In vitro assessment of anti-fibrotic activity does not predict their in vivo efficacy in murine models of Duchenne muscular dystrophy

CPEB1 or CPEB4 knockdown suppresses the TAK1 and Smad signalings in THP-1 macrophage-like cells and dermal fibroblasts

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Pathogenic Potential of Hic1-Expressing Cardiac Stromal Progenitors

(2020) Hesham Soliman et al.   Cell Stem Cell

High prevalence of plasma lipid abnormalities in human and canine Duchenne and Becker muscular dystrophies depict a new type of primary genetic dyslipidemia.

(2020) Zoe White et al.   Journal of Clinical Lipidology

Catalpol counteracts the pathology in a mouse model of Duchenne muscular dystrophy by inhibiting the TGF-β1/TAK1 signaling pathway

(2020) Deng-qiu Xu et al.   ACTA PHARMACOLOGICA SINICA

A potential therapeutic effect of catalpol in Duchenne muscular dystrophy revealed by binding with TAK1

(2020) Dengqiu Xu et al.   Journal of Cachexia Sarcopenia and Muscle

Fibrosis: from mechanisms to medicines

(2020) Neil C. Henderson et al.   NATURE

Open-CSAM, a new tool for semi-automated analysis of myofiber cross-sectional area in regenerating adult skeletal muscle

(2019) Thibaut Desgeorges et al.   Skeletal Muscle

Sunitinib promotes myogenic regeneration and mitigates disease progression in the mdx mouse model of Duchenne muscular dystrophy

(2019) Tatiana M Fontelonga et al.   HUMAN MOLECULAR GENETICS

Mesenchymal Stromal Cells Are Required for Regeneration and Homeostatic Maintenance of Skeletal Muscle

(2019) Michael N. Wosczyna et al.   Cell Reports

Yin/Yang expression of CCN family members: Transforming growth factor beta 1, via ALK5/FAK/MEK, induces CCN1 and CCN2, yet suppresses CCN3, expression in human dermal fibroblasts

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Bromodomain inhibitor JQ1 reversibly blocks IFN-γ production

(2019) Hunter R. Gibbons et al.   Scientific Reports

Dynamic Chromatin Targeting of BRD4 Stimulates Cardiac Fibroblast Activation

(2019) Matthew S. Stratton et al.   CIRCULATION RESEARCH

Incremental load training improves renal fibrosis by regulating the TGF‑β1/TAK1/MKK3/p38MAPK signaling pathway and inducing the activation of autophagy in aged mice

(2019) Chuncha Bao et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Cross-talk between TGF-β and PDGFRα signaling pathways regulates the fate of stromal fibro–adipogenic progenitors

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Interleukin-15 facilitates muscle regeneration through modulation of fibro/adipogenic progenitors

(2018) Xia Kang et al.   Cell Communication and Signaling

Nintedanib decreases muscle fibrosis and improves muscle function in a murine model of dystrophinopathy

(2018) Patricia Piñol-Jurado et al.   Cell Death & Disease

An Adaptogen: Withaferin A Ameliorates in Vitro and in Vivo Pulmonary Fibrosis by Modulating the Interplay of Fibrotic, Matricelluar Proteins, and Cytokines

(2018) Swarna Bale et al.   Frontiers in Pharmacology

Withaferin A Associated Differential Regulation of Inflammatory Cytokines

(2018) Seema Dubey et al.   Frontiers in Immunology

Nilotinib impairs skeletal myogenesis by increasing myoblast proliferation

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Role of p38 MAPK in Atherosclerosis and Aortic Valve Sclerosis

(2018) Anna Reustle et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

AMPK Activation Regulates LTBP4-Dependent TGF-β1 Secretion by Pro-inflammatory Macrophages and Controls Fibrosis in Duchenne Muscular Dystrophy

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BET bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failure

(2017) Qiming Duan et al.   Science Translational Medicine

Fibrosis development in early-onset muscular dystrophies: Mechanisms and translational implications

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A Clinical Perspective of Anti-Fibrotic Therapies for Cardiovascular Disease

(2017) Lu Fang et al.   Frontiers in Pharmacology

Brd4 inhibition attenuates unilateral ureteral obstruction-induced fibrosis by blocking TGF-β-mediated Nox4 expression

(2017) Baoshang Zhou et al.   Redox Biology

ALS skeletal muscle shows enhanced TGF-β signaling, fibrosis and induction of fibro/adipogenic progenitor markers

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Bromodomains: Structure, function and pharmacology of inhibition

(2016) Elena Ferri et al.   BIOCHEMICAL PHARMACOLOGY

Connective tissue cells expressing fibro/adipogenic progenitor markers increase under chronic damage: relevance in fibroblast-myofibroblast differentiation and skeletal muscle fibrosis

(2016) Osvaldo Contreras et al.   CELL AND TISSUE RESEARCH

PDGFRα signalling promotes fibrogenic responses in collagen-producing cells in Duchenne muscular dystrophy

(2016) Nicholas Ieronimakis et al.   JOURNAL OF PATHOLOGY

Chronic p38 mitogen-activated protein kinase inhibition improves vascular function and remodeling in angiotensin II-dependent hypertension

(2016) S. Potthoff et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

Pharmacological blockage of fibro/adipogenic progenitor expansion and suppression of regenerative fibrogenesis is associated with impaired skeletal muscle regeneration

(2016) Daniela Fiore et al.   Stem Cell Research

Myostatin induces interstitial fibrosis in the heart via TAK1 and p38

(2015) Nadine Biesemann et al.   CELL AND TISSUE RESEARCH

The role of tyrosine kinases in the pathogenesis of idiopathic pulmonary fibrosis

(2015) Friedrich Grimminger et al.   EUROPEAN RESPIRATORY JOURNAL

Tyrosine Kinase Inhibitor–Associated Cardiovascular Toxicity in Chronic Myeloid Leukemia

(2015) Javid J. Moslehi et al.   JOURNAL OF CLINICAL ONCOLOGY

Nilotinib reduces muscle fibrosis in chronic muscle injury by promoting TNF-mediated apoptosis of fibro/adipogenic progenitors

(2015) Dario R Lemos et al.   NATURE MEDICINE

BRD4 is a novel therapeutic target for liver fibrosis

(2015) Ning Ding et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of adipocytes derived from fibro/adipogenic progenitors resident in human skeletal muscle

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TAK1 modulates satellite stem cell homeostasis and skeletal muscle repair

(2015) Yuji Ogura et al.   Nature Communications

Matrix Biology of Idiopathic Pulmonary Fibrosis

(2014) Victor J. Thannickal et al.   AMERICAN JOURNAL OF PATHOLOGY

Withaferin A inhibits NF-kappaB activation by targeting cysteine 179 in IKKβ

(2014) Karen Heyninck et al.   BIOCHEMICAL PHARMACOLOGY

Glucocorticoids increase adipocytes in muscle by affecting IL-4 regulated FAP activity

(2014) Yanjun Dong et al.   FASEB JOURNAL

HDAC-regulated myomiRs control BAF60 variant exchange and direct the functional phenotype of fibro-adipogenic progenitors in dystrophic muscles

(2014) V. Saccone et al.   GENES & DEVELOPMENT

Asynchronous remodeling is a driver of failed regeneration in Duchenne muscular dystrophy

(2014) Sherry Dadgar et al.   JOURNAL OF CELL BIOLOGY

p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice

(2014) Jennifer D Bernet et al.   NATURE MEDICINE

Identification and characterization of PDGFRα+ mesenchymal progenitors in human skeletal muscle

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Understanding the Process of Fibrosis in Duchenne Muscular Dystrophy

(2014) Yacine Kharraz et al.   Biomed Research International

Assessment of Brd4 Inhibition in Idiopathic Pulmonary Fibrosis Lung Fibroblasts and in Vivo Models of Lung Fibrosis

(2013) Xiaoyan Tang et al.   AMERICAN JOURNAL OF PATHOLOGY

A Special Population of Regulatory T Cells Potentiates Muscle Repair

(2013) Dalia Burzyn et al.   CELL

Type 2 Innate Signals Stimulate Fibro/Adipogenic Progenitors to Facilitate Muscle Regeneration

(2013) Jose E. Heredia et al.   CELL

BET Bromodomains Mediate Transcriptional Pause Release in Heart Failure

(2013) Priti Anand et al.   CELL

Fibroadipogenic progenitors mediate the ability of HDAC inhibitors to promote regeneration in dystrophic muscles of young, but not old Mdx mice

(2013) Chiara Mozzetta et al.   EMBO Molecular Medicine

Molecular basis of organ fibrosis: Potential therapeutic approaches

(2013) Asish K Ghosh et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

BET Protein Function Is Required for Inflammation: Brd2 Genetic Disruption and BET Inhibitor JQ1 Impair Mouse Macrophage Inflammatory Responses

(2013) A. C. Belkina et al.   JOURNAL OF IMMUNOLOGY

TAK1 Is Required for Dermal Wound Healing and Homeostasis

(2013) Fen Guo et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Imatinib attenuates severe mouse dystrophy and inhibits proliferation and fibrosis-marker expression in muscle mesenchymal progenitors

(2013) Takahito Ito et al.   NEUROMUSCULAR DISORDERS

Tyrosine kinase signaling in fibrotic disorders

(2012) Christian Beyer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Strategies for anti-fibrotic therapies

(2012) Joel Rosenbloom et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The big clinical trials in idiopathic pulmonary fibrosis

(2012) Fabrizio Luppi et al.   CURRENT OPINION IN PULMONARY MEDICINE

PAI-1–regulated miR-21 defines a novel age-associated fibrogenic pathway in muscular dystrophy

(2012) Esther Ardite et al.   JOURNAL OF CELL BIOLOGY

The Effects of Low Levels of Dystrophin on Mouse Muscle Function and Pathology

(2012) Maaike van Putten et al.   PLoS One

Withaferin-A Reduces Type I Collagen Expression In Vitro and Inhibits Development of Myocardial Fibrosis In Vivo

(2012) Azariyas A. Challa et al.   PLoS One

TGF-β Signaling via TAK1 Pathway: Role in Kidney Fibrosis

(2012) Mary E. Choi et al.   SEMINARS IN NEPHROLOGY

The Actin–MRTF–SRF Gene Regulatory Axis and Myofibroblast Differentiation

(2012) Eric M. Small   Journal of Cardiovascular Translational Research

p38/MKP-1–regulated AKT coordinates macrophage transitions and resolution of inflammation during tissue repair

(2011) Eusebio Perdiguero et al.   JOURNAL OF CELL BIOLOGY

Fibrosis and adipogenesis originate from a common mesenchymal progenitor in skeletal muscle

(2011) A. Uezumi et al.   JOURNAL OF CELL SCIENCE

Nilotinib Attenuates Renal Injury and Prolongs Survival in Chronic Kidney Disease

(2011) M. Iyoda et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

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(2011) Allison R. Gillies et al.   MUSCLE & NERVE

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

(2011) Mark A. Dawson et al.   NATURE

Effect of Nilotinib on Bleomycin-Induced Acute Lung Injury and Pulmonary Fibrosis in Mice

(2011) Chin Kook Rhee et al.   RESPIRATION

Fibro/adipogenic progenitors: A double-edged sword in skeletal muscle regeneration

(2010) Anuradha Natarajan et al.   CELL CYCLE

Connective tissue fibroblasts and Tcf4 regulate myogenesis

(2010) S. J. Mathew et al.   DEVELOPMENT

Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle

(2010) Akiyoshi Uezumi et al.   NATURE CELL BIOLOGY

Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis

(2010) Aaron W. B. Joe et al.   NATURE CELL BIOLOGY

Transforming Growth Factor-β-activated Kinase 1 Is an Essential Regulator of Myogenic Differentiation

(2009) Shephali Bhatnagar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of NFκB by the natural product Withaferin A in cellular models of Cystic Fibrosis inflammation

(2009) Rangan Maitra et al.   Journal of Inflammation-London

Masitinib (AB1010), a Potent and Selective Tyrosine Kinase Inhibitor Targeting KIT

(2009) Patrice Dubreuil et al.   PLoS One

Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis

(2009) S. Inokuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

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(2008) Ying E Zhang   CELL RESEARCH

Treatment with inhibitors of the NF-κB pathway improves whole body tension development in the mdx mouse

(2008) Ashley L. Siegel et al.   NEUROMUSCULAR DISORDERS

Haploinsufficiency of utrophin gene worsens skeletal muscle inflammation and fibrosis in mdx mice

(2007) Lan Zhou et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES