Genetic deletion of α7 nicotinic acetylcholine receptors induces an age-dependent Alzheimer’s disease-like pathology

Reactive astrocyte nomenclature, definitions, and future directions

(2021) Carole Escartin et al.   NATURE NEUROSCIENCE

Tau is not necessary for amyloid-beta–induced synaptic and memory impairments

(2020) Daniela Puzzo et al.   JOURNAL OF CLINICAL INVESTIGATION

Recurrent herpes simplex virus-1 infection induces hallmarks of neurodegeneration and cognitive deficits in mice

(2019) Giovanna De Chiara et al.   PLoS Pathogens

Pathological Tau From Alzheimer’s Brain Induces Site-Specific Hyperphosphorylation and SDS- and Reducing Agent-Resistant Aggregation of Tau in vivo

(2019) Jin Miao et al.   Frontiers in Aging Neuroscience

Neuromodulatory action of picomolar extracellular Aβ42 oligomers on pre- and postsynaptic mechanisms underlying synaptic function and memory

(2019) Walter Gulisano et al.   JOURNAL OF NEUROSCIENCE

Herpes Simplex Virus Type-1 Infection Impairs Adult Hippocampal Neurogenesis via Amyloid-β Protein Accumulation

(2019) Domenica Donatella Li Puma et al.   STEM CELLS

Amyloid, APP, and Electrical Activity of the Brain

(2019) Dimitri Hefter et al.   NEUROSCIENTIST

A Study of Amyloid-β and Phosphotau in Plaques and Neurons in the Hippocampus of Alzheimer’s Disease Patients

(2018) Diana Furcila et al.   JOURNAL OF ALZHEIMERS DISEASE

The effect of amyloid-β peptide on synaptic plasticity and memory is influenced by different isoforms, concentrations and aggregation status

(2018) Walter Gulisano et al.   NEUROBIOLOGY OF AGING

Phosphorylation of different tau sites during progression of Alzheimer’s disease

(2018) Joerg Neddens et al.   Acta Neuropathologica Communications

Heterogeneity of Astrocytic and Neuronal GLT-1 at Cortical Excitatory Synapses, as Revealed by its Colocalization With Na+/K+-ATPase α Isoforms

(2018) Marcello Melone et al.   CEREBRAL CORTEX

The Presence and Origin of Autoantibodies Against α4 and α7 Nicotinic Acetylcholine Receptors in the Human Blood: Possible Relevance to Alzheimer's Pathology

(2018) Lyudmyla Koval et al.   JOURNAL OF ALZHEIMERS DISEASE

Picomolar Amyloid-β Peptides Enhance Spontaneous Astrocyte Calcium Transients

(2018) Linda Lee et al.   JOURNAL OF ALZHEIMERS DISEASE

Modulation of astrocyte reactivity improves functional deficits in mouse models of Alzheimer’s disease

(2018) Kelly Ceyzériat et al.   Acta Neuropathologica Communications

Anti-inflammatory effects of astroglial α7 nicotinic acetylcholine receptors are mediated by inhibition of the NF-κB pathway and activation of the Nrf2 pathway

(2017) Hiral Patel et al.   Journal of Neuroinflammation

Amyloid-β Peptide Is Needed for cGMP-Induced Long-Term Potentiation and Memory

(2017) Agostino Palmeri et al.   JOURNAL OF NEUROSCIENCE

Human Brain-Derived Aβ Oligomers Bind to Synapses and Disrupt Synaptic Activity in a Manner That Requires APP

(2017) Zemin Wang et al.   JOURNAL OF NEUROSCIENCE

LTP and memory impairment caused by extracellular Aβ and Tau oligomers is APP-dependent

(2017) Daniela Puzzo et al.   eLife

Involvement of Astrocytes in Alzheimer’s Disease from a Neuroinflammatory and Oxidative Stress Perspective

(2017) Rodrigo E. González-Reyes et al.   Frontiers in Molecular Neuroscience

Physiological Concentrations of Amyloid Beta Regulate Recycling of Synaptic Vesicles via Alpha7 Acetylcholine Receptor and CDK5/Calcineurin Signaling

(2017) Vesna Lazarevic et al.   Frontiers in Molecular Neuroscience

Amyloid β-Exposed Human Astrocytes Overproduce Phospho-Tau and Overrelease It within Exosomes, Effects Suppressed by Calcilytic NPS 2143—Further Implications for Alzheimer's Therapy

(2017) Anna Chiarini et al.   Frontiers in Neuroscience

Tau oligomers in cerebrospinal fluid in Alzheimer's disease

(2017) Urmi Sengupta et al.   Annals of Clinical and Translational Neurology

A Physiological Role for Amyloid-β Protein: Enhancement of Learning and Memory

(2017) John E. Morley et al.   JOURNAL OF ALZHEIMERS DISEASE

Non-Demented Individuals with Alzheimer's Disease Neuropathology: Resistance to Cognitive Decline May Reveal New Treatment Strategies

(2016) Olga Zolochevska et al.   CURRENT PHARMACEUTICAL DESIGN

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Astrocyte calcium signaling: the third wave

(2016) Narges Bazargani et al.   NATURE NEUROSCIENCE

APP Receptor? To Be or Not To Be

(2016) Carole Deyts et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Mechanisms of Aβ Clearance and Degradation by Glial Cells

(2016) Miriam Ries et al.   Frontiers in Aging Neuroscience

Extracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory

(2016) M. Fá et al.   Scientific Reports

Time-dependent reversal of synaptic plasticity induced by physiological concentrations of oligomeric Aβ42: an early index of Alzheimer’s disease

(2016) Peter Koppensteiner et al.   Scientific Reports

Extracellular association of APP and tau fibrils induces intracellular aggregate formation of tau

(2015) Muneaki Takahashi et al.   ACTA NEUROPATHOLOGICA

The aqueous phase of Alzheimer's disease brain contains assemblies built from ∼4 and ∼7 kDa Aβ species

(2015) Jessica M. Mc Donald et al.   Alzheimers & Dementia

The effect of α7 nicotinic receptor activation on glutamatergic transmission in the hippocampus

(2015) Qing Cheng et al.   BIOCHEMICAL PHARMACOLOGY

Amyloid-β dimers in the absence of plaque pathology impair learning and synaptic plasticity

(2015) Andreas Müller-Schiffmann et al.   BRAIN

The case for rejecting the amyloid cascade hypothesis

(2015) Karl Herrup   NATURE NEUROSCIENCE

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

Role of F3/contactin expression profile in synaptic plasticity and memory in aged mice

(2015) Daniela Puzzo et al.   NEUROBIOLOGY OF AGING

The keystone of Alzheimer pathogenesis might be sought in Aβ physiology

(2015) D. Puzzo et al.   NEUROSCIENCE

Astrocytes in Neurodegenerative Disease: Table 1.

(2015) Hemali Phatnani et al.   Cold Spring Harbor Perspectives in Biology

α7 Nicotinic Acetylcholine Receptor-Specific Antibody Induces Inflammation and Amyloid β42 Accumulation in the Mouse Brain to Impair Memory

(2015) Olena Lykhmus et al.   PLoS One

A novel mechanism for cyclic adenosine monophosphate-mediated memory formation: Role of amyloid beta

(2014) Roberta Ricciarelli et al.   ANNALS OF NEUROLOGY

Behavioral assays with mouse models of Alzheimer's disease: Practical considerations and guidelines

(2014) Daniela Puzzo et al.   BIOCHEMICAL PHARMACOLOGY

Regulation of Presynaptic Ca2+, Synaptic Plasticity and Contextual Fear Conditioning by a N-terminal  -Amyloid Fragment

(2014) J. L. M. Lawrence et al.   JOURNAL OF NEUROSCIENCE

Nicotinic ACh receptors in the hippocampal circuit; functional expression and role in synaptic plasticity

(2014) Jerrel L. Yakel   JOURNAL OF PHYSIOLOGY-LONDON

Deep brain stimulation of the nucleus basalis of Meynert in Alzheimer’s dementia

(2014) J Kuhn et al.   MOLECULAR PSYCHIATRY

Deficits of synaptic functions in hippocampal slices prepared from aged mice null α7 nicotinic acetylcholine receptors

(2014) Luyao Ma et al.   NEUROSCIENCE LETTERS

APP Homodimers Transduce an Amyloid-β-Mediated Increase in Release Probability at Excitatory Synapses

(2014) Hilla Fogel et al.   Cell Reports

A review on cholinesterase inhibitors for Alzheimer’s disease

(2013) Preet Anand et al.   ARCHIVES OF PHARMACAL RESEARCH

On the Interaction of β-Amyloid Peptides and α7-Nicotinic Acetylcholine Receptors in Alzheimer’s Disease

(2013) Murat Oz et al.   Current Alzheimer Research

Effect of phosphodiesterase-5 inhibition on apoptosis and beta amyloid load in aged mice

(2013) Daniela Puzzo et al.   NEUROBIOLOGY OF AGING

Phosphorylation of tau protein at sites Ser396-404is one of the earliest events in Alzheimer's disease and Down syndrome

(2013) S. Mondragón-Rodríguez et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Evaluating Amyloid-β Oligomers in Cerebrospinal Fluid as a Biomarker for Alzheimer’s Disease

(2013) Mikko Hölttä et al.   PLoS One

α7 Nicotinic Receptor-Mediated Astrocytic Gliotransmitter Release: Aβ Effects in a Preclinical Alzheimer’s Mouse Model

(2013) Tiina Maria Pirttimaki et al.   PLoS One

Amyloid imaging in cognitively normal individuals, at-risk populations and preclinical Alzheimer's disease

(2013) Gaël Chételat et al.   NeuroImage-Clinical

Identification of oligomers at early stages of tau aggregation in Alzheimer's disease

(2012) Cristian A. Lasagna-Reeves et al.   FASEB JOURNAL

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

(2012) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Dual Effect of Beta-Amyloid on α7 and α4β2 Nicotinic Receptors Controlling the Release of Glutamate, Aspartate and GABA in Rat Hippocampus

(2012) Elisa Mura et al.   PLoS One

The effect of amyloid associated proteins on the expression of genes involved in amyloid-β clearance by adult human astrocytes

(2011) Sandra D. Mulder et al.   EXPERIMENTAL NEUROLOGY

Post-translational modifications of tau protein: Implications for Alzheimer's disease

(2011) Ludovic Martin et al.   NEUROCHEMISTRY INTERNATIONAL

Requirement of α7 nicotinic acetylcholine receptors for amyloid beta protein-induced depression of hippocampal long-term potentiation in CA1 region of rats in vivo

(2011) Shao-Feng Li et al.   SYNAPSE

Endogenous amyloid-β is necessary for hippocampal synaptic plasticity and memory

(2010) Daniela Puzzo et al.   ANNALS OF NEUROLOGY

The presence of sodium dodecyl sulphate-stable Aβ dimers is strongly associated with Alzheimer-type dementia

(2010) Jessica M. Mc Donald et al.   BRAIN

Activation of α7 nicotinic receptor affects APP processing by regulating secretase activity in SH-EP1-α7 nAChR-hAPP695 cells

(2010) Hui Zhen Nie et al.   BRAIN RESEARCH

Layer-specific alterations to CA1 dendritic spines in a mouse model of Alzheimer's disease

(2010) P. Merino-Serrais et al.   HIPPOCAMPUS

Loss of  7 Nicotinic Receptors Enhances  -Amyloid Oligomer Accumulation, Exacerbating Early-Stage Cognitive Decline and Septohippocampal Pathology in a Mouse Model of Alzheimer's Disease

(2010) C. M. Hernandez et al.   JOURNAL OF NEUROSCIENCE

GLT-1 promoter activity in astrocytes and neurons of mouse hippocampus and somatic sensory cortex

(2010) Luisa de Vivo   Frontiers in Neuroanatomy

Selective α7 nicotinic acetylcholine receptor activation regulates glycogen synthase kinase3β and decreases tau phosphorylation in vivo

(2009) Robert S. Bitner et al.   BRAIN RESEARCH

Neuronal death in Alzheimer’s disease and therapeutic opportunities

(2009) Rossen Donev et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Picomolar Amyloid-  Positively Modulates Synaptic Plasticity and Memory in Hippocampus

(2009) D. Puzzo et al.   JOURNAL OF NEUROSCIENCE

Amyloid beta mediates memory formation

(2009) A. Garcia-Osta et al.   LEARNING & MEMORY

The Nun Study: Clinically silent AD, neuronal hypertrophy, and linguistic skills in early life

(2009) D. Iacono et al.   NEUROLOGY

Nicotinic Acetylcholine Receptor Signalling: Roles in Alzheimer's Disease and Amyloid Neuroprotection

(2009) S. D. Buckingham et al.   PHARMACOLOGICAL REVIEWS

Role of GSK-3 activation and 7 nAChRs in A142-induced tau phosphorylation in PC12 cells

(2008) Min Hu et al.   JOURNAL OF NEUROCHEMISTRY

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Nicotinic receptor agonists and antagonists increase sAPPα secretion and decrease Aβ levels in vitro

(2008) M. Mousavi et al.   NEUROCHEMISTRY INTERNATIONAL

Mechanisms of glutamate release from astrocytes

(2007) Erik B. Malarkey et al.   NEUROCHEMISTRY INTERNATIONAL