Mitochondrial Mechanisms of Apoptosis and Necroptosis in Liver Diseases

Cell death pathways: intricate connections and disease implications

(2021) Matthias Kist et al.   EMBO JOURNAL

Mitochondrial Dysfunction and Oxidative Stress in Liver Transplantation and Underlying Diseases

(2021) Shaojun Shi et al.   TRANSPLANTATION

Necroptosis Underlies Hepatic Damage in a Piglet Model of Lipopolysaccharide-Induced Sepsis

(2021) Qiao Xu et al.   Frontiers in Immunology

Mitochondrial quality control: from molecule to organelle

(2021) Alba Roca-Portoles et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Remodeling of Mitochondrial Plasticity: The Key Switch from NAFLD/NASH to HCC

(2021) Miriam Longo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Necroptosis Signaling Promotes Inflammation, Airway Remodeling, and Emphysema in Chronic Obstructive Pulmonary Disease

(2021) Zhe Lu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Programming inflammatory cell death for therapy

(2021) Shelbi Christgen et al.   PHARMACOLOGY & THERAPEUTICS

Mitochondrial Fusion Via OPA1 and MFN1 Supports Liver Tumor Cell Metabolism and Growth

(2020) Meng Li et al.   Cells

Hepatocyte mitochondria-derived danger signals directly activate hepatic stellate cells and drive progression of liver fibrosis

(2020) Ping An et al.   Nature Communications

A decade of cell death studies: Breathing new life into necroptosis

(2020) Imran Khan et al.   PHARMACOLOGY & THERAPEUTICS

Therapeutic potential of targeting mitochondrial dynamics in cancer

(2020) Tiago Rodrigues et al.   BIOCHEMICAL PHARMACOLOGY

Mitochondrial Mechanisms of Necroptosis in Liver Diseases

(2020) Chen Xue et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

GDF15 as a central mediator for integrated stress response and a promising therapeutic molecule for metabolic disorders and NASH

(2020) Kook Hwan Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Mitochondrial fission-induced mtDNA stress promotes tumor-associated macrophage infiltration and HCC progression

(2019) Dengke Bao et al.   ONCOGENE

Mdivi-1 and mitochondrial fission: recent insights from fungal pathogens

(2019) Barbara Koch et al.   CURRENT GENETICS

Cell death: a review of the major forms of apoptosis, necrosis and autophagy

(2019) Mark S D’Arcy   CELL BIOLOGY INTERNATIONAL

Mitochondria as multifaceted regulators of cell death

(2019) Florian J. Bock et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MFN1-dependent alteration of mitochondrial dynamics drives hepatocellular carcinoma metastasis by glucose metabolic reprogramming

(2019) Ze Zhang et al.   BRITISH JOURNAL OF CANCER

Mitochondrial double‐stranded RNA in exosome promotes interleukin‐17 production through toll‐like receptor 3 in alcoholic liver injury

(2019) Jun‐Hee Lee et al.   HEPATOLOGY

Mitochondrial fission promotes cell migration by Ca2+ /CaMKII/ERK/FAK pathway in hepatocellular carcinoma

(2018) Xiacheng Sun et al.   LIVER INTERNATIONAL

Mitochondrial dynamics in adaptive and maladaptive cellular stress responses

(2018) Verónica Eisner et al.   NATURE CELL BIOLOGY

RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis

(2018) Zhentao Yang et al.   NATURE CELL BIOLOGY

Bax retrotranslocation potentiates Bcl-xL’s antiapoptotic activity and is essential for switch-like transitions between MOMP competency and resistance

(2018) Annika Hantusch et al.   Cell Death & Disease

Apoptosis and necroptosis in the liver: a matter of life and death

(2018) Robert F. Schwabe et al.   Nature Reviews Gastroenterology & Hepatology

Characterization of ferroptosis in murine models of hemochromatosis

(2017) Hao Wang et al.   HEPATOLOGY

Caspases Connect Cell-Death Signaling to Organismal Homeostasis

(2016) Lorenzo Galluzzi et al.   IMMUNITY

A Small Molecule That Protects the Integrity of the Electron Transfer Chain Blocks the Mitochondrial Apoptotic Pathway

(2016) Xian Jiang et al.   MOLECULAR CELL

Mitochondrial dynamics and viral infections: A close nexus

(2015) Mohsin Khan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The retinoblastoma (Rb) protein regulates ferroptosis induced by sorafenib in human hepatocellular carcinoma cells

(2015) Christophe Louandre et al.   CANCER LETTERS

Adaptation of Hepatic Mitochondrial Function in Humans with Non-Alcoholic Fatty Liver Is Lost in Steatohepatitis

(2015) Chrysi Koliaki et al.   Cell Metabolism

Necroptosis and its role in inflammation

(2015) Manolis Pasparakis et al.   NATURE

Erratum: Molecular mechanisms of cell death: central implication of ATP synthase in mitochondrial permeability transition

(2015) M Bonora et al.   ONCOGENE

Hepatic DNA deposition drives drug-induced liver injury and inflammation in mice

(2014) Pedro Elias Marques et al.   HEPATOLOGY

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

(2014) Huayi Wang et al.   MOLECULAR CELL

Necroptosis in health and diseases

(2014) Wen Zhou et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Necroptosis: An emerging type of cell death in liver diseases

(2014) Waqar Khalid Saeed   WORLD JOURNAL OF GASTROENTEROLOGY

Necroptosis: is there a role for mitochondria?

(2014) Kurt D. Marshall et al.   Frontiers in Physiology

NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice

(2013) Alexander Wree et al.   HEPATOLOGY

Oxidative stress and hepatitis C virus

(2013) Usman Paracha et al.   Virology Journal

Widespread Mitochondrial Depletion via Mitophagy Does Not Compromise Necroptosis

(2013) Stephen W.G. Tait et al.   Cell Reports

The Mitochondrial Phosphatase PGAM5 Functions at the Convergence Point of Multiple Necrotic Death Pathways

(2012) Zhigao Wang et al.   CELL

Mitochondrial Control of Cellular Life, Stress, and Death

(2012) Lorenzo Galluzzi et al.   CIRCULATION RESEARCH

Chemokines and mitochondrial products activate neutrophils to amplify organ injury during mouse acute liver failure

(2012) Pedro E. Marques et al.   HEPATOLOGY

Alterations in the redox state and liver damage: Hints from the EASL Basic School of Hepatology

(2012) Gianluca Tell et al.   JOURNAL OF HEPATOLOGY

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

Central role of mitochondria in drug-induced liver injury

(2011) Dominique Pessayre et al.   DRUG METABOLISM REVIEWS

Beginnings of a Good Apoptotic Meal: The Find-Me and Eat-Me Signaling Pathways

(2011) Kodi S. Ravichandran   IMMUNITY

Small Molecule Inhibitors of Mitochondrial Division: Tools that Translate Basic Biological Research into Medicine

(2010) Laura L. Lackner et al.   CHEMISTRY & BIOLOGY

Necroptosis as an alternative form of programmed cell death

(2010) Dana E Christofferson et al.   CURRENT OPINION IN CELL BIOLOGY

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

Tissue-, substrate-, and site-specific characteristics of mitochondrial reactive oxygen species generation

(2009) Erich B. Tahara et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Patched dependence receptor triggers apoptosis through a DRAL–caspase-9 complex

(2009) Frédéric Mille et al.   NATURE CELL BIOLOGY

Identification of functionally important amino acid residues in the mitochondria targeting sequence of Hepatitis B virus X protein

(2008) Sai Kam Li et al.   VIROLOGY