Suppressor of Cytokine Signaling 2 Regulates Retinal Pigment Epithelium Metabolism by Enhancing Autophagy

GSK3B induces autophagy by phosphorylating ULK1

(2021) Hye Young Ryu et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Efficient Dissection and Culture of Primary Mouse Retinal Pigment Epithelial Cells

(2021) Blanca Chinchilla et al.   Jove-Journal of Visualized Experiments

Mechanisms and Therapeutic Implications of GSK-3 in Treating Neurodegeneration

(2021) Ido Rippin et al.   Cells

The ElonginB/C-Cullin5-SOCS-Box-Complex Is a Potential Biomarker for Growth Hormone Disorders

(2021) Wilhelm Gossing et al.   Biomedicines

The CD36 Ligand-Promoted Autophagy Protects Retinal Pigment Epithelial Cells from Oxidative Stress

(2021) Marie-France Dorion et al.   Oxidative Medicine and Cellular Longevity

Suppressor of cytokine signaling 2 is induced in Huntington’s disease and involved in autophagy

(2021) KyoungJoo Cho et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Insulin Resistance Exacerbates Alzheimer Disease via Multiple Mechanisms

(2021) Zenghui Wei et al.   Frontiers in Neuroscience

Conditional Knock out of High-Mobility Group Box 1 (HMGB1) in Rods Reduces Autophagy Activation after Retinal Detachment

(2021) Bing X. Ross et al.   Cells

Ischemic Postconditioning Alleviates Intestinal Ischemia-Reperfusion Injury by Enhancing Autophagy and Suppressing Oxidative Stress through the Akt/GSK-3β/Nrf2 Pathway in Mice

(2020) Rong Chen et al.   Oxidative Medicine and Cellular Longevity

Integrated bioinformatics analysis of aberrantly-methylated differentially-expressed genes and pathways in age-related macular degeneration

(2020) Yinchen Shen et al.   BMC Ophthalmology

Protective Effect of Metformin against Hydrogen Peroxide-Induced Oxidative Damage in Human Retinal Pigment Epithelial (RPE) Cells by Enhancing Autophagy through Activation of AMPK Pathway

(2020) Xia Zhao et al.   Oxidative Medicine and Cellular Longevity

Autophagy Upregulation by the TFEB Inducer Trehalose Protects against Oxidative Damage and Cell Death Associated with NRF2 Inhibition in Human RPE Cells

(2020) Samuel Abokyi et al.   Oxidative Medicine and Cellular Longevity

Two different axes CALCOCO2-RB1CC1 and OPTN-ATG9A initiate PRKN-mediated mitophagy

(2020) Koji Yamano et al.   Autophagy

Suppression of autophagic activity by Rubicon is a signature of aging

(2019) Shuhei Nakamura et al.   Nature Communications

Structural insights into substrate recognition by the SOCS2 E3 ubiquitin ligase

(2019) Wei-Wei Kung et al.   Nature Communications

IL-1β Induces SOCS2 Expression in Human Dendritic Cells

(2019) Muamera Sarajlic et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inhibition of lncRNA XIST Improves Myocardial I/R Injury by Targeting miR-133a through Inhibition of Autophagy and Regulation of SOCS2

(2019) Zhiqiang Li et al.   Molecular Therapy-Nucleic Acids

Phasing out the bad—How SQSTM1/p62 sequesters ubiquitinated proteins for degradation by autophagy

(2018) Gabriele Zaffagnini et al.   Autophagy

Total RNA extraction from tissues for microRNA and target gene expression analysis: not all kits are created equal

(2018) Rikki A. M. Brown et al.   BMC BIOTECHNOLOGY

Genome-wide association study suggests four variants influencing outcomes with ranibizumab therapy in exudative age-related macular degeneration

(2018) Masato Akiyama et al.   JOURNAL OF HUMAN GENETICS

Age-related macular degeneration

(2018) Paul Mitchell et al.   LANCET

Publisher Correction: Autophagy as a promoter of longevity: insights from model organisms

(2018) Malene Hansen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin in humans?

(2018) Frank Madeo et al.   Autophagy

Nimbolide, a neem limonoid inhibits cytoprotective autophagy to activate apoptosis via modulation of the PI3K/Akt/GSK-3β signalling pathway in oral cancer

(2018) Josephraj Sophia et al.   Cell Death & Disease

Age-Dependent Dopaminergic Neurodegeneration and Impairment of the Autophagy-Lysosomal Pathway in LRRK -Deficient Mice

(2017) Emilie Giaime et al.   NEURON

A growth hormone receptor SNP promotes lung cancer by impairment of SOCS2-mediated degradation

(2017) Y Chhabra et al.   ONCOGENE

Insights into links between autophagy and the ubiquitin system from the structure of LC3B bound to the LIR motif from the E3 ligase NEDD4

(2017) Yu Qiu et al.   PROTEIN SCIENCE

The ubiquitin ligase Cullin5SOCS2 regulates NDR1/STK38 stability and NF-κB transactivation

(2017) Indranil Paul et al.   Scientific Reports

Crosstalk Between the Autophagy-Lysosome Pathway and the Ubiquitin-Proteasome Pathway in Retinal Pigment Epithelial Cells

(2016) J. Zhan et al.   CURRENT MOLECULAR MEDICINE

Isolation, culture and characterization of primary mouse RPE cells

(2016) Rosario Fernandez-Godino et al.   Nature Protocols

The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome activation by promoting proteasomal degradation of NLRP3

(2016) Hui Song et al.   Nature Communications

mTOR: a pharmacologic target for autophagy regulation

(2015) Young Chul Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of autophagy by E3 ubiquitin ligase RNF216 through BECN1 ubiquitination

(2014) Congfeng Xu et al.   Autophagy

Autophagic Clearance of PolyQ Proteins Mediated by Ubiquitin-Atg8 Adaptors of the Conserved CUET Protein Family

(2014) Kefeng Lu et al.   CELL

Autophagy-related gene Atg5 is essential for astrocyte differentiation in the developing mouse cortex

(2014) S. Wang et al.   EMBO REPORTS

Biophysical Studies on Interactions and Assembly of Full-size E3 Ubiquitin Ligase

(2014) Emil Bulatov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interactions between Autophagy Receptors and Ubiquitin-like Proteins Form the Molecular Basis for Selective Autophagy

(2014) Vladimir Rogov et al.   MOLECULAR CELL

The Proteomics of Drusen

(2014) J. W. Crabb   Cold Spring Harbor Perspectives in Medicine

11′-Deoxyverticillin A (C42) promotes autophagy through K-Ras/GSK3 signaling pathway in HCT116 cells

(2014) Shubin Niu et al.   Protein & Cell

The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution

(2014) Nico P. Dantuma et al.   Frontiers in Molecular Neuroscience

An Overview of Autophagy: Morphology, Mechanism, and Regulation

(2013) Katherine R. Parzych et al.   ANTIOXIDANTS & REDOX SIGNALING

Noncanonical Autophagy Promotes the Visual Cycle

(2013) Ji-Young Kim et al.   CELL

Insulin and IGF1 enhance IL-17-induced chemokine expression through a GSK3B-dependent mechanism: a new target for melatonin's anti-inflammatory action

(2013) Dongxia Ge et al.   JOURNAL OF PINEAL RESEARCH

Differential Roles of GSK-3β During Myocardial Ischemia and Ischemia/Reperfusion

(2011) Peiyong Zhai et al.   CIRCULATION RESEARCH

p62 Is a Key Regulator of Nutrient Sensing in the mTORC1 Pathway

(2011) Angeles Duran et al.   MOLECULAR CELL

The SOCS2 Ubiquitin Ligase Complex Regulates Growth Hormone Receptor Levels

(2011) Mattias Vesterlund et al.   PLoS One

Parallel findings in age-related macular degeneration and Alzheimer’s disease

(2011) Kyoko Ohno-Matsui   PROGRESS IN RETINAL AND EYE RESEARCH

Oxidative Stress Stimulates Autophagic Flux During Ischemia/Reperfusion

(2010) Nirmala Hariharan et al.   ANTIOXIDANTS & REDOX SIGNALING

Abundant Lipid and Protein Components of Drusen

(2010) Lan Wang et al.   PLoS One

Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3

(2009) Martin Gamerdinger et al.   EMBO JOURNAL

A Role for NBR1 in Autophagosomal Degradation of Ubiquitinated Substrates

(2009) Vladimir Kirkin et al.   MOLECULAR CELL

The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria

(2009) Teresa L M Thurston et al.   NATURE IMMUNOLOGY

Lack of Socs2 expression reduces lifespan in high-growth mice

(2008) Joaquim Casellas et al.   AGE

Ubiquitin signals autophagic degradation of cytosolic proteins and peroxisomes

(2008) P. K. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA