Asymmetric drug binding in an ATP-loaded inward-facing state of an ABC transporter
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Title
Asymmetric drug binding in an ATP-loaded inward-facing state of an ABC transporter
Authors
Keywords
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Journal
Nature Chemical Biology
Volume 18, Issue 2, Pages 226-235
Publisher
Springer Science and Business Media LLC
Online
2021-12-21
DOI
10.1038/s41589-021-00936-x
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Note: Only part of the references are listed.- Protein functional dynamics from the rigorous global analysis of DEER data: Conditions, components, and conformations
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- (2019) Susanne Hofmann et al. NATURE
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- (2019) I. Barry Holland RESEARCH IN MICROBIOLOGY
- Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix
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- (2017) Wei Mi et al. NATURE
- Energy transduction and alternating access of the mammalian ABC transporter P-glycoprotein
- (2017) Brandy Verhalen et al. NATURE
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- EMRinger: side chain–directed model and map validation for 3D cryo-electron microscopy
- (2015) Benjamin A Barad et al. NATURE METHODS
- Collaborative Computational Project for Electron cryo-Microscopy
- (2015) Chris Wood et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- SymD webserver: a platform for detecting internally symmetric protein structures
- (2014) Chin-Hsien Tai et al. NUCLEIC ACIDS RESEARCH
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- (2014) M. Hohl et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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