Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan

Losing balance: the origin and impact of aneuploidy in cancer

(2012) Andrew J Holland et al.   EMBO REPORTS

Chromosomal instability and aneuploidy in cancer: from yeast to man

(2012) Sarah J Pfau et al.   EMBO REPORTS

Insufficiency of BUBR1, a mitotic spindle checkpoint regulator, causes impaired ciliogenesis in vertebrates

(2011) Tatsuo Miyamoto et al.   HUMAN MOLECULAR GENETICS

Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivation

(2011) Robin M. Ricke et al.   JOURNAL OF CELL BIOLOGY

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress

(2011) Claudia Lukas et al.   NATURE CELL BIOLOGY

Aging mice have increased chromosome instability that is exacerbated by elevated Mdm2 expression

(2011) T Lushnikova et al.   ONCOGENE

Chromosome Segregation Errors as a Cause of DNA Damage and Structural Chromosome Aberrations

(2011) A. Janssen et al.   SCIENCE

Adult hematopoietic stem cells require NKAP for maintenance and survival

(2010) A. G. Pajerowski et al.   BLOOD

Cdc20 hypomorphic mice fail to counteract de novo synthesis of cyclin B1 in mitosis

(2010) Liviu Malureanu et al.   JOURNAL OF CELL BIOLOGY

Overexpression of the E2 ubiquitin–conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation

(2010) Janine H. van Ree et al.   JOURNAL OF CELL BIOLOGY

Progeria syndromes and ageing: what is the connection?

(2010) Christopher R. Burtner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Whole Chromosome Instability Caused by Bub1 Insufficiency Drives Tumorigenesis through Tumor Suppressor Gene Loss of Heterozygosity

(2009) Darren J. Baker et al.   CANCER CELL

A Centrosomal Cdc20-APC Pathway Controls Dendrite Morphogenesis in Postmitotic Neurons

(2009) Albert H. Kim et al.   CELL

BubR1 N Terminus Acts as a Soluble Inhibitor of Cyclin B Degradation by APC/CCdc20 in Interphase

(2009) Liviu A. Malureanu et al.   DEVELOPMENTAL CELL

Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis

(2009) Andrew J. Holland et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Cdc20-APC Ubiquitin Signaling Pathway Regulates Presynaptic Differentiation

(2009) Y. Yang et al.   SCIENCE

Evidence for Cardiomyocyte Renewal in Humans

(2009) Olaf Bergmann et al.   SCIENCE

Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging

(2008) R. I. Morimoto   GENES & DEVELOPMENT

DNA double-strand breaks: A potential causative factor for mammalian aging?

(2008) Han Li et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Puzzles, promises and a cure for ageing

(2008) Jan Vijg et al.   NATURE

Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency

(2008) Darren J. Baker et al.   NATURE CELL BIOLOGY