Development of SARS-CoV-2 vaccines: should we focus on mucosal immunity?

Subunit Vaccines Against Emerging Pathogenic Human Coronaviruses

(2020) Ning Wang et al.   Frontiers in Microbiology

Efficient oral vaccination by bioengineering virus-like particles with protozoan surface proteins

(2019) Marianela C. Serradell et al.   Nature Communications

Subunit-based mucosal vaccine delivery systems for pulmonary delivery - Are they feasible?

(2019) Nirmal Marasini et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Induction of mycobacterial protective immunity by sublingual BCG vaccination

(2019) Christopher S. Eickhoff et al.   VACCINE

Parenteral Vaccination With a Tuberculosis Subunit Vaccine in Presence of Retinoic Acid Provides Early but Transient Protection to M. Tuberculosis Infection

(2019) Antonella Riccomi et al.   Frontiers in Immunology

Mucosal Vaccination via the Respiratory Tract

(2019) Hellfritzsch et al.   Pharmaceutics

A Novel Bacterium-Like Particle Vaccine Displaying the MERS-CoV Receptor-Binding Domain Induces Specific Mucosal and Systemic Immune Responses in Mice

(2019) Li et al.   Viruses-Basel

The establishment of resident memory B cells in the lung requires local antigen encounter

(2018) S. Rameeza Allie et al.   NATURE IMMUNOLOGY

Protective efficacy of a novel simian adenovirus vaccine against lethal MERS-CoV challenge in a transgenic human DPP4 mouse model

(2017) Vincent J. Munster et al.   npj Vaccines

Dry influenza vaccines: towards a stable, effective and convenient alternative to conventional parenteral influenza vaccination

(2016) Jasmine Tomar et al.   Expert Review of Vaccines

Recent advances in nontoxic Escherichia coli heat-labile toxin and its derivative adjuvants

(2016) Yongping Ma   Expert Review of Vaccines

Airway Memory CD4 + T Cells Mediate Protective Immunity against Emerging Respiratory Coronaviruses

(2016) Jincun Zhao et al.   IMMUNITY

Vaccine-induced Th17 cells are established as resident memory cells in the lung and promote local IgA responses

(2016) D Christensen et al.   Mucosal Immunology

Food-Grade Organisms as Vaccine Biofactories and Oral Delivery Vehicles

(2016) Sergio Rosales-Mendoza et al.   TRENDS IN BIOTECHNOLOGY

An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels

(2015) B. L. Haagmans et al.   SCIENCE

Regulation of lung immunity and host defense by the intestinal microbiota

(2015) Derrick R. Samuelson et al.   Frontiers in Microbiology

Intranasal Vaccination of Recombinant Adeno-Associated Virus Encoding Receptor-Binding Domain of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) Spike Protein Induces Strong Mucosal Immune Responses and Provides Long-Term Protection against SARS-CoV Infection

(2014) L. Du et al.   JOURNAL OF IMMUNOLOGY

Sublingual immunization with a subunit influenza vaccine elicits comparable systemic immune response as intramuscular immunization, but also induces local IgA and TH17 responses

(2014) Simona Gallorini et al.   VACCINE

Intranasal vaccination with recombinant receptor-binding domain of MERS-CoV spike protein induces much stronger local mucosal immune responses than subcutaneous immunization: Implication for designing novel mucosal MERS vaccines

(2014) Cuiqing Ma et al.   VACCINE

Dendritic Cell Targeted Chitosan Nanoparticles for Nasal DNA Immunization against SARS CoV Nucleocapsid Protein

(2012) Dharmendra Raghuwanshi et al.   MOLECULAR PHARMACEUTICS

Sublingual immunization with recombinant adenovirus encoding SARS-CoV spike protein induces systemic and mucosal immunity without redirection of the virus to the brain

(2012) Byoung-Shik Shim et al.   Virology Journal

Intranasal immunization with plasmid DNA encoding spike protein of SARS-coronavirus/polyethylenimine nanoparticles elicits antigen-specific humoral and cellular immune responses

(2011) Byoung-Shik Shim et al.   BMC IMMUNOLOGY

PIKA provides an adjuvant effect to induce strong mucosal and systemic humoral immunity against SARS-CoV

(2011) Wei-wei Gai et al.   VIROLOGICA SINICA

Effect of mucosal and systemic immunization with virus-like particles of severe acute respiratory syndrome coronavirus in mice

(2010) Baojing Lu et al.   IMMUNOLOGY

The M Cell-Targeting Ligand Promotes Antigen Delivery and Induces Antigen-Specific Immune Responses in Mucosal Vaccination

(2010) S.-H. Kim et al.   JOURNAL OF IMMUNOLOGY

The spike protein of SARS-CoV — a target for vaccine and therapeutic development

(2009) Lanying Du et al.   NATURE REVIEWS MICROBIOLOGY

A Novel Replication-Competent Vaccinia Vector MVTT Is Superior to MVA for Inducing High Levels of Neutralizing Antibody via Mucosal Vaccination

(2009) Xiaoxing Huang et al.   PLoS One

A prime-boost vaccination protocol optimizes immune responses against the nucleocapsid protein of the SARS coronavirus

(2008) Kai Schulze et al.   VACCINE