Neuropathogenesis of HIV: From Initial Neuroinvasion to HIV-Associated Neurocognitive Disorder (HAND)

Low levels of HIV-1 RNA detected in the cerebrospinal fluid after up to 10 years of suppressive therapy are associated with local immune activation

(2014) Viktor Dahl et al.   AIDS

Antiretroviral-Free HIV-1 Remission and Viral Rebound After Allogeneic Stem Cell Transplantation

(2014) Timothy J. Henrich et al.   ANNALS OF INTERNAL MEDICINE

In-silico analysis of claudin-5 reveals novel putative sites for post-translational modifications: Insights into potential molecular determinants of blood–brain barrier breach during HIV-1 infiltration

(2014) Faryal Mehwish Awan et al.   INFECTION GENETICS AND EVOLUTION

Neonatal intrahippocampal HIV-1 protein Tat1–86 injection: neurobehavioral alterations in the absence of increased inflammatory cytokine activation

(2014) Landhing M. Moran et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Differential Effects of Tat Proteins Derived from HIV-1 Subtypes B and Recombinant CRF02_AG on Human Brain Microvascular Endothelial Cells: Implications for Blood–Brain Barrier Dysfunction

(2014) Shawna M Woollard et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Heme oxygenase-1 deficiency accompanies neuropathogenesis of HIV-associated neurocognitive disorders

(2014) Alexander J. Gill et al.   JOURNAL OF CLINICAL INVESTIGATION

Spatiotemporal dynamics of simian immunodeficiency virus brain infection in CD8+ lymphocyte-depleted rhesus macaques with neuroAIDS

(2014) S. L. Strickland et al.   JOURNAL OF GENERAL VIROLOGY

CD8+T Cells Maintain Suppression of Simian Immunodeficiency Virus in the Central Nervous System

(2014) Maria Cecilia G. Marcondes et al.   JOURNAL OF INFECTIOUS DISEASES

Astrocytes mediate HIV-1 Tat-induced neuronal damage via ligand-gated ion channel P2X7R

(2014) Manju Tewari et al.   JOURNAL OF NEUROCHEMISTRY

Progressive increase in central nervous system immune activation in untreated primary HIV-1 infection

(2014) Joome Suh et al.   Journal of Neuroinflammation

Form follows function: astrocyte morphology and immune dysfunction in SIV neuroAIDS

(2014) Kim M. Lee et al.   JOURNAL OF NEUROVIROLOGY

Stochastic population switch may explain the latent reservoir stability and intermittent viral blips in HIV patients on suppressive therapy

(2014) Sunpeng Wang et al.   JOURNAL OF THEORETICAL BIOLOGY

Emergence of CD4 Independence Envelopes and Astrocyte Infection in R5 Simian-Human Immunodeficiency Virus Model of Encephalitis

(2014) K. Zhuang et al.   JOURNAL OF VIROLOGY

Autophagy Restricts HIV-1 Infection by Selectively Degrading Tat in CD4+T Lymphocytes

(2014) Sophie Sagnier et al.   JOURNAL OF VIROLOGY

Cerebral metabolite changes prior to and after antiretroviral therapy in primary HIV infection

(2014) A. C. Young et al.   NEUROLOGY

HIV-1 endocytosis in astrocytes: A kiss of death or survival of the fittest?

(2014) Ashok Chauhan et al.   NEUROSCIENCE RESEARCH

Biomarker Evidence of Axonal Injury in Neuroasymptomatic HIV-1 Patients

(2014) Jan Jessen Krut et al.   PLoS One

Dopamine Receptor Activation Increases HIV Entry into Primary Human Macrophages

(2014) Peter J. Gaskill et al.   PLoS One

Treatment of HIV in the Central Nervous System

(2014) Magnus Gisslén et al.   SEMINARS IN NEUROLOGY

Neuroimaging of HIV-associated neurocognitive disorders (HAND)

(2014) Beau M. Ances et al.   Current Opinion in HIV and AIDS

Treatment of HIV in the CNS: Effects of Antiretroviral Therapy and the Promise of Non-Antiretroviral Therapeutics

(2014) Michael J. Peluso et al.   Current HIV/AIDS Reports

Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes

(2013) Daigo Hashimoto et al.   IMMUNITY

Aspirin Attenuates Platelet Activation and Immune Activation in HIV-1-Infected Subjects on Antiretroviral Therapy

(2013) Meagan O’Brien et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Cerebrospinal Fluid and Neuroimaging Biomarker Abnormalities Suggest Early Neurological Injury in a Subset of Individuals During Primary HIV Infection

(2013) M. J. Peluso et al.   JOURNAL OF INFECTIOUS DISEASES

An Example of Genetically Distinct HIV Type 1 Variants in Cerebrospinal Fluid and Plasma During Suppressive Therapy

(2013) Viktor Dahl et al.   JOURNAL OF INFECTIOUS DISEASES

Cytochromecdysregulation induced by HIV infection of astrocytes results in bystander apoptosis of uninfected astrocytes by an IP3and calcium-dependent mechanism

(2013) Eliseo A. Eugenin et al.   JOURNAL OF NEUROCHEMISTRY

HIV-1-Related Central Nervous System Disease: Current Issues in Pathogenesis, Diagnosis, and Treatment

(2013) S. Spudich et al.   Cold Spring Harbor Perspectives in Medicine

The cardiovascular risk marker asymmetric dimethylarginine is elevated in asymptomatic, untreated HIV-1 infection and correlates with markers of immune activation and disease progression

(2013) C. L. Hudson et al.   ANNALS OF CLINICAL BIOCHEMISTRY

Cerebrospinal fluid HIV escape associated with progressive neurologic dysfunction in patients on antiretroviral therapy with well controlled plasma viral load

(2012) Michael J. Peluso et al.   AIDS

Antiretroviral monocyte efficacy score linked to cognitive impairment in HIV

(2012) Cecilia M Shikuma et al.   ANTIVIRAL THERAPY

Neurocognitive Impairment in HIV-Infected Naïve Patients with Advanced Disease: The Role of Virus and Intrathecal Immune Activation

(2012) Monica Airoldi et al.   Clinical & Developmental Immunology

Monocyte Activation Markers in Cerebrospinal Fluid Associated With Impaired Neurocognitive Testing in Advanced HIV Infection

(2012) Anupa Kamat et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Central Nervous System Viral Invasion and Inflammation During Acute HIV Infection

(2012) Victor Valcour et al.   JOURNAL OF INFECTIOUS DISEASES

Platelet-derived growth factor (PDGF)-BB-mediated induction of monocyte chemoattractant protein 1 in human astrocytes: implications for HIV-associated neuroinflammation

(2012) Crystal Bethel-Brown et al.   Journal of Neuroinflammation

Change in Brain Magnetic Resonance Spectroscopy after Treatment during Acute HIV Infection

(2012) Napapon Sailasuta et al.   PLoS One

Brain Cell Reservoirs of Latent Virus in Presymptomatic HIV-Infected Individuals

(2011) Katherine A. Thompson et al.   AMERICAN JOURNAL OF PATHOLOGY

Breaking down the barrier: The effects of HIV-1 on the blood–brain barrier

(2011) Marianne Strazza et al.   BRAIN RESEARCH

HIV-1 Tat protein increases the permeability of brain endothelial cells by both inhibiting occludin expression and cleaving occludin via matrix metalloproteinase-9

(2011) Ruifen Xu et al.   BRAIN RESEARCH

Subtype selective NMDA receptor antagonists induce recovery of synapses lost following exposure to HIV-1 Tat

(2011) AH Shin et al.   BRITISH JOURNAL OF PHARMACOLOGY

Central Nervous System Immune Activation Characterizes Primary Human Immunodeficiency Virus 1 Infection Even in Participants With Minimal Cerebrospinal Fluid Viral Burden

(2011) Serena Spudich et al.   JOURNAL OF INFECTIOUS DISEASES

Alterations in brain metabolism during the first year of HIV infection

(2011) Margaret R. Lentz et al.   JOURNAL OF NEUROVIROLOGY

Prevalence of non-confounded HIV-associated neurocognitive impairment in the context of plasma HIV RNA suppression

(2011) Lucette A. Cysique et al.   JOURNAL OF NEUROVIROLOGY

HIV-1 Replication in the Central Nervous System Occurs in Two Distinct Cell Types

(2011) Gretja Schnell et al.   PLoS Pathogens

Discordance Between Cerebral Spinal Fluid and Plasma HIV Replication in Patients with Neurological Symptoms Who Are Receiving Suppressive Antiretroviral Therapy

(2010) Ana Canestri et al.   CLINICAL INFECTIOUS DISEASES

Hyperammonemia Induces Neuroinflammation That Contributes to Cognitive Impairment in Rats With Hepatic Encephalopathy

(2010) Regina Rodrigo et al.   GASTROENTEROLOGY

HIV‐1 Viral Escape in Cerebrospinal Fluid of Subjects on Suppressive Antiretroviral Treatment

(2010) Arvid Edén et al.   JOURNAL OF INFECTIOUS DISEASES

Simian Immunodeficiency Virus–Infected Macaques Treated with Highly Active Antiretroviral Therapy Have Reduced Central Nervous System Viral Replication and Inflammation but Persistence of Viral DNA

(2010) M. Christine Zink et al.   JOURNAL OF INFECTIOUS DISEASES

HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study

(2010) R. K. Heaton et al.   NEUROLOGY

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Cerebrospinal fluid neopterin: an informative biomarker of central nervous system immune activation in HIV-1 infection

(2010) Lars Hagberg et al.   AIDS Research and Therapy

Extensive astrocyte infection is prominent in human immunodeficiency virus-associated dementia

(2009) Melissa J. Churchill et al.   ANNALS OF NEUROLOGY

Microglial Physiology: Unique Stimuli, Specialized Responses

(2009) Richard M. Ransohoff et al.   Annual Review of Immunology

Persistent Intrathecal Immune Activation in HIV-1-Infected Individuals on Antiretroviral Therapy

(2009) Aylin Yilmaz et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Functions of Tat: the versatile protein of human immunodeficiency virus type 1

(2009) B. Romani et al.   JOURNAL OF GENERAL VIROLOGY

Compartmentalization and Clonal Amplification of HIV-1 Variants in the Cerebrospinal Fluid during Primary Infection

(2009) G. Schnell et al.   JOURNAL OF VIROLOGY

Changes in MRS neuronal markers and T cell phenotypes observed during early HIV infection

(2009) M. R. Lentz et al.   NEUROLOGY

HIV-1 genome-encoded hiv1-mir-H1 impairs cellular responses to infection

(2008) Deepak Kaul et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY