Novel CB1 receptor antagonist BAR-1 modifies pancreatic islet function and clinical parameters in prediabetic and diabetic mice

CB1 receptor blockade ameliorates hepatic fat infiltration and inflammation and increases Nrf2-AMPK pathway in a rat model of severely uncontrolled diabetes

(2018) Eugene Chang et al.   PLoS One

Crystal Structure of the Human Cannabinoid Receptor CB 1

(2016) Tian Hua et al.   CELL

Cannabinoid 2 Receptor Agonist Improves Systemic Sensitivity to Insulin in High-Fat Diet/Streptozotocin-Induced Diabetic Mice

(2016) Xiuyuan Zhang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Blockade of cannabinoid 1 receptor improves GLP-1R mediated insulin secretion in mice

(2016) Isabel González-Mariscal et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Controlled downregulation of the cannabinoid CB1 receptor provides a promising approach for the treatment of obesity and obesity-derived type 2 diabetes

(2015) Dai Lu et al.   CELL STRESS & CHAPERONES

The cannabinoid CB1receptor and mTORC1 signalling pathways interact to modulate glucose homeostasis in mice

(2015) Francisco J. Bermudez-Silva et al.   Disease Models & Mechanisms

Biochemical and immunohistochemical changes in delta-9-tetrahydrocannabinol-treated type 2 diabetic rats

(2013) Zeynep Mine Coskun et al.   ACTA HISTOCHEMICA

The complex effects of cannabinoids on insulin secretion from rat isolated islets of Langerhans

(2013) Richard L. Anderson et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

CB1Cannabinoid Receptors Couple to Focal Adhesion Kinase to Control Insulin Release

(2013) Katarzyna Malenczyk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Islet Cannabinoid Receptors

(2013) Luis E. Flores et al.   PANCREAS

Reduced Food Intake is the Major Contributor to the Protective Effect of Rimonabant on Islet in Established Obesity-Associated Type 2 Diabetes

(2013) Sang-Man Jin et al.   YONSEI MEDICAL JOURNAL

Expression and Function of Monoacylglycerol Lipase in Mouse ß-cells and Human Islets of Langerhans

(2012) Chen Li et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Chronic activation of cannabinoid receptorsin vitrodoes not compromise mouse islet function

(2012) Alonso Vilches-Flores et al.   CLINICAL SCIENCE

Ibipinabant attenuates β-cell loss in male Zucker diabetic fatty rats independently of its effects on body weight

(2012) K. Rohrbach et al.   DIABETES OBESITY & METABOLISM

Probing the Interaction of SR141716A with the CB1 Receptor

(2012) Joong-Youn Shim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cannabis exposure associated with weight reduction and β-cell protection in an obese rat model

(2012) R-A. Levendal et al.   PHYTOMEDICINE

Endocannabinoids Measurement in Human Saliva as Potential Biomarker of Obesity

(2012) Isabelle Matias et al.   PLoS One

Some cannabinoid receptor ligands and their distomers are direct-acting openers of SUR1 KATP channels

(2011) Christopher J. Lynch et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Cannabinoids Inhibit Insulin Receptor Signaling in Pancreatic  -Cells

(2011) W. Kim et al.   DIABETES

Cannabinoid receptor agonists and antagonists stimulate insulin secretion from isolated human islets of Langerhans

(2011) C. Li et al.   DIABETES OBESITY & METABOLISM

The role of the endocannabinoid system in the neuroendocrine regulation of energy balance

(2011) Francisco Javier Bermudez-Silva et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Expression and function of cannabinoid receptors in mouse islets

(2011) Chen Li et al.   Islets

Cannabinoid Receptors are Coupled to Stimulation of Insulin Secretion from Mouse MIN6 β-cells

(2010) Chen Li et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Neuropsychiatric Adverse Effects of Centrally Acting Antiobesity Drugs

(2010) Pradeep J. Nathan et al.   CNS Neuroscience & Therapeutics

Virtual screening with AutoDock: theory and practice

(2010) Sandro Cosconati et al.   Expert Opinion on Drug Discovery

CB1 cannabinoid receptor expression is regulated by glucose and feeding in rat pancreatic islets

(2010) Alonso Vilches-Flores et al.   REGULATORY PEPTIDES

Use of cannabinoid CB1 receptor antagonists for the treatment of metabolic disorders

(2009) André J. Scheen et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Beneficial effect of a chronic treatment with rimonabant on pancreatic function and β-cell morphology in Zucker Fatty rats

(2009) Valérie F. Duvivier et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The CB1 Antagonist Rimonabant Decreases Insulin Hypersecretion in Rat Pancreatic Islets

(2009) Lisa Getty-Kaushik et al.   Obesity

Discontinuation due to adverse events in randomized trials of orlistat, sibutramine and rimonabant: a meta-analysis

(2009) K. Johansson et al.   Obesity Reviews

Cannabinoid type 1 receptors in human skeletal muscle cells participate in the negative crosstalk between fat and muscle

(2008) K. Eckardt et al.   DIABETOLOGIA

Endocannabinoid Dysregulation in the Pancreas and Adipose Tissue of Mice Fed With a High-fat Diet

(2008) Katarzyna M. Starowicz et al.   Obesity

Cannabinoids inhibit insulin secretion and cytosolic Ca2+ oscillation in islet β-cells via CB1 receptors

(2007) Masanori Nakata et al.   REGULATORY PEPTIDES