Autophagy Upregulation by the TFEB Inducer Trehalose Protects against Oxidative Damage and Cell Death Associated with NRF2 Inhibition in Human RPE Cells

Central Role of Oxidative Stress in Age-Related Macular Degeneration: Evidence from a Review of the Molecular Mechanisms and Animal Models

(2020) Samuel Abokyi et al.   Oxidative Medicine and Cellular Longevity

Trehalose as a promising therapeutic candidate for the treatment of Parkinson's disease

(2019) Masoomeh Khalifeh et al.   BRITISH JOURNAL OF PHARMACOLOGY

Activators and Inhibitors of NRF2: A Review of Their Potential for Clinical Development

(2019) Natalia Robledinos-Antón et al.   Oxidative Medicine and Cellular Longevity

Oral trehalose maybe helpful for patients with spinocerebellar ataxia 3 and should be better evaluated

(2019) M.A. Noorasyikin et al.   PARKINSONISM & RELATED DISORDERS

Trehalose reduces retinal degeneration, neuroinflammation and storage burden caused by a lysosomal hydrolase deficiency

(2018) Parisa Lotfi et al.   Autophagy

Retinal pigment epithelial cells as a therapeutic tool and target against retinopathies

(2018) Barbara Pavan et al.   DRUG DISCOVERY TODAY

Autophagy induction by trehalose: Molecular mechanisms and therapeutic impacts

(2018) Kiana Hosseinpour-Moghaddam et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The coming of age of chaperone-mediated autophagy

(2018) Susmita Kaushik et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TFEB dysregulation as a driver of autophagy dysfunction in neurodegenerative disease: Molecular mechanisms, cellular processes, and emerging therapeutic opportunities

(2018) Constanza J. Cortes et al.   NEUROBIOLOGY OF DISEASE

Till Death Do Us Part: The Marriage of Autophagy and Apoptosis

(2018) Katrina F. Cooper   Oxidative Medicine and Cellular Longevity

Canonical and non-canonical mechanisms of Nrf2 activation

(2018) Carlos Alfredo Silva-Islas et al.   PHARMACOLOGICAL RESEARCH

Autophagy Dysfunction and Oxidative Stress, Two Related Mechanisms Implicated in Retinitis Pigmentosa

(2018) Mari-Luz Moreno et al.   Frontiers in Physiology

Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration

(2018) Paola Rusmini et al.   Autophagy

Is trehalose an autophagic inducer? Unraveling the roles of non-reducing disaccharides on autophagic flux and alpha-synuclein aggregation

(2017) Ye-Seul Yoon et al.   Cell Death & Disease

Assays to Monitor Autophagy Progression in Cell Cultures

(2017) Idil Orhon et al.   Cells

Systemic, Ocular and Genetic Risk Factors for Age-related Macular Degeneration and Polypoidal Choroidal Vasculopathy in Singaporeans

(2017) Chui Ming Gemmy Cheung et al.   Scientific Reports

Transcriptional Regulation by Nrf2

(2017) Claudia Tonelli et al.   ANTIOXIDANTS & REDOX SIGNALING

Retinal pigment epithelial cell multinucleation in the aging eye - a mechanism to repair damage and maintain homoeostasis

(2016) Mei Chen et al.   AGING CELL

Autophagy substrate SQSTM1/p62 regulates chromatin ubiquitination during the DNA damage response

(2016) Yanan Wang et al.   Autophagy

Pharmacology of the retinal pigment epithelium, the interface between retina and body system

(2016) Olaf Strauß   EUROPEAN JOURNAL OF PHARMACOLOGY

Trehalose Alters Subcellular Trafficking and the Metabolism of the Alzheimer-associated Amyloid Precursor Protein

(2016) Nguyen T. Tien et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rotenone down-regulates HSPA8/hsc70 chaperone protein in vitro : A new possible toxic mechanism contributing to Parkinson’s disease

(2016) Gessica Sala et al.   NEUROTOXICOLOGY

Risk factors and biomarkers of age-related macular degeneration

(2016) Nathan G. Lambert et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Defects in retinal pigment epithelial cell proteolysis and the pathology associated with age-related macular degeneration

(2016) Deborah A. Ferrington et al.   PROGRESS IN RETINAL AND EYE RESEARCH

The Autophagy–Lysosomal Pathway in Neurodegeneration: A TFEB Perspective

(2016) Heidi Martini-Stoica et al.   TRENDS IN NEUROSCIENCES

Impaired nuclear factor erythroid 2-related factor 2 expression increases apoptosis of airway epithelial cells in patients with chronic obstructive pulmonary disease due to cigarette smoking

(2016) Kazuhiro Yamada et al.   BMC Pulmonary Medicine

p62/SQSTM1 functions as a signaling hub and an autophagy adaptor

(2015) Yoshinori Katsuragi et al.   FEBS Journal

Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

(2015) Lauren E. Tebay et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pharmacologic agents targeting autophagy

(2015) Helin Vakifahmetoglu-Norberg et al.   JOURNAL OF CLINICAL INVESTIGATION

Phagocytosis of apoptotic cells in homeostasis

(2015) Sanja Arandjelovic et al.   NATURE IMMUNOLOGY

DIFFERENTIAL EXPRESSION OF VASCULAR ENDOTHELIAL GROWTH FACTOR-A ISOFORMS IN NEOVASCULAR AGE-RELATED MACULAR DEGENERATION

(2015) Swaantje Grisanti et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

Autophagy and apoptosis: where do they meet?

(2014) Subhadip Mukhopadhyay et al.   APOPTOSIS

Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD

(2014) Sayak K Mitter et al.   Autophagy

Expression of the autophagy substrate SQSTM1/p62 is restored during prolonged starvation depending on transcriptional upregulation and autophagy-derived amino acids

(2014) Mayurbhai Himatbhai Sahani et al.   Autophagy

Can Trehalose Prevent Neurodegeneration? Insights from Experimental Studies

(2014) Enzo Emanuele   CURRENT DRUG TARGETS

Nrf2 signaling modulates cigarette smoke-induced complement activation in retinal pigmented epithelial cells

(2014) Lei Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cigarette Smoking and the Natural History of Age-Related Macular Degeneration

(2014) Chelsea E. Myers et al.   OPHTHALMOLOGY

Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration

(2013) Kai Kaarniranta et al.   Autophagy

Nrf2 signaling is impaired in the aging RPE given an oxidative insult

(2013) Mira M. Sachdeva et al.   EXPERIMENTAL EYE RESEARCH

TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop

(2013) Carmine Settembre et al.   NATURE CELL BIOLOGY

Autophagy as an essential cellular antioxidant pathway in neurodegenerative disease

(2013) Samantha Giordano et al.   Redox Biology

Eat-Me: Autophagy, Phagocytosis, and Reactive Oxygen Species Signaling

(2012) Philip J. Vernon et al.   ANTIOXIDANTS & REDOX SIGNALING

Autophagy and cell death

(2012) Simone Fulda   Autophagy

LAMP2A overexpression in breast tumors promotes cancer cell survival via chaperone-mediated autophagy

(2012) Tapas Saha   Autophagy

Cathepsin-mediated regulation of autophagy in saposin C deficiency

(2012) Massimo Tatti et al.   Autophagy

Autophagosomal Membrane Serves as Platform for Intracellular Death-inducing Signaling Complex (iDISC)-mediated Caspase-8 Activation and Apoptosis

(2012) Megan M. Young et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective autophagy mediated by autophagic adapter proteins

(2011) Terje Johansen et al.   Autophagy

TFEB regulates autophagy: An integrated coordination of cellular degradation and recycling processes

(2011) Carmine Settembre et al.   Autophagy

Dissecting the dynamic turnover of GFP-LC3 in the autolysosome

(2011) Hong-Min Ni et al.   Autophagy

Concurrent detection of autolysosome formation and lysosomal degradation by flow cytometry in a high-content screen for inducers of autophagy

(2011) Phillip Hundeshagen et al.   BMC BIOLOGY

Signal transduction by reactive oxygen species

(2011) Toren Finkel   JOURNAL OF CELL BIOLOGY

Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells

(2011) J. Martinez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chloroquine treatment of ARPE-19 cells leads to lysosome dilation and intracellular lipid accumulation: possible implications of lysosomal dysfunction in macular degeneration

(2011) Patrick M Chen et al.   Cell and Bioscience

Cigarette Smoke-Related Hydroquinone Induces Filamentous Actin Reorganization and Heat Shock Protein 27 Phosphorylation through p38 and Extracellular Signal-Regulated Kinase 1/2 in Retinal Pigment Epithelium

(2010) Marianne Pons et al.   AMERICAN JOURNAL OF PATHOLOGY

Quantification of nonselective bulk autophagy inS. cerevisiaeusing Pgk1-GFP

(2010) Evelyn Welter et al.   Autophagy

Molecular regulation of cigarette smoke induced-oxidative stress in human retinal pigment epithelial cells: implications for age-related macular degeneration

(2009) Kurt M. Bertram et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Trehalose protects against ocular surface disorders in experimental murine dry eye through suppression of apoptosis

(2009) Wei Chen et al.   EXPERIMENTAL EYE RESEARCH

Impaired Autolysosome Formation Correlates With Lamp-2 Depletion: Role of Apoptosis, Autophagy, and Necrosis in Pancreatitis

(2009) Franco Fortunato et al.   GASTROENTEROLOGY

Constitutive and oxidative-stress-induced expression of VEGF in the RPE are differently regulated by different Mitogen-activated protein kinases

(2009) Alexa Klettner et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Cigarette smoking, oxidative stress, the anti-oxidant response through Nrf2 signaling, and Age-related Macular Degeneration

(2009) Marisol Cano et al.   VISION RESEARCH

Cathepsin D—Many functions of one aspartic protease

(2008) Petr Benes et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Oxidative Inactivation of the Proteasome in Retinal Pigment Epithelial Cells

(2008) Alexandre F. Fernandes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Constitutive Activation of Chaperone-mediated Autophagy in Cells with Impaired Macroautophagy

(2008) Susmita Kaushik et al.   MOLECULAR BIOLOGY OF THE CELL

Chronic Cigarette Smoke Causes Oxidative Damage and Apoptosis to Retinal Pigmented Epithelial Cells in Mice

(2008) Masashi Fujihara et al.   PLoS One