Novel Zn2+ Modulated GPR39 Receptor Agonists Do Not Drive Acute Insulin Secretion in Rodents

Target identification for a Hedgehog pathway inhibitor reveals the receptor GPR39

(2014) Frederic Bassilana et al.   Nature Chemical Biology

Discovery of 2-Pyridylpyrimidines as the First Orally Bioavailable GPR39 Agonists

(2014) Stefan Peukert et al.   ACS Medicinal Chemistry Letters

The fatty acid receptor FFA1/GPR40 a decade later: how much do we know?

(2013) Arturo D. Mancini et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Chemical Probe Identification Platform for Orphan GPCRs Using Focused Compound Screening: GPR39 as a Case Example

(2013) Markus Boehm et al.   ACS Medicinal Chemistry Letters

GI functions of GPR39: novel biology

(2012) Inge Depoortere   CURRENT OPINION IN PHARMACOLOGY

The therapeutic potential of GPR119 agonists for type 2 diabetes

(2012) Takahide Ohishi et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

A Molecular Mechanism for Modulating Plasma Zn Speciation by Fatty Acids

(2012) Jin Lu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Deficiency of the GPR39 receptor is associated with obesity and altered adipocyte metabolism

(2011) Pia Steen Petersen et al.   FASEB JOURNAL

GPR39, a Receptor of the Ghrelin Receptor Family, Plays a Role in the Regulation of Glucose Homeostasis in a Mouse Model of Early Onset Diet-Induced Obesity

(2011) P. J. Verhulst et al.   JOURNAL OF NEUROENDOCRINOLOGY

Upregulation of KCC2 Activity by Zinc-Mediated Neurotransmission via the mZnR/GPR39 Receptor

(2011) E. Chorin et al.   JOURNAL OF NEUROSCIENCE

GPR39: a Zn2+-activated G protein-coupled receptor that regulates pancreatic, gastrointestinal and neuronal functions

(2010) Petra Popovics et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Deconvolution of complex G protein–coupled receptor signaling in live cells using dynamic mass redistribution measurements

(2010) Ralf Schröder et al.   NATURE BIOTECHNOLOGY

Disruption of G Protein-Coupled Receptor 39 Impairs Insulin Secretionin Vivo

(2009) Frédéric Tremblay et al.   ENDOCRINOLOGY

G Protein-Coupled Receptor 39 Deficiency Is Associated with Pancreatic Islet Dysfunction

(2009) Birgitte Holst et al.   ENDOCRINOLOGY

Synaptically Released Zinc Triggers Metabotropic Signaling via a Zinc-Sensing Receptor in the Hippocampus

(2009) L. Besser et al.   JOURNAL OF NEUROSCIENCE

Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes

(2009) Bo Ahrén   NATURE REVIEWS DRUG DISCOVERY

Molecular mechanism of Zn2+agonism in the extracellular domain of GPR39

(2008) Laura Storjohann et al.   FEBS LETTERS