Long-term treatment with acylated analogues of apelin-13 amide ameliorates diabetes and improves lipid profile of high-fat fed mice

Apelin-13 analogues show potent in vitro and in vivo insulinotropic and glucose lowering actions

(2018) F.P.M. O’Harte et al.   PEPTIDES

Development of original metabolically stable apelin-17 analogs with diuretic and cardiovascular effects

(2017) Romain Gerbier et al.   FASEB JOURNAL

Beneficial Effects of Apelin on Vascular Function in Patients With Central ObesityNovelty and Significance

(2017) Francesca Schinzari et al.   HYPERTENSION

Metabolic and neuroprotective effects of dapagliflozin and liraglutide in diabetic mice

(2017) Paul Millar et al.   JOURNAL OF ENDOCRINOLOGY

An enzymatically stable GIP/xenin hybrid peptide restores GIP sensitivity, enhances beta cell function and improves glucose homeostasis in high-fat-fed mice

(2016) Annie Hasib et al.   DIABETOLOGIA

Apelin/APJ system as a therapeutic target in diabetes and its complications

(2016) Haoliang Hu et al.   MOLECULAR GENETICS AND METABOLISM

The Current Drug Treatment Landscape for Diabetes and Perspectives for the Future

(2015) CJ Bailey   CLINICAL PHARMACOLOGY & THERAPEUTICS

Apelin targets gut contraction to control glucose metabolism via the brain

(2015) Audren Fournel et al.   GUT

Apelin and energy metabolism

(2015) Chantal Bertrand et al.   Frontiers in Physiology

Type 2 diabetes mellitus

(2015) Ralph A. DeFronzo et al.   Nature Reviews Disease Primers

Two novel glucagon receptor antagonists prove effective therapeutic agents in high-fat-fed and obese diabetic mice

(2014) F. P. M. O'Harte et al.   DIABETES OBESITY & METABOLISM

Transition from metabolic adaptation to maladaptation of the heart in obesity: role of apelin

(2014) C Alfarano et al.   INTERNATIONAL JOURNAL OF OBESITY

Obesity-Associated Oxidative Stress: Strategies Finalized to Improve Redox State

(2013) Isabella Savini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis

(2013) Anne-Marie O'Carroll et al.   JOURNAL OF ENDOCRINOLOGY

Randomized Double-Blind Placebo-Controlled Trial of Powdered Brassica rapa Ethanol Extract on Alteration of Body Composition and Plasma Lipid and Adipocytokine Profiles in Overweight Subjects

(2013) Seon-Min Jeon et al.   JOURNAL OF MEDICINAL FOOD

The global NAFLD epidemic

(2013) Rohit Loomba et al.   Nature Reviews Gastroenterology & Hepatology

Chronic GLP-1 Receptor Activation by Exendin-4 Induces Expansion of Pancreatic Duct Glands in Rats and Accelerates Formation of Dysplastic Lesions and Chronic Pancreatitis in the KrasG12DMouse Model

(2012) Belinda Gier et al.   DIABETES

Socio-Economic Position and Type 2 Diabetes Risk Factors: Patterns in UK Children of South Asian, Black African-Caribbean and White European Origin

(2012) Claudia Thomas et al.   PLoS One

Rapid Tachyphylaxis of the Glucagon-Like Peptide 1-Induced Deceleration of Gastric Emptying in Humans

(2011) M. A. Nauck et al.   DIABETES

Loss of Incretin Effect Is a Specific, Important, and Early Characteristic of Type 2 Diabetes

(2011) J. J. Holst et al.   DIABETES CARE

Apelin stimulates glucose uptake through the PI3K/Akt pathway and improves insulin resistance in 3T3-L1 adipocytes

(2011) Shunming Zhu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Apelin and APJ regulation in adipose tissue and skeletal muscle of type 2 diabetic mice and humans

(2010) Cédric Dray et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Apelin is necessary for the maintenance of insulin sensitivity

(2009) Patrick Yue et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Apelin Stimulates Glucose Utilization in Normal and Obese Insulin-Resistant Mice

(2008) Cédric Dray et al.   Cell Metabolism

Effect of hypocaloric diet-induced weight loss in obese women on plasma apelin and adipose tissue expression of apelin and APJ.

(2008) Isabelle Castan-Laurell et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Cardiovascular disease risk in type 2 diabetes mellitus: insights from mechanistic studies

(2008) Theodore Mazzone et al.   LANCET