Insights into the HIV Latency and the Role of Cytokines

Novel Latency Reversal Agents for HIV-1 Cure

(2018) Adam M. Spivak et al.   Annual Review of Medicine

Interleukin-15-Stimulated Natural Killer Cells Clear HIV-1-Infected Cells following Latency Reversal Ex Vivo

(2018) Carolina Garrido et al.   JOURNAL OF VIROLOGY

Are microRNAs Important Players in HIV-1 Infection? An Update

(2018) Muthukumar Balasubramaniam et al.   Viruses-Basel

TGF-β inhibits IL-7-induced proliferation in memory but not naive human CD4 + T cells

(2017) Thao P. Nguyen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The Role of Transforming Growth Factor Beta-1 in the Progression of HIV/AIDS and Development of Non-AIDS-Defining Fibrotic Disorders

(2017) Annette J. Theron et al.   Frontiers in Immunology

Progress Toward HIV Eradication: Case Reports, Current Efforts, and the Challenges Associated with Cure

(2016) Alyssa R. Martin et al.   Annual Review of Medicine

Repeated Cycles of Recombinant Human Interleukin 7 in HIV-Infected Patients With Low CD4 T-Cell Reconstitution on Antiretroviral Therapy: Results of 2 Phase II Multicenter Studies

(2016) Rodolphe Thiébaut et al.   CLINICAL INFECTIOUS DISEASES

TGFβ Induces a SAMHD1-Independent Post-Entry Restriction to HIV-1 Infection of Human Epithelial Langerhans Cells

(2016) Magdalena A. Czubala et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Interferon Alpha Subtype-Specific Suppression of HIV-1 InfectionIn Vivo

(2016) Kerry J. Lavender et al.   JOURNAL OF VIROLOGY

Reversal of Latency as Part of a Cure for HIV-1

(2016) Thomas Aagaard Rasmussen et al.   TRENDS IN MICROBIOLOGY

HIV-1 Eradication: Early Trials (and Tribulations)

(2016) Adam M. Spivak et al.   TRENDS IN MOLECULAR MEDICINE

Ongoing Clinical Trials of Human Immunodeficiency Virus Latency-Reversing and Immunomodulatory Agents

(2016) Héloïse M. Delagrèverie et al.   Open Forum Infectious Diseases

CD4 T-Cell Memory Generation and Maintenance

(2014) David J. Gasper et al.   CRITICAL REVIEWS IN IMMUNOLOGY

TGF-  Inhibits IL-2 Production and Promotes Cell Cycle Arrest in TCR-Activated Effector/Memory T Cells in the Presence of Sustained TCR Signal Transduction

(2014) L. Das et al.   JOURNAL OF IMMUNOLOGY

New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo

(2014) C Korin Bullen et al.   NATURE MEDICINE

Eradicating HIV-1 infection: seeking to clear a persistent pathogen

(2014) Nancie M. Archin et al.   NATURE REVIEWS MICROBIOLOGY

Quantification of HIV-1 latency reversal in resting CD4+ T cells from patients on suppressive antiretroviral therapy

(2014) A. R. Cillo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How Might We Cure HIV?

(2014) David M. Margolis   Current Infectious Disease Reports

Interleukin-7 promotes HIV persistence during antiretroviral therapy

(2013) C. Vandergeeten et al.   BLOOD

Replication-Competent Noninduced Proviruses in the Latent Reservoir Increase Barrier to HIV-1 Cure

(2013) Ya-Chi Ho et al.   CELL

Dicer's role as an antiviral: still an enigma

(2013) Christopher R MacKay et al.   CURRENT OPINION IN IMMUNOLOGY

Reactivation of latent HIV: do all roads go through P-TEFb?

(2013) Sona Budhiraja et al.   Future Virology

Effects of Recombinant Human Interleukin 7 on T-Cell Recovery and Thymic Output in HIV-Infected Patients Receiving Antiretroviral Therapy: Results of a Phase I/IIa Randomized, Placebo-Controlled, Multicenter Study

(2012) Y. Lévy et al.   CLINICAL INFECTIOUS DISEASES

Targeting HIV latency: pharmacologic strategies toward eradication

(2012) Sifei Xing et al.   DRUG DISCOVERY TODAY

Redefining the Viral Reservoirs that Prevent HIV-1 Eradication

(2012) Evelyn Eisele et al.   IMMUNITY

Unknown

(2012) Mudit Tyagi et al.   MOLECULAR MEDICINE

Shock and kill

(2012) Steven G. Deeks   NATURE

New and novel intrinsic host repressive factors against HIV-1: PAF1 complex, HERC5 and others

(2012) Mudit Tyagi et al.   Retrovirology

An “Escape Clock” for Estimating the Turnover of SIV DNA in Resting CD4+ T Cells

(2012) Jeanette Reece et al.   PLoS Pathogens

Curing HIV: Pharmacologic Approaches to Target HIV-1 Latency

(2011) Shailesh K. Choudhary et al.   Annual Review of Pharmacology and Toxicology

T-Cell Receptor Signaling Enhances Transcriptional Elongation from Latent HIV Proviruses by Activating P-TEFb through an ERK-Dependent Pathway

(2011) Young Kyeung Kim et al.   JOURNAL OF MOLECULAR BIOLOGY

Epigenetic Silencing of HIV-1 by the Histone H3 Lysine 27 Methyltransferase Enhancer of Zeste 2

(2011) J. Friedman et al.   JOURNAL OF VIROLOGY

Establishment of HIV Latency in Primary CD4+ Cells Is due to Epigenetic Transcriptional Silencing and P-TEFb Restriction

(2010) M. Tyagi et al.   JOURNAL OF VIROLOGY

Maintenance of CD4+ T-cell memory and HIV persistence: keeping memory, keeping HIV

(2010) Nicolas Chomont et al.   Current Opinion in HIV and AIDS

Zoledronic acid and interleukin-2 treatment improves immunocompetence in HIV-infected persons by activating Vγ9Vδ2 T cells

(2009) Fabrizio Poccia et al.   AIDS

IL-7 administration drives T cell-cycle entry and expansion in HIV-1 infection

(2009) I. Sereti et al.   BLOOD

Stochastic gene expression as a molecular switch for viral latency

(2009) Abhyudai Singh et al.   CURRENT OPINION IN MICROBIOLOGY

Homeostatic proliferation and survival of naïve and memory T cells

(2009) Onur Boyman et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Enhanced T cell recovery in HIV-1–infected adults through IL-7 treatment

(2009) Yves Levy et al.   JOURNAL OF CLINICAL INVESTIGATION

HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation

(2009) Nicolas Chomont et al.   NATURE MEDICINE

The Challenge of Finding a Cure for HIV Infection

(2009) D. D. Richman et al.   SCIENCE

Orientation-Dependent Regulation of Integrated HIV-1 Expression by Host Gene Transcriptional Readthrough

(2008) Yefei Han et al.   Cell Host & Microbe

Transcriptional Interference Antagonizes Proviral Gene Expression to Promote HIV Latency

(2008) Tina Lenasi et al.   Cell Host & Microbe

Homeostasis of Naive and Memory T Cells

(2008) Charles D. Surh et al.   IMMUNITY

Epigenetic Silencing of Human Immunodeficiency Virus (HIV) Transcription by Formation of Restrictive Chromatin Structures at the Viral Long Terminal Repeat Drives the Progressive Entry of HIV into Latency

(2008) R. Pearson et al.   JOURNAL OF VIROLOGY

Differential effects of phorbol-13-monoesters on human immunodeficiency virus reactivation

(2007) Nieves Márquez et al.   BIOCHEMICAL PHARMACOLOGY