Vitamin D deficiency accelerates ageing and age-related diseases: a novel hypothesis

Autophagy and Microglia: Novel Partners in Neurodegeneration and Aging

(2017) Ainhoa Plaza-Zabala et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dissociating Normal Aging from Alzheimer’s Disease: A View from Cognitive Neuroscience

(2017) Max Toepper   JOURNAL OF ALZHEIMERS DISEASE

Association of VDR polymorphisms (Taq I and Bsm I) with prostate cancer: a new meta-analysis

(2017) Sheng Liu et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Serum 25-Hydroxyvitamin D Has a Modest Positive Association with Leukocyte Telomere Length in Middle-Aged US Adults

(2017) Julia Beilfuss et al.   JOURNAL OF NUTRITION

Physiological functions of Vitamin D in adipose tissue

(2017) Manal A. Abbas   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

1,25-Dihydroxyvitamin-D3 prevents the development of diabetic cardiomyopathy in type 1 diabetic rats by enhancing autophagy via inhibiting the β-catenin/TCF4/GSK-3β/mTOR pathway

(2017) Huili Wei et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Vitamin D and muscle function

(2017) Bess Dawson-Hughes   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Activation-Induced Autophagy Is Preserved in CD4+ T-Cells in Familial Longevity

(2017) Yotam Raz et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Telomere shortening during aging: Attenuation by antioxidants and anti-inflammatory agents

(2017) Kedar N. Prasad et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The brain, sirtuins, and ageing

(2017) Akiko Satoh et al.   NATURE REVIEWS NEUROSCIENCE

Mitophagy in neurodegeneration and aging

(2017) Elayne M. Fivenson et al.   NEUROCHEMISTRY INTERNATIONAL

Sleep and Human Aging

(2017) Bryce A. Mander et al.   NEURON

Contribution of neuroinflammation and immunity to brain aging and the mitigating effects of physical and cognitive interventions

(2017) Svetlana Di Benedetto et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Mitophagy and age-related pathologies: Development of new therapeutics by targeting mitochondrial turnover

(2017) Konstantinos Palikaras et al.   PHARMACOLOGY & THERAPEUTICS

Vitamin D receptor regulates autophagy in the normal mammary gland and in luminal breast cancer cells

(2017) Luz E. Tavera-Mendoza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy and vitamin D

(2017) Alexandra A. Mushegian   Science Signaling

Autophagy and vitamin D

(2017) Alexandra A. Mushegian   Science Signaling

Vitamin D and Chronic Diseases

(2017) Hanmin Wang et al.   Aging and Disease

Biological Age Predictors

(2017) Juulia Jylhävä et al.   EBioMedicine

Vitamin D and mortality: Individual participant data meta-analysis of standardized 25-hydroxyvitamin D in 26916 individuals from a European consortium

(2017) Martin Gaksch et al.   PLoS One

DNA methylation patterns associated with oxidative stress in an ageing population

(2016) Åsa K. Hedman et al.   BMC Medical Genomics

Molecular and biological hallmarks of ageing

(2016) J. R. Aunan et al.   BRITISH JOURNAL OF SURGERY

Epigenetic Mechanisms of Longevity and Aging

(2016) Payel Sen et al.   CELL

Repression of the Antioxidant NRF2 Pathway in Premature Aging

(2016) Nard Kubben et al.   CELL

Intracellular Ca 2+ signaling and Ca 2+ microdomains in the control of cell survival, apoptosis and autophagy

(2016) Rita M.L. La Rovere et al.   CELL CALCIUM

Vitamin D induces autophagy of pancreatic β-cells and enhances insulin secretion

(2016) Yubin Wang et al.   Molecular Medicine Reports

Mitochondrial dysfunction in bipolar disorder: Evidence, pathophysiology and translational implications

(2016) Giselli Scaini et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Vitamin D decreases adipocyte lipid storage and increases NAD-SIRT1 pathway in 3T3-L1 adipocytes

(2016) Eugene Chang et al.   NUTRITION

Ageing-Associated Oxidative Stress and Inflammation Are Alleviated by Products from Grapes

(2016) K. S. Petersen et al.   Oxidative Medicine and Cellular Longevity

Vitamin D, reactive oxygen species and calcium signalling in ageing and disease

(2016) Michael J. Berridge   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Regulation of autophagy by Ca2+

(2016) Fang Sun et al.   TUMOR BIOLOGY

Vitamin D receptor signaling improves Hutchinson-Gilford progeria syndrome cellular phenotypes

(2016) Ray Kreienkamp et al.   Oncotarget

Maternal vitamin D depletion alters DNA methylation at imprinted loci in multiple generations

(2016) Jing Xue et al.   Clinical Epigenetics

Epigenetics and aging

(2016) S. Pal et al.   Science Advances

Inflammaging: disturbed interplay between autophagy and inflammasomes

(2016) Antero Salminen et al.   Aging-US

So depression is an inflammatory disease, but where does the inflammation come from?

(2016) Michael Berk et al.   BMC Medicine

Model of human aging: Recent findings on Werner’s and Hutchinson-Gilford progeria syndromes

(2016) Shian-ling Ding et al.   Clinical Interventions in Aging

Vitamin D cell signalling in health and disease

(2015) Michael J. Berridge   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Vitamin D: a custodian of cell signalling stability in health and disease

(2015) Michael J. Berridge   BIOCHEMICAL SOCIETY TRANSACTIONS

Ageing is associated with deterioration of calcium homeostasis in isolated human right atrial myocytes

(2015) Adela Herraiz-Martínez et al.   CARDIOVASCULAR RESEARCH

The role of telomeres and vitamin D in cellular aging and age-related diseases

(2015) Irene Pusceddu et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

The potential regulatory role of vitamin D in the bioenergetics of inflammation

(2015) Emily K. Calton et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Mitochondrial and lipogenic effects of vitamin D on differentiating and proliferating human keratinocytes

(2015) Marco Consiglio et al.   EXPERIMENTAL DERMATOLOGY

The relationship between dietary magnesium intake, stroke and its major risk factors, blood pressure and cholesterol, in the EPIC-Norfolk cohort

(2015) Lucy K.M. Bain et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

1α,25-Dihydroxyvitamin D3Regulates Mitochondrial Oxygen Consumption and Dynamics in Human Skeletal Muscle Cells

(2015) Zachary C. Ryan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Essential role for autophagy in life span extension

(2015) Frank Madeo et al.   JOURNAL OF CLINICAL INVESTIGATION

Reversal of Aging-Related Neuronal Ca2+ Dysregulation and Cognitive Impairment by Delivery of a Transgene Encoding FK506-Binding Protein 12.6/1b to the Hippocampus

(2015) J. C. Gant et al.   JOURNAL OF NEUROSCIENCE

Ageing, metabolism and cardiovascular disease

(2015) Sarah Costantino et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mitochondrial function in ageing: coordination with signalling and transcriptional pathways

(2015) Fei Yin et al.   JOURNAL OF PHYSIOLOGY-LONDON

Physiological geroscience: targeting function to increase healthspan and achieve optimal longevity

(2015) Douglas R. Seals et al.   JOURNAL OF PHYSIOLOGY-LONDON

Epigenetic regulation of ageing: linking environmental inputs to genomic stability

(2015) Bérénice A. Benayoun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Genomic integrity and the ageing brain

(2015) Hei-man Chow et al.   NATURE REVIEWS NEUROSCIENCE

Mechanisms Underlying the Regulation of Innate and Adaptive Immunity by Vitamin D

(2015) Ran Wei et al.   Nutrients

Relationship between the Concentrations of Heavy Metals and Bioelements in Aging Men with Metabolic Syndrome

(2015) Iwona Rotter et al.   International Journal of Environmental Research and Public Health

Vitamin D protects endothelial cells from irradiation-induced senescence and apoptosis by modulating MAPK/SirT1 axis

(2015) F. Marampon et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging

(2015) Gaetano Santulli et al.   Current Molecular Pharmacology

Calcium Signaling Alterations, Oxidative Stress, and Autophagy in Aging

(2014) Rodrigo Portes Ureshino et al.   ANTIOXIDANTS & REDOX SIGNALING

Oxidative Stress, Redox Signaling, and Autophagy: Cell Death Versus Survival

(2014) Juliana Navarro-Yepes et al.   ANTIOXIDANTS & REDOX SIGNALING

1,25-Dyhydroxyvitamin D3 attenuates rotenone-induced neurotoxicity in SH-SY5Y cells through induction of autophagy

(2014) Wooyoung Jang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Vitamin D status is independently associated with plasma glutathione and cysteine thiol/disulphide redox status in adults

(2014) Jessica A. Alvarez et al.   CLINICAL ENDOCRINOLOGY

Serum 25-Hydroxyvitamin D and Cognitive Decline: A Longitudinal Study among Non-Demented Older Adults

(2014) Laura Perna et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Vitamin D Inhibits COX-2 Expression and Inflammatory Response by Targeting Thioesterase Superfamily Member 4

(2014) Qingsong Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidation and nitration in dopaminergic areas of the prefrontal cortex from patients with bipolar disorder and schizophrenia

(2014) Helena Kim et al.   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

Vitamin D deficiency predicts cognitive decline in older men and women: The Pro.V.A. Study

(2014) E. D. Toffanello et al.   NEUROLOGY

Vitamin D prevents cognitive decline and enhances hippocampal synaptic function in aging rats

(2014) C. S. Latimer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA methylation, ageing and the influence of early life nutrition

(2014) Karen A. Lillycrop et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Elevation of brain magnesium prevents synaptic loss and reverses cognitive deficits in Alzheimer’s disease mouse model

(2014) Wei Li et al.   Molecular Brain

Vitamin D and the epigenome

(2014) Irfete S. Fetahu et al.   Frontiers in Physiology

Plasma Vitamin D Biomarkers and Leukocyte Telomere Length

(2013) J. J. Liu et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Vitamin D Activates the Nrf2-Keap1 Antioxidant Pathway and Ameliorates Nephropathy in Diabetic Rats

(2013) K. Nakai et al.   AMERICAN JOURNAL OF HYPERTENSION

Role of mitochondrial dysfunction and altered autophagy in cardiovascular aging and disease: from mechanisms to therapeutics

(2013) Emanuele Marzetti et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Sex- and dose-dependent effects of post-trial calcium channel blockade by magnesium chloride on memory for inhibitory avoidance conditioning

(2013) Lynda A. Wilmott et al.   BEHAVIOURAL BRAIN RESEARCH

Do age-related changes in DNA methylation play a role in the development of age-related diseases?

(2013) Sanne D. van Otterdijk et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Magnesium, vitamin D status and mortality: results from US National Health and Nutrition Examination Survey (NHANES) 2001 to 2006 and NHANES III

(2013) Xinqing Deng et al.   BMC Medicine

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

FK506-binding protein 1b/12.6: A key to aging-related hippocampal Ca2+ dysregulation?

(2013) J.C. Gant et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Oxidative stress response elicited by mitochondrial dysfunction: Implication in the pathophysiology of aging

(2013) Chih-Hao Wang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

BRCA1 loss activates cathepsin L–mediated degradation of 53BP1 in breast cancer cells

(2013) David A. Grotsky et al.   JOURNAL OF CELL BIOLOGY

Vitamin D, Mitochondria, and Muscle

(2013) Roger Bouillon et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Vitamin D Protects Human Endothelial Cells From Oxidative Stress Through the Autophagic and Survival Pathways

(2013) F. Uberti et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Vitamin D for Health: A Global Perspective

(2013) Arash Hossein-nezhad et al.   MAYO CLINIC PROCEEDINGS

Systemic Lupus Erythematosus and Vitamin D Deficiency Are Associated with Shorter Telomere Length among African Americans: A Case-Control Study

(2013) Brett M. Hoffecker et al.   PLoS One

Serum 25-hydroxyvitamin D levels and overall mortality. A systematic review and meta-analysis of prospective cohort studies

(2012) Ben Schöttker et al.   AGEING RESEARCH REVIEWS

Effect of vitamin D3 in reducing metabolic and oxidative stress in the liver of streptozotocin-induced diabetic rats

(2012) Naijil George et al.   BRITISH JOURNAL OF NUTRITION

Vitamin D has wide regulatory effects on histone demethylase genes

(2012) Fábio Pereira et al.   CELL CYCLE

Optimize dietary intake of vitamin D

(2012) Arash Hossein-nezhad et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Inflamm-ageing

(2012) Elisa Cevenini et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Effects of a 1-year supplementation with cholecalciferol on interleukin-6, tumor necrosis factor-alpha and insulin resistance in overweight and obese subjects

(2012) Julia Beilfuss et al.   CYTOKINE

Calcitriol protects renovascular function in hypertension by down-regulating angiotensin II type 1 receptors and reducing oxidative stress

(2012) Jinghui Dong et al.   EUROPEAN HEART JOURNAL

Impact of vitamin D supplementation on markers of inflammation in adults with cystic fibrosis hospitalized for a pulmonary exacerbation

(2012) R E Grossmann et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Vitamin D mitigates age-related cognitive decline through the modulation of pro-inflammatory state and decrease in amyloid burden

(2012) Teresita L Briones et al.   Journal of Neuroinflammation

The cognitive neuroscience of ageing

(2012) Cheryl Grady   NATURE REVIEWS NEUROSCIENCE

Vitamin D Protects Human Endothelial Cells from H2O2 Oxidant Injury Through the Mek/Erk-Sirt1 Axis Activation

(2012) Lorella Polidoro et al.   Journal of Cardiovascular Translational Research

Age-related loss of calcium buffering and selective neuronal vulnerability in Alzheimer’s disease

(2011) David Riascos et al.   ACTA NEUROPATHOLOGICA

Promoter methylation and age-related downregulation of Klotho in rhesus monkey

(2011) Gwendalyn D. King et al.   AGE

Vitamin D receptor controls expression of the anti-aging klotho gene in mouse and human renal cells

(2011) Ryan E. Forster et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Selective autophagy in the maintenance of cellular homeostasis in aging organisms

(2011) Vanessa M. Hubbard et al.   BIOGERONTOLOGY

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

Bcl-2 interaction with the inositol 1,4,5-trisphosphate receptor: Role in Ca2+ signaling and disease

(2011) Clark W. Distelhorst et al.   CELL CALCIUM

A dual role for Ca2+ in autophagy regulation

(2011) Jean-Paul Decuypere et al.   CELL CALCIUM

A new pathway that regulates 53BP1 stability implicates Cathepsin L and vitamin D in DNA repair

(2011) Ignacio Gonzalez-Suarez et al.   EMBO JOURNAL

Influence of aging on membrane permeability transition in brain mitochondria

(2011) Julia Toman et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Mitochondrial dysfunction in brain aging: Role of oxidative stress and cardiolipin

(2011) Giuseppe Paradies et al.   NEUROCHEMISTRY INTERNATIONAL

Calcium Ions Promote Formation of Amyloid β-Peptide (1–40) Oligomers Causally Implicated in Neuronal Toxicity of Alzheimer's Disease

(2011) Anna Itkin et al.   PLoS One

The potential role of epigenetic responses to diet in ageing

(2011) Dianne Ford et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Mitochondria and the Autophagy-Inflammation-Cell Death Axis in Organismal Aging

(2011) D. R. Green et al.   SCIENCE

Vitamin D and Susceptibility of Chronic Lung Diseases: Role of Epigenetics

(2011) Isaac K. Sundar et al.   Frontiers in Pharmacology

Aging and disease: connections to sirtuins

(2010) Gizem Donmez et al.   AGING CELL

The role of the antioxidant and longevity-promoting Nrf2 pathway in metabolic regulation

(2010) Gerasimos P Sykiotis et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Age-Related Inflammation: the Contribution of Different Organs, Tissues and Systems. How to Face it for Therapeutic Approaches

(2010) E. Cevenini et al.   CURRENT PHARMACEUTICAL DESIGN

Vitamin D and the Immune System: New Perspectives on an Old Theme

(2010) Martin Hewison   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Vitamin D status and measures of cognitive function in healthy older European adults

(2010) K M Seamans et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Vitamin D, NOD2, autophagy and Crohn’s disease

(2010) Mark Verway et al.   Expert Review of Clinical Immunology

Regulation of calcium signaling in dendritic cells by 1,25-dihydroxyvitamin D3

(2010) Ekaterina Shumilina et al.   FASEB JOURNAL

Nrf2, a Guardian of Healthspan and Gatekeeper of Species Longevity

(2010) K. N. Lewis et al.   INTEGRATIVE AND COMPARATIVE BIOLOGY

Epigenetic alterations in aging

(2010) Susana Gonzalo   JOURNAL OF APPLIED PHYSIOLOGY

The nuclear vitamin D receptor controls the expression of genes encoding factors which feed the “Fountain of Youth” to mediate healthful aging

(2010) Mark R. Haussler et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Vitamin D and diabetes

(2010) Anastassios G. Pittas et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Vitamin D Deficiency in Adults: When to Test and How to Treat

(2010) Kurt A. Kennel et al.   MAYO CLINIC PROCEEDINGS

Stimulation of Sirt1-Regulated FoxO Protein Function by the Ligand-Bound Vitamin D Receptor

(2010) B.-S. An et al.   MOLECULAR AND CELLULAR BIOLOGY

Progeria syndromes and ageing: what is the connection?

(2010) Christopher R. Burtner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Epigenetic GABAergic targets in schizophrenia and bipolar disorder

(2010) A. Guidotti et al.   NEUROPHARMACOLOGY

Vitamin D and Ageing: Neurological Issues

(2010) Cédric Annweiler et al.   NEUROPSYCHOBIOLOGY

Chromatin regulation and genome maintenance by mammalian SIRT6

(2010) Ruth I. Tennen et al.   TRENDS IN BIOCHEMICAL SCIENCES

Autophagy as a basis for the health-promoting effects of vitamin D

(2010) Maria Høyer-Hansen et al.   TRENDS IN MOLECULAR MEDICINE

The ER and ageing II: Calcium homeostasis

(2009) Monika Puzianowska-Kuznicka et al.   AGEING RESEARCH REVIEWS

Mitochondrial Turnover and Aging of Long-Lived Postmitotic Cells: The Mitochondrial–Lysosomal Axis Theory of Aging

(2009) Alexei Terman et al.   ANTIOXIDANTS & REDOX SIGNALING

Klotho and aging

(2009) Makoto Kuro-o   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Vitamin D3 Induces Autophagy in Human Monocytes/Macrophages via Cathelicidin

(2009) Jae-Min Yuk et al.   Cell Host & Microbe

Epigenetic oxidative redox shift (EORS) theory of aging unifies the free radical and insulin signaling theories

(2009) Gregory J. Brewer   EXPERIMENTAL GERONTOLOGY

Tumor Necrosis Factor-α-mediated Regulation of the Inositol 1,4,5-Trisphosphate Receptor Promoter

(2009) Keigan M. Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alterations in calcium signaling and a decrease in Bcl-2 expression: Possible correlation with apoptosis in aged striatum

(2009) R.P. Ureshino et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Vitamin D and aging

(2009) Pentti Tuohimaa   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Premature aging in vitamin D receptor mutant mice

(2009) Tiina Keisala et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Epigenetic factors in aging and longevity

(2009) Silvia Gravina et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Telomere biology in healthy aging and disease

(2009) Hisko Oeseburg et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins

(2009) Ivy K. M. Law et al.   PROTEOMICS

Nrf2 signaling and cell survival

(2009) Suryakant K. Niture et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Susceptibility to calcium dysregulation during brain aging

(2009) Ashok Kumar   Frontiers in Aging Neuroscience

Mitochondrial dysfunction in rat brain with agingInvolvement of complex I, reactive oxygen species and cardiolipin

(2008) G PETROSILLO et al.   NEUROCHEMISTRY INTERNATIONAL

Linking Calcium to Aβ and Alzheimer's Disease

(2008) Kim N. Green et al.   NEURON