The Interplay of Vitamin D Deficiency and Cellular Senescence in The Pathogenesis of Obesity-Related Co-Morbidities

Does vitamin D deficiency increase the risk of obesity in adults and the elderly? A systematic review of prospective cohort studies

(2021) M. Pereira et al.   PUBLIC HEALTH

Childhood and Adolescent Obesity: A Review

(2021) Alvina R. Kansra et al.   Frontiers in Pediatrics

Lack of Seasonal Variations in Vitamin D Concentrations among Hospitalized Elderly Patients

(2021) Justyna Nowak et al.   International Journal of Environmental Research and Public Health

Decreasing Prevalence of Vitamin D Deficiency in the Central Region of Saudi Arabia (2008-2017)

(2021) Nasser M. Al-Daghri et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Cellular Senescence and Vitamin D Deficiency Play a Role in the Pathogenesis of Obesity-Associated Subclinical Atherosclerosis: Study of the Potential Protective Role of Vitamin D Supplementation

(2021) Abdulhadi I. Bima et al.   Cells

Genetic Polymorphism of Vitamin D Family Genes CYP2R1, CYP24A1, and CYP27B1 Are Associated With a High Risk of Non-alcoholic Fatty Liver Disease: A Case-Control Study

(2021) Minxian Wang et al.   Frontiers in Genetics

Vitamin D deficiency 2.0: an update on the current status worldwide

(2020) Karin Amrein et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Waist circumference as a vital sign in clinical practice: a Consensus Statement from the IAS and ICCR Working Group on Visceral Obesity

(2020) Robert Ross et al.   Nature Reviews Endocrinology

Vitamin D Binding Protein: A Historic Overview

(2020) Roger Bouillon et al.   Frontiers in Endocrinology

Contribution of CYP24A1 variants in coronary heart disease among the Chinese population

(2020) Peng Qian et al.   Lipids in Health and Disease

NAFLD as a continuum: from obesity to metabolic syndrome and diabetes

(2020) Amélio F. Godoy-Matos et al.   Diabetology & Metabolic Syndrome

Association Between Body Size Phenotypes and Subclinical Atherosclerosis

(2020) Xavier Rossello et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Association of vitamin D levels and vitamin D-related gene polymorphisms with liver fibrosis in patients with biopsy-proven nonalcoholic fatty liver disease

(2019) Taeang Arai et al.   DIGESTIVE AND LIVER DISEASE

1,25‐Dihydroxyvitamin D exerts an antiaging role by activation of Nrf2‐antioxidant signaling and inactivation of p16/p53‐senescence signaling

(2019) Lulu Chen et al.   AGING CELL

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis

(2019) Mikolaj Ogrodnik et al.   Cell Metabolism

Vitamin D Binding Protein, Total and Free Vitamin D Levels in Different Physiological and Pathophysiological Conditions

(2019) Daniel David Bikle et al.   Frontiers in Endocrinology

The role of senescence in the development of non-alcoholic fatty liver disease and progression to non-alcoholic steatohepatitis

(2019) Alkistis-Maria Papatheodoridi et al.   HEPATOLOGY

Vitamin D Deficiency: Consequence or Cause of Obesity?

(2019) Luka Vranić et al.   Medicina-Lithuania

Obesity and overweight decreases the effect of vitamin D supplementation in adults: systematic review and meta-analysis of randomized controlled trials

(2019) Lara Fonseca de Oliveira et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Subclinical atherosclerosis, cardiovascular health, and disease risk: is there a case for the Cardiovascular Health Index in the primary prevention population?

(2018) Sarah S. Singh et al.   BMC PUBLIC HEALTH

New insights into NAFLD and subclinical coronary atherosclerosis

(2018) Lisa B. VanWagner   JOURNAL OF HEPATOLOGY

Adiposity, vitamin D requirements, and clinical implications for obesity-related metabolic abnormalities

(2018) Elina Hyppönen et al.   NUTRITION REVIEWS

Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels

(2018) Xia Jiang et al.   Nature Communications

25-Hydroxyvitamin D levels and bone mineral density evaluation in patients with cholecystectomy: a case-control study

(2018) Timur Ekiz et al.   Archives of Osteoporosis

Vitamin D deficiency: a worldwide problem with health consequences

(2018) Michael F Holick et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Obesity and type-2 diabetes as inducers of premature cellular senescence and ageing

(2018) Dominick G. A. Burton et al.   BIOGERONTOLOGY

Elimination of Age-Associated Hepatic Steatosis and Correction of Aging Phenotype by Inhibition of cdk4-C/EBPα-p300 Axis

(2018) Phuong Nguyen et al.   Cell Reports

Obesity and nonalcoholic fatty liver disease: From pathophysiology to therapeutics

(2018) Stergios A. Polyzos et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Senescence and aging: Causes, consequences, and therapeutic avenues

(2017) Domhnall McHugh et al.   JOURNAL OF CELL BIOLOGY

Vitamin D deficiency accelerates ageing and age-related diseases: a novel hypothesis

(2017) Michael J. Berridge   JOURNAL OF PHYSIOLOGY-LONDON

The Metabolic Phenotype in Obesity: Fat Mass, Body Fat Distribution, and Adipose Tissue Function

(2017) Gijs H. Goossens   Obesity Facts

Vitamin D in obesity

(2017) Jennifer S. Walsh et al.   Current Opinion in Endocrinology Diabetes and Obesity

Cellular senescence drives age-dependent hepatic steatosis

(2017) Mikolaj Ogrodnik et al.   Nature Communications

Vitamin D in Chronic Kidney Disease and Dialysis Patients

(2017) Guillaume Jean et al.   Nutrients

Vascular aging and subclinical atherosclerosis: why such a “never ending” and challenging story in cardiology?

(2017) Stela Iurciuc et al.   Clinical Interventions in Aging

Relationship between Nonalcoholic Fatty Liver Disease and Vitamin D Nutritional Status in Extreme Obesity

(2017) Adryana Cordeiro et al.   Canadian Journal of Gastroenterology and Hepatology

Telomeres and Cell Senescence - Size Matters Not

(2017) Stella Victorelli et al.   EBioMedicine

Metabolically healthy obesity across the life course: epidemiology, determinants, and implications

(2016) Catherine M. Phillips   Annals of the New York Academy of Sciences

Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice

(2016) Sarah J. Mitchell et al.   Cell Metabolism

Obesity-Induced Changes in Adipose Tissue Microenvironment and Their Impact on Cardiovascular Disease

(2016) José J. Fuster et al.   CIRCULATION RESEARCH

Adipose tissue macrophages: going off track during obesity

(2016) Lily Boutens et al.   DIABETOLOGIA

Vitamin D Regulates Fatty Acid Composition in Subcutaneous Adipose Tissue Through Elovl3

(2016) Lijuan Ji et al.   ENDOCRINOLOGY

Plasma DNA methylation: a potential biomarker for stratification of liver fibrosis in non-alcoholic fatty liver disease

(2016) Timothy Hardy et al.   GUT

Short Telomere Load, Telomere Length, and Subclinical Atherosclerosis

(2016) Juan M. Fernández-Alvira et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

A Significant Positive Association of Vitamin D Deficiency with Coronary Artery Calcification among Middle-aged Men: For the ERA JUMP Study

(2016) Sunghee Lee et al.   JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION

Molecular mechanisms of lipotoxicity and glucotoxicity in nonalcoholic fatty liver disease

(2016) Manoela Mota et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The Mitochondrial Basis of Aging

(2016) Nuo Sun et al.   MOLECULAR CELL

Importancia relativa de los factores determinantes de los niveles séricos de 25-hidroxi-colecalciferol en la enfermedad renal crónica

(2016) Fernando Caravaca-Fontán et al.   NEFROLOGIA

ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases

(2016) Pierpaola Davalli et al.   Oxidative Medicine and Cellular Longevity

Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects

(2016) Sylvia Christakos et al.   PHYSIOLOGICAL REVIEWS

The Potential Protective Action of Vitamin D in Hepatic Insulin Resistance and Pancreatic Islet Dysfunction in Type 2 Diabetes Mellitus

(2016) Po Leung   Nutrients

Cellular Senescence as the Causal Nexus of Aging

(2016) Naina Bhatia-Dey et al.   Frontiers in Genetics

Serum Vitamin D Levels Are Independently Associated With Severity of Coronary Artery Disease

(2016) Fatih Akin et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Effect of lipopolysaccharides on adipogenic potential and premature senescence of adipocyte progenitors

(2015) Ming Zhao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Association between serum vitamin D levels and subclinical coronary atherosclerosis and plaque burden/composition in young adult population

(2015) Seckin Satilmis et al.   Bosnian Journal of Basic Medical Sciences

Normal-weight obesity is associated with increased risk of subclinical atherosclerosis

(2015) Sohee Kim et al.   Cardiovascular Diabetology

Association Between Shortened Leukocyte Telomere Length and Cardio-Metabolic Outcomes

(2015) Steven C. Hunt et al.   Circulation-Cardiovascular Genetics

Beta Cell Function and the Nutritional State: Dietary Factors that Influence Insulin Secretion

(2015) William T. Moore et al.   Current Diabetes Reports

Effect of adipose tissue volume loss on circulating 25-hydroxyvitamin D levels: results from a 1-year lifestyle intervention in viscerally obese men

(2015) A Gangloff et al.   INTERNATIONAL JOURNAL OF OBESITY

Vitamin D in Primary Hyperparathyroidism: Effects on Clinical, Biochemical, and Densitometric Presentation

(2015) Marcella D. Walker et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Vitamin D deficiency in patients with intestinal malabsorption syndromes - think in and outside the gut

(2015) Samantha L Margulies et al.   Journal of Digestive Diseases

NAFLD: A multisystem disease

(2015) Christopher D. Byrne et al.   JOURNAL OF HEPATOLOGY

Ablation of XP-V gene causes adipose tissue senescence and metabolic abnormalities

(2015) Yih-Wen Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA damage response (DDR) and senescence: shuttled inflamma-miRNAs on the stage of inflamm-aging

(2015) Fabiola Olivieri et al.   Oncotarget

Association Between Shortened Leukocyte Telomere Length and Cardio-Metabolic Outcomes

(2015) Steven C. Hunt et al.   Circulation-Cardiovascular Genetics

Targeting senescent cells enhances adipogenesis and metabolic function in old age

(2015) Ming Xu et al.   eLife

DNA methylation age of blood predicts all-cause mortality in later life

(2015) Riccardo E Marioni et al.   GENOME BIOLOGY

Subclinical Atherosclerosis and Obesity Phenotypes Among Mexican Americans

(2015) S. T. Laing et al.   Journal of the American Heart Association

The Impact of Vitamin D Levels on Inflammatory Status: A Systematic Review of Immune Cell Studies

(2015) Emily K. Calton et al.   PLoS One

Mitochondrial effectors of cellular senescence: beyond the free radical theory of aging

(2014) Dorian V. Ziegler et al.   AGING CELL

Gene polymorphisms of cellular senescence marker p21 and disease progression in non-alcohol-related fatty liver disease

(2014) Aloysious Aravinthan et al.   CELL CYCLE

Human stem cell aging: do mitochondrial DNA mutations have a causal role?

(2013) Holly L. Baines et al.   AGING CELL

Vitamin D and incident Alzheimer's disease in the Cardiovascular Health Cognition Study

(2013) Thomas Littlejohns et al.   Alzheimers & Dementia

Plasma Vitamin D Biomarkers and Leukocyte Telomere Length

(2013) J. J. Liu et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Vitamin D Activates the Nrf2-Keap1 Antioxidant Pathway and Ameliorates Nephropathy in Diabetic Rats

(2013) K. Nakai et al.   AMERICAN JOURNAL OF HYPERTENSION

The Free Radical Theory of Aging Is Dead. Long Live the Damage Theory!

(2013) Vadim N. Gladyshev   ANTIOXIDANTS & REDOX SIGNALING

Vitamin D and Aging

(2013) J. Christopher Gallagher   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Vitamin D serum levels are associated with cardiovascular outcome in coronary artery disease

(2013) Gerasimos Siasos et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Accelerated fat cell aging links oxidative stress and insulin resistance in adipocytes

(2013) Finny Monickaraj et al.   JOURNAL OF BIOSCIENCES

Adipokines: A link between obesity and cardiovascular disease

(2013) Kazuto Nakamura et al.   Journal of Cardiology

Early vascular ageing in translation

(2013) Peter M. Nilsson et al.   JOURNAL OF HYPERTENSION

Adipogenic Differentiation Is Impaired in Replicative Senescent Human Subcutaneous Adipose-Derived Stromal/Progenitor Cells

(2013) M. C. Mitterberger et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Systemic Lupus Erythematosus and Vitamin D Deficiency Are Associated with Shorter Telomere Length among African Americans: A Case-Control Study

(2013) Brett M. Hoffecker et al.   PLoS One

Vitamin D and Obesity

(2013) Simon Vanlint   Nutrients

Natural Vitamin D Content in Animal Products

(2013) Alexandra Schmid et al.   Advances in Nutrition

Causal Relationship between Obesity and Vitamin D Status: Bi-Directional Mendelian Randomization Analysis of Multiple Cohorts

(2013) Karani S. Vimaleswaran et al.   PLOS MEDICINE

Metabolically healthy obesity: epidemiology, mechanisms, and clinical implications

(2013) Norbert Stefan et al.   Lancet Diabetes & Endocrinology

Vitamin D deficiency parallels inflammation and immune activation, the Ludwigshafen Risk and Cardiovascular Health (LURIC) study

(2012) Christian Murr et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

D-livering the message: The importance of vitamin D status in chronic liver disease

(2012) Matthew T. Kitson et al.   JOURNAL OF HEPATOLOGY

Hepatocyte senescence predicts progression in non-alcohol-related fatty liver disease

(2012) Aloysious Aravinthan et al.   JOURNAL OF HEPATOLOGY

Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan

(2012) Darren J. Baker et al.   NATURE CELL BIOLOGY

Weight Loss Is Associated With Increased Serum 25-Hydroxyvitamin D in Overweight or Obese Women

(2012) Cheryl L. Rock et al.   Obesity

Genetics of atherosclerosis

(2012) Aldons J. Lusis   TRENDS IN GENETICS

Hepatic cellular senescence pathway genes are induced through histone modifications in a diet-induced obese rat model

(2011) Xiyuan Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Association Between Obesity, High-Sensitivity C-Reactive Protein ≥2 mg/L, and Subclinical Atherosclerosis

(2011) Michael J. Blaha et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Vitamin D receptor controls expression of the anti-aging klotho gene in mouse and human renal cells

(2011) Ryan E. Forster et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Serum Vitamin D Concentrations and Unexplained Elevation in ALT Among US Adults

(2011) Suthat Liangpunsakul et al.   DIGESTIVE DISEASES AND SCIENCES

Vitamin D deficiency in obese rats exacerbates nonalcoholic fatty liver disease and increases hepatic resistin and toll-like receptor activation

(2011) Christian L. Roth et al.   HEPATOLOGY

Vitamin D deficiency is associated with significant coronary stenoses in asymptomatic African American chronic cocaine users

(2011) Hong Lai et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Four faces of cellular senescence

(2011) Francis Rodier et al.   JOURNAL OF CELL BIOLOGY

Evaluation, Treatment, and Prevention of Vitamin D Deficiency: an Endocrine Society Clinical Practice Guideline

(2011) Michael F. Holick et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

VITAMIN D STATUS IS ASSOCIATED WITH ARTERIAL STIFFNESS AND VASCULAR DYSFUNCTION IN HEALTHY HUMANS

(2011) Ibhar Al Mheid et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Health and economic burden of the projected obesity trends in the USA and the UK

(2011) Y Claire Wang et al.   LANCET

Telomere dysfunction induces metabolic and mitochondrial compromise

(2011) Ergün Sahin et al.   NATURE

Atherosclerosis: current pathogenesis and therapeutic options

(2011) Christian Weber et al.   NATURE MEDICINE

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Nrf2, a Guardian of Healthspan and Gatekeeper of Species Longevity

(2010) K. N. Lewis et al.   INTEGRATIVE AND COMPARATIVE BIOLOGY

Impact of artificial sunlight therapy on the progress of non-alcoholic fatty liver disease in rats

(2010) Toshiaki Nakano et al.   JOURNAL OF HEPATOLOGY

Vitamin D Deficiency in Adults: When to Test and How to Treat

(2010) Kurt A. Kennel et al.   MAYO CLINIC PROCEEDINGS

Serum 25-hydroxyvitamin D status of vegetarians, partial vegetarians, and nonvegetarians: the Adventist Health Study-2

(2009) Jacqueline Chan et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Implications of vitamin D deficiency in pregnancy and lactation

(2009) Megan L. Mulligan et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Klotho and aging

(2009) Makoto Kuro-o   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

1,25(OH) 2 Vitamin D Inhibits Foam Cell Formation and Suppresses Macrophage Cholesterol Uptake in Patients With Type 2 Diabetes Mellitus

(2009) Jisu Oh et al.   CIRCULATION

Vascular Aging

(2009) Peter M. Nilsson et al.   HYPERTENSION

Body mass index determines sunbathing habits: implications on vitamin D levels

(2009) M. Kull et al.   INTERNAL MEDICINE JOURNAL

Effect of Vitamin D Deficiency and Replacement on Endothelial Function in Asymptomatic Subjects

(2009) Ozlem Tarcin et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Mitochondrial Dysfunction Contributes to Oncogene-Induced Senescence

(2009) O. Moiseeva et al.   MOLECULAR AND CELLULAR BIOLOGY

A crucial role for adipose tissue p53 in the regulation of insulin resistance

(2009) Tohru Minamino et al.   NATURE MEDICINE

Femoral Plaques Confound the Association of Circulating Oxidized Low-Density Lipoprotein With Carotid Atherosclerosis in a General Population Aged 35 to 55 Years

(2008) Michel R. Langlois et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Adipokines, Insulin Resistance, and Coronary Artery Calcification

(2008) Atif Qasim et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

General and Abdominal Adiposity and Risk of Death in Europe

(2008) T. Pischon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice

(2007) Colin Selman et al.   FASEB JOURNAL