Recent advances in the biosynthesis strategies of nitrogen heterocyclic natural products

Inverted Binding of Non-natural Substrates in Strictosidine Synthase Leads to a Switch of Stereochemical Outcome in Enzyme-Catalyzed Pictet–Spengler Reactions

(2020) Elisabeth Eger et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Engineering Tropane Alkaloid Production Based on Metabolic Characterization of Ornithine Decarboxylase in Atropa belladonna

(2020) Tengfei Zhao et al.   ACS Synthetic Biology

Pictet–Spenglerases in alkaloid biosynthesis: Future applications in biocatalysis

(2020) Rebecca Roddan et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Enzyme-Catalyzed Azepinoindole Formation in Clavine Alkaloid Biosynthesis

(2020) Kuan-Lin Chen et al.   ORGANIC LETTERS

Structure-Guided Engineering of a Scoulerine 9-O-Methyltransferase Enables the Biosynthesis of Tetrahydropalmatrubine and Tetrahydropalmatine in Yeast

(2020) Timothy R. Valentic et al.   ACS Catalysis

Engineering Improves Enzymatic Synthesis of L-Tryptophan by Tryptophan Synthase from Escherichia coli

(2020) Lisheng Xu et al.   Microorganisms

De novo resveratrol production through modular engineering of an Escherichia coli–Saccharomyces cerevisiae co-culture

(2020) Shuo-Fu Yuan et al.   Microbial Cell Factories

Discovery and engineering of colchicine alkaloid biosynthesis

(2020) Ryan S. Nett et al.   NATURE

A yeast platform for high-level synthesis of tetrahydroisoquinoline alkaloids

(2020) Michael E. Pyne et al.   Nature Communications

Biocatalytic Access to 1,4-Diazepanes via Imine Reductase-Catalyzed Intramolecular Asymmetric Reductive Amination

(2020) Zefei Xu et al.   ACS Catalysis

Recent Advances in Re-engineering Modular PKS and NRPS Assembly Lines

(2020) Charlotte Beck et al.   BIOTECHNOLOGY AND BIOPROCESS ENGINEERING

Manuscript Template: Current perspectives in the application of medicinal plants against cancer: novel therapeutic agents Running Title: Medicinal plants as anticancer agents

(2019) Sevgi Gezici et al.   Anti-Cancer Agents in Medicinal Chemistry

Building Microbial Hosts for Heterologous Production of N-Methylpyrrolinium

(2019) Yu Ping et al.   ACS Synthetic Biology

Neopinone isomerase is involved in codeine and morphine biosynthesis in opium poppy

(2019) Mehran Dastmalchi et al.   Nature Chemical Biology

Multi-Functional Oxidase Activity of CYP102A1 (P450BM3) in the Oxidation of Quinolines and Tetrahydroquinolines

(2019) Yushu Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biochemical characterization reveals the functional divergence of two tropinone reductases from Przewalskia tangutica

(2019) Nianyang Wu et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Molecular basis for the plasticity of aromatic prenyltransferases in hapalindole biosynthesis

(2019) Takayoshi Awakawa et al.   Beilstein Journal of Organic Chemistry

Alkaloid chemodiversity in Mandragora spp. is associated with loss-of-functionality of MoH6H, a hyoscyamine 6β-hydroxylase gene

(2019) Daniel Schlesinger et al.   PLANT SCIENCE

Synthetic biology strategies for microbial biosynthesis of plant natural products

(2019) Aaron Cravens et al.   Nature Communications

Mechanism-based tuning of insect 3,4-dihydroxyphenylacetaldehyde synthase for synthetic bioproduction of benzylisoquinoline alkaloids

(2019) Christopher J. Vavricka et al.   Nature Communications

De Novo Production of the Plant-Derived Tropine and Pseudotropine in Yeast

(2019) Yu Ping et al.   ACS Synthetic Biology

Global Concerns with B Vitamin Statuses: Biofortification, Fortification, Hidden Hunger, Interactions, and Toxicity

(2019) Tyler J. Titcomb et al.   COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY

Catalytic Asymmetric Total Syntheses of (−)-Galanthamine and (−)-Lycoramine

(2019) Qing Zhang et al.   JOURNAL OF ORGANIC CHEMISTRY

Purine permease-type benzylisoquinoline alkaloid transporters in opium poppy

(2019) Mehran Dastmalchi et al.   PLANT PHYSIOLOGY

Molecular Origins of Functional Diversity in Benzylisoquinoline Alkaloid Methyltransferases

(2019) Peter J. Facchini et al.   Frontiers in Plant Science

Present status of Catharanthus roseus monoterpenoid indole alkaloids engineering in homo- and hetero-logous systems

(2019) Abhishek Sharma et al.   BIOTECHNOLOGY LETTERS

Functional genomics analysis reveals two novel genes required for littorine biosynthesis

(2019) Fei Qiu et al.   NEW PHYTOLOGIST

Engineering a microbial biosynthesis platform for de novo production of tropane alkaloids

(2019) Prashanth Srinivasan et al.   Nature Communications

Tropane alkaloids biosynthesis involves an unusual type III polyketide synthase and non-enzymatic condensation

(2019) Jian-Ping Huang et al.   Nature Communications

Directed Evolution of a Tryptophan 2,3-Dioxygenase for the Diastereoselective Monooxygenation of Tryptophans

(2019) Yanxin Wei et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Evolution and Diversity of Assembly-Line Polyketide Synthases

(2019) Aleksandra Nivina et al.   CHEMICAL REVIEWS

Directed Evolution of an FeII-Dependent Halogenase for Asymmetric C(sp3)–H Chlorination

(2019) Sabine Duewel et al.   ACS Catalysis

Rational Engineered C-Acyltransferase Transforms Sterically Demanding Acyl Donors

(2019) Anna Żądło-Dobrowolska et al.   ACS Catalysis

Engineering of Thermovibrio ammonificans carbonic anhydrase mutants with increased thermostability

(2019) Ricardo Parra-Cruz et al.   Journal of CO2 Utilization

Convenient synthetic approach for tri- and tetraprenylated cyclodipeptides by consecutive enzymatic prenylations

(2018) Viola Wohlgemuth et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Comparison of two hyoscyamine 6β-hydroxylases in engineering scopolamine biosynthesis in root cultures of Scopolia lurida

(2018) Xiaozhong Lan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Characterization of a new microbial Pictet-Spenglerase NscbB affording the β-carboline skeletons from Nocardiopsis synnemataformans DSM 44143

(2018) Qi Chen et al.   JOURNAL OF BIOTECHNOLOGY

Improved Synthesis of 4-Cyanotryptophan and Other Tryptophan Analogues in Aqueous Solvent Using Variants of TrpB from Thermotoga maritima

(2018) Christina E. Boville et al.   JOURNAL OF ORGANIC CHEMISTRY

Natural products from thioester reductase containing biosynthetic pathways

(2018) Michael W. Mullowney et al.   NATURAL PRODUCT REPORTS

A pathogenesis-related 10 protein catalyzes the final step in thebaine biosynthesis

(2018) Xue Chen et al.   Nature Chemical Biology

Codeinone reductase isoforms with differential stability, efficiency and product selectivity in opium poppy

(2018) Mehran Dastmalchi et al.   PLANT JOURNAL

Complete biosynthesis of noscapine and halogenated alkaloids in yeast

(2018) Yanran Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biocatalytic Access to Piperazines from Diamines and Dicarbonyls

(2018) Niels Borlinghaus et al.   ACS Catalysis

A Comprehensive Overview of the Cyclodipeptide Synthase Family Enriched with the Characterization of 32 New Enzymes

(2018) Muriel Gondry et al.   Frontiers in Microbiology

Synthesis of 2,5-Disubstituted Pyrrolidine Alkaloids via A One-Pot Cascade Using Transaminase and Reductive Aminase Biocatalysts

(2018) Bruna Z. Costa et al.   ChemCatChem

Biomimetic synthesis of 2-substituted N-heterocycle alkaloids by one-pot hydrolysis, transamination and decarboxylative Mannich reaction

(2018) James L. Galman et al.   CHEMICAL COMMUNICATIONS

Protein–protein interactions in polyketide synthase–nonribosomal peptide synthetase hybrid assembly lines

(2018) Akimasa Miyanaga et al.   NATURAL PRODUCT REPORTS

The opium poppy genome and morphinan production

(2018) Li Guo et al.   SCIENCE

Molecular mechanism of metabolic NAD(P)H-dependent electron-transfer systems: The role of redox cofactors

(2018) Takashi Iyanagi   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Analgesic efficacy and safety of morphine in the Procedural Pain in Premature Infants (Poppi) study: randomised placebo-controlled trial

(2018) Caroline Hartley et al.   LANCET

Complete Decoration of the Indolyl Residue in cyclo-l-Trp-l-Trp with Geranyl Moieties by Using Engineered Dimethylallyl Transferases

(2018) Ge Liao et al.   ORGANIC LETTERS

A Phenylpyruvic Acid Reductase Is Required for Biosynthesis of Tropane Alkaloids

(2018) Fei Qiu et al.   ORGANIC LETTERS

Tropinone synthesis via an atypical polyketide synthase and P450-mediated cyclization

(2018) Matthew A. Bedewitz et al.   Nature Communications

A Highly Characterized Synthetic Landing Pad System for Precise Multicopy Gene Integration in Yeast

(2018) Leanne Bourgeois et al.   ACS Synthetic Biology

Microbial cell factories for the sustainable manufacturing of B vitamins

(2018) Carlos G Acevedo-Rocha et al.   CURRENT OPINION IN BIOTECHNOLOGY

Mutations of Residues in Pocket P1 of a Cyclodipeptide Synthase Strongly Increase Product Formation

(2017) Kirsten Brockmeyer et al.   JOURNAL OF NATURAL PRODUCTS

Unlocking Reactivity of TrpB: A General Biocatalytic Platform for Synthesis of Tryptophan Analogues

(2017) David K. Romney et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pervasive coexpression of spatially proximal genes is buffered at the protein level

(2017) Georg Kustatscher et al.   Molecular Systems Biology

A heme-dependent enzyme forms the nitrogen–nitrogen bond in piperazate

(2017) Yi-Ling Du et al.   Nature Chemical Biology

A multidrug and toxic compound extrusion transporter mediates berberine accumulation into vacuoles in Coptis japonica

(2017) Kojiro Takanashi et al.   PHYTOCHEMISTRY

Combinatorial metabolic engineering using an orthogonal tri-functional CRISPR system

(2017) Jiazhang Lian et al.   Nature Communications

Library of Norcoclaurine Synthases and Their Immobilization for Biocatalytic Transformations

(2017) Horst Lechner et al.   Biotechnology Journal

Anti-fatigue Effects of Active Ingredients from Traditional Chinese Medicine: A Review

(2017) Si-Si Zhou et al.   CURRENT MEDICINAL CHEMISTRY

A Panel of TrpB Biocatalysts Derived from Tryptophan Synthase through the Transfer of Mutations that Mimic Allosteric Activation

(2016) Javier Murciano-Calles et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Saturation mutagenesis on Arg244 of the tryptophan C4-prenyltransferase FgaPT2 leads to enhanced catalytic ability and different preferences for tryptophan-containing cyclic dipeptides

(2016) Aili Fan et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Biosynthesis of oxygen and nitrogen-containing heterocycles in polyketides

(2016) Franziska Hemmerling et al.   Beilstein Journal of Organic Chemistry

Beyond the outer limits of nature by directed evolution

(2016) Patricia Molina-Espeja et al.   BIOTECHNOLOGY ADVANCES

Tools of pathway reconstruction and production of economically relevant plant secondary metabolites in recombinant microorganisms

(2016) Clarissa Dziggel et al.   Biotechnology Journal

Total Synthesis of Gelsedilam by Means of a Thiol-Mediated Diastereoselective Conjugate Addition-Aldol Reaction

(2016) You-Ming Huang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Exploiting plant alkaloids

(2016) Sabrina Schläger et al.   CURRENT OPINION IN BIOTECHNOLOGY

Indoles — A promising scaffold for drug development

(2016) T.V. Sravanthi et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Synthesis of β-Branched Tryptophan Analogues Using an Engineered Subunit of Tryptophan Synthase

(2016) Michael Herger et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nitrogenous Compounds from Marine Aspergillus sp.

(2016) Kui-Wu Wang et al.   MINI-REVIEWS IN ORGANIC CHEMISTRY

Evaluation of Biosynthetic Pathway and Engineered Biosynthesis of Alkaloids

(2016) Shinji Kishimoto et al.   MOLECULES

Human commensals producing a novel antibiotic impair pathogen colonization

(2016) Alexander Zipperer et al.   NATURE

Asymmetric Total Synthesis of (−)-Lycospidine A

(2016) Shiyan Xu et al.   ORGANIC LETTERS

Functional characterisation of a tropine-forming reductase gene from Brugmansia arborea, a woody plant species producing tropane alkaloids

(2016) Wei Qiang et al.   PHYTOCHEMISTRY

Potato plants with genetically engineered tropane alkaloid precursors

(2016) Nadine Küster et al.   PLANTA

Total biosynthesis of opiates by stepwise fermentation using engineered Escherichia coli

(2016) Akira Nakagawa et al.   Nature Communications

Engineering biosynthesis of the anticancer alkaloid noscapine in yeast

(2016) Yanran Li et al.   Nature Communications

One-Pot Cascade Synthesis of Mono- and Disubstituted Piperidines and Pyrrolidines using Carboxylic Acid Reductase (CAR), ω-Transaminase (ω-TA), and Imine Reductase (IRED) Biocatalysts

(2016) Scott P. France et al.   ACS Catalysis

Tools of pathway reconstruction and production of economically relevant plant secondary metabolites in recombinant microorganisms

(2016) Clarissa Dziggel et al.   Biotechnology Journal

A Novel Enzymatic Strategy for the Synthesis of Substituted Tetrahydroisoquinolines

(2016) Alessandra Bonamore et al.   ChemistrySelect

Expanding the Enzyme Universe: Accessing Non-Natural Reactions by Mechanism-Guided Directed Evolution

(2015) Hans Renata et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective total synthesis of (+)-methoxystemofoline and (+)-isomethoxystemofoline

(2015) Pei-Qiang Huang et al.   CHEMICAL COMMUNICATIONS

Structural Basis for β-Carboline Alkaloid Production by the Microbial Homodimeric Enzyme McbB

(2015) Takahiro Mori et al.   CHEMISTRY & BIOLOGY

One-pot triangular chemoenzymatic cascades for the syntheses of chiral alkaloids from dopamine

(2015) B. R. Lichman et al.   GREEN CHEMISTRY

Efficient biosynthesis of rare natural product scopolamine using E. coli cells expressing a S14P/K97A mutant of hyoscyamine 6β-hydroxylase AaH6H

(2015) Yue-De Cao et al.   JOURNAL OF BIOTECHNOLOGY

Transcriptome exploration for further understanding of the tropane alkaloids biosynthesis in Anisodus acutangulus

(2015) Lijie Cui et al.   MOLECULAR GENETICS AND GENOMICS

Discovery of a New Family of Dieckmann Cyclases Essential to Tetramic Acid and Pyridone-Based Natural Products Biosynthesis

(2015) Chun Gui et al.   ORGANIC LETTERS

Metabolic engineering for the production of plant isoquinoline alkaloids

(2015) Andrew Diamond et al.   PLANT BIOTECHNOLOGY JOURNAL

Stereoselective Cascade to C3-Methylated Strictosidine Derivatives Employing Transaminases and Strictosidine Synthases

(2015) Eva-Maria Fischereder et al.   ACS Catalysis

Two Distinct Cyclodipeptide Synthases from a Marine Actinomycete Catalyze Biosynthesis of the Same Diketopiperazine Natural Product

(2015) Elle D. James et al.   ACS Synthetic Biology

Total Syntheses of (−)-Huperzine Q and (+)-Lycopladines B and C

(2014) Benke Hong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Acetylation serves as a protective group in noscapine biosynthesis in opium poppy

(2014) Thu-Thuy T Dang et al.   Nature Chemical Biology

Alkaloids as drug leads – A predictive structural and biodiversity-based analysis

(2014) Vafa Amirkia et al.   Phytochemistry Letters

Biosynthetic Pathways of Ergot Alkaloids

(2014) Nina Gerhards et al.   Toxins

Regio- and Stereoselective Monoamination of Diketones without Protecting Groups

(2012) Robert C. Simon et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

2,5-Diketopiperazines: Synthesis, Reactions, Medicinal Chemistry, and Bioactive Natural Products

(2012) Alan D. Borthwick   CHEMICAL REVIEWS

Characterization of Coptis japonica CjABCB2, an ATP-binding cassette protein involved in alkaloid transport

(2012) Nobukazu Shitan et al.   PHYTOCHEMISTRY

A Papaver somniferum 10-Gene Cluster for Synthesis of the Anticancer Alkaloid Noscapine

(2012) T. Winzer et al.   SCIENCE

Reengineering a Tryptophan Halogenase To Preferentially Chlorinate a Direct Alkaloid Precursor

(2011) Weslee S. Glenn et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Directed enzyme evolution: climbing fitness peaks one amino acid at a time

(2009) Cara A Tracewell et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Secondary Metabolites from Cyanobacteria: Complex Structures and Powerful Bioactivities

(2008) Karl Gademann et al.   CURRENT ORGANIC CHEMISTRY