Double-edge sword roles of iron in driving energy production versus instigating ferroptosis

DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer

(2021) Chao Mao et al.   NATURE

Relieving ferroptosis may partially reverse neurodegeneration of the auditory cortex

(2020) Xi Chen et al.   FEBS Journal

Energy-stress-mediated AMPK activation inhibits ferroptosis

(2020) Hyemin Lee et al.   NATURE CELL BIOLOGY

Identification of Frataxin as a regulator of ferroptosis

(2020) Jing Du et al.   Redox Biology

Ferroptosis in Cancer Cell Biology

(2020) Christina M. Bebber et al.   Cancers

Molecular Mechanisms Linking Oxidative Stress and Diabetes Mellitus

(2020) Habib Yaribeygi et al.   Oxidative Medicine and Cellular Longevity

Ferroptosis and Its Potential Role in Human Diseases

(2020) Chu Han et al.   Frontiers in Pharmacology

Targeting Metabolism to Improve the Tumor Microenvironment for Cancer Immunotherapy

(2020) Jackie E. Bader et al.   MOLECULAR CELL

Changes in ferrous iron and glutathione promote ferroptosis and frailty in aging Caenorhabditis elegans

(2020) Nicole L Jenkins et al.   eLife

Bilirubin Protects Transplanted Islets by Targeting Ferroptosis

(2020) Qing Yao et al.   Frontiers in Pharmacology

Diabetes Mellitus, Mitochondrial Dysfunction and Ca2+-Dependent Permeability Transition Pore

(2020) Konstantin N. Belosludtsev et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hyperandrogenism and insulin resistance modulate gravid uterine and placental ferroptosis in PCOS-like rats

(2020) Yuehui Zhang et al.   JOURNAL OF ENDOCRINOLOGY

Effects of dietary iron restriction on kidney mitochondria function and oxidative stress in streptozotocin-diabetic rats

(2020) Donovan J. Peña-Montes et al.   MITOCHONDRION

The Emerging Roles of Ferroptosis in Huntington’s Disease

(2019) Yajing Mi et al.   NEUROMOLECULAR MEDICINE

NCOA4-Mediated Ferritinophagy: A Potential Link to Neurodegeneration

(2019) Maria Quiles del Rey et al.   Frontiers in Neuroscience

BOLA3 Deficiency Controls Endothelial Metabolism and Glycine Homeostasis in Pulmonary Hypertension

(2019) Qiujun Yu et al.   CIRCULATION

Liver stage malaria infection is controlled by host regulators of lipid peroxidation

(2019) Heather S. Kain et al.   CELL DEATH AND DIFFERENTIATION

Ferritinophagy activation and sideroflexin1-dependent mitochondria iron overload is involved in apelin-13-induced cardiomyocytes hypertrophy

(2019) Mingzhu Tang et al.   FREE RADICAL BIOLOGY AND MEDICINE

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

(2019) Weimin Wang et al.   NATURE

Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling

(2019) Jiao Wu et al.   NATURE

Acute Iron Deprivation Reprograms Human Macrophage Metabolism and Reduces Inflammation In Vivo

(2019) Marie Pereira et al.   Cell Reports

Ferroptosis is governed by differential regulation of transcription in liver cancer

(2019) Xiao Zhang et al.   Redox Biology

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

(2019) Kirill Bersuker et al.   NATURE

Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer’s disease from a ferroptosis perspective

(2019) Paul J. Derry et al.   PROGRESS IN NEUROBIOLOGY

Determination of the Subcellular Localization and Mechanism of Action of Ferrostatins in Suppressing Ferroptosis

(2018) Michael M. Gaschler et al.   ACS Chemical Biology

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

(2018) Irina Ingold et al.   CELL

Potentiation of glutathione loss and nerve cell death by the transition metals iron and copper: Implications for age-related neurodegenerative diseases

(2018) Pamela Maher   FREE RADICAL BIOLOGY AND MEDICINE

Placental iron transport: the mechanism and regulatory circuits

(2018) Veena Sangkhae et al.   FREE RADICAL BIOLOGY AND MEDICINE

Acute loss of iron–sulfur clusters results in metabolic reprogramming and generation of lipid droplets in mammalian cells

(2018) Daniel R. Crooks et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid accumulation in human breast cancer cells injured by iron depletors

(2018) Maida De Bortoli et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Quantifying iron deposition within the substantia nigra of Parkinson's disease by quantitative susceptibility mapping

(2018) Hedi An et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Oxygen radicals, nitric oxide, and peroxynitrite: Redox pathways in molecular medicine

(2018) Rafael Radi   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Nrf2 to Suppress Ferroptosis and Mitochondrial Dysfunction in Neurodegeneration

(2018) Moataz Abdalkader et al.   Frontiers in Neuroscience

Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis

(2018) Ron Shah et al.   ACS Central Science

AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc– Activity

(2018) Xinxin Song et al.   CURRENT BIOLOGY

Iron catalysis of lipid peroxidation in ferroptosis: Regulated enzymatic or random free radical reaction?

(2018) D.A. Stoyanovsky et al.   FREE RADICAL BIOLOGY AND MEDICINE

Striking while the iron is hot: Iron metabolism and Ferroptosis in neurodegeneration

(2018) Shashank Masaldan et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Development of the Concept of Ferroptosis

(2018) Tal Hirschhorn et al.   FREE RADICAL BIOLOGY AND MEDICINE

Iron deficiency as energetic insult to skeletal muscle in chronic diseases

(2018) Magdalena Dziegala et al.   Journal of Cachexia Sarcopenia and Muscle

p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression

(2018) Sung-Hwan Moon et al.   CELL

Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis 

(2018) Bo Zhou et al.   CELL RESEARCH

Role of Mitochondria in Ferroptosis

(2018) Minghui Gao et al.   MOLECULAR CELL

Iron- and Reactive Oxygen Species-Dependent Ferroptotic Cell Death in Rice-Magnaporthe oryzae Interactions

(2018) Sarmina Dangol et al.   PLANT CELL

Overview of iron metabolism in health and disease

(2017) Som Dev et al.   Hemodialysis International

Iron and ferroptosis: A still ill-defined liaison

(2017) Sebastian Doll et al.   IUBMB LIFE

Iron homeostasis: An anthropocentric perspective

(2017) Richard Coffey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

(2017) Matthew J. Hangauer et al.   NATURE

Alterations in neuronal control of body weight and anxiety behavior by glutathione peroxidase 4 deficiency

(2017) Sonja C. Schriever et al.   NEUROSCIENCE

Fe-S Clusters Emerging as Targets of Therapeutic Drugs

(2017) Laurence Vernis et al.   Oxidative Medicine and Cellular Longevity

Mitochondrial complex I inhibition triggers a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis in melanoma cells

(2017) Farhan Basit et al.   Cell Death & Disease

Transferrin receptor 1 upregulation in primary tumor and downregulation in benign kidney is associated with progression and mortality in renal cell carcinoma patients

(2017) Christopher J. Greene et al.   Oncotarget

Iron Regulation of Pancreatic Beta-Cell Functions and Oxidative Stress

(2016) Marie Balslev Backe et al.   Annual Review of Nutrition

Autophagy promotes ferroptosis by degradation of ferritin

(2016) Wen Hou et al.   Autophagy

CISD1 inhibits ferroptosis by protection against mitochondrial lipid peroxidation

(2016) Hua Yuan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Glutamine transporters in mammalian cells and their functions in physiology and cancer

(2016) Yangzom D. Bhutia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Ferroptosis is an autophagic cell death process

(2016) Minghui Gao et al.   CELL RESEARCH

Intracellular labile iron determines H 2 O 2 -induced apoptotic signaling via sustained activation of ASK1/JNK-p38 axis

(2016) M.D. Mantzaris et al.   FREE RADICAL BIOLOGY AND MEDICINE

An Endoperoxide Reactivity-Based FRET Probe for Ratiometric Fluorescence Imaging of Labile Iron Pools in Living Cells

(2016) Allegra T. Aron et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Ferroptosis, a newly characterized form of cell death in Parkinson's disease that is regulated by PKC

(2016) Bruce Do Van et al.   NEUROBIOLOGY OF DISEASE

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

(2016) Wan Seok Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative Susceptibility Mapping Suggests Altered Brain Iron in Premanifest Huntington Disease

(2015) J. M. G. van Bergen et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Expression of Inactive Glutathione Peroxidase 4 Leads to Embryonic Lethality, and Inactivation of the Alox15 Gene Does Not Rescue Such Knock-In Mice

(2015) Simone Hanna Brütsch et al.   ANTIOXIDANTS & REDOX SIGNALING

Ironing out Ferroportin

(2015) Hal Drakesmith et al.   Cell Metabolism

Mitochondrial calpain-1 disrupts ATP synthase and induces superoxide generation in type-1 diabetic hearts: a novel mechanism contributing to diabetic cardiomyopathy

(2015) Rui Ni et al.   DIABETES

T cell lipid peroxidation induces ferroptosis and prevents immunity to infection

(2015) Mai Matsushita et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Functional Splicing Network Reveals Extensive Regulatory Potential of the Core Spliceosomal Machinery

(2015) Panagiotis Papasaikas et al.   MOLECULAR CELL

Glutaminolysis and Transferrin Regulate Ferroptosis

(2015) Minghui Gao et al.   MOLECULAR CELL

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

Clioquinol rescues Parkinsonism and dementia phenotypes of the tau knockout mouse

(2015) Peng Lei et al.   NEUROBIOLOGY OF DISEASE

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Disordered hepcidin–ferroportin signaling promotes breast cancer growth

(2014) Shuping Zhang et al.   CELLULAR SIGNALLING

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Iron Metabolism Regulates p53 Signaling through Direct Heme-p53 Interaction and Modulation of p53 Localization, Stability, and Function

(2014) Jia Shen et al.   Cell Reports

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

(2014) Scott J Dixon et al.   eLife

Effects of iron overload on chronic metabolic diseases

(2014) José Manuel Fernández-Real et al.   Lancet Diabetes & Endocrinology

Iron regulates glucose homeostasis in liver and muscle via AMP-activated protein kinase in mice

(2013) Jingyu Huang et al.   FASEB JOURNAL

Hepatocyte divalent metal-ion transporter-1 is dispensable for hepatic iron accumulation and non-transferrin-bound iron uptake in mice

(2013) Chia-Yu Wang et al.   HEPATOLOGY

Mutations in LYRM4, encoding iron–sulfur cluster biogenesis factor ISD11, cause deficiency of multiple respiratory chain complexes

(2013) Sze Chern Lim et al.   HUMAN MOLECULAR GENETICS

Bio-inspired amino acid oxidation by a non-heme iron catalyst

(2013) Szabina Góger et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

The role of iron and reactive oxygen species in cell death

(2013) Scott J Dixon et al.   Nature Chemical Biology

Mechanism of Fatty-Acid-Dependent UCP1 Uncoupling in Brown Fat Mitochondria

(2012) Andriy Fedorenko et al.   CELL

Structure and function of atypically coordinated enzymatic mononuclear non-heme-Fe(II) centers

(2012) Daniela Buongiorno et al.   COORDINATION CHEMISTRY REVIEWS

Mitochondrial respiratory chain dysfunction: Implications in neurodegeneration

(2012) María Morán et al.   FREE RADICAL BIOLOGY AND MEDICINE

Enhanced expression of lipogenic genes may contribute to hyperglycemia and alterations in plasma lipids in response to dietary iron deficiency

(2012) McKale R. Davis et al.   Genes and Nutrition

Induction of carnitine palmitoyl transferase 1 and fatty acid oxidation by retinoic acid in HepG2 cells

(2012) Jaume Amengual et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export

(2012) Peng Lei et al.   NATURE MEDICINE

The role of iron in tumour cell proliferation

(2011) Juan Luis Steegmann-Olmedillas   Clinical & Translational Oncology

Iron sensing and signalling

(2011) Rayko Evstatiev et al.   GUT

Iron Efflux from Oligodendrocytes Is Differentially Regulated in Gray and White Matter

(2011) K. Schulz et al.   JOURNAL OF NEUROSCIENCE

Iron, oxidative stress and the example of solar ultraviolet A radiation

(2011) Asma Aroun et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Modulation of lipid peroxidation and mitochondrial function improves neuropathology in Huntington’s disease mice

(2010) Junghee Lee et al.   ACTA NEUROPATHOLOGICA

Nitric oxide mechanism in the protective effect of antidepressants against 3-nitropropionic acid-induced cognitive deficit, glutathione and mitochondrial alterations in animal model of Huntingtonʼs disease

(2010) Puneet Kumar et al.   BEHAVIOURAL PHARMACOLOGY

Iron Overload and Diabetes Risk: A Shift From Glucose to Fatty Acid Oxidation and Increased Hepatic Glucose Production in a Mouse Model of Hereditary Hemochromatosis

(2010) J. Huang et al.   DIABETES

Clinically available iron chelators induce neuroprotection in the 6-OHDA model of Parkinson’s disease after peripheral administration

(2010) David T. Dexter et al.   JOURNAL OF NEURAL TRANSMISSION

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

The role of iron in type 2 diabetes in humans

(2008) Swapnil N. Rajpathak et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death

(2008) Alexander Seiler et al.   Cell Metabolism

Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

(2008) Wan Seok Yang et al.   CHEMISTRY & BIOLOGY

Fatty acids as modulators of the cellular production of reactive oxygen species

(2008) Peter Schönfeld et al.   FREE RADICAL BIOLOGY AND MEDICINE