Nanotechnologies in Delivery of DNA and mRNA Vaccines to the Nasal and Pulmonary Mucosa

STING activation in alveolar macrophages and group 2 innate lymphoid cells suppresses IL-33-driven type 2 immunopathology

(2021) Li She et al.   JCI Insight

Engineered drug delivery devices to address Global Health challenges

(2021) Ilin Sadeghi et al.   JOURNAL OF CONTROLLED RELEASE

An Update on Self-Amplifying mRNA Vaccine Development

(2021) Anna K. Blakney et al.   Vaccines

What scientists do and don’t know about the Oxford–AstraZeneca COVID vaccine

(2021) Smriti Mallapaty et al.   NATURE

India’s DNA COVID vaccine is a world first – more are coming

(2021) Smriti Mallapaty   NATURE

mRNA vaccines for infectious diseases: principles, delivery and clinical translation

(2021) Namit Chaudhary et al.   NATURE REVIEWS DRUG DISCOVERY

CpG Oligodeoxynucleotide Developed to Activate Primate Immune Responses Promotes Antitumoral Effects in Combination with a Neoantigen-Based mRNA Cancer Vaccine

(2021) Qin Li et al.   Drug Design Development and Therapy

An mRNA SARS-CoV-2 Vaccine Employing Charge-Altering Releasable Transporters with a TLR-9 Agonist Induces Neutralizing Antibodies and T Cell Memory

(2021) Ole A. W. Haabeth et al.   ACS Central Science

In Vitro Investigations on Optimizing and Nebulization of IVT-mRNA Formulations for Potential Pulmonary-Based Alpha-1-Antitrypsin Deficiency Treatment

(2021) Shan Guan et al.   Pharmaceutics

Gold-Nanostar-Chitosan-Mediated Delivery of SARS-CoV-2 DNA Vaccine for Respiratory Mucosal Immunization: Development and Proof-of-Principle

(2021) Uday S. Kumar et al.   ACS Nano

Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses

(2021) Mohamad-Gabriel Alameh et al.   IMMUNITY

First COVID-19 DNA vaccine approved, others in hot pursuit

(2021) Cormac Sheridan   NATURE BIOTECHNOLOGY

Niosomes formation using a continuous supercritical CO2 assisted process

(2021) Lucia Baldino et al.   Journal of CO2 Utilization

Aerosol Delivery of Synthetic mRNA to Vaginal Mucosa Leads to Durable Expression of Broadly Neutralizing Antibodies against HIV

(2020) Kevin E. Lindsay et al.   MOLECULAR THERAPY

Pulmonary surfactant–biomimetic nanoparticles potentiate heterosubtypic influenza immunity

(2020) Ji Wang et al.   SCIENCE

The Effects of Secretory IgA in the Mucosal Immune System

(2020) Yue Li et al.   Biomed Research International

Engineered Nanodelivery Systems to Improve DNA Vaccine Technologies

(2020) Michael Lim et al.   Pharmaceutics

Development of SARS-CoV-2 vaccines: should we focus on mucosal immunity?

(2020) Leticia Moreno-Fierros et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

DNA vaccine protection against SARS-CoV-2 in rhesus macaques

(2020) Jingyou Yu et al.   SCIENCE

mRNA Vaccines Encoding the HA Protein of Influenza A H1N1 Virus Delivered by Cationic Lipid Nanoparticles Induce Protective Immune Responses in Mice

(2020) Xinyu Zhuang et al.   Vaccines

Intranasal delivery of cationic liposome-protamine complex mRNA vaccine elicits effective anti-tumor immunity

(2020) Yaping Mai et al.   CELLULAR IMMUNOLOGY

An mRNA Vaccine against SARS-CoV-2 — Preliminary Report

(2020) Lisa A. Jackson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Niosomal Drug Delivery Systems for Ocular Disease—Recent Advances and Future Prospects

(2020) Saliha Durak et al.   Nanomaterials

A Single-Dose Intranasal ChAd Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2

(2020) Ahmed O. Hassan et al.   CELL

Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates

(2020) Edward E. Walsh et al.   NEW ENGLAND JOURNAL OF MEDICINE

Attenuated Influenza Virions Expressing the SARS-CoV-2 Receptor-Binding Domain Induce Neutralizing Antibodies in Mice

(2020) Andrea N. Loes et al.   Viruses-Basel

Synthetic mRNA Encoding VEGF-A in Patients Undergoing Coronary Artery Bypass Grafting: Design of a Phase 2a Clinical Trial

(2020) Vesa Anttila et al.   Molecular Therapy-Methods & Clinical Development

SARS-CoV-2 mRNA Vaccines Foster Potent Antigen-Specific Germinal Center Responses Associated with Neutralizing Antibody Generation

(2020) Katlyn Lederer et al.   IMMUNITY

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

(2020) Lindsey R. Baden et al.   NEW ENGLAND JOURNAL OF MEDICINE

DNA vaccines against COVID-19: Perspectives and challenges

(2020) Marcelle Moura Silveira et al.   LIFE SCIENCES

A Liposome-Based Adjuvant Containing Two Delivery Systems with the Ability to Induce Mucosal Immunoglobulin A Following a Parenteral Immunization

(2019) Dennis Christensen et al.   ACS Nano

Inhaled Nanoformulated mRNA Polyplexes for Protein Production in Lung Epithelium

(2019) Asha Kumari Patel et al.   ADVANCED MATERIALS

Cationic Niosomes as Non-Viral Vehicles for Nucleic Acids: Challenges and Opportunities in Gene Delivery

(2019) Santiago Grijalvo et al.   Pharmaceutics

Self-assembled peptide–poloxamine nanoparticles enable in vitro and in vivo genome restoration for cystic fibrosis

(2019) Shan Guan et al.   Nature Nanotechnology

Friend or Foe: The Protective and Pathological Roles of Inducible Bronchus-Associated Lymphoid Tissue in Pulmonary Diseases

(2019) Nancy D. Marin et al.   JOURNAL OF IMMUNOLOGY

Mucosal vaccines and technology

(2019) A. Miquel‐Clopés et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Safety and immunogenicity of an anti-Middle East respiratory syndrome coronavirus DNA vaccine: a phase 1, open-label, single-arm, dose-escalation trial

(2019) Kayvon Modjarrad et al.   LANCET INFECTIOUS DISEASES

Parenteral Vaccination With a Tuberculosis Subunit Vaccine in Presence of Retinoic Acid Provides Early but Transient Protection to M. Tuberculosis Infection

(2019) Antonella Riccomi et al.   Frontiers in Immunology

Intrapulmonary Cellular-Level Distribution of Inhaled Nanoparticles with Defined Functional Groups and Its Correlations with Protein Corona and Inflammatory Response

(2019) Bohan Yin et al.   ACS Nano

Effective mRNA pulmonary delivery by dry powder formulation of PEGylated synthetic KL4 peptide

(2019) Yingshan Qiu et al.   JOURNAL OF CONTROLLED RELEASE

Nasal route for vaccine and drug delivery: Features and current opportunities

(2019) Yadira Lobaina Mato   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Lipid Nanoparticle-Delivered Chemically Modified mRNA Restores Chloride Secretion in Cystic Fibrosis

(2018) Ema Robinson et al.   MOLECULAR THERAPY

mRNA vaccines — a new era in vaccinology

(2018) Norbert Pardi et al.   NATURE REVIEWS DRUG DISCOVERY

A revised airway epithelial hierarchy includes CFTR-expressing ionocytes

(2018) Daniel T. Montoro et al.   NATURE

Engineered mRNA-expressed antibodies prevent respiratory syncytial virus infection

(2018) Pooja Munnilal Tiwari et al.   Nature Communications

Mechanism of action of mRNA-based vaccines

(2017) Carlo Iavarone et al.   Expert Review of Vaccines

Nanotechnologies in delivery of mRNA therapeutics using nonviral vector-based delivery systems

(2017) S Guan et al.   GENE THERAPY

Safety and immunogenicity of a mRNA rabies vaccine in healthy adults: an open-label, non-randomised, prospective, first-in-human phase 1 clinical trial

(2017) Martin Alberer et al.   LANCET

Preclinical and Clinical Demonstration of Immunogenicity by mRNA Vaccines against H10N8 and H7N9 Influenza Viruses

(2017) Kapil Bahl et al.   MOLECULAR THERAPY

Intranasal Vaccination with Mannosylated Chitosan Formulated DNA Vaccine Enables Robust IgA and Cellular Response Induction in the Lungs of Mice and Improves Protection against Pulmonary Mycobacterial Challenge

(2017) Manli Wu et al.   Frontiers in Cellular and Infection Microbiology

Tools for translation: non-viral materials for therapeutic mRNA delivery

(2017) Khalid A. Hajj et al.   Nature Reviews Materials

Comparisons of the Humoral and Cellular Immune Responses Induced by Live Attenuated Influenza Vaccine and Inactivated Influenza Vaccine in Adults

(2016) Daniel F. Hoft et al.   Clinical and Vaccine Immunology

Dendritic Cell Immunotherapy for HIV-1 Infection Using Autologous HIV-1 RNA

(2016) Jeffrey M. Jacobson et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Mucosal vaccine delivery: Current state and a pediatric perspective

(2016) Akhilesh Kumar Shakya et al.   JOURNAL OF CONTROLLED RELEASE

Enhanced intranasal delivery of mRNA vaccine by overcoming the nasal epithelial barrier via intra- and paracellular pathways

(2016) Man Li et al.   JOURNAL OF CONTROLLED RELEASE

Intranasal administration of RSV antigen-expressing MCMV elicits robust tissue-resident effector and effector memory CD8+ T cells in the lung

(2016) K M Morabito et al.   Mucosal Immunology

Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

(2016) Lena M. Kranz et al.   NATURE

Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination

(2016) Hok Hei Tam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteomic and Lipidomic Analysis of Nanoparticle Corona upon Contact with Lung Surfactant Reveals Differences in Protein, but Not Lipid Composition

(2015) Simon Sebastian Raesch et al.   ACS Nano

Effect of vaccine administration modality on immunogenicity and efficacy

(2015) Lu Zhang et al.   Expert Review of Vaccines

Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes

(2015) Norbert Pardi et al.   JOURNAL OF CONTROLLED RELEASE

Sequence-engineered mRNA Without Chemical Nucleoside Modifications Enables an Effective Protein Therapy in Large Animals

(2015) Andreas Thess et al.   MOLECULAR THERAPY

From sewer to saviour — targeting the lymphatic system to promote drug exposure and activity

(2015) Natalie L. Trevaskis et al.   NATURE REVIEWS DRUG DISCOVERY

Nebulisation of IVT mRNA Complexes for Intrapulmonary Administration

(2015) Sarah M. Johler et al.   PLoS One

Current progress in pulmonary delivery of measles vaccine

(2014) Diane E Griffin   Expert Review of Vaccines

Tissue-Resident Memory T Cells

(2014) Jason M. Schenkel et al.   IMMUNITY

T Cell Responses to Whole SARS Coronavirus in Humans

(2014) C. K.-f. Li et al.   JOURNAL OF IMMUNOLOGY

A Cationic Nanoemulsion for the Delivery of Next-generation RNA Vaccines

(2014) Luis A Brito et al.   MOLECULAR THERAPY

mRNA-based therapeutics — developing a new class of drugs

(2014) Ugur Sahin et al.   NATURE REVIEWS DRUG DISCOVERY

Non-viral vectors for gene-based therapy

(2014) Hao Yin et al.   NATURE REVIEWS GENETICS

Intranasal mRNA nanoparticle vaccination induces prophylactic and therapeutic anti-tumor immunity

(2014) Kyle K. L. Phua et al.   Scientific Reports

Self-replicating Replicon-RNA Delivery to Dendritic Cells by Chitosan-nanoparticles for Translation In Vitro and In Vivo

(2014) Kenneth C McCullough et al.   Molecular Therapy-Nucleic Acids

Mucosal Resident Memory CD4 T Cells in Protection and Immunopathology

(2014) Damian Lanz Turner et al.   Frontiers in Immunology

Intranasal DNA Vaccine for Protection against Respiratory Infectious Diseases: The Delivery Perspectives

(2014) Yingying Xu et al.   Pharmaceutics

Size-Dependent Uptake of Particles by Pulmonary Antigen-Presenting Cell Populations and Trafficking to Regional Lymph Nodes

(2013) Fabian Blank et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Pulmonary delivery of DNA vaccine constructs using deacylated PEI elicits immune responses and protects against viral challenge infection

(2013) Jamie F.S. Mann et al.   JOURNAL OF CONTROLLED RELEASE

Dendritic Cells Are the Major Antigen Presenting Cells in Inflammatory Lesions of Murine Mycoplasma Respiratory Disease

(2013) Xiangle Sun et al.   PLoS One

Vaccine adjuvant formulations: A pharmaceutical perspective

(2013) Luis A. Brito et al.   SEMINARS IN IMMUNOLOGY

Biomedical applications of amino acid-modified chitosans: A review

(2012) Luca Casettari et al.   BIOMATERIALS

Vaccination with mRNA-Electroporated Dendritic Cells Induces Robust Tumor Antigen-Specific CD4+ and CD8+ T Cells Responses in Stage III and IV Melanoma Patients

(2012) E. H. J. G. Aarntzen et al.   CLINICAL CANCER RESEARCH

Novel vaccine development strategies for inducing mucosal immunity

(2012) Yoshiko Fukuyama et al.   Expert Review of Vaccines

Dendritic Cell Targeted Chitosan Nanoparticles for Nasal DNA Immunization against SARS CoV Nucleocapsid Protein

(2012) Dharmendra Raghuwanshi et al.   MOLECULAR PHARMACEUTICS

Airway CD8+ T cells induced by pulmonary DNA immunization mediate protective anti-viral immunity

(2012) M Bivas-Benita et al.   Mucosal Immunology

Polyethyleneimine is a potent mucosal adjuvant for viral glycoprotein antigens

(2012) Frank Wegmann et al.   NATURE BIOTECHNOLOGY

Biomolecular coronas provide the biological identity of nanosized materials

(2012) Marco P. Monopoli et al.   Nature Nanotechnology

Mucosal IgA responses in influenza virus infections; thoughts for vaccine design

(2012) Elly van Riet et al.   VACCINE

The mucosal immune system of the respiratory tract

(2012) Shintaro Sato et al.   Current Opinion in Virology

Intranasal immunization with plasmid DNA encoding spike protein of SARS-coronavirus/polyethylenimine nanoparticles elicits antigen-specific humoral and cellular immune responses

(2011) Byoung-Shik Shim et al.   BMC IMMUNOLOGY

Particulate vaccines: on the quest for optimal delivery and immune response

(2011) Marie-Luce De Temmerman et al.   DRUG DISCOVERY TODAY

Cutting Edge: Tissue-Retentive Lung Memory CD4 T Cells Mediate Optimal Protection to Respiratory Virus Infection

(2011) J. R. Teijaro et al.   JOURNAL OF IMMUNOLOGY

Regulation of the polymeric immunoglobulin receptor and IgA transport: new advances in environmental factors that stimulate pIgR expression and its role in mucosal immunity

(2011) F-E Johansen et al.   Mucosal Immunology

Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA

(2011) Katalin Karikó et al.   NUCLEIC ACIDS RESEARCH

Intranasal Delivery of Cationic PLGA Nano/Microparticles- Loaded FMDV DNA Vaccine Encoding IL-6 Elicited Protective Immunity against FMDV Challenge

(2011) Gang Wang et al.   PLoS One

Intranasal vaccination with messenger RNA as a new approach in gene therapy: Use against tuberculosis

(2010) Julio CC Lorenzi et al.   BMC BIOTECHNOLOGY

DNA vaccines for targeting bacterial infections

(2010) Mariana Ingolotti et al.   Expert Review of Vaccines

Macrophages and dendritic cells express tight junction proteins and exchange particles in an in vitro model of the human airway wall

(2010) Fabian Blank et al.   IMMUNOBIOLOGY

Enhancement of Transdermal Absorption, Gene Expression and Stability of Tyrosinase Plasmid (pMEL34)-Loaded Elastic Cationic Niosomes: Potential Application in Vitiligo Treatment

(2010) Jiradej Manosroi et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Efficient Generation of Mucosal and Systemic Antigen-Specific CD8+ T-Cell Responses following Pulmonary DNA Immunization

(2010) M. Bivas-Benita et al.   JOURNAL OF VIROLOGY

Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms

(2010) Akin Akinc et al.   MOLECULAR THERAPY

Intranasal DNA Vaccination Induces Potent Mucosal and Systemic Immune Responses and Cross-protective Immunity Against Influenza Viruses

(2010) Lea Torrieri-Dramard et al.   MOLECULAR THERAPY

Phase 1 clinical trials of the safety and immunogenicity of adjuvanted plasmid DNA vaccines encoding influenza A virus H5 hemagglutinin

(2010) Larry R. Smith et al.   VACCINE

Application of chitosan microspheres for nasal delivery of vaccines

(2009) Mi Lan Kang et al.   BIOTECHNOLOGY ADVANCES

DNA Vaccination with Electroporation Induces Increased Antibody Responses in Patients with Prostate Cancer

(2009) Lindsey Low et al.   HUMAN GENE THERAPY

An overview of liposome lyophilization and its future potential

(2009) Chengjun Chen et al.   JOURNAL OF CONTROLLED RELEASE

Direct Injection of Protamine-protected mRNA: Results of a Phase 1/2 Vaccination Trial in Metastatic Melanoma Patients

(2009) Benjamin Weide et al.   JOURNAL OF IMMUNOTHERAPY

Distinct Profiles of Cytotoxic Granules in Memory CD8 T Cells Correlate with Function, Differentiation Stage, and Antigen Exposure

(2009) A. Harari et al.   JOURNAL OF VIROLOGY

Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge

(2009) Scott G Hansen et al.   NATURE MEDICINE

Inducible Bronchus-Associated Lymphoid Tissue Elicited by a Protein Cage Nanoparticle Enhances Protection in Mice against Diverse Respiratory Viruses

(2009) James A. Wiley et al.   PLoS One

Cationic lipid/DNA complexes (JVRS-100) combined with influenza vaccine (Fluzone®) increases antibody response, cellular immunity, and antigenically drifted protection

(2009) Marla Lay et al.   VACCINE

Protection against tuberculosis by a single intranasal administration of DNA-hsp65 vaccine complexed with cationic liposomes

(2008) Rogério S Rosada et al.   BMC IMMUNOLOGY

Results of the First Phase I/II Clinical Vaccination Trial With Direct Injection of mRNA

(2008) Benjamin Weide et al.   JOURNAL OF IMMUNOTHERAPY

Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability

(2008) Katalin Karikó et al.   MOLECULAR THERAPY

DNA vaccines: ready for prime time?

(2008) Michele A. Kutzler et al.   NATURE REVIEWS GENETICS

Tight junction-based epithelial microenvironment and cell proliferation

(2008) S Tsukita et al.   ONCOGENE

The effect of particle design on cellular internalization pathways

(2008) S. E. A. Gratton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Surface modified liposomes for nasal delivery of DNA vaccine

(2008) Kapil Khatri et al.   VACCINE

Biodegradable particle formation for drug and gene delivery using supercritical fluid and dense gas

(2007) Kenji Mishima   ADVANCED DRUG DELIVERY REVIEWS