABETES

Phase 3 Trial of Transplantation of Human Islets in Type 1 Diabetes Complicated by Severe Hypoglycemia

(2016) Bernhard J. Hering et al.   DIABETES CARE

Diabetes: Encapsulating the problem

(2016) Elie Dolgin   NATURE

Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates

(2016) Arturo J Vegas et al.   NATURE BIOTECHNOLOGY

Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice

(2016) Arturo J Vegas et al.   NATURE MEDICINE

Modified alginates provide a long-term disguise against the foreign body response

(2016) Natasha Bray   NATURE REVIEWS DRUG DISCOVERY

Advances in islet encapsulation technologies

(2016) Tejal Desai et al.   NATURE REVIEWS DRUG DISCOVERY

Assessment of Immune Isolation of Allogeneic Mouse Pancreatic Progenitor Cells by a Macroencapsulation Device

(2016) Gaetano Faleo et al.   TRANSPLANTATION

Generation of stem cell-derived β-cells from patients with type 1 diabetes

(2016) Jeffrey R. Millman et al.   Nature Communications

Polycaprolactone Thin-Film Micro- and Nanoporous Cell-Encapsulation Devices

(2015) Crystal E. Nyitray et al.   ACS Nano

A prevascularized subcutaneous device-less site for islet and cellular transplantation

(2015) Andrew R Pepper et al.   NATURE BIOTECHNOLOGY

Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates

(2015) Omid Veiseh et al.   NATURE MATERIALS

CD8 T-cell recognition of acquired alloantigen promotes acute allograft rejection

(2015) Simon J. F. Harper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generation of Functional Human Pancreatic β Cells In Vitro

(2014) Felicia W. Pagliuca et al.   CELL

Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

(2014) Alireza Rezania et al.   NATURE BIOTECHNOLOGY

Encapsulate this: the do's and don'ts

(2014) Gorka Orive et al.   NATURE MEDICINE

Encapsulate this

(2014) Elie Dolgin   NATURE MEDICINE

Macrophage functional polarization (M1/M2) in response to varying fiber and pore dimensions of electrospun scaffolds

(2013) Koyal Garg et al.   BIOMATERIALS

Enhanced function of immuno-isolated islets in diabetes therapy by co-encapsulation with an anti-inflammatory drug

(2013) Tram T. Dang et al.   BIOMATERIALS

Noninvasive evaluation of the vascular response to transplantation of alginate encapsulated islets using the dorsal skin-fold model

(2013) Rahul Krishnan et al.   BIOMATERIALS

The TheraCyte™ Device Protects against Islet Allograft Rejection in Immunized Hosts

(2013) Makiko Kumagai-Braesch et al.   CELL TRANSPLANTATION

Maturation and function of human embryonic stem cell-derived pancreatic progenitors in macroencapsulation devices following transplant into mice

(2013) Jennifer E. Bruin et al.   DIABETOLOGIA

Enrichment of human embryonic stem cell-derived NKX6.1-expressing pancreatic progenitor cells accelerates the maturation of insulin-secreting cells in vivo

(2013) Alireza Rezania et al.   STEM CELLS

Hydrogels for biomedical applications

(2012) Allan S. Hoffman   ADVANCED DRUG DELIVERY REVIEWS

Cellular Plasticity of Inflammatory Myeloid Cells in the Peritoneal Foreign Body Response

(2009) Jane E. Mooney et al.   AMERICAN JOURNAL OF PATHOLOGY

Teratoma formation by human embryonic stem cells: Evaluation of essential parameters for future safety studies

(2009) Hannes Hentze et al.   Stem Cell Research

Optimal implantation site for pancreatic islet transplantation

(2008) S. Merani et al.   BRITISH JOURNAL OF SURGERY

Cytokine-Induced  -Cell Death Is Independent of Endoplasmic Reticulum Stress Signaling

(2008) M. C. Akerfeldt et al.   DIABETES

Innate immunity and intestinal microbiota in the development of Type 1 diabetes

(2008) Li Wen et al.   NATURE