The apelin receptor: physiology, pathology, cell signalling, and ligand modulation of a peptide-activated class A GPCR

Heterodimerization of human apelin and bradykinin 1 receptors: Novel signal transduction characteristics

(2014) Bo Bai et al.   CELLULAR SIGNALLING

Toddler: An Embryonic Signal That Promotes Cell Movement via Apelin Receptors

(2014) A. Pauli et al.   SCIENCE

Pyroglutamyl apelin-13 identified as the major apelin isoform in human plasma

(2013) Eugene Y. Zhen et al.   ANALYTICAL BIOCHEMISTRY

Apelin-APJ Signaling Is a Critical Regulator of Endothelial MEF2 Activation in Cardiovascular Development

(2013) Yujung Kang et al.   CIRCULATION RESEARCH

ELABELA: A Hormone Essential for Heart Development Signals via the Apelin Receptor

(2013) Serene C. Chng et al.   DEVELOPMENTAL CELL

Tumour co-expression of apelin and its receptor is the basis of an autocrine loop involved in the growth of colon adenocarcinomas

(2013) François-Xavier Picault et al.   EUROPEAN JOURNAL OF CANCER

Thrombin-mediated Proteoglycan Synthesis Utilizes Both Protein-tyrosine Kinase and Serine/Threonine Kinase Receptor Transactivation in Vascular Smooth Muscle Cells

(2013) Micah L. Burch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis

(2013) Anne-Marie O'Carroll et al.   JOURNAL OF ENDOCRINOLOGY

Apelin acts in the subfornical organ to influence neuronal excitability and cardiovascular function

(2013) Li Dai et al.   JOURNAL OF PHYSIOLOGY-LONDON

G protein-coupled receptor dimers: look like their parents, but act like teenagers!

(2013) Jaime Wertman et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Emerging non-canonical functions for heterotrimeric G proteins in cellular signaling

(2013) Syed M. Ahmed et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Loss of Apelin Exacerbates Myocardial Infarction Adverse Remodeling and Ischemia‐reperfusion Injury: Therapeutic Potential of Synthetic Apelin Analogues

(2013) Wang Wang et al.   Journal of the American Heart Association

Preferential apelin-13 production by the proprotein convertase PCSK3 is implicated in obesity

(2013) Kyungsoo Shin et al.   FEBS Open Bio

The apelin receptor inhibits the angiotensin II type 1 receptor via allosteric trans-inhibition

(2012) K Siddiquee et al.   BRITISH JOURNAL OF PHARMACOLOGY

Stress-dependent and gender-specific neuroregulatory roles of the apelin receptor in the hypothalamic–pituitary–adrenal axis response to acute stress

(2012) M J F Newson et al.   JOURNAL OF ENDOCRINOLOGY

APJ acts as a dual receptor in cardiac hypertrophy

(2012) Maria Cecilia Scimia et al.   NATURE

Apelin, a promising target for type 2 diabetes treatment?

(2012) Isabelle Castan-laurell et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Heterodimerization of human apelin and kappa opioid receptors: Roles in signal transduction

(2011) Yalin Li et al.   CELLULAR SIGNALLING

Discovery of a Competitive Apelin Receptor (APJ) Antagonist

(2011) N. J. Maximilian Macaluso et al.   ChemMedChem

Elucidation of the Structure-Activity Relationships of Apelin: Influence of Unnatural Amino Acids on Binding, Signaling, and Plasma Stability

(2011) Alexandre Murza et al.   ChemMedChem

Apelin Treatment Increases Complete Fatty Acid Oxidation, Mitochondrial Oxidative Capacity, and Biogenesis in Muscle of Insulin-Resistant Mice

(2011) C. Attane et al.   DIABETES

Identification and Characterization of Apelin Peptides in Bovine Colostrum and Milk by Liquid Chromatography–Mass Spectrometry

(2011) Cédric Mesmin et al.   JOURNAL OF PROTEOME RESEARCH

The apelinergic system in the developing lung: Expression and signaling

(2011) Paulina Piairo et al.   PEPTIDES

Apelin alleviates diabetes-associated endoplasmic reticulum stress in the pancreas of Akita mice

(2011) Hong Chen et al.   PEPTIDES

The fate of the internalized apelin receptor is determined by different isoforms of apelin mediating differential interaction with β-arrestin

(2010) Dennis K. Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Exploring the ‘RPRL’ Motif of Apelin-13 through Molecular Simulation and Biological Evaluation of Cyclic Peptide Analogues

(2010) N. J. Maximilian Macaluso et al.   ChemMedChem

Stimulus-Specific Neuroendocrine Responses to Osmotic Challenges in Apelin Receptor Knockout Mice

(2010) E. M. Roberts et al.   JOURNAL OF NEUROENDOCRINOLOGY

Functional Selectivity and Biased Receptor Signaling

(2010) T. Kenakin   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

EGF receptor activation by GPCRs: An universal pathway reveals different versions

(2010) Claus Liebmann   MOLECULAR AND CELLULAR ENDOCRINOLOGY

International Union of Basic and Clinical Pharmacology. LXXIV. Apelin Receptor Nomenclature, Distribution, Pharmacology, and Function

(2010) S. L. Pitkin et al.   PHARMACOLOGICAL REVIEWS

Liquid chromatography/tandem mass spectrometry assay for the absolute quantification of the expected circulating apelin peptides in human plasma

(2010) Cédric Mesmin et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Apelin is necessary for the maintenance of insulin sensitivity

(2009) Patrick Yue et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Structural Insight into G-Protein Coupled Receptor Binding by Apelin†

(2009) David N. Langelaan et al.   BIOCHEMISTRY

Apelin Gene Transfer Into the Rostral Ventrolateral Medulla Induces Chronic Blood Pressure Elevation in Normotensive Rats

(2009) Qi Zhang et al.   CIRCULATION RESEARCH

[Pyr 1 ]Apelin-13 Identified as the Predominant Apelin Isoform in the Human Heart

(2009) Janet J. Maguire et al.   HYPERTENSION

Headgroup-Dependent Membrane Catalysis of Apelin−Receptor Interactions Is Likely

(2009) David N. Langelaan et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis

(2008) Hyung J. Chun et al.   JOURNAL OF CLINICAL INVESTIGATION

Diminished Metabolic Responses to Centrally-Administered Apelin-13 in Diet-Induced Obese Rats Fed a High-Fat Diet

(2008) K. J. Clarke et al.   JOURNAL OF NEUROENDOCRINOLOGY

Reciprocal Regulation of Plasma Apelin and Vasopressin by Osmotic Stimuli

(2008) M. Azizi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY