Exploring conformational equilibria of a heterodimeric ABC transporter

Toward a Better Understanding of the Complexity of Cancer Drug Resistance

(2016) Michael M. Gottesman et al.   Annual Review of Pharmacology and Toxicology

The Heterodimeric ABC Transporter EfrCD Mediates Multidrug Efflux in Enterococcus faecalis

(2016) Lea M. Hürlimann et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Obligate coupling of CFTR pore opening to tight nucleotide-binding domain dimerization

(2016) Csaba Mihályi et al.   eLife

Timing of CFTR Pore Opening and Structure of Its Transition State

(2015) Ben Sorum et al.   CELL

Crystal structures of a polypeptide processing and secretion transporter

(2015) David Yin-wei Lin et al.   NATURE

Structure and mechanism of an active lipid-linked oligosaccharide flippase

(2015) Camilo Perez et al.   NATURE

N-lactoyl-amino acids are ubiquitous metabolites that originate from CNDP2-mediated reverse proteolysis of lactate and amino acids

(2015) Robert S. Jansen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct Conformational Spectrum of Homologous Multidrug ABC Transporters

(2015) Arne Moeller et al.   STRUCTURE

Subnanometre-resolution electron cryomicroscopy structure of a heterodimeric ABC exporter

(2014) JungMin Kim et al.   NATURE

What do drug transporters really do?

(2014) Sanjay K. Nigam   NATURE REVIEWS DRUG DISCOVERY

Structural basis for allosteric cross-talk between the asymmetric nucleotide binding sites of a heterodimeric ABC exporter

(2014) M. Hohl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for gating mechanisms of a eukaryotic P-glycoprotein homolog

(2014) A. Kodan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of an antibacterial peptide ATP-binding cassette transporter in a novel outward occluded state

(2014) H. G. Choudhury et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis for Heavy Metal Detoxification by an Atm1-Type ABC Exporter

(2014) J. Y. Lee et al.   SCIENCE

Mechanistic determinants of the directionality and energetics of active export by a heterodimeric ABC transporter

(2014) Nina Grossmann et al.   Nature Communications

Diversity in ATP concentrations in a single bacterial cell population revealed by quantitative single-cell imaging

(2014) Hideyuki Yaginuma et al.   Scientific Reports

Conformational dynamics of the nucleotide binding domains and the power stroke of a heterodimeric ABC transporter

(2014) Smriti Mishra et al.   eLife

The Deviant ATP-binding Site of the Multidrug Efflux Pump Pdr5 Plays an Active Role in the Transport Cycle

(2013) Christopher Furman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reinterpreting the Action of ATP Analogs on KATPChannels

(2013) David Ortiz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states

(2013) C. A. Shintre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformational dynamics and distribution of nitroxide spin labels

(2013) Gunnar Jeschke   PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

Refined structures of mouse P-glycoprotein

(2013) Jingzhi Li et al.   PROTEIN SCIENCE

Asymmetry in the Homodimeric ABC Transporter MsbA Recognized by a DARPin

(2012) Anshumali Mittal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Probing the ATP Hydrolysis Cycle of the ABC Multidrug Transporter LmrA by Pulsed EPR Spectroscopy

(2012) Ute A. Hellmich et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Crystal structure of a heterodimeric ABC transporter in its inward-facing conformation

(2012) Michael Hohl et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

High sensitivity and versatility of the DEER experiment on nitroxide radical pairs at Q-band frequencies

(2012) Yevhen Polyhach et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Perspectives on the structure–function of ABC transporters: The Switch and Constant Contact Models

(2012) Anthony M. George et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

ABCA4 is an N-retinylidene-phosphatidylethanolamine and phosphatidylethanolamine importer

(2012) Faraz Quazi et al.   Nature Communications

A Versatile and Efficient High-Throughput Cloning Tool for Structural Biology

(2011) Eric R. Geertsma et al.   BIOCHEMISTRY

Transportomics: screening for substrates of ABC transporters in body fluids using vesicular transport assays

(2011) Petra Krumpochova et al.   FASEB JOURNAL

Characterization of an Asymmetric Occluded State of P-glycoprotein with Two Bound Nucleotides

(2010) Alena Siarheyeva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stable ATP binding mediated by a partial NBD dimer of the CFTR chloride channel

(2010) Ming-Feng Tsai et al.   JOURNAL OF GENERAL PHYSIOLOGY

Rotamer libraries of spin labelled cysteines for protein studies

(2010) Yevhen Polyhach et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Conformational Cycle of the ABC Transporter MsbA in Liposomes: Detailed Analysis Using Double Electron–Electron Resonance Spectroscopy

(2009) Ping Zou et al.   JOURNAL OF MOLECULAR BIOLOGY

Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout

(2009) O. M. Woodward et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular basis of multidrug transport by ABC transporters

(2008) Markus A. Seeger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Structure, Function, and Evolution of Bacterial ATP-Binding Cassette Systems

(2008) A. L. Davidson et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Membrane reconstitution of ABC transporters and assays of translocator function

(2008) Eric R Geertsma et al.   Nature Protocols

SUR1: a unique ATP-binding cassette protein that functions as an ion channel regulator

(2008) J. Aittoniemi et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

A mutation of the H-loop selectively affects rhodamine transport by the yeast multidrug ABC transporter Pdr5

(2008) Robert Ernst et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA