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Stachybotrys chartarum-Induced Hypersensitivity Pneumonitis Is TLR9 Dependent

(2011) Urvashi Bhan et al.   AMERICAN JOURNAL OF PATHOLOGY

NLRP3 inflammasome-mediated neutrophil recruitment and hypernociception depend on leukotriene B4 in a murine model of gout

(2011) Flávio A. Amaral et al.   ARTHRITIS AND RHEUMATISM

Receptor binding mode and pharmacological characterization of a potent and selective dual CXCR1/CXCR2 non-competitive allosteric inhibitor

(2011) R Bertini et al.   BRITISH JOURNAL OF PHARMACOLOGY

Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity

(2011) Hartmut Jaeschke et al.   LIVER INTERNATIONAL

The neutrophil in vascular inflammation

(2011) Mia Phillipson et al.   NATURE MEDICINE

Sensing sterile injury: Opportunities for pharmacological control

(2011) Gustavo B. Menezes et al.   PHARMACOLOGY & THERAPEUTICS

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(2010) Kenneth L. Rock et al.   Annual Review of Immunology

Evaluation of drug toxicity with hepatocytes cultured in a micro-space cell culture system

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Phosphoinositide 3-kinase γ plays a critical role in bleomycin-induced pulmonary inflammation and fibrosis in mice

(2010) Remo C. Russo et al.   JOURNAL OF LEUKOCYTE BIOLOGY

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(2010) William Bernal et al.   LANCET

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Functional role of chemokines in liver disease models

(2010) Hacer Sahin et al.   Nature Reviews Gastroenterology & Hepatology

Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation

(2010) B. McDonald et al.   SCIENCE

International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the Formyl Peptide Receptor (FPR) Family

(2009) R. D. Ye et al.   PHARMACOLOGICAL REVIEWS

The chemokine receptors CXCR1/CXCR2 modulate antigen-induced arthritis by regulating adhesion of neutrophils to the synovial microvasculature

(2008) Fernanda M. Coelho et al.   ARTHRITIS AND RHEUMATISM