HIV-1 persistence in the CNS: Mechanisms of latency, pathogenesis and an update on eradication strategies

AP‐1 and NF‐κB synergize to transcriptionally activate latent HIV upon T‐cell receptor activation

(2021) Joseph Hokello et al.   FEBS LETTERS

Circumcision as an Intervening Strategy against HIV Acquisition in the Male Genital Tract

(2021) Adhikarimayum Lakhikumar Sharma et al.   Pathogens

Novel elvitegravir nanoformulation for drug delivery across the blood-brain barrier to achieve HIV-1 suppression in the CNS macrophages

(2020) Yuqing Gong et al.   Scientific Reports

Synthetic Abortive HIV-1 RNAs Induce Potent Antiviral Immunity

(2020) Melissa Stunnenberg et al.   Frontiers in Immunology

Late boosting of the RV144 regimen with AIDSVAX B/E and ALVAC-HIV in HIV-uninfected Thai volunteers: a double-blind, randomised controlled trial

(2020) Punnee Pitisuttithum et al.   Lancet HIV

HIV-1 infection and latency-reversing agents bryostatin-1 and JQ1 disrupt amyloid beta homeostasis in human astrocytes

(2020) Alizé Proust et al.   GLIA

Shedding Light on the Role of Extracellular Vesicles in HIV Infection and Wound Healing

(2020) Aseel Alqatawni et al.   Viruses-Basel

The multifaceted nature of HIV latency

(2020) Caroline Dufour et al.   JOURNAL OF CLINICAL INVESTIGATION

The Paradox of HIV Blood–Brain Barrier Penetrance and Antiretroviral Drug Delivery Deficiencies

(2020) Olivia Osborne et al.   TRENDS IN NEUROSCIENCES

Efficient Non-Epigenetic Activation of HIV Latency through the T-Cell Receptor Signalosome

(2020) Joseph Hokello et al.   Viruses-Basel

CBF-1 Promotes the Establishment and Maintenance of HIV Latency by Recruiting Polycomb Repressive Complexes, PRC1 and PRC2, at HIV LTR

(2020) Adhikarimayum Lakhikumar Sharma et al.   Viruses-Basel

HIV-1 remission following CCR5Δ32/Δ32 haematopoietic stem-cell transplantation

(2019) Ravindra K. Gupta et al.   NATURE

CAR T-cell associated neurotoxicity: Mechanisms, clinicopathologic correlates, and future directions

(2019) Bradley D Hunter et al.   JNCI-Journal of the National Cancer Institute

What can characterization of CSF escape populations teach us about viral reservoirs in the CNS?

(2019) Sarah B. Joseph et al.   AIDS

Perspective on potential impact of HIV CNS latency on eradication

(2019) Phillip Chan et al.   AIDS

Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice

(2019) Prasanta K. Dash et al.   Nature Communications

Insights into the HIV Latency and the Role of Cytokines

(2019) Joseph Hokello et al.   Pathogens

Baricitinib reverses HIV-associated neurocognitive disorders in a SCID mouse model and reservoir seeding in vitro

(2019) Christina Gavegnano et al.   Journal of Neuroinflammation

Evaluation of Targeted Delivery to the Brain Using Magnetic Immunoliposomes and Magnetic Force

(2019) Louiza Bohn Thomsen et al.   Materials

Microglial Cells: The Main HIV-1 Reservoir in the Brain

(2019) Clementine Wallet et al.   Frontiers in Cellular and Infection Microbiology

New Challenges of HIV-1 Infection: How HIV-1 Attacks and Resides in the Central Nervous System

(2019) Victoria Rojas-Celis et al.   Cells

Novel Latency Reversal Agents for HIV-1 Cure

(2018) Adam M. Spivak et al.   Annual Review of Medicine

Astrocytes sustain long-term productive HIV-1 infection without establishment of reactivable viral latency

(2018) Corinne Barat et al.   GLIA

HIV latency is reversed by ACSS2-driven histone crotonylation

(2018) Guochun Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Host and Viral Factors Influencing Interplay between the Macrophage and HIV-1

(2018) Viviane Machado Andrade et al.   Journal of Neuroimmune Pharmacology

CRISPR-Cas based antiviral strategies against HIV-1

(2018) Gang Wang et al.   VIRUS RESEARCH

Advances in HIV-1 Vaccine Development

(2018) Yong Gao et al.   Viruses-Basel

Creation of a long-acting nanoformulated dolutegravir

(2018) Brady Sillman et al.   Nature Communications

Characterization of Nanodiamond-based anti-HIV drug Delivery to the Brain

(2018) Upal Roy et al.   Scientific Reports

Barriers for HIV Cure: The Latent Reservoir

(2018) Sergio Castro-Gonzalez et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Neural-Tube Defects with Dolutegravir Treatment from the Time of Conception

(2018) Rebecca Zash et al.   NEW ENGLAND JOURNAL OF MEDICINE

CD32 Expression is not Associated to HIV-DNA content in CD4 cell subsets of individuals with Different Levels of HIV Control

(2018) Marcial García et al.   Scientific Reports

Drug targeting strategies into the brain for treating neurological diseases

(2018) Wilson Barnabas   JOURNAL OF NEUROSCIENCE METHODS

Human Immunodeficiency Virus and the Nervous System

(2018) Emily Jane Sutherland et al.   NEUROLOGIC CLINICS

Therapeutic Targeting of HIV Reservoirs: How to Give T Cells a New Direction

(2018) Hongbing Yang et al.   Frontiers in Immunology

Severe depression as a neuropsychiatric side effect induced by dolutegravir

(2017) H Scheper et al.   HIV MEDICINE

Sequential Vacc-4x and romidepsin during combination antiretroviral therapy (cART): Immune responses to Vacc-4x regions on p24 and changes in HIV reservoirs

(2017) G. Tapia et al.   JOURNAL OF INFECTION

Teriflunomide and monomethylfumarate target HIV-induced neuroinflammation and neurotoxicity

(2017) Björn Ambrosius et al.   Journal of Neuroinflammation

HIV-1-associated neurocognitive disorder: epidemiology, pathogenesis, diagnosis, and treatment

(2017) Christian Eggers et al.   JOURNAL OF NEUROLOGY

CD32a is a marker of a CD4 T-cell HIV reservoir harbouring replication-competent proviruses

(2017) Benjamin Descours et al.   NATURE

HIV integration sites in latently infected cell lines: evidence of ongoing replication

(2017) Jori Symons et al.   Retrovirology

A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma

(2017) Donald M. O’Rourke et al.   Science Translational Medicine

Underlying mechanisms of HIV-1 latency

(2017) Bizhan Romani et al.   VIRUS GENES

Mechanisms of CNS Viral Seeding by HIV + CD14 + CD16 + Monocytes: Establishment and Reseeding of Viral Reservoirs Contributing to HIV-Associated Neurocognitive Disorders

(2017) Mike Veenstra et al.   mBio

Astrocytes Resist HIV-1 Fusion but Engulf Infected Macrophage Material

(2017) Rebecca A. Russell et al.   Cell Reports

Antiviral treatment strategies based on gene silencing and genome editing

(2017) Roger Badia et al.   Current Opinion in Virology

Distribution and fate of HIV-1 unintegrated DNA species: a comprehensive update

(2017) Faysal Bin Hamid et al.   AIDS Research and Therapy

Myeloid Cell Interaction with HIV: A Complex Relationship

(2017) Vasco Rodrigues et al.   Frontiers in Immunology

Nucleoside reverse transcriptase inhibitors (NRTIs) induce proinflammatory cytokines in the CNS via Wnt5a signaling

(2017) Ting Wu et al.   Scientific Reports

Getting into the brain: Potential of nanotechnology in the management of NeuroAIDS

(2016) Madhavan Nair et al.   ADVANCED DRUG DELIVERY REVIEWS

Phylogenetics and Phyloanatomy of HIV/SIV Intra-Host Compartments and Reservoirs: The Key Role of the Central Nervous System

(2016) Marco Salemi et al.   CURRENT HIV RESEARCH

Solving the Blood-Brain Barrier Challenge for the Effective Treatment of HIV Replication in the Central Nervous System

(2016) Luc Bertrand et al.   CURRENT PHARMACEUTICAL DESIGN

Toxicity and in vitro activity of HIV-1 latency-reversing agents in primary CNS cells

(2016) Lachlan R. Gray et al.   JOURNAL OF NEUROVIROLOGY

Erratum: Corrigendum: Structural and functional features of central nervous system lymphatic vessels

(2016) Antoine Louveau et al.   NATURE

Nuclear landscape of HIV-1 infection and integration

(2016) Marina Lusic et al.   NATURE REVIEWS MICROBIOLOGY

Position effects influence HIV latency reversal

(2016) Heng-Chang Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Janus kinase inhibitor ruxolitinib reduces HIV replication in human macrophages and ameliorates HIV encephalitis in a murine model

(2016) Woldeab B. Haile et al.   NEUROBIOLOGY OF DISEASE

Neuroinflammation in treated HIV-positive individuals

(2016) Jaime H. Vera et al.   NEUROLOGY

Latency reversal and viral clearance to cure HIV-1

(2016) D. M. Margolis et al.   SCIENCE

Long noncoding RNA NRON contributes to HIV-1 latency by specifically inducing tat protein degradation

(2016) Jun Li et al.   Nature Communications

Immune activation in the central nervous system throughout the course of HIV infection

(2016) Serena S. Spudich   Current Opinion in HIV and AIDS

Position effects influence HIV latency reversal

(2016) Heng-Chang Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Could antiretroviral neurotoxicity play a role in the pathogenesis of cognitive impairment in treated HIV disease?

(2015) Jonathan Underwood et al.   AIDS

Self-Assembled DNA Nanoclews for the Efficient Delivery of CRISPR-Cas9 for Genome Editing

(2015) Wujin Sun et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Understanding HIV Latency: The Road to an HIV Cure

(2015) Matthew S. Dahabieh et al.   Annual Review of Medicine

A Hardwired HIV Latency Program

(2015) Brandon S. Razooky et al.   CELL

Didehydro-Cortistatin A Inhibits HIV-1 Tat Mediated Neuroinflammation and Prevents Potentiation of Cocaine Reward in Tat Transgenic Mice

(2015) Sonia Mediouni et al.   CURRENT HIV RESEARCH

A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules

(2015) Aleksanteri Aspelund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Antibody-Dependent Cellular Cytotoxicity against Reactivated HIV-1-Infected Cells

(2015) Wen Shi Lee et al.   JOURNAL OF VIROLOGY

Intracellular Crotonyl-CoA Stimulates Transcription through p300-Catalyzed Histone Crotonylation

(2015) Benjamin R. Sabari et al.   MOLECULAR CELL

CNS-specific regulatory elements in brain-derived HIV-1 strains affect responses to latency-reversing agents with implications for cure strategies

(2015) L R Gray et al.   MOLECULAR PSYCHIATRY

RNA-mediated epigenetic regulation of gene expression

(2015) Daniel Holoch et al.   NATURE REVIEWS GENETICS

Long lasting control of viral rebound with a new drug ABX464 targeting Rev – mediated viral RNA biogenesis

(2015) Noëlie Campos et al.   Retrovirology

HIV-1 transcriptional silencing caused by TRIM22 inhibition of Sp1 binding to the viral promoter

(2015) Filippo Turrini et al.   Retrovirology

An In-Depth Comparison of Latency-Reversing Agent Combinations in Various In Vitro and Ex Vivo HIV-1 Latency Models Identified Bryostatin-1+JQ1 and Ingenol-B+JQ1 to Potently Reactivate Viral Gene Expression

(2015) Gilles Darcis et al.   PLoS Pathogens

Neuropathogenesis of HIV: From Initial Neuroinvasion to HIV-Associated Neurocognitive Disorder (HAND)

(2015) Zaina Zayyad et al.   Current HIV/AIDS Reports

Low levels of HIV-1 RNA detected in the cerebrospinal fluid after up to 10 years of suppressive therapy are associated with local immune activation

(2014) Viktor Dahl et al.   AIDS

Understanding the relationship between DNA methylation and histone lysine methylation

(2014) Nathan R. Rose et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Rolling circle amplification: a versatile tool for chemical biology, materials science and medicine

(2014) M. Monsur Ali et al.   CHEMICAL SOCIETY REVIEWS

ING116070: A Study of the Pharmacokinetics and Antiviral Activity of Dolutegravir in Cerebrospinal Fluid in HIV-1-Infected, Antiretroviral Therapy-Naive Subjects

(2014) S. L. Letendre et al.   CLINICAL INFECTIOUS DISEASES

Neonatal intrahippocampal HIV-1 protein Tat1–86 injection: neurobehavioral alterations in the absence of increased inflammatory cytokine activation

(2014) Landhing M. Moran et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Combined antiretroviral therapy reduces brain viral load and pathological features of HIV encephalitis in a mouse model

(2014) Rajeth Koneru et al.   JOURNAL OF NEUROVIROLOGY

HMGA1 recruits CTIP2-repressed P-TEFb to the HIV-1 and cellular target promoters

(2014) Sebastian Eilebrecht et al.   NUCLEIC ACIDS RESEARCH

HIV-1 Entry and Trans-Infection of Astrocytes Involves CD81 Vesicles

(2014) Lachlan R. Gray et al.   PLoS One

Chemokine CXCL8 Promotes HIV-1 Replication in Human Monocyte-Derived Macrophages and Primary Microglia via Nuclear Factor-κB Pathway

(2014) Manmeet K. Mamik et al.   PLoS One

HIV-1 Latency in Monocytes/Macrophages

(2014) Amit Kumar et al.   Viruses-Basel

Is the central nervous system a reservoir of HIV-1?

(2014) Lachlan R. Gray et al.   Current Opinion in HIV and AIDS

Dynamics of HIV Latency and Reactivation in a Primary CD4+ T Cell Model

(2014) Pejman Mohammadi et al.   PLoS Pathogens

Monocyte/macrophages and their role in HIV neuropathogenesis

(2013) Tricia H. Burdo et al.   IMMUNOLOGICAL REVIEWS

Immune restoration after antiretroviral therapy: the pitfalls of hasty or incomplete repairs

(2013) Eleanor M. P. Wilson et al.   IMMUNOLOGICAL REVIEWS

Cerebrospinal Fluid and Neuroimaging Biomarker Abnormalities Suggest Early Neurological Injury in a Subset of Individuals During Primary HIV Infection

(2013) M. J. Peluso et al.   JOURNAL OF INFECTIOUS DISEASES

Apolipoprotein E-Dependent Differences in Innate Immune Responses of Maturing Human Neuroepithelial Progenitor Cells Exposed to HIV-1

(2013) Rebeca Geffin et al.   Journal of Neuroimmune Pharmacology

HIV-associated neurocognitive disorder

(2013) David B Clifford et al.   LANCET INFECTIOUS DISEASES

Molecular and pathologic insights from latent HIV-1 infection in the human brain

(2013) P. Desplats et al.   NEUROLOGY

CTIP2 is a negative regulator of P-TEFb

(2013) T. Cherrier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual-acting stapled peptides target both HIV-1 entry and assembly

(2013) Hongtao Zhang et al.   Retrovirology

Roles and functions of HIV-1 Tat protein in the CNS: an overview

(2013) Asen Bagashev et al.   Virology Journal

Externally controlled on-demand release of anti-HIV drug using magneto-electric nanoparticles as carriers

(2013) Madhavan Nair et al.   Nature Communications

Harnessing the CRISPR/Cas9 system to disrupt latent HIV-1 provirus

(2013) Hirotaka Ebina et al.   Scientific Reports

HIV Latency

(2013) R. F. Siliciano et al.   Cold Spring Harbor Perspectives in Medicine

HIV-1-Related Central Nervous System Disease: Current Issues in Pathogenesis, Diagnosis, and Treatment

(2013) S. Spudich et al.   Cold Spring Harbor Perspectives in Medicine

An Analog of the Natural Steroidal Alkaloid Cortistatin A Potently Suppresses Tat-Dependent HIV Transcription

(2012) Guillaume Mousseau et al.   Cell Host & Microbe

Redefining the Viral Reservoirs that Prevent HIV-1 Eradication

(2012) Evelyn Eisele et al.   IMMUNITY

Immunologic Privilege in the Central Nervous System and the Blood–Brain Barrier

(2012) Leslie L Muldoon et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cell-Based Measures of Viral Persistence Are Associated With Immune Activation and Programmed Cell Death Protein 1 (PD-1)–Expressing CD4+ T cells

(2012) Hiroyu Hatano et al.   JOURNAL OF INFECTIOUS DISEASES

Central Nervous System Viral Invasion and Inflammation During Acute HIV Infection

(2012) Victor Valcour et al.   JOURNAL OF INFECTIOUS DISEASES

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(2012) Mudit Tyagi et al.   MOLECULAR MEDICINE

Quantification of increased cellularity during inflammatory demyelination

(2011) Yong Wang et al.   BRAIN

HIV-1 Tat protein increases the permeability of brain endothelial cells by both inhibiting occludin expression and cleaving occludin via matrix metalloproteinase-9

(2011) Ruifen Xu et al.   BRAIN RESEARCH

Transcription of Preintegrated HIV-1 cDNA Modulates Cell Surface Expression of Major Histocompatibility Complex Class I via Nef

(2011) R. D. Sloan et al.   JOURNAL OF VIROLOGY

LSD1 cooperates with CTIP2 to promote HIV-1 transcriptional silencing

(2011) V. Le Douce et al.   NUCLEIC ACIDS RESEARCH

Genome-Wide Identification of Bcl11b Gene Targets Reveals Role in Brain-Derived Neurotrophic Factor Signaling

(2011) Bin Tang et al.   PLoS One

Eradication of HIV from the brain: reasons for pause

(2010) Avindra Nath et al.   AIDS

Discordance Between Cerebral Spinal Fluid and Plasma HIV Replication in Patients with Neurological Symptoms Who Are Receiving Suppressive Antiretroviral Therapy

(2010) Ana Canestri et al.   CLINICAL INFECTIOUS DISEASES

Long-Term Impact of Efavirenz on Neuropsychological Performance and Symptoms in HIV-Infected Individuals (ACTG 5097s)

(2010) David B. Clifford et al.   HIV CLINICAL TRIALS

HIV-1 phylogenetic analysis shows HIV-1 transits through the meninges to brain and peripheral tissues

(2010) Susanna L. Lamers et al.   INFECTION GENETICS AND EVOLUTION

HIV‐1 Viral Escape in Cerebrospinal Fluid of Subjects on Suppressive Antiretroviral Treatment

(2010) Arvid Edén et al.   JOURNAL OF INFECTIOUS DISEASES

Cliniconeuropathologic correlates of human immunodeficiency virus in the era of antiretroviral therapy

(2010) I Everall et al.   JOURNAL OF NEUROVIROLOGY

Peripheral biomarkers do not correlate with cognitive impairment in highly active antiretroviral therapy–treated subjects with human immunodeficiency virus type 1 infection

(2010) Bing Sun et al.   JOURNAL OF NEUROVIROLOGY

Establishment of HIV Latency in Primary CD4+ Cells Is due to Epigenetic Transcriptional Silencing and P-TEFb Restriction

(2010) M. Tyagi et al.   JOURNAL OF VIROLOGY

HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study

(2010) R. K. Heaton et al.   NEUROLOGY

HIV Persistence and the Prospect of Long-Term Drug-Free Remissions for HIV-Infected Individuals

(2010) D. Trono et al.   SCIENCE

Arginine/lysine–methyl/methyl switches: biochemical role of histone arginine methylation in transcriptional regulation

(2010) Valentina Migliori et al.   Epigenomics

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

Extensive astrocyte infection is prominent in human immunodeficiency virus-associated dementia

(2009) Melissa J. Churchill et al.   ANNALS OF NEUROLOGY

Multidrug‐Resistant Variants of HIV Type 1 (HIV‐1) Can Exist in Cells as Defective Quasispecies and Be Rescued by Superinfection with Other Defective HIV‐1 Variants

(2009) Yudong Quan et al.   JOURNAL OF INFECTIOUS DISEASES

Compartmentalization and Clonal Amplification of HIV-1 Variants in the Cerebrospinal Fluid during Primary Infection

(2009) G. Schnell et al.   JOURNAL OF VIROLOGY

A Limited Group of Class I Histone Deacetylases Acts To Repress Human Immunodeficiency Virus Type 1 Expression

(2009) K. S. Keedy et al.   JOURNAL OF VIROLOGY

Small RNAs in transcriptional gene silencing and genome defence

(2009) Danesh Moazed   NATURE

Neutralizing antibodies generated during natural HIV-1 infection: good news for an HIV-1 vaccine?

(2009) Leonidas Stamatatos et al.   NATURE MEDICINE

Linking DNA methylation and histone modification: patterns and paradigms

(2009) Howard Cedar et al.   NATURE REVIEWS GENETICS

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

Vaccination with ALVAC and AIDSVAX to Prevent HIV-1 Infection in Thailand

(2009) Supachai Rerks-Ngarm et al.   NEW ENGLAND JOURNAL OF MEDICINE

CpG Methylation Controls Reactivation of HIV from Latency

(2009) Jana Blazkova et al.   PLoS Pathogens

Orientation-Dependent Regulation of Integrated HIV-1 Expression by Host Gene Transcriptional Readthrough

(2008) Yefei Han et al.   Cell Host & Microbe

Transcriptional Interference Antagonizes Proviral Gene Expression to Promote HIV Latency

(2008) Tina Lenasi et al.   Cell Host & Microbe

HIV-1-infected and/or immune-activated macrophages regulate astrocyte CXCL8 production through IL-1β and TNF-α: Involvement of mitogen-activated protein kinases and protein kinase R

(2008) Jialin C. Zheng et al.   JOURNAL OF NEUROIMMUNOLOGY

Epigenetic Silencing of Human Immunodeficiency Virus (HIV) Transcription by Formation of Restrictive Chromatin Structures at the Viral Long Terminal Repeat Drives the Progressive Entry of HIV into Latency

(2008) R. Pearson et al.   JOURNAL OF VIROLOGY

HIV-1 gp120 induces cytokine expression, leukocyte adhesion, and transmigration across the blood–brain barrier: modulatory effects of STAT1 signaling

(2008) Bo Yang et al.   MICROVASCULAR RESEARCH

Functional roles for the striatal-enriched transcription factor, Bcl11b, in the control of striatal gene expression and transcriptional dysregulation in Huntington's disease

(2008) Paula A. Desplats et al.   NEUROBIOLOGY OF DISEASE

Microbial Translocation Is Associated with Increased Monocyte Activation and Dementia in AIDS Patients

(2008) Petronela Ancuta et al.   PLoS One

Viral complementation allows HIV-1 replication without integration

(2008) Huub C Gelderblom et al.   Retrovirology