Fibrogenesis in LAMA2-Related Muscular Dystrophy Is a Central Tenet of Disease Etiology

Identification of Candidate Protein Markers in Skeletal Muscle of Laminin-211-Deficient CMD Type 1A-Patients

(2019) Heike Kölbel et al.   Frontiers in Neurology

Elevated H3K27ac in aged skeletal muscle leads to increase in extracellular matrix and fibrogenic conversion of muscle satellite cells

(2019) Jiajian Zhou et al.   AGING CELL

A mutation-independent approach for muscular dystrophy via upregulation of a modifier gene

(2019) Dwi U. Kemaladewi et al.   NATURE

Long-term natural history data in Duchenne muscular dystrophy ambulant patients with mutations amenable to skip exons 44, 45, 51 and 53

(2019) Claudia Brogna et al.   PLoS One

Electrical impedance myography in facioscapulohumeral muscular dystrophy: A 1-year follow-up study

(2018) Karlien Mul et al.   MUSCLE & NERVE

Robust inflammatory and fibrotic signaling following volumetric muscle loss: a barrier to muscle regeneration

(2018) Jacqueline Larouche et al.   Cell Death & Disease

Electrical impedance myography in individuals with collagen 6 and laminin α-2 congenital muscular dystrophy: a cross-sectional and 2-year analysis

(2017) Carmel Nichols et al.   MUSCLE & NERVE

Non-invasive evaluation of muscle disease in the canine model of Duchenne muscular dystrophy by electrical impedance myography

(2017) Chady H. Hakim et al.   PLoS One

αv integrins on mesenchymal cells regulate skeletal and cardiac muscle fibrosis

(2017) I. R. Murray et al.   Nature Communications

Halofuginone inhibits TGF-β/BMP signaling and in combination with zoledronic acid enhances inhibition of breast cancer bone metastasis

(2017) Patricia Juárez et al.   Oncotarget

Potent pro-inflammatory and pro-fibrotic molecules, osteopontin and galectin-3, are not major disease modulators of laminin α2 chain-deficient muscular dystrophy

(2017) Kinga I. Gawlik et al.   Scientific Reports

αv integrins: key regulators of tissue fibrosis

(2016) Kylie P. Conroy et al.   CELL AND TISSUE RESEARCH

Connective tissue cells expressing fibro/adipogenic progenitor markers increase under chronic damage: relevance in fibroblast-myofibroblast differentiation and skeletal muscle fibrosis

(2016) Osvaldo Contreras et al.   CELL AND TISSUE RESEARCH

Angiotensin-(1-7) Prevents Skeletal Muscle Atrophy Induced by Transforming Growth Factor Type Beta (TGF-β) via Mas Receptor Activation

(2016) Johanna Ábrigo et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Angiotensin-(1-7) attenuates disuse skeletal muscle atrophy in mice via its receptor, Mas

(2016) María Gabriela Morales et al.   Disease Models & Mechanisms

IGF-1/GH axis enhances losartan treatment in Lama2-related muscular dystrophy

(2016) Anthony Accorsi et al.   HUMAN MOLECULAR GENETICS

Osteopontin ablation ameliorates muscular dystrophy by shifting macrophages to a pro-regenerative phenotype

(2016) Joana Capote et al.   JOURNAL OF CELL BIOLOGY

Renin Angiotensin Aldosterone System Inhibitors in Hypertension: Is There Evidence for Benefit Independent of Blood Pressure Reduction?

(2016) Chirag Bavishi et al.   PROGRESS IN CARDIOVASCULAR DISEASES

The extracellular matrix and transforming growth factor-β1: Tale of a strained relationship

(2015) Boris Hinz   MATRIX BIOLOGY

Nilotinib reduces muscle fibrosis in chronic muscle injury by promoting TNF-mediated apoptosis of fibro/adipogenic progenitors

(2015) Dario R Lemos et al.   NATURE MEDICINE

Fibrogenic Cell Plasticity Blunts Tissue Regeneration and Aggravates Muscular Dystrophy

(2015) Patrizia Pessina et al.   Stem Cell Reports

Magnetic Resonance Imaging Is Sensitive to Pathological Amelioration in a Model for Laminin-Deficient Congenital Muscular Dystrophy (MDC1A)

(2015) Ravneet Vohra et al.   PLoS One

Chronic oral administration of Ang-(1–7) improves skeletal muscle, autonomic and locomotor phenotypes in muscular dystrophy

(2014) Rasna Sabharwal et al.   CLINICAL SCIENCE

Extracellular matrix regulation in the muscle satellite cell niche

(2014) Kelsey Thomas et al.   CONNECTIVE TISSUE RESEARCH

Dysregulation of matricellular proteins is an early signature of pathology in laminin-deficient muscular dystrophy

(2014) Thomas Mehuron et al.   Skeletal Muscle

Twist reverses muscle cell differentiation through transcriptional down-regulation of myogenin

(2013) Nikolaos P. Mastroyiannopoulos et al.   BIOSCIENCE REPORTS

Triggering regeneration and tackling apoptosis: a combinatorial approach to treating congenital muscular dystrophy type 1 A

(2013) J. Yamauchi et al.   HUMAN MOLECULAR GENETICS

Restoration of muscle strength in dystrophic muscle by angiotensin-1-7 through inhibition of TGF-β signalling

(2013) María José Acuña et al.   HUMAN MOLECULAR GENETICS

Laminin-211 in skeletal muscle function

(2013) Johan Holmberg et al.   Cell Adhesion & Migration

Laminin-111 Protein Therapy Reduces Muscle Pathology and Improves Viability of a Mouse Model of Merosin-Deficient Congenital Muscular Dystrophy

(2012) Jachinta E. Rooney et al.   AMERICAN JOURNAL OF PATHOLOGY

Angiotensin II: Role in Skeletal Muscle Atrophy

(2012) Claudio Cabello-Verrugio et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

The myofibroblast matrix: implications for tissue repair and fibrosis

(2012) Franco Klingberg et al.   JOURNAL OF PATHOLOGY

Snail Regulates MyoD Binding-Site Occupancy to Direct Enhancer Switching and Differentiation-Specific Transcription in Myogenesis

(2012) Vahab D. Soleimani et al.   MOLECULAR CELL

Deletion of periostin reduces muscular dystrophy and fibrosis in mice by modulating the transforming growth factor-  pathway

(2012) A. Lorts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Substrate stiffness affects skeletal myoblast differentiationin vitro

(2012) Sara Romanazzo et al.   SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS

Angiotensin II type 1 receptor antagonists alleviate muscle pathology in the mouse model for laminin-α2-deficient congenital muscular dystrophy (MDC1A)

(2012) Sarina Meinen et al.   Skeletal Muscle

Losartan, a therapeutic candidate in congenital muscular dystrophy: Studies in the dy2J/dy2J Mouse

(2011) Moran Elbaz et al.   ANNALS OF NEUROLOGY

The Dystrophin-Glycoprotein Complex in the Prevention of Muscle Damage

(2011) Jessica D. Gumerson et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

aV integrins and TGF-β-induced EMT: a circle of regulation

(2011) Fahmy A. Mamuya et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Congenital Muscular Dystrophies: A Brief Review

(2011) Enrico Bertini et al.   Seminars in Pediatric Neurology

Cross Talk among TGF-  Signaling Pathways, Integrins, and the Extracellular Matrix

(2011) J. S. Munger et al.   Cold Spring Harbor Perspectives in Biology

Skeletal muscle laminin and MDC1A: pathogenesis and treatment strategies

(2011) Kinga I Gawlik et al.   Skeletal Muscle

Congenital Muscular Dystrophies: Toward Molecular Therapeutic Interventions

(2010) James Collins et al.   Current Neurology and Neuroscience Reports

Transforming Growth Factor-β1 Induces Transdifferentiation of Myoblasts into Myofibroblasts via Up-Regulation of Sphingosine Kinase-1/S1P3 Axis

(2010) Francesca Cencetti et al.   MOLECULAR BIOLOGY OF THE CELL

Fibrosis inhibition and muscle histopathology improvement in laminin-α2-deficient mice

(2010) Yoram Nevo et al.   MUSCLE & NERVE

Genotype–phenotype correlation in a large population of muscular dystrophy patients with LAMA2 mutations

(2010) Fatemeh Geranmayeh et al.   NEUROMUSCULAR DISORDERS

TGFβ: a sleeping giant awoken by integrins

(2010) John J. Worthington et al.   TRENDS IN BIOCHEMICAL SCIENCES

TGF-β and fibrosis in different organs — molecular pathway imprints

(2009) Dirk Pohlers et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Synthesis and biological evaluation of febrifugine analogues as potential antimalarial agents

(2009) Shuren Zhu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The myofibroblast: Paradigm for a mechanically active cell

(2009) Boris Hinz   JOURNAL OF BIOMECHANICS

Omigapil Ameliorates the Pathology of Muscle Dystrophy Caused by Laminin- 2 Deficiency

(2009) M. Erb et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Intramuscular renin–angiotensin system is activated in human muscular dystrophy

(2009) Guilian Sun et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

αvβ3 and αvβ5 integrins and their role in muscle precursor cell adhesion

(2008) Andrea C. M. Sinanan et al.   BIOLOGY OF THE CELL

Angiotensin II activates the Smad pathway during epithelial mesenchymal transdifferentiation

(2008) Gisselle Carvajal et al.   KIDNEY INTERNATIONAL

Gene-mediated Restoration of Normal Myofiber Elasticity in Dystrophic Muscles

(2008) Stefania Puttini et al.   MOLECULAR THERAPY

Bridging structure with function: Structural, regulatory, and developmental role of laminins

(2007) Julia Tzu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY