Bax retrotranslocation potentiates Bcl-xL’s antiapoptotic activity and is essential for switch-like transitions between MOMP competency and resistance

Quantitative interactome of a membrane Bcl-2 network identifies a hierarchy of complexes for apoptosis regulation

(2017) Stephanie Bleicken et al.   Nature Communications

Targeting the differential addiction to anti-apoptotic BCL-2 family for cancer therapy

(2017) Akane Inoue-Yamauchi et al.   Nature Communications

The deadly landscape of pro-apoptotic BCL-2 proteins in the outer mitochondrial membrane

(2016) Mark P.A. Luna-Vargas et al.   FEBS Journal

The porin VDAC2 is the mitochondrial platform for Bax retrotranslocation

(2016) Joachim Lauterwasser et al.   Scientific Reports

Distinct lipid effects on tBid and Bim activation of membrane permeabilization by pro-apoptotic Bax

(2015) Aisha Shamas-Din et al.   BIOCHEMICAL JOURNAL

Mitochondrial apoptosis: killing cancer using the enemy within

(2015) J Lopez et al.   BRITISH JOURNAL OF CANCER

Attacking cancer's Achilles heel: antagonism of anti-apoptotic BCL-2 family members

(2015) Joseph T. Opferman   FEBS Journal

Limited Mitochondrial Permeabilization Causes DNA Damage and Genomic Instability in the Absence of Cell Death

(2015) Gabriel Ichim et al.   MOLECULAR CELL

Bax monomers form dimer units in the membrane that further self-assemble into multiple oligomeric species

(2015) Yamunadevi Subburaj et al.   Nature Communications

The BCL2 Family: Key Mediators of the Apoptotic Response to Targeted Anticancer Therapeutics

(2015) A. N. Hata et al.   Cancer Discovery

Regulating cell death at, on, and in membranes

(2014) Xiaoke Chi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondrial alterations in apoptosis

(2014) Katia Cosentino et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Differential retrotranslocation of mitochondrial Bax and Bak

(2014) F. Todt et al.   EMBO JOURNAL

After Embedding in Membranes Antiapoptotic Bcl-XL Protein Binds Both Bcl-2 Homology Region 3 and Helix 1 of Proapoptotic Bax Protein to Inhibit Apoptotic Mitochondrial Permeabilization

(2014) Jingzhen Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bak Core and Latch Domains Separate during Activation, and Freed Core Domains Form Symmetric Homodimers

(2014) Jason M. Brouwer et al.   MOLECULAR CELL

Multiple partners can kiss-and-run: Bax transfers between multiple membranes and permeabilizes those primed by tBid

(2014) A Shamas-Din et al.   Cell Death & Disease

From computational modelling of the intrinsic apoptosis pathway to a systems-based analysis of chemotherapy resistance: achievements, perspectives and challenges in systems medicine

(2014) M L Würstle et al.   Cell Death & Disease

Mechanistic Differences in the Membrane Activity of Bax and Bcl-xL Correlate with Their Opposing Roles in Apoptosis

(2013) Stephanie Bleicken et al.   BIOPHYSICAL JOURNAL

Bax Crystal Structures Reveal How BH3 Domains Activate Bax and Nucleate Its Oligomerization to Induce Apoptosis

(2013) Peter E. Czabotar et al.   CELL

The rheostat in the membrane: BCL-2 family proteins and apoptosis

(2013) N Volkmann et al.   CELL DEATH AND DIFFERENTIATION

Bax Exists in a Dynamic Equilibrium between the Cytosol and Mitochondria to Control Apoptotic Priming

(2013) Barbara Schellenberg et al.   MOLECULAR CELL

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

(2013) Peter E. Czabotar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The C-terminal helix of Bcl-xL mediates Bax retrotranslocation from the mitochondria

(2012) F Todt et al.   CELL DEATH AND DIFFERENTIATION

BH3-only proteins in apoptosis at a glance

(2012) L. Happo et al.   JOURNAL OF CELL SCIENCE

Bcl-xL Retrotranslocates Bax from the Mitochondria into the Cytosol

(2011) Frank Edlich et al.   CELL

Mathematical modelling of the mitochondrial apoptosis pathway

(2010) Heinrich J. Huber et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Apoptosis: embedded in membranes

(2010) Christian Bogner et al.   CURRENT OPINION IN CELL BIOLOGY

BH3-Triggered Structural Reorganization Drives the Activation of Proapoptotic BAX

(2010) Evripidis Gavathiotis et al.   MOLECULAR CELL

Imaging Interorganelle Contacts and Local Calcium Dynamics at the ER-Mitochondrial Interface

(2010) György Csordás et al.   MOLECULAR CELL

Synergistic induction of cell death in liver tumor cells by TRAIL and chemotherapeutic drugs via the BH3-only proteins Bim and Bid

(2010) S Schneider-Jakob et al.   Cell Death & Disease

Dynamics of outer mitochondrial membrane permeabilization during apoptosis

(2009) M Rehm et al.   CELL DEATH AND DIFFERENTIATION

Single-cell quantification of Bax activation and mathematical modelling suggest pore formation on minimal mitochondrial Bax accumulation

(2009) H Düssmann et al.   CELL DEATH AND DIFFERENTIATION

Membrane promotes tBID interaction with BCLXL

(2009) Ana J García-Sáez et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Membrane Binding by tBid Initiates an Ordered Series of Events Culminating in Membrane Permeabilization by Bax

(2008) Jonathan F. Lovell et al.   CELL

Bax targeting to mitochondria occurs via both tail anchor-dependent and -independent mechanisms

(2008) A J Valentijn et al.   CELL DEATH AND DIFFERENTIATION

Bcl-XL Inhibits Membrane Permeabilization by Competing with Bax

(2008) Lieven P Billen et al.   PLOS BIOLOGY