Obesity-induced changes in human islet G protein-coupled receptor expression: Implications for metabolic regulation

Changes over 15 years in the contribution of adiposity and smoking to deaths in England and Scotland

(2021) Frederick K. Ho et al.   BMC PUBLIC HEALTH

Oral Semaglutide Reduces HbA1c and Body Weight in Patients with Type 2 Diabetes Regardless of Background Glucose-Lowering Medication: PIONEER Subgroup Analyses

(2021) Richard E. Pratley et al.   Diabetes Therapy

GPR52 Accelerates Fatty Acid Biosynthesis In a Ligand-dependent Manner in Hepatocytes and In Response to Excessive Fat Intake in Mice

(2021) Mitsuo Wada et al.   iScience

Hydrocarboxylic acid receptor 1 in BAT regulates glucose uptake in mice fed a high-fat diet

(2020) Eunjin Kwon et al.   PLoS One

Novel CB1 receptor antagonist BAR-1 modifies pancreatic islet function and clinical parameters in prediabetic and diabetic mice

(2020) Lesly Nava-Molina et al.   Nutrition & Diabetes

Hedgehog and Gpr161: Regulating cAMP Signaling in the Primary Cilium

(2020) Philipp Tschaikner et al.   Cells

Secretory Functions of Macrophages in the Human Pancreatic Islet Are Regulated by Endogenous Purinergic Signaling

(2020) Jonathan R. Weitz et al.   DIABETES

The repertoire of Adhesion G protein-coupled receptors in adipocytes and their functional relevance

(2020) Tomáš Suchý et al.   INTERNATIONAL JOURNAL OF OBESITY

Obesity-induced overexpression of miR-802 impairs insulin transcription and secretion

(2020) Fangfang Zhang et al.   Nature Communications

Bioinformatics Analysis of Prognostic Tumor Microenvironment-Related Genes in the Tumor Microenvironment of Hepatocellular Carcinoma

(2020) Zongbiao Tian et al.   MEDICAL SCIENCE MONITOR

GLP-1 Analogs and DPP-4 Inhibitors in Type 2 Diabetes Therapy: Review of Head-to-Head Clinical Trials

(2020) Matthew P. Gilbert et al.   Frontiers in Endocrinology

β-Arrestin-2-Dependent Mechanism of GPR52 Signaling in Frontal Cortical Neurons

(2020) Cassandra J. Hatzipantelis et al.   ACS Chemical Neuroscience

Is GPR146 really the receptor for proinsulin C-peptide?

(2020) Lina Lindfors et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Islet inflammation is associated with pancreatic fatty infiltration and hyperglycemia in type 2 diabetes

(2020) Tomomi Horii et al.   BMJ Open Diabetes Research & Care

Leptin modulates pancreatic β-cell membrane potential through Src kinase-mediated phosphorylation of NMDA receptors

(2020) Veronica A. Cochrane et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of the CCL25-CCR9 axis in beta-cell function: potential for therapeutic intervention in type 2 diabetes

(2020) Patricio Atanes et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Violet-light suppression of thermogenesis by opsin 5 hypothalamic neurons

(2020) Kevin X. Zhang et al.   NATURE

Wntless regulates lipogenic gene expression in adipocytes and protects against diet-induced metabolic dysfunction

(2020) Devika P. Bagchi et al.   Molecular Metabolism

Tributyrin Attenuates Metabolic and Inflammatory Changes Associated with Obesity through a GPR109A-Dependent Mechanism

(2020) Fabio Takeo Sato et al.   Cells

Adipose Tissue Lipokines: Recent Progress and Future Directions

(2020) Veronica L. Li et al.   DIABETES

Vasopressin receptors in islets enhance glucose tolerance, pancreatic beta-cell secretory function, proliferation and survival

(2019) Shruti Mohan et al.   BIOCHIMIE

Obesity alters adrenergic and chemosensory signaling pathways that regulate ghrelin secretion in the human gut

(2019) Qiaoling Wang et al.   FASEB JOURNAL

Opposing Actions of Adrenocorticotropic Hormone and Glucocorticoids on UCP1-Mediated Respiration in Brown Adipocytes

(2019) Katharina Schnabl et al.   Frontiers in Physiology

CCR9 Expressing T Helper and T Follicular Helper Cells Exhibit Site-Specific Identities During Inflammatory Disease

(2019) Ilaria Cosorich et al.   Frontiers in Immunology

Adhesion G-protein coupled receptors: Implications for metabolic function

(2019) Oladapo E. Olaniru et al.   PHARMACOLOGY & THERAPEUTICS

Chemerin Isoforms and Activity in Obesity

(2019) Christa Buechler et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The neuropeptide 26RFa (QRFP) is a key regulator of glucose homeostasis and its activity is markedly altered in obese/hyperglycemic mice

(2019) Gaëtan Prévost et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Hyperglycemia Triggered S1P/S1 PR 3 Signaling Worsens Liver Ischemia/Reperfusion Injury by Regulating M1/M2 Polarization

(2019) Yuanchang Hu et al.   LIVER TRANSPLANTATION

MRGPRX4 is a G protein-coupled receptor activated by bile acids that may contribute to cholestatic pruritus

(2019) James Meixiong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Adverse Effects of Thyrotropin Absence on Pancreatic β Cell Function in Mice

(2019) Yu Yang et al.   Journal of Diabetes Research

The Bile Acid TUDCA Improves Beta-Cell Mass and Reduces Insulin Degradation in Mice With Early-Stage of Type-1 Diabetes

(2019) Gabriela Alves Bronczek et al.   Frontiers in Physiology

What role do fat cells play in pancreatic tissue?

(2019) Felicia Gerst et al.   Molecular Metabolism

Plasma lactate as a marker of metabolic health: Implications of elevated lactate for impairment of aerobic metabolism in the metabolic syndrome

(2019) Terry E. Jones et al.   SURGERY

Oxytocin and Vasopressin Systems in Obesity and Metabolic Health: Mechanisms and Perspectives

(2019) Cherlyn Ding et al.   Current Obesity Reports

Adipose tissue–derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases

(2019) Ioannis Akoumianakis et al.   Science Translational Medicine

CXCL13 is a differentiation- and hypoxia-induced adipocytokine that exacerbates the inflammatory phenotype of adipocytes through PHLPP1 induction

(2019) Joji Kusuyama et al.   BIOCHEMICAL JOURNAL

Neuromedin U suppresses insulin secretion by triggering mitochondrial dysfunction and endoplasmic reticulum stress in pancreatic β‐cells

(2019) Weidong Zhang et al.   FASEB JOURNAL

Adipsin preserves beta cells in diabetic mice and associates with protection from type 2 diabetes in humans

(2019) Nicolás Gómez-Banoy et al.   NATURE MEDICINE

Small-Molecule Lysophosphatidic Acid Receptor 5 (LPAR5) Antagonists: Versatile Pharmacological Tools to Regulate Inflammatory Signaling in BV-2 Microglia Cells

(2019) Ioanna Plastira et al.   Frontiers in Cellular Neuroscience

Blockade of multiple monoamines receptors reduce insulin secretion from pancreatic β-cells

(2019) Mao Nagata et al.   Scientific Reports

l-DOPA and Its Receptor GPR143: Implications for Pathogenesis and Therapy in Parkinson’s Disease

(2019) Yoshio Goshima et al.   Frontiers in Pharmacology

New roles for prokineticin 2 in feeding behavior, insulin resistance and type 2 diabetes: Studies in mice and humans

(2019) Marie Mortreux et al.   Molecular Metabolism

Phoenixin-14 stimulates proliferation and insulin secretion in insulin producing INS-1E cells

(2019) Maria Billert et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Serotonin Regulates Adult β-Cell Mass by Stimulating Perinatal β-Cell Proliferation

(2019) Joon Ho Moon et al.   DIABETES

Projected U.S. State-Level Prevalence of Adult Obesity and Severe Obesity

(2019) Zachary J. Ward et al.   NEW ENGLAND JOURNAL OF MEDICINE

Proresolving protein Annexin A1: The role in type 2 diabetes mellitus and obesity

(2018) Nathalia T. Pietrani et al.   BIOMEDICINE & PHARMACOTHERAPY

The adhesion receptor GPR56 is activated by extracellular matrix collagen III to improve β-cell function

(2018) Oladapo E. Olaniru et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Identifying Signalling Pathways Regulated by GPRC5B in β-Cells by CRISPR-Cas9-Mediated Genome Editing

(2018) Patricio Atanes et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

SDF-1 Is an Autocrine Insulin-Desensitizing Factor in Adipocytes

(2018) Jihoon Shin et al.   DIABETES

Decreased Serum Relaxin-2 Is Correlated with Impaired Islet β-Cell Function in Patients with Unstable Angina and Abnormal Glucose Metabolism

(2018) Xiangyu Gao et al.   International Heart Journal

The Zinc Sensing Receptor, ZnR/GPR39, in Health and Disease

(2018) Michal Hershfinkel   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

G Protein-Coupled Receptors as Targets for Approved Drugs: How Many Targets and How Many Drugs?

(2018) Krishna Sriram et al.   MOLECULAR PHARMACOLOGY

DP1 receptor agonist, BW245C inhibits diet-induced obesity in ApoE −/− mice

(2018) Sunil Kumar et al.   Obesity Research & Clinical Practice

Apelin-13 analogues show potent in vitro and in vivo insulinotropic and glucose lowering actions

(2018) F.P.M. O’Harte et al.   PEPTIDES

Lysophosphatidic Acid Signaling in Obesity and Insulin Resistance

(2018) et al.   Nutrients

Thyroid stimulating hormone stimulates the expression of glucose transporter 2 via its receptor in pancreatic β cell line, INS-1 cells

(2018) Jingya Lyu et al.   Scientific Reports

Lipidized prolactin-releasing peptide improved glucose tolerance in metabolic syndrome: Koletsky and spontaneously hypertensive rat study

(2018) Barbora Mikulášková et al.   Nutrition & Diabetes

The Role of Apelin in Cardiovascular Diseases, Obesity and Cancer

(2018) Marta B. Wysocka et al.   Frontiers in Physiology

Identifying novel therapeutic targets for diabetes through improved understanding of islet adhesion receptors

(2018) Oladapo E Olaniru et al.   CURRENT OPINION IN PHARMACOLOGY

Long-term treatment with acylated analogues of apelin-13 amide ameliorates diabetes and improves lipid profile of high-fat fed mice

(2018) Finbarr P. M. O’Harte et al.   PLoS One

Elevated G-Protein Receptor 125 (GPR125) Expression Predicts Good Outcomes in Colorectal Cancer and Inhibits Wnt/β-Catenin Signaling Pathway

(2018) Yibin Wu et al.   MEDICAL SCIENCE MONITOR

Intestinal bitter taste receptor activation alters hormone secretion and imparts metabolic benefits

(2018) Bernard P. Kok et al.   Molecular Metabolism

Association of Vitamin D and Parathyroid Hormone with Insulin Sensitivity, Beta Cell Function and Gestational Diabetes in Pregnancy: A Cross-Sectional, Observational Study

(2018) Amit Nachankar et al.   Diabetes Therapy

GLP-1RAs in type 2 diabetes: mechanisms that underlie cardiovascular effects and overview of cardiovascular outcome data

(2018) Andrei C. Sposito et al.   Cardiovascular Diabetology

Adipose tissue expression of CCL19 chemokine is positively associated with insulin resistance

(2018) Shihab Kochumon et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Prostaglandin E2/EP2 receptor signalling pathway promotes diabetic retinopathy in a rat model of diabetes

(2018) Man Wang et al.   DIABETOLOGIA

Thrombin promotes diet-induced obesity through fibrin-driven inflammation

(2017) Anna K. Kopec et al.   JOURNAL OF CLINICAL INVESTIGATION

Orphan Gpr182 suppresses ERK-mediated intestinal proliferation during regeneration and adenoma formation

(2017) Daniel O. Kechele et al.   JOURNAL OF CLINICAL INVESTIGATION

Beta 2-adrenergic receptor agonists are novel regulators of macrophage activation in diabetic renal and cardiovascular complications

(2017) Hyunjin Noh et al.   KIDNEY INTERNATIONAL

Trends in GPCR drug discovery: new agents, targets and indications

(2017) Alexander S. Hauser et al.   NATURE REVIEWS DRUG DISCOVERY

Phoenixin is negatively associated with anxiety in obese men

(2017) Tobias Hofmann et al.   PEPTIDES

Impact of novel palmitoylated prolactin-releasing peptide analogs on metabolic changes in mice with diet-induced obesity

(2017) Veronika Pražienková et al.   PLoS One

Hydroxy-Carboxylic Acid Receptor Actions in Metabolism

(2017) Stefan Offermanns   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Visualizing the GPCR Network: Classification and Evolution

(2017) Geng-Ming Hu et al.   Scientific Reports

A comparative analysis of human and mouse islet G-protein coupled receptor expression

(2017) Stefan Amisten et al.   Scientific Reports

A bitter pill for type 2 diabetes? The activation of bitter taste receptor TAS2R38 can stimulate GLP-1 release from enteroendocrine L-cells

(2016) Hung Pham et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Microarray analysis of transcripts with elevated expressions in the rat medial or lateral habenula suggest fast GABAergic excitation in the medial habenula and habenular involvement in the regulation of feeding and energy balance

(2016) Franziska Wagner et al.   Brain Structure & Function

Adiponectin, Leptin, and Fatty Acids in the Maintenance of Metabolic Homeostasis through Adipose Tissue Crosstalk

(2016) Jennifer H. Stern et al.   Cell Metabolism

Oxytocin Improves β-Cell Responsivity and Glucose Tolerance in Healthy Men

(2016) Johanna Klement et al.   DIABETES

Serotonin (5-HT) receptor 2b activation augments glucose-stimulated insulin secretion in human and mouse islets of Langerhans

(2016) Hedvig Bennet et al.   DIABETOLOGIA

Blockade of Sphingosine 1-Phosphate Receptor 2 Signaling Attenuates High-Fat Diet-Induced Adipocyte Hypertrophy and Systemic Glucose Intolerance in Mice

(2016) Yoshihiko Kitada et al.   ENDOCRINOLOGY

‘Globesity’? The effects of globalization on obesity and caloric intake

(2016) Joan Costa-Font et al.   FOOD POLICY

Niacin receptor GPR109A inhibits insulin secretion and is down-regulated in type 2 diabetic islet beta-cells

(2016) Na Wang et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

CCR1 antagonism attenuates T cell trafficking to omentum and liver in obesity-associated cancer

(2016) Melissa J Conroy et al.   IMMUNOLOGY AND CELL BIOLOGY

Oxytocin’s inhibitory effect on food intake is stronger in obese than normal-weight men

(2016) M Thienel et al.   INTERNATIONAL JOURNAL OF OBESITY

Adhesion G Protein-Coupled Receptor G1 (ADGRG1/GPR56) and Pancreatic β-Cell Function

(2016) Pontus Dunér et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Prolactin-releasing peptide: a new tool for obesity treatment

(2016) Jaroslav Kuneš et al.   JOURNAL OF ENDOCRINOLOGY

Targeting orphan G protein-coupled receptors for the treatment of diabetes and its complications: C-peptide and GPR146

(2016) G. R. Kolar et al.   JOURNAL OF INTERNAL MEDICINE

The bile acid TUDCA increases glucose-induced insulin secretion via the cAMP/PKA pathway in pancreatic beta cells

(2016) Jean Franciesco Vettorazzi et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Hypoxic Exercise Training Promotes apelin/APJ Expression in Skeletal Muscles of High Fat Diet-Induced Obese Mice

(2016) Weixiu Ji et al.   PROTEIN AND PEPTIDE LETTERS

Orphan GPR110 (ADGRF1) targeted by N-docosahexaenoylethanolamine in development of neurons and cognitive function

(2016) Ji-Won Lee et al.   Nature Communications

Critical role of the C5a-activated neutrophils in high-fat diet-induced vascular inflammation

(2016) Mizuko Osaka et al.   Scientific Reports

Regulating the effects of GPR21, a novel target for type 2 diabetes

(2016) Siobhán Leonard et al.   Scientific Reports

Adipose- and muscle-derived Wnts trigger pancreatic β-cell adaptation to systemic insulin resistance

(2016) Kamil Kozinski et al.   Scientific Reports

The G protein-coupled receptor GPR157 regulates neuronal differentiation of radial glial progenitors through the Gq-IP3 pathway

(2016) Yutaka Takeo et al.   Scientific Reports

Human Beta Cells Produce and Release Serotonin to Inhibit Glucagon Secretion from Alpha Cells

(2016) Joana Almaça et al.   Cell Reports

The Neuropeptide 26RFa (QRFP) and Its Role in the Regulation of Energy Homeostasis: A Mini-Review

(2016) Nicolas Chartrel et al.   Frontiers in Neuroscience

Novel Zn2+ Modulated GPR39 Receptor Agonists Do Not Drive Acute Insulin Secretion in Rodents

(2016) Ola Fjellström et al.   PLoS One

High-fat diet decreases energy expenditure and expression of genes controlling lipid metabolism, mitochondrial function and skeletal system development in the adipose tissue, along with increased expression of extracellular matrix remodelling- and inflammation-related genes

(2015) Myung-Sook Choi et al.   BRITISH JOURNAL OF NUTRITION

Hypothalamic Neuropeptide 26RFa Acts as an Incretin to Regulate Glucose Homeostasis

(2015) Gaëtan Prévost et al.   DIABETES

Vasopressin and hydration play a major role in the development of glucose intolerance and hepatic steatosis in obese rats

(2015) Christopher Taveau et al.   DIABETOLOGIA

Sphingosine 1-phosphate counteracts insulin signaling in pancreatic β-cells via the sphingosine 1-phosphate receptor subtype 2

(2015) Lukasz Japtok et al.   FASEB JOURNAL

Prostaglandin profiling reveals a role for haematopoietic prostaglandin D synthase in adipose tissue macrophage polarisation in mice and humans

(2015) S Virtue et al.   INTERNATIONAL JOURNAL OF OBESITY

Orphan Receptor GPR158 Is an Allosteric Modulator of RGS7 Catalytic Activity with an Essential Role in Dictating Its Expression and Localization in the Brain

(2015) Cesare Orlandi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of A-971432, An Orally Bioavailable Selective Sphingosine-1-Phosphate Receptor 5 (S1P5) Agonist for the Potential Treatment of Neurodegenerative Disorders

(2015) Adrian D. Hobson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Thyrotropin and Obesity: Increased Adipose Triglyceride Content Through Glycerol-3-Phosphate Acyltransferase 3

(2015) Shizhan Ma et al.   Scientific Reports

Two Birds with One Stone: Possible Dual-Role of Oxytocin in the Treatment of Diabetes and Osteoporosis

(2015) Seham Elabd et al.   Frontiers in Endocrinology

Neuropeptide Y in the noradrenergic neurones induces obesity and inhibits sympathetic tone in mice

(2014) L. H. Vähätalo et al.   Acta Physiologica

The apelin receptor: physiology, pathology, cell signalling, and ligand modulation of a peptide-activated class A GPCR

(2014) Nigel A. Chapman et al.   Biochemistry and Cell Biology

Induction of insulin secretion by apolipoprotein M, a carrier for sphingosine 1-phosphate

(2014) Makoto Kurano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Adipsin Is an Adipokine that Improves β Cell Function in Diabetes

(2014) James C. Lo et al.   CELL

Circulating Apelin is increased in patients with type 1 or type 2 diabetes and is associated with better glycaemic control

(2014) Marana Habchi et al.   CLINICAL ENDOCRINOLOGY

Temperature-Acclimated Brown Adipose Tissue Modulates Insulin Sensitivity in Humans

(2014) Paul Lee et al.   DIABETES

CXCL12 secreted from adipose tissue recruits macrophages and induces insulin resistance in mice

(2014) Dayea Kim et al.   DIABETOLOGIA

The G Protein-coupled Receptor P2Y14Influences Insulin Release and Smooth Muscle Function in Mice

(2014) Jaroslawna Meister et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss

(2014) Anna Secher et al.   JOURNAL OF CLINICAL INVESTIGATION

Increased serum CXCL1 and CXCL5 are linked to obesity, hyperglycemia, and impaired islet function

(2014) Craig S Nunemaker et al.   JOURNAL OF ENDOCRINOLOGY

Gpr1 is an active chemerin receptor influencing glucose homeostasis in obese mice

(2014) Jillian L Rourke et al.   JOURNAL OF ENDOCRINOLOGY

Expression of orphan receptors GPR22 and GPR162 in streptozotocin-induced diabetic rats

(2014) Armando Ruiz-Hernández et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Type IV collagen is an activating ligand for the adhesion G protein-coupled receptor GPR126

(2014) K. J. Paavola et al.   Science Signaling

Autonomic regulation of brown adipose tissue thermogenesis in health and disease: potential clinical applications for altering BAT thermogenesis

(2014) Domenico Tupone et al.   Frontiers in Neuroscience

The ω6-fatty acid, arachidonic acid, regulates the conversion of white to brite adipocyte through a prostaglandin/calcium mediated pathway

(2014) Didier F. Pisani et al.   Molecular Metabolism

Propionic acid and butyric acid inhibit lipolysis and de novo lipogenesis and increase insulin-stimulated glucose uptake in primary rat adipocytes

(2014) Emilia Heimann et al.   Adipocyte

Involvement of autotaxin/lysophosphatidic acid signaling in obesity and impaired glucose homeostasis

(2013) Chloé Rancoule et al.   BIOCHIMIE

An overview of the diverse roles of G-protein coupled receptors (GPCRs) in the pathophysiology of various human diseases

(2013) Boon Chin Heng et al.   BIOTECHNOLOGY ADVANCES

Anatomical Locations of Human Brown Adipose Tissue: Functional Relevance and Implications in Obesity and Type 2 Diabetes

(2013) H. Sacks et al.   DIABETES

Relaxin Treatment Reverses Insulin Resistance in Mice Fed a High-Fat Diet

(2013) Jeffrey S. Bonner et al.   DIABETES

Quercetin Suppresses MIP-1α–Induced Adipose Inflammation by Downregulating Its Receptors CCR1/CCR5 and Inhibiting Inflammatory Signaling

(2013) Hye-Ji Noh et al.   JOURNAL OF MEDICINAL FOOD

Minireview: Dopaminergic Regulation of Insulin Secretion from the Pancreatic Islet

(2013) Alessandro Ustione et al.   MOLECULAR ENDOCRINOLOGY

Short-term, high fat feeding-induced changes in white adipose tissue gene expression are highly predictive for long-term changes

(2013) Anja Voigt et al.   MOLECULAR NUTRITION & FOOD RESEARCH

An atlas and functional analysis of G-protein coupled receptors in human islets of Langerhans

(2013) Stefan Amisten et al.   PHARMACOLOGY & THERAPEUTICS

Plasma Sphingosine-1-Phosphate Is Elevated in Obesity

(2013) Greg M. Kowalski et al.   PLoS One

Increased Adiposity in Annexin A1-Deficient Mice

(2013) Rand T. Akasheh et al.   PLoS One

The adipokine apelin and human uterine contractility

(2012) Mark P. Hehir et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Improved blood glucose disposal and altered insulin secretion patterns in adenosine A1 receptor knockout mice

(2012) Gary K. Yang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Chemokine Superfamily Revisited

(2012) Albert Zlotnik et al.   IMMUNITY

G protein–coupled receptor 21 deletion improves insulin sensitivity in diet-induced obese mice

(2012) Olivia Osborn et al.   JOURNAL OF CLINICAL INVESTIGATION

Brown adipose tissue regulates glucose homeostasis and insulin sensitivity

(2012) Kristin I. Stanford et al.   JOURNAL OF CLINICAL INVESTIGATION

GPR105 Ablation Prevents Inflammation and Improves Insulin Sensitivity in Mice with Diet-Induced Obesity

(2012) J. Xu et al.   JOURNAL OF IMMUNOLOGY

Role of leptin in the pancreatic β-cell: effects and signaling pathways

(2012) Laura Marroquí et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Distinct effects of calorie restriction on adipose tissue cytokine and angiogenesis profiles in obese and lean mice

(2012) Eveliina Kurki et al.   Nutrition & Metabolism

GPRC5B Activates Obesity-Associated Inflammatory Signaling in Adipocytes

(2012) Y.-J. Kim et al.   Science Signaling

Planar Cell Polarity Controls Pancreatic Beta Cell Differentiation and Glucose Homeostasis

(2012) Cedric Cortijo et al.   Cell Reports

Getting ‘Smad’ about obesity and diabetes

(2012) C K Tan et al.   Nutrition & Diabetes

A review of the evidence for the canonical Wnt pathway in autism spectrum disorders

(2012) Hans Kalkman   Molecular Autism

G-protein-coupled receptor GPR21 knockout mice display improved glucose tolerance and increased insulin response

(2011) Jonitha Gardner et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Genetics of the HLA Region in the Prediction of Type 1 Diabetes

(2011) Janelle A. Noble et al.   Current Diabetes Reports

Epinephrine and the Metabolic Syndrome

(2011) Michael G. Ziegler et al.   CURRENT HYPERTENSION REPORTS

New Insight Into A1 Adenosine Receptors in Diabetes Treatment

(2011) Marzena Wojcik et al.   CURRENT PHARMACEUTICAL DESIGN

Impaired Glucose Tolerance in the Absence of Adenosine A1 Receptor Signaling

(2011) R. Faulhaber-Walter et al.   DIABETES

Cannabinoid receptor agonists and antagonists stimulate insulin secretion from isolated human islets of Langerhans

(2011) C. Li et al.   DIABETES OBESITY & METABOLISM

Deficiency of the GPR39 receptor is associated with obesity and altered adipocyte metabolism

(2011) Pia Steen Petersen et al.   FASEB JOURNAL

A Subset of Interleukin-21+ Chemokine Receptor CCR9+ T Helper Cells Target Accessory Organs of the Digestive System in Autoimmunity

(2011) Helen M. McGuire et al.   IMMUNITY

Control of bone formation by the serpentine receptor Frizzled-9

(2011) Joachim Albers et al.   JOURNAL OF CELL BIOLOGY

Apelin stimulates glucose uptake through the PI3K/Akt pathway and improves insulin resistance in 3T3-L1 adipocytes

(2011) Shunming Zhu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Characterization of murine melanocortin receptors mediating adipocyte lipolysis and examination of signalling pathways involved

(2011) Cathrine Laustrup Møller et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Domain coupling in GPCRs: the engine for induced conformational changes

(2011) Hamiyet Unal et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Expression and function of cannabinoid receptors in mouse islets

(2011) Chen Li et al.   Islets

Chemerin regulates β-cell function in mice

(2011) Michiko Takahashi et al.   Scientific Reports

A Genome-wide Study Reveals Copy Number Variants Exclusive to Childhood Obesity Cases

(2010) Joseph T. Glessner et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Ghrelin Suppresses Glucose-Stimulated Insulin Secretion and Deteriorates Glucose Tolerance in Healthy Humans

(2010) J. Tong et al.   DIABETES

Metabolomic Analysis of Livers and Serum from High-Fat Diet Induced Obese Mice

(2010) Hyun-Jin Kim et al.   JOURNAL OF PROTEOME RESEARCH

GPR103b Functions in the Peripheral Regulation of Adipogenesis

(2010) Mukandila Mulumba et al.   MOLECULAR ENDOCRINOLOGY

Gene Expression Profiles of Beta-Cell Enriched Tissue Obtained by Laser Capture Microdissection from Subjects with Type 2 Diabetes

(2010) Lorella Marselli et al.   PLoS One

Opn5 is a UV-sensitive bistable pigment that couples with Gi subtype of G protein

(2010) T. Yamashita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Monocytes/macrophages express chemokine receptor CCR9 in rheumatoid arthritis and CCL25 stimulates their differentiation

(2010) Caroline Schmutz et al.   ARTHRITIS RESEARCH & THERAPY

The Expanded Biology of Serotonin

(2009) Miles Berger et al.   Annual Review of Medicine

Interplay Between Human Adipocytes and T Lymphocytes in Obesity

(2009) Carine Duffaut et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Antagonism of Human Adiponectin Receptors and Their Membrane Progesterone Receptor Paralogs by TNFα and a Ceramidase Inhibitor

(2009) Brian R. Kupchak et al.   BIOCHEMISTRY

CXC Ligand 5 Is an Adipose-Tissue Derived Factor that Links Obesity to Insulin Resistance

(2009) Carine Chavey et al.   Cell Metabolism

Chemokine and chemokine receptor gene expression in the mesenteric adipose tissue of KKAy mice

(2009) Han-Sam Lee et al.   CYTOKINE

Prokineticin 2 Is a Hypothalamic Neuropeptide That Potently Inhibits Food Intake

(2009) J. V. Gardiner et al.   DIABETES

Butyrate Improves Insulin Sensitivity and Increases Energy Expenditure in Mice

(2009) Z. Gao et al.   DIABETES

Disruption of G Protein-Coupled Receptor 39 Impairs Insulin Secretionin Vivo

(2009) Frédéric Tremblay et al.   ENDOCRINOLOGY

The Antiobesity Effects of Centrally Administered Neuromedin U and Neuromedin S Are Mediated Predominantly by the Neuromedin U Receptor 2 (NMUR2)

(2009) Andrea Peier et al.   ENDOCRINOLOGY

G Protein-Coupled Receptor 39 Deficiency Is Associated with Pancreatic Islet Dysfunction

(2009) Birgitte Holst et al.   ENDOCRINOLOGY

CCR9 and inflammatory bowel disease

(2009) Christian Koenecke et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Obesity is associated with increased parathyroid hormone levels independent of glomerular filtration rate in chronic kidney disease

(2009) Georges Saab et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The CB1 Antagonist Rimonabant Decreases Insulin Hypersecretion in Rat Pancreatic Islets

(2009) Lisa Getty-Kaushik et al.   Obesity

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