Fibro-adipogenic progenitors in skeletal muscle homeostasis, regeneration and diseases

SCA-1 micro-heterogeneity in the fate decision of dystrophic fibro/adipogenic progenitors

(2021) Giulio Giuliani et al.   Cell Death & Disease

In vitro assessment of anti-fibrotic activity does not predict their in vivo efficacy in murine models of Duchenne muscular dystrophy

(2021) Marine Theret et al.   LIFE SCIENCES

Evolving Roles of Muscle-Resident Fibro-Adipogenic Progenitors in Health, Regeneration, Neuromuscular Disorders, and Aging

(2021) Marine Theret et al.   Frontiers in Physiology

Origins, potency, and heterogeneity of skeletal muscle fibro-adipogenic progenitors—time for new definitions

(2021) Osvaldo Contreras et al.   Skeletal Muscle

Characterization of the Skeletal Muscle Secretome Reveals a Role for Extracellular Vesicles and IL1α/IL1β in Restricting Fibro/Adipogenic Progenitor Adipogenesis

(2021) Simone Vumbaca et al.   Biomolecules

Tissue-Resident PDGFRα+ Progenitor Cells Contribute to Fibrosis versus Healing in a Context- and Spatiotemporally Dependent Manner

(2020) Maria Paola Santini et al.   Cell Reports

Fibrogenesis in LAMA2-Related Muscular Dystrophy Is a Central Tenet of Disease Etiology

(2020) Anthony Accorsi et al.   Frontiers in Molecular Neuroscience

Adipogenesis of skeletal muscle fibro/adipogenic progenitors is affected by the WNT5a/GSK3/β-catenin axis

(2020) Alessio Reggio et al.   CELL DEATH AND DIFFERENTIATION

Murine Tissue‐Resident PDGFRα+ Fibro‐Adipogenic Progenitors Spontaneously Acquire Osteogenic Phenotype in an Altered Inflammatory Environment

(2020) Christine Eisner et al.   JOURNAL OF BONE AND MINERAL RESEARCH

TGF-β-driven downregulation of the Wnt/β-Catenin transcription factor TCF7L2/TCF4 in PDGFRα+ fibroblasts

(2020) Osvaldo Contreras et al.   JOURNAL OF CELL SCIENCE

Interstitial Cell Remodeling Promotes Aberrant Adipogenesis in Dystrophic Muscles

(2020) Jordi Camps et al.   Cell Reports

Single-Cell Analysis of the Muscle Stem Cell Hierarchy Identifies Heterotypic Communication Signals Involved in Skeletal Muscle Regeneration

(2020) Andrea J. De Micheli et al.   Cell Reports

Tissue cross talks governing limb muscle development and regeneration

(2020) Françoise Helmbacher et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

High-Dimensional Single-Cell Quantitative Profiling of Skeletal Muscle Cell Population Dynamics during Regeneration

(2020) Lucia Lisa Petrilli et al.   Cells

Retinoic acid signalling in fibro/adipogenic progenitors robustly enhances muscle regeneration

(2020) Liang Zhao et al.   EBioMedicine

Mesenchymal Bmp3b expression maintains skeletal muscle integrity and decreases in age-related sarcopenia

(2020) Akiyoshi Uezumi et al.   JOURNAL OF CLINICAL INVESTIGATION

High-Dimensional Single-Cell Cartography Reveals Novel Skeletal Muscle-Resident Cell Populations

(2019) Lorenzo Giordani et al.   MOLECULAR CELL

Single-cell analysis of adult skeletal muscle stem cells in homeostatic and regenerative conditions

(2019) Stefania Dell'Orso et al.   DEVELOPMENT

Aging Disrupts Muscle Stem Cell Function by Impairing Matricellular WISP1 Secretion from Fibro-Adipogenic Progenitors

(2019) Laura Lukjanenko et al.   Cell Stem Cell

Biallelic variants in the transcription factor PAX7 are a new genetic cause of myopathy

(2019) René G. Feichtinger et al.   GENETICS IN MEDICINE

Cellular Senescence: Aging, Cancer, and Injury

(2019) Arianna Calcinotto et al.   PHYSIOLOGICAL REVIEWS

Mesenchymal Stromal Cells Are Required for Regeneration and Homeostatic Maintenance of Skeletal Muscle

(2019) Michael N. Wosczyna et al.   Cell Reports

Identification of Candidate Protein Markers in Skeletal Muscle of Laminin-211-Deficient CMD Type 1A-Patients

(2019) Heike Kölbel et al.   Frontiers in Neurology

Fibroadipogenic progenitors are responsible for muscle loss in limb girdle muscular dystrophy 2B

(2019) Marshall W. Hogarth et al.   Nature Communications

Macrophages Are Key Regulators of Stem Cells during Skeletal Muscle Regeneration and Diseases

(2019) Junio Dort et al.   Stem Cells International

Cross-talk between TGF-β and PDGFRα signaling pathways regulates the fate of stromal fibro–adipogenic progenitors

(2019) Osvaldo Contreras et al.   JOURNAL OF CELL SCIENCE

Fibro–Adipogenic Progenitors Cross-Talk in Skeletal Muscle: The Social Network

(2019) Beatrice Biferali et al.   Frontiers in Physiology

Hic1 Defines Quiescent Mesenchymal Progenitor Subpopulations with Distinct Functions and Fates in Skeletal Muscle Regeneration

(2019) R. Wilder Scott et al.   Cell Stem Cell

Understanding muscle regenerative decline with aging: new approaches to bring back youthfulness to aged stem cells

(2019) Pura Muñoz‐Cánoves et al.   FEBS Journal

Oxidative stress-mediated senescence in mesenchymal progenitor cells causes the loss of their fibro/adipogenic potential and abrogates myoblast fusion

(2018) Hidetoshi Sugihara et al.   Aging-US

Interleukin-15 facilitates muscle regeneration through modulation of fibro/adipogenic progenitors

(2018) Xia Kang et al.   Cell Communication and Signaling

Basal lamina remodeling at the skeletal muscle stem cell niche mediates stem cell self-renewal

(2018) Shantisree Sandeepani Rayagiri et al.   Nature Communications

Activin-dependent signaling in fibro/adipogenic progenitors causes fibrodysplasia ossificans progressiva

(2018) John B. Lees-Shepard et al.   Nature Communications

Inhibition of the Activin Receptor Type-2B Pathway Restores Regenerative Capacity in Satellite Cell-Depleted Skeletal Muscle

(2018) Luigi Formicola et al.   Frontiers in Physiology

Nilotinib impairs skeletal myogenesis by increasing myoblast proliferation

(2018) Osvaldo Contreras et al.   Skeletal Muscle

Reciprocal signalling by Notch–Collagen V–CALCR retains muscle stem cells in their niche

(2018) Meryem B. Baghdadi et al.   NATURE

The exerkine apelin reverses age-associated sarcopenia

(2018) Claire Vinel et al.   NATURE MEDICINE

Odd skipped-related 1 (Osr1) identifies muscle-interstitial fibro-adipogenic progenitors (FAPs) activated by acute injury

(2018) Jürgen Stumm et al.   Stem Cell Research

Dynamics of cellular states of fibro-adipogenic progenitors during myogenesis and muscular dystrophy

(2018) Barbora Malecova et al.   Nature Communications

Muscle Satellite Cell Cross-Talk with a Vascular Niche Maintains Quiescence via VEGF and Notch Signaling

(2018) Mayank Verma et al.   Cell Stem Cell

IL-1β- and IL-4-polarized macrophages have opposite effects on adipogenesis of intramuscular fibro-adipogenic progenitors in humans

(2018) C. Moratal et al.   Scientific Reports

AMPK Activation Regulates LTBP4-Dependent TGF-β1 Secretion by Pro-inflammatory Macrophages and Controls Fibrosis in Duchenne Muscular Dystrophy

(2018) Gaëtan Juban et al.   Cell Reports

IL-10 prevents aging-associated inflammation and insulin resistance in skeletal muscle

(2017) Sezin Dagdeviren et al.   FASEB JOURNAL

Odd skipped-related 1 identifies a population of embryonic fibro-adipogenic progenitors regulating myogenesis during limb development

(2017) Pedro Vallecillo-García et al.   Nature Communications

Muscle Weakness and Fibrosis Due to Cell Autonomous and Non-cell Autonomous Events in Collagen VI Deficient Congenital Muscular Dystrophy

(2017) Satoru Noguchi et al.   EBioMedicine

ALS skeletal muscle shows enhanced TGF-β signaling, fibrosis and induction of fibro/adipogenic progenitor markers

(2017) David Gonzalez et al.   PLoS One

Connective tissue cells expressing fibro/adipogenic progenitor markers increase under chronic damage: relevance in fibroblast-myofibroblast differentiation and skeletal muscle fibrosis

(2016) Osvaldo Contreras et al.   CELL AND TISSUE RESEARCH

Poor Repair of Skeletal Muscle in Aging Mice Reflects a Defect in Local, Interleukin-33-Dependent Accumulation of Regulatory T Cells

(2016) Wilson Kuswanto et al.   IMMUNITY

PDGFRα signalling promotes fibrogenic responses in collagen-producing cells in Duchenne muscular dystrophy

(2016) Nicholas Ieronimakis et al.   JOURNAL OF PATHOLOGY

Regenerative decline of stem cells in sarcopenia

(2016) Pedro Sousa-Victor et al.   MOLECULAR ASPECTS OF MEDICINE

Intronic polyadenylation of PDGFRα in resident stem cells attenuates muscle fibrosis

(2016) Alisa A. Mueller et al.   NATURE

Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice

(2016) Laura Lukjanenko et al.   NATURE MEDICINE

Histological effects of givinostat in boys with Duchenne muscular dystrophy

(2016) Paolo Bettica et al.   NEUROMUSCULAR DISORDERS

TGF-β Small Molecule Inhibitor SB431542 Reduces Rotator Cuff Muscle Fibrosis and Fatty Infiltration By Promoting Fibro/Adipogenic Progenitor Apoptosis

(2016) Michael R. Davies et al.   PLoS One

Pharmacological blockage of fibro/adipogenic progenitor expansion and suppression of regenerative fibrogenesis is associated with impaired skeletal muscle regeneration

(2016) Daniela Fiore et al.   Stem Cell Research

Primary Cilia and Mammalian Hedgehog Signaling

(2016) Fiona Bangs et al.   Cold Spring Harbor Perspectives in Biology

Intrinsic and extrinsic mechanisms regulating satellite cell function

(2015) N. A. Dumont et al.   DEVELOPMENT

Cellular senescence in aging and age-related disease: from mechanisms to therapy

(2015) Bennett G Childs et al.   NATURE MEDICINE

Nilotinib reduces muscle fibrosis in chronic muscle injury by promoting TNF-mediated apoptosis of fibro/adipogenic progenitors

(2015) Dario R Lemos et al.   NATURE MEDICINE

Diabetic mice exhibited a peculiar alteration in body composition with exaggerated ectopic fat deposition after muscle injury due to anomalous cell differentiation

(2015) Masaki Mogi et al.   Journal of Cachexia Sarcopenia and Muscle

Fibrogenic Cell Plasticity Blunts Tissue Regeneration and Aggravates Muscular Dystrophy

(2015) Patrizia Pessina et al.   Stem Cell Reports

IL-33: an alarmin cytokine with crucial roles in innate immunity, inflammation and allergy

(2014) Corinne Cayrol et al.   CURRENT OPINION IN IMMUNOLOGY

Glucocorticoids increase adipocytes in muscle by affecting IL-4 regulated FAP activity

(2014) Yanjun Dong et al.   FASEB JOURNAL

HDAC-regulated myomiRs control BAF60 variant exchange and direct the functional phenotype of fibro-adipogenic progenitors in dystrophic muscles

(2014) V. Saccone et al.   GENES & DEVELOPMENT

Myokine IL-15 regulates the crosstalk of co-cultured porcine skeletal muscle satellite cells and preadipocytes

(2014) Yinghui Li et al.   MOLECULAR BIOLOGY REPORTS

Geriatric muscle stem cells switch reversible quiescence into senescence

(2014) Pedro Sousa-Victor et al.   NATURE

STAT3 signaling controls satellite cell expansion and skeletal muscle repair

(2014) Matthew Timothy Tierney et al.   NATURE MEDICINE

Inducible depletion of satellite cells in adult, sedentary mice impairs muscle regenerative capacity without affecting sarcopenia

(2014) Christopher S Fry et al.   NATURE MEDICINE

Targeting TGF-β Signaling by Antisense Oligonucleotide-mediated Knockdown of TGF-β Type I Receptor

(2014) Dwi U Kemaladewi et al.   Molecular Therapy-Nucleic Acids

Dystrophin complex functions as a scaffold for signalling proteins

(2013) Bruno Constantin   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Type 2 Innate Signals Stimulate Fibro/Adipogenic Progenitors to Facilitate Muscle Regeneration

(2013) Jose E. Heredia et al.   CELL

Hox11 genes are required for regional patterning and integration of muscle, tendon and bone

(2013) I. T. Swinehart et al.   DEVELOPMENT

Fibroadipogenic progenitors mediate the ability of HDAC inhibitors to promote regeneration in dystrophic muscles of young, but not old Mdx mice

(2013) Chiara Mozzetta et al.   EMBO Molecular Medicine

Cellular dynamics in the muscle satellite cell niche

(2013) C Florian Bentzinger et al.   EMBO REPORTS

Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia

(2013) Edward W. Roberts et al.   JOURNAL OF EXPERIMENTAL MEDICINE

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(2013) Silvia Consalvi et al.   MOLECULAR MEDICINE

Imatinib attenuates severe mouse dystrophy and inhibits proliferation and fibrosis-marker expression in muscle mesenchymal progenitors

(2013) Takahito Ito et al.   NEUROMUSCULAR DISORDERS

Analysis of fatty infiltration and inflammation of the pelvic and thigh muscles in boys with Duchenne muscular dystrophy (DMD): grading of disease involvement on MR imaging and correlation with clinical assessments

(2013) Hee Kyung Kim et al.   PEDIATRIC RADIOLOGY

Collagen VI regulates satellite cell self-renewal and muscle regeneration

(2013) Anna Urciuolo et al.   Nature Communications

Multipotent progenitors resident in the skeletal muscle interstitium exhibit robust BMP-dependent osteogenic activity and mediate heterotopic ossification

(2012) Michael N Wosczyna et al.   JOURNAL OF BONE AND MINERAL RESEARCH

PAI-1–regulated miR-21 defines a novel age-associated fibrogenic pathway in muscular dystrophy

(2012) Esther Ardite et al.   JOURNAL OF CELL BIOLOGY

IL-10 Triggers Changes in Macrophage Phenotype That Promote Muscle Growth and Regeneration

(2012) B. Deng et al.   JOURNAL OF IMMUNOLOGY

Functionally Convergent White Adipogenic Progenitors of Different Lineages Participate in a Diffused System Supporting Tissue Regeneration

(2012) Dario R. Lemos et al.   STEM CELLS

Losartan, a therapeutic candidate in congenital muscular dystrophy: Studies in the dy2J/dy2J Mouse

(2011) Moran Elbaz et al.   ANNALS OF NEUROLOGY

Satellite cells, connective tissue fibroblasts and their interactions are crucial for muscle regeneration

(2011) M. M. Murphy et al.   DEVELOPMENT

Pax7-expressing satellite cells are indispensable for adult skeletal muscle regeneration

(2011) R. Sambasivan et al.   DEVELOPMENT

Fibrosis and adipogenesis originate from a common mesenchymal progenitor in skeletal muscle

(2011) A. Uezumi et al.   JOURNAL OF CELL SCIENCE

Muscle fat-fraction and mapping in Duchenne muscular dystrophy: evaluation of disease distribution and correlation with clinical assessments

(2011) Michele Gaeta et al.   SKELETAL RADIOLOGY

Fetal muscle contains different CD34+ cell subsets that distinctly differentiate into adipogenic, angiogenic and myogenic lineages

(2011) Tanaelle Dupas et al.   Stem Cell Research

Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models

(2011) Stefano Schiaffino et al.   Skeletal Muscle

Matrix Metalloproteinase Inhibitor Batimastat Alleviates Pathology and Improves Skeletal Muscle Function in Dystrophin-Deficient mdx Mice

(2010) Akhilesh Kumar et al.   AMERICAN JOURNAL OF PATHOLOGY

Connective tissue fibroblasts and Tcf4 regulate myogenesis

(2010) S. J. Mathew et al.   DEVELOPMENT

Tbx4 and Tbx5 Acting in Connective Tissue Are Required for Limb Muscle and Tendon Patterning

(2010) Peleg Hasson et al.   DEVELOPMENTAL CELL

DNA binding-dependent glucocorticoid receptor activity promotes adipogenesis via Krüppel-like factor 15 gene expression

(2010) Maki Asada et al.   LABORATORY INVESTIGATION

Fibrosis inhibition and muscle histopathology improvement in laminin-α2-deficient mice

(2010) Yoram Nevo et al.   MUSCLE & NERVE

Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle

(2010) Akiyoshi Uezumi et al.   NATURE CELL BIOLOGY

Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis

(2010) Aaron W. B. Joe et al.   NATURE CELL BIOLOGY

Proteomic profile of differentially expressed plasma proteins from dystrophic mice and following suberoylanilide hydroxamic acid treatment

(2010) C. Colussi et al.   Proteomics Clinical Applications

Imatinib attenuates skeletal muscle dystrophy in mdx mice

(2009) Ping Huang et al.   FASEB JOURNAL

Endomysial Fibrosis in Duchenne Muscular Dystrophy: A Marker of Poor Outcome Associated With Macrophage Alternative Activation

(2009) Isabelle Desguerre et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Interleukin-6 Is an Essential Regulator of Satellite Cell-Mediated Skeletal Muscle Hypertrophy

(2008) Antonio L. Serrano et al.   Cell Metabolism