Mechanism of allosteric modulation of P-glycoprotein by transport substrates and inhibitors
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Mechanism of allosteric modulation of P-glycoprotein by transport substrates and inhibitors
Authors
Keywords
-
Journal
SCIENCE
Volume 364, Issue 6441, Pages 689-692
Publisher
American Association for the Advancement of Science (AAAS)
Online
2019-05-17
DOI
10.1126/science.aav9406
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Comparison of mechanistic transport cycle models of ABC exporters
- (2018) Dániel Szöllősi et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Conformational Coupling and trans-Inhibition in the Human Antigen Transporter Ortholog TmrAB Resolved with Dipolar EPR Spectroscopy
- (2018) Katja Barth et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1
- (2018) Amer Alam et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Molecular structure of human P-glycoprotein in the ATP-bound, outward-facing conformation
- (2018) Youngjin Kim et al. SCIENCE
- Confidence Analysis of DEER Data and Its Structural Interpretation with Ensemble-Biased Metadynamics
- (2018) Eric J. Hustedt et al. BIOPHYSICAL JOURNAL
- Substrate-induced conformational changes in the nucleotide-binding domains of lipid bilayer–associated P-glycoprotein during ATP hydrolysis
- (2017) Maria E. Zoghbi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Effects of a detergent micelle environment on P-glycoprotein (ABCB1)-ligand interactions
- (2017) Suneet Shukla et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structure of the human multidrug transporter ABCG2
- (2017) Nicholas M. I. Taylor et al. NATURE
- Energy transduction and alternating access of the mammalian ABC transporter P-glycoprotein
- (2017) Brandy Verhalen et al. NATURE
- About P-glycoprotein: a new drugable domain is emerging from structural data
- (2017) Ricardo J. Ferreira et al. Wiley Interdisciplinary Reviews-Computational Molecular Science
- Drug–protein hydrogen bonds govern the inhibition of the ATP hydrolysis of the multidrug transporter P-glycoprotein
- (2016) Eduardo E. Chufan et al. BIOCHEMICAL PHARMACOLOGY
- Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity
- (2016) Lothar Esser et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mechanistic diversity in ATP-binding cassette (ABC) transporters
- (2016) Kaspar P Locher NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Mechanistic diversity in ATP-binding cassette (ABC) transporters
- (2016) Kaspar P Locher NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Tariquidar inhibits P-glycoprotein drug efflux but activates ATPase activity by blocking transition to an open conformation
- (2014) Tip W. Loo et al. BIOCHEMICAL PHARMACOLOGY
- Conformational dynamics of the nucleotide binding domains and the power stroke of a heterodimeric ABC transporter
- (2014) Smriti Mishra et al. eLife
- Refined structures of mouse P-glycoprotein
- (2013) Jingzhi Li et al. PROTEIN SCIENCE
- DEER Distance Measurements on Proteins
- (2012) Gunnar Jeschke Annual Review of Physical Chemistry
- Snapshots of the maltose transporter during ATP hydrolysis
- (2011) M. L. Oldham et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Toward the Fourth Dimension of Membrane Protein Structure: Insight into Dynamics from Spin-Labeling EPR Spectroscopy
- (2011) Hassane S. Mchaourab et al. STRUCTURE
- Increased Sensitivity and Extended Range of Distance Measurements in Spin-Labeled Membrane Proteins: Q-Band Double Electron-Electron Resonance and Nanoscale Bilayers
- (2010) Ping Zou et al. BIOPHYSICAL JOURNAL
- Characterization of an Asymmetric Occluded State of P-glycoprotein with Two Bound Nucleotides
- (2010) Alena Siarheyeva et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Rotamer libraries of spin labelled cysteines for protein studies
- (2010) Yevhen Polyhach et al. PHYSICAL CHEMISTRY CHEMICAL PHYSICS
- Mapping Daunorubicin-binding Sites in the ATP-binding Cassette Transporter MsbA Using Site-specific Quenching by Spin Labels
- (2009) Smriti et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- ABC transporters: the power to change
- (2009) Douglas C. Rees et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- ATP Occlusion by P-Glycoprotein as a Surrogate Measure for Drug Coupling†
- (2008) Gregory Tombline et al. BIOCHEMISTRY
- ABC multidrug transporters: structure, function and role in chemoresistance
- (2007) Frances J Sharom PHARMACOGENOMICS
Become a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get StartedAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started