Fe-S Clusters Emerging as Targets of Therapeutic Drugs

Binding of Nitric Oxide in CDGSH-type [2Fe-2S] Clusters of the Human Mitochondrial Protein Miner2

(2017) Zishuo Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Reactive Oxygen Species (ROS) in Therapeutics and Drug Resistance in Cancer and Bacteria

(2017) Allimuthu T. Dharmaraja   JOURNAL OF MEDICINAL CHEMISTRY

Nitrosylation of Nitric-Oxide-Sensing Regulatory Proteins Containing [4Fe-4S] Clusters Gives Rise to Multiple Iron-Nitrosyl Complexes

(2016) Pauline N. Serrano et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

l-Serine potentiates fluoroquinolone activity againstEscherichia coliby enhancing endogenous reactive oxygen species production

(2016) Xiangke Duan et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Breast cancer tumorigenicity is dependent on high expression levels of NAF-1 and the lability of its Fe-S clusters

(2016) Merav Darash-Yahana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The antimalarial drug primaquine targets Fe–S cluster proteins and yeast respiratory growth

(2016) Anaïs Lalève et al.   Redox Biology

DNA replication inhibitor hydroxyurea alters Fe-S centers by producing reactive oxygen species in vivo

(2016) Meng-Er Huang et al.   Scientific Reports

Reactive Oxygen Species Contribute to the Bactericidal Effects of the Fluoroquinolone Moxifloxacin in Streptococcus pneumoniae

(2015) M. J. Ferrándiz et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Novel thiazolidinedione mitoNEET ligand-1 acutely improves cardiac stem cell survival under oxidative stress

(2015) Suzanna J. Logan et al.   BASIC RESEARCH IN CARDIOLOGY

Emerging critical roles of Fe–S clusters in DNA replication and repair

(2015) Jill O. Fuss et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Oncogenic Small Tumor Antigen of Merkel Cell Polyomavirus Is an Iron-Sulfur Cluster Protein That Enhances Viral DNA Replication

(2015) Sabrina H. Tsang et al.   JOURNAL OF VIROLOGY

Design, Synthesis and Evaluation of Fe-S Targeted Adenosine 5′-Phosphosulfate Reductase Inhibitors

(2015) Hanumantharao Paritala et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Energy metabolism determines the sensitivity of human hepatocellular carcinoma cells to mitochondrial inhibitors and biguanide drugs

(2015) CHIA-CHI HSU et al.   ONCOLOGY REPORTS

The Fe-S cluster-containing NEET proteins mitoNEET and NAF-1 as chemotherapeutic targets in breast cancer

(2015) Fang Bai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Iron–Sulfur Clusters as Biological Sensors: The Chemistry of Reactions with Molecular Oxygen and Nitric Oxide

(2014) Jason C. Crack et al.   ACCOUNTS OF CHEMICAL RESEARCH

Targeting Bacterial Central Metabolism for Drug Development

(2014) Paul Murima et al.   CHEMISTRY & BIOLOGY

Structural Re-arrangement and Peroxidase Activation of Cytochromecby Anionic Analogues of Vitamin E, Tocopherol Succinate and Tocopherol Phosphate

(2014) Naveena Yanamala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Diabetes Drug Target MitoNEET Governs a Novel Trafficking Pathway to Rebuild an Fe-S Cluster into Cytosolic Aconitase/Iron Regulatory Protein 1

(2014) Ioana Ferecatu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Iron-Sulphur Cluster Biosynthesis Regulator IscR Contributes to Iron Homeostasis and Resistance to Oxidants in Pseudomonas aeruginosa

(2014) Adisak Romsang et al.   PLoS One

WhiB7, an Fe-S-dependent Transcription Factor That Activates Species-specific Repertoires of Drug Resistance Determinants in Actinobacteria

(2013) Santiago Ramón-García et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

The mycobacterial antibiotic resistance determinant WhiB7 acts as a transcriptional activator by binding the primary sigma factor SigA (RpoV)

(2013) Ján Burian et al.   NUCLEIC ACIDS RESEARCH

Nutrient-Deprivation Autophagy Factor-1 (NAF-1): Biochemical Properties of a Novel Cellular Target for Anti-Diabetic Drugs

(2013) Sagi Tamir et al.   PLoS One

NAF-1 and mitoNEET are central to human breast cancer proliferation by maintaining mitochondrial homeostasis and promoting tumor growth

(2013) Yang-Sung Sohn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fe-S Cluster Biosynthesis Controls Uptake of Aminoglycosides in a ROS-Less Death Pathway

(2013) B. Ezraty et al.   SCIENCE

Cell Death from Antibiotics Without the Involvement of Reactive Oxygen Species

(2013) Y. Liu et al.   SCIENCE

Killing by Bactericidal Antibiotics Does Not Depend on Reactive Oxygen Species

(2013) I. Keren et al.   SCIENCE

Targeting cellular metabolism to improve cancer therapeutics

(2013) Y Zhao et al.   Cell Death & Disease

Parasites FeS Up: Iron-Sulfur Cluster Biogenesis in Eukaryotic Pathogens

(2013) Teegan A. Dellibovi-Ragheb et al.   PLoS Pathogens

Silver(I), Mercury(II), Cadmium(II), and Zinc(II) Target Exposed Enzymic Iron-Sulfur Clusters when They Toxify Escherichia coli

(2012) Fang Fang Xu et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Characterization of the [2Fe-2S] Cluster of Escherichia coli Transcription Factor IscR

(2012) Angela S. Fleischhacker et al.   BIOCHEMISTRY

Mitochondrial biogenesis in epithelial cancer cells promotes breast cancer tumor growth and confers autophagy resistance

(2012) Ahmed F. Salem et al.   CELL CYCLE

A defect in iron uptake enhances the susceptibility of Cryptococcus neoformans to azole antifungal drugs

(2012) Jeongmi Kim et al.   FUNGAL GENETICS AND BIOLOGY

NADPH Inhibits [2Fe-2S] Cluster Protein Transfer from Diabetes Drug Target MitoNEET to an Apo-acceptor Protein

(2012) John A. Zuris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glutathione Complexed Fe–S Centers

(2012) Wenbin Qi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The essential iron-sulfur protein Rli1 is an important target accounting for inhibition of cell growth by reactive oxygen species

(2012) Alawiah Alhebshi et al.   MOLECULAR BIOLOGY OF THE CELL

Mutation of the His ligand in mitoNEET stabilizes the 2Fe–2S cluster despite conformational heterogeneity in the ligand environment

(2011) Andrea R. Conlan et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Inhibition of Mitochondrial Respiration and Rapid Depletion of Mitochondrial Glutathione by β-Phenethyl Isothiocyanate: Mechanisms for Anti-Leukemia Activity

(2011) Gang Chen et al.   ANTIOXIDANTS & REDOX SIGNALING

Mycobacterium tuberculosis WhiB3: A Novel Iron–Sulfur Cluster Protein That Regulates Redox Homeostasis and Virulence

(2011) Vikram Saini et al.   ANTIOXIDANTS & REDOX SIGNALING

Iron Regulation in Tuberculosis Research: Promise and Challenges

(2011) A.K. Sharma et al.   CURRENT MEDICINAL CHEMISTRY

The Mycobacterial Transcriptional RegulatorwhiB7Gene Links Redox Homeostasis and Intrinsic Antibiotic Resistance

(2011) Ján Burian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cobalt stress in Escherichia coli and Salmonella enterica: molecular bases for toxicity and resistance

(2011) F. Barras et al.   Metallomics

Kinetic analysis reveals the ordered coupling of translation termination and ribosome recycling in yeast

(2011) C. J. Shoemaker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Binding of Reduced Nicotinamide Adenine Dinucleotide Phosphate Destabilizes the Iron−Sulfur Clusters of Human MitoNEET

(2010) Tao Zhou et al.   BIOCHEMISTRY

Structure-based design of a thiazolidinedione which targets the mitochondrial protein mitoNEET

(2010) Werner J. Geldenhuys et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Chemogenomic and transcriptome analysis identifies mode of action of the chemosensitizing agent CTBT (7-chlorotetrazolo[5,1-c]benzo[1,2,4]triazine)

(2010) Monika Batova et al.   BMC GENOMICS

Nitric Oxide and Cancer Therapy: The Emperor has NO Clothes

(2010) Jason Hickok et al.   CURRENT PHARMACEUTICAL DESIGN

The iron–sulphur protein RNase L inhibitor functions in translation termination

(2010) Sohail Khoshnevis et al.   EMBO REPORTS

A genetic analysis of the response of Escherichia coli to cobalt stress

(2010) Jean-Raphaël Fantino et al.   ENVIRONMENTAL MICROBIOLOGY

Contribution of reactive oxygen species to pathways of quinolone-mediated bacterial cell death

(2010) X. Wang et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Mechanistic Insight into the Nitrosylation of the [4Fe−4S] Cluster of WhiB-like Proteins

(2010) Jason C. Crack et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Synthetic Caged Garcinia Xanthone Cluvenone Induces Cell Stress and Apoptosis and Has Immune Modulatory Activity

(2010) A. Batova et al.   MOLECULAR CANCER THERAPEUTICS

Building Fe–S proteins: bacterial strategies

(2010) Béatrice Py et al.   NATURE REVIEWS MICROBIOLOGY

Redox Characterization of the FeS Protein MitoNEET and Impact of Thiazolidinedione Drug Binding

(2009) Daniel W. Bak et al.   BIOCHEMISTRY

Tellurite-mediated disabling of [4Fe-4S] clusters of Escherichia coli dehydratases

(2009) I. L. Calderon et al.   MICROBIOLOGY-SGM

The iron-sulfur clusters of dehydratases are primary intracellular targets of copper toxicity

(2009) L. Macomber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mycobacterium tuberculosis WhiB3 Maintains Redox Homeostasis by Regulating Virulence Lipid Anabolism to Modulate Macrophage Response

(2009) Amit Singh et al.   PLoS Pathogens

Iron-Based Redox Switches in Biology

(2008) F. Wayne Outten et al.   ANTIOXIDANTS & REDOX SIGNALING

Reactions of Synthetic [2Fe-2S] and [4Fe-4S] Clusters with Nitric Oxide and Nitrosothiols

(2008) Todd C. Harrop et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Recent developments in nitric oxide donor drugs

(2007) M R Miller et al.   BRITISH JOURNAL OF PHARMACOLOGY