Effect of vaccine administration modality on immunogenicity and efficacy

Ultrasound induced cancer immunotherapy

(2014) Johan Unga et al.   ADVANCED DRUG DELIVERY REVIEWS

Cryotherapy with Concurrent CpG Oligonucleotide Treatment Controls Local Tumor Recurrence and Modulates HER2/neu Immunity

(2014) J. J. Veenstra et al.   CANCER RESEARCH

Toll-Like Receptor 7 Agonist Imiquimod in Combination with Influenza Vaccine Expedites and Augments Humoral Immune Responses against Influenza A(H1N1)pdm09 Virus Infection in BALB/c Mice

(2014) Anna J. X. Zhang et al.   Clinical and Vaccine Immunology

The Yin–Yang arms of vaccines: disease-fighting power versus tissue-destructive inflammation

(2014) De-chu Christopher Tang et al.   Expert Review of Vaccines

Are the anatomical sites for vaccine administration selected judiciously?

(2014) Basant Malik et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Microneedle delivery of an M2e-TLR5 ligand fusion protein to skin confers broadly cross-protective influenza immunity

(2014) Bao-Zhong Wang et al.   JOURNAL OF CONTROLLED RELEASE

Needle-free jet injection for administration of influenza vaccine: a randomised non-inferiority trial

(2014) Linda McAllister et al.   LANCET

Phase I Randomized Clinical Trial of VRC DNA and rAd5 HIV-1 Vaccine Delivery by Intramuscular (IM), Subcutaneous (SC) and Intradermal (ID) Administration (VRC 011)

(2014) Mary E. Enama et al.   PLoS One

Glucopyranosyl Lipid A Adjuvant Significantly Enhances HIV Specific T and B Cell Responses Elicited by a DNA-MVA-Protein Vaccine Regimen

(2014) Paul F. McKay et al.   PLoS One

Systems vaccinology: Probing humanity's diverse immune systems with vaccines

(2014) B. Pulendran   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sublingual immunization with a subunit influenza vaccine elicits comparable systemic immune response as intramuscular immunization, but also induces local IgA and TH17 responses

(2014) Simona Gallorini et al.   VACCINE

Microneedle patches: Usability and acceptability for self-vaccination against influenza

(2014) James J. Norman et al.   VACCINE

Microneedle-mediated immunization of an adenovirus-based malaria vaccine enhances antigen-specific antibody immunity and reduces anti-vector responses compared to the intradermal route

(2014) John B. Carey et al.   Scientific Reports

Comparative humoral and cellular immunogenicity and safety of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine and HPV-6/11/16/18 vaccine in healthy women aged 18–45 years: Follow-up through Month 48 in a Phase III randomized study

(2014) Mark H Einstein et al.   Human Vaccines & Immunotherapeutics

Polyelectrolyte/silver nanocomposite multilayer films as multifunctional thin film platforms for remote activated protein and drug delivery

(2013) S. Anandhakumar et al.   Acta Biomaterialia

Hepatitis B DNA Vaccine-Polycation Nano-Complexes Enhancing Immune Response by Percutaneous Administration with Microneedle

(2013) Dongfeng Yin et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Transcutaneous antigen delivery system

(2013) Mi-Young Lee et al.   BMB Reports

Development andin vitroevaluation of a nanoemulsion for transcutaneous delivery

(2013) Grace Ledet et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Production of dissolvable microneedles using an atomised spray process: Effect of microneedle composition on skin penetration

(2013) Marie G. McGrath et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Immunity to viruses: learning from successful human vaccines

(2013) Bali Pulendran et al.   IMMUNOLOGICAL REVIEWS

Comparison of the Immunogenicity of Intramuscular Versus Subcutaneous Administration of Trivalent Inactivated Influenza Vaccine in Individuals With Neuromuscular Diseases

(2013) Marjorie C. Golekoh et al.   JOURNAL OF CHILD NEUROLOGY

Prime-Boost Interval Matters: A Randomized Phase 1 Study to Identify the Minimum Interval Necessary to Observe the H5 DNA Influenza Vaccine Priming Effect

(2013) Julie E. Ledgerwood, Kathryn Zephir, Zonghui Hu, Chih-Jen Wei, LeeJah Chang, Mary E. Enama, Cynthia S. Hendel, Sandra Sitar, Robert T. Bailer, Richard A. Koup, John R. Mascola, Gary J. Nabel, Barney S. Graham et al.   JOURNAL OF INFECTIOUS DISEASES

The Differential Impact of Coadministered Vaccines, Geographic Region, Vaccine Product and Other Covariates on Pneumococcal Conjugate Vaccine Immunogenicity

(2013) Daniel E. Park et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

DNA Vaccine Delivered by a Needle-Free Injection Device Improves Potency of Priming for Antibody and CD8+ T-Cell Responses after rAd5 Boost in a Randomized Clinical Trial

(2013) Barney S. Graham et al.   PLoS One

Mucosal and Systemic Immune Responses to Mycobacterium tuberculosis Antigen 85A following Its Co-Delivery with CpG, MPLA or LTB to the Lungs in Mice

(2013) Julie Todoroff et al.   PLoS One

Vaccine adjuvant formulations: A pharmaceutical perspective

(2013) Luis A. Brito et al.   SEMINARS IN IMMUNOLOGY

Frontiers of transcutaneous vaccination systems: Novel technologies and devices for vaccine delivery

(2013) Kazuhiko Matsuo et al.   VACCINE

Safety and immunogenicity of a new purified vero cell rabies vaccine (PVRV) administered by intramuscular and intradermal routes in healthy volunteers

(2013) Prasad S. Kulkarni et al.   VACCINE

A pilot randomized study to assess immunogenicity, reactogenicity, safety and tolerability of two human papillomavirus vaccines administered intramuscularly and intradermally to females aged 18–26 years

(2013) E. Anthony S. Nelson et al.   VACCINE

Particle based vaccine formulations for transcutaneous immunization

(2013) Ankit Mittal et al.   Human Vaccines & Immunotherapeutics

The TLR7 agonist imiquimod as an adjuvant for radiotherapy-elicited in situ vaccination against breast cancer

(2013) Sandra Demaria et al.   OncoImmunology

Shortened Interval between Tetanus Vaccines

(2012) Amy E Lodolce   ANNALS OF PHARMACOTHERAPY

Calcium Phosphate Nanoparticles for Transcutaneous Vaccine Delivery

(2012) Preety Sahdev et al.   Journal of Biomedical Nanotechnology

Transcutaneous vaccination via laser microporation

(2012) Richard Weiss et al.   JOURNAL OF CONTROLLED RELEASE

Microneedle technologies for (trans)dermal drug and vaccine delivery

(2012) Koen van der Maaden et al.   JOURNAL OF CONTROLLED RELEASE

Vaccine Injection Site Matters: Qualitative and Quantitative Defects in CD8 T Cells Primed as a Function of Proximity to the Tumor in a Murine Glioma Model

(2012) J. R. Ohlfest et al.   JOURNAL OF IMMUNOLOGY

Effect of needle length for response to hepatitis B vaccine in macrosomic neonates: A prospective randomized study

(2012) Ramazan Ozdemir et al.   VACCINE

Transcutaneous immunization with Intercell's vaccine delivery system

(2012) Robert C. Seid et al.   VACCINE

Dose sparing and enhanced immunogenicity of inactivated rotavirus vaccine administered by skin vaccination using a microneedle patch

(2012) Sungsil Moon et al.   VACCINE

Measles vaccination using a microneedle patch

(2012) Chris Edens et al.   VACCINE

Intradermal delivery for vaccine dose sparing: Overview of current issues

(2012) Darin Zehrung et al.   VACCINE

Phase 4 randomized trial of intradermal low-antigen-content inactivated influenza vaccine vs. standard-dose intramuscular vaccine in HIV-1-infected adults

(2012) Filippo Ansaldi et al.   Human Vaccines & Immunotherapeutics

Schistosoma mansoni antigen Sm-p80: Prophylactic efficacy of a vaccine formulated in human approved plasmid vector and adjuvant (VR 1020 and alum)

(2011) Weidong Zhang et al.   ACTA TROPICA

Immune Adjuvant Efficacy of CpG Oligonucleotide in Cancer Treatment Is Founded Specifically upon TLR9 Function in Plasmacytoid Dendritic Cells

(2011) S. Nierkens et al.   CANCER RESEARCH

A phase III, randomized, open-label study to assess the tolerability and immunogenicity of an H5N1 influenza vaccine administered to healthy adults with a 1-, 2-, 3-, or 6-week interval between first and second doses

(2011) Jiri Beran et al.   CLINICAL THERAPEUTICS

Polyvalent AIDS Vaccines

(2011) Shan Lu et al.   CURRENT HIV RESEARCH

Vaccine adjuvants: The dream becomes real

(2011) Aldo Tagliabue et al.   Human vaccines & immunotherapeutics

Novel vaccines and adjuvant systems: The utility of animal models for predicting immunogenicity in humans

(2011) Heather L. Davis   Human vaccines & immunotherapeutics

Assessment of the safety, tolerability and kinetics of the immune response to A/H1N1v vaccine formulations with and without adjuvant in healthy pediatric subjects from 3 through 17 years of age

(2011) Adriano Arguedas et al.   Human vaccines & immunotherapeutics

Topical Imiquimod has Therapeutic and Immunomodulatory Effects Against Intracranial Tumors

(2011) Zhengming Xiong et al.   JOURNAL OF IMMUNOTHERAPY

Phase I clinical trial of CpG oligonucleotide 7909 (PF-03512676) in patients with previously treated chronic lymphocytic leukemia

(2011) Clive S. Zent et al.   LEUKEMIA & LYMPHOMA

A Single Sublingual Dose of an Adenovirus-Based Vaccine Protects against Lethal Ebola Challenge in Mice and Guinea Pigs

(2011) Jin Huk Choi et al.   MOLECULAR PHARMACEUTICS

Intracerebral administration of CpG oligonucleotide for patients with recurrent glioblastoma: a phase II study

(2011) A. Carpentier et al.   NEURO-ONCOLOGY

Immunogenicity and safety of a measles–mumps–rubella–varicella vaccine following a 4-week or a 12-month interval between two doses

(2011) H.C. Rümke et al.   VACCINE

Devices for intradermal vaccination

(2011) Elsa E. Kis et al.   VACCINE

Systems vaccinology

(2011) Helder I. Nakaya et al.   Current Opinion in HIV and AIDS

Development of an ultrasound-responsive and mannose-modified gene carrier for DNA vaccine therapy

(2010) Keita Un et al.   BIOMATERIALS

Options for Inactivation, Adjuvant, and Route of Topical Administration of a Killed, Unencapsulated Pneumococcal Whole-Cell Vaccine

(2010) Y.-J. Lu et al.   Clinical and Vaccine Immunology

Safety, immunogenicity and immediate pain of intramuscular versus subcutaneous administration of a measles–mumps–rubella–varicella vaccine to children aged 11–21 months

(2010) Markus Knuf et al.   EUROPEAN JOURNAL OF PEDIATRICS

Heterologous Prime/Boost Immunization With p53-based Vaccines Combined With Toll-like Receptor Stimulation Enhances Tumor Regression

(2010) Hidenobu Ishizaki et al.   JOURNAL OF IMMUNOTHERAPY

Effect of Needle Length When Immunizing Obese Adolescents With Hepatitis B Vaccine

(2010) A. B. Middleman et al.   PEDIATRICS

Multiple tandem copies of conserved gp41 epitopes incorporated in gag virus-like particles elicit systemic and mucosal antibodies in an optimized heterologous vector delivery regimen

(2010) Sumiti Jain et al.   VACCINE

Intradermal hepatitis B vaccination in non-responders after topical application of imiquimod (Aldara®)

(2010) Anna H. Roukens et al.   VACCINE

Antibody responses elicited through homologous or heterologous prime-boost DNA and protein vaccinations differ in functional activity and avidity

(2010) Michael Vaine et al.   VACCINE

Immunogenicity and safety of different injection routes and schedules of IC41, a Hepatitis C virus (HCV) peptide vaccine

(2010) Christa Firbas et al.   VACCINE

Enhanced humoral and cellular immune responses after sublingual immunization against human papillomavirus 16 L1 protein with adjuvants

(2010) Hee-Jeong Cho et al.   VACCINE

Quantitative analysis of influenza virus-specific B cell memory generated by different routes of inactivated virus vaccination

(2010) Hye Mee Joo et al.   VACCINE

Safety and efficacy of novel dermal and epidermal microneedle delivery systems for rabies vaccination in healthy adults

(2010) Philippe E. Laurent et al.   VACCINE

A mucosal vaccination approach for herpes simplex virus type 2

(2010) Rebecca S. Tirabassi et al.   VACCINE

Immunotherapeutic applications of CpG oligodeoxynucleotide TLR9 agonists

(2009) Jörg Vollmer et al.   ADVANCED DRUG DELIVERY REVIEWS

Intradermal Versus Intramuscular Hepatitis B Vaccination in Hemodialysis Patients: A Prospective Open-Label Randomized Controlled Trial in Nonresponders to Primary Vaccination

(2009) Katherine A. Barraclough et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Structural modifications of outer membrane vesicles to refine them as vaccine delivery vehicles

(2009) Sang-Hyun Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Prevention of bubonic and pneumonic plague using plant-derived vaccines

(2009) M. Lucrecia Alvarez et al.   BIOTECHNOLOGY ADVANCES

Immunogenicity and safety of concomitant administration of a measles, mumps and rubella vaccine (M-M-RvaxPro®) and a varicella vaccine (VARIVAX®) by intramuscular or subcutaneous routes at separate injection sites: a randomised clinical trial

(2009) Yves Gillet et al.   BMC Medicine

Heterologous prime–boost vaccination

(2009) Shan Lu   CURRENT OPINION IN IMMUNOLOGY

Virosomal Hepatitis A Vaccine: Comparing Intradermal and Subcutaneous With Intramuscular Administration

(2009) Gert Frösner et al.   JOURNAL OF TRAVEL MEDICINE

Immunogenicity of an inactivated adjuvanted whole-virion influenza A (H5N1, NIBRG-14) vaccine administered by intramuscular or subcutaneous injection

(2009) Daisuke Ikeno et al.   MICROBIOLOGY AND IMMUNOLOGY

PolyI:polyC12U adjuvant-combined intranasal vaccine protects mice against highly pathogenic H5N1 influenza virus variants

(2009) Takeshi Ichinohe et al.   VACCINE

Transcutaneous immunization with novel lipid-based adjuvants induces protection against gastric Helicobacter pylori infection

(2009) Danica K. Hickey et al.   VACCINE

Influence of the route of administration on immunomodulatory properties of bovine β-lactoglobulin-producing Lactobacillus casei

(2009) S. Hazebrouck et al.   VACCINE

Immunogenicity and safety of intradermal versus intramuscular route of influenza immunization in infants less than 6 months of age: A randomized controlled trial

(2009) Susan S. Chiu et al.   VACCINE

Immunogenicity and safety of low dose virosomal adjuvanted influenza vaccine administered intradermally compared to intramuscular full dose administration

(2009) Valérie Künzi et al.   VACCINE

A prime–boost vaccination of mice with heterologous H5N1 strains

(2009) Daisuke Ikeno et al.   VACCINE

Lipid vesicle size of an oral influenza vaccine delivery vehicle influences the Th1/Th2 bias in the immune response and protection against infection

(2009) Jamie F.S. Mann et al.   VACCINE

Single dose vaccination with AS03-adjuvanted H5N1 vaccines in a randomized trial induces strong and broad immune responsiveness to booster vaccination in adults

(2009) Tino F. Schwarz et al.   VACCINE

Induction of mucosal and systemic antibody responses against the HIV coreceptor CCR5 upon intramuscular immunization and aerosol delivery of a virus-like particle based vaccine

(2009) Zoe Hunter et al.   VACCINE

Systemic, nasal and oral live vaccines against Pseudomonas aeruginosa: A clinical trial of immunogenicity in lower airways of human volunteers

(2009) Dirk Bumann et al.   VACCINE

A phase I evaluation of inactivated influenza A/H5N1 vaccine administered by the intradermal or the intramuscular route

(2009) Shital M. Patel et al.   VACCINE

A systematic review of measures for reducing injection pain during adult immunization

(2009) Mary-Ellen Hogan et al.   VACCINE

Oral immunization with a novel lipid-based adjuvant protects against genital Chlamydia infection

(2009) Danica K. Hickey et al.   VACCINE

Principles of vaccination and possible development strategies for rational design

(2008) Claire J.P. Boog   IMMUNOLOGY LETTERS

Transcutaneous delivery and thermostability of a dry trivalent inactivated influenza vaccine patch

(2008) Vladimir G. Frolov et al.   Influenza and Other Respiratory Viruses

Prospective Assessment of the Effect of Needle Length and Injection Site on the Risk of Local Reactions to the Fifth Diphtheria-Tetanus-Acellular Pertussis Vaccination

(2008) L. A. Jackson et al.   PEDIATRICS

Biochemical and immunological characterization of the plant-derived candidate human immunodeficiency virus type 1 mucosal vaccine CTB-MPR649-684

(2008) Nobuyuki Matoba et al.   PLANT BIOTECHNOLOGY JOURNAL

Heterologous HA DNA vaccine prime—inactivated influenza vaccine boost is more effective than using DNA or inactivated vaccine alone in eliciting antibody responses against H1 or H3 serotype influenza viruses

(2008) Shixia Wang et al.   VACCINE

The relative immunogenicity of DNA vaccines delivered by the intramuscular needle injection, electroporation and gene gun methods

(2008) Shixia Wang et al.   VACCINE

Safety and efficacy of a novel microneedle device for dose sparing intradermal influenza vaccination in healthy adults

(2008) Pierre Van Damme et al.   VACCINE