Natural products from thioester reductase containing biosynthetic pathways

Cyclizidine-Type Alkaloids from Streptomyces sp. HNA39

(2018) Yong-Jun Jiang et al.   JOURNAL OF NATURAL PRODUCTS

New Insights into the Biosynthesis Pathway of Polyketide Alkaloid Argimycins P in Streptomyces argillaceus

(2018) Suhui Ye et al.   Frontiers in Microbiology

Covalent binding design strategy: A prospective method for discovery of potent targeted anticancer agents

(2017) Luhong Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A tricyclic pyrrolobenzodiazepine produced byKlebsiella oxytocais associated with cytotoxicity in antibiotic-associated hemorrhagic colitis

(2017) Herman Tse et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peptide Macrocyclization Inspired by Non-Ribosomal Imine Natural Products

(2017) Lara R. Malins et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rovalpituzumab tesirine, a DLL3-targeted antibody-drug conjugate, in recurrent small-cell lung cancer: a first-in-human, first-in-class, open-label, phase 1 study

(2017) Charles M Rudin et al.   LANCET ONCOLOGY

Structures of carboxylic acid reductase reveal domain dynamics underlying catalysis

(2017) Deepankar Gahloth et al.   Nature Chemical Biology

Activation of a Cryptic Gene Cluster in Lysobacter enzymogenes Reveals a Module/Domain Portable Mechanism of Nonribosomal Peptide Synthetases in the Biosynthesis of Pyrrolopyrazines

(2017) Shanren Li et al.   ORGANIC LETTERS

Thioester reduction and aldehyde transamination are universal steps in actinobacterial polyketide alkaloid biosynthesis

(2017) U. R. Awodi et al.   Chemical Science

Resistance Gene-Guided Genome Mining: Serial Promoter Exchanges in Aspergillus nidulans Reveal the Biosynthetic Pathway for Fellutamide B, a Proteasome Inhibitor

(2016) Hsu-Hua Yeh et al.   ACS Chemical Biology

Deciphering Piperidine Formation in Polyketide-Derived Indolizidines Reveals a Thioester Reduction, Transamination, and Unusual Imine Reduction Process

(2016) Haidong Peng et al.   ACS Chemical Biology

Partial In Vitro Reconstitution of an Orphan Polyketide Synthase Associated with Clinical Cases of Nocardiosis

(2016) James Kuo et al.   ACS Chemical Biology

From Anthramycin to Pyrrolobenzodiazepine (PBD)-Containing Antibody-Drug Conjugates (ADCs)

(2016) Julia Mantaj et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Natural Products as Sources of New Drugs from 1981 to 2014

(2016) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Structural insights into the regulation of NADPH binding to reductase domains of nonribosomal peptide synthetases: A concerted loop movement model

(2016) Priyadarshan Kinatukara et al.   JOURNAL OF STRUCTURAL BIOLOGY

Targeting Reactive Carbonyls for Identifying Natural Products and Their Biosynthetic Origins

(2016) Tucker Maxson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Human commensals producing a novel antibiotic impair pathogen colonization

(2016) Alexander Zipperer et al.   NATURE

The molecular steps of citrinin biosynthesis in fungi

(2016) Yi He et al.   Chemical Science

Biosynthesis of Antibiotic Leucinostatins in Bio-control Fungus Purpureocillium lilacinum and Their Inhibition on Phytophthora Revealed by Genome Mining

(2016) Gang Wang et al.   PLoS Pathogens

Large-Scale Metabolomics Reveals a Complex Response of Aspergillus nidulans to Epigenetic Perturbation

(2015) Jessica C. Albright et al.   ACS Chemical Biology

Identification and Characterization of the Streptazone E Biosynthetic Gene Cluster inStreptomycessp. MSC090213JE08

(2015) Shoto Ohno et al.   CHEMBIOCHEM

Comprehensive Structural and Biochemical Analysis of the Terminal Myxalamid Reductase Domain for the Engineered Production of Primary Alcohols

(2015) Jesus F. Barajas et al.   CHEMISTRY & BIOLOGY

Identification and analysis of the bacterial endosymbiont specialized for production of the chemotherapeutic natural product ET-743

(2015) Michael M. Schofield et al.   ENVIRONMENTAL MICROBIOLOGY

Equisetin, reutericyclin and streptolodygin as natural product lead structures for novel antibiotic libraries

(2015) Yong-Chul Jeong et al.   Future Medicinal Chemistry

Ecteinascidins. A review of the chemistry, biology and clinical utility of potent tetrahydroisoquinoline antitumor antibiotics

(2015) V. H. Le et al.   NATURAL PRODUCT REPORTS

Identification of the Polyketide Biosynthetic Machinery for the Indolizidine Alkaloid Cyclizidine

(2015) Wei Huang et al.   ORGANIC LETTERS

A combination of polyunsaturated fatty acid, nonribosomal peptide and polyketide biosynthetic machinery is used to assemble the zeamine antibiotics

(2015) Joleen Masschelein et al.   Chemical Science

Sequence analysis of porothramycin biosynthetic gene cluster

(2014) Lucie Najmanova et al.   FOLIA MICROBIOLOGICA

A New Lyngbyatoxin from the Hawaiian Cyanobacterium Moorea producens

(2014) Weina Jiang et al.   Marine Drugs

Structure of a modular polyketide synthase

(2014) Somnath Dutta et al.   NATURE

Structural rearrangements of a polyketide synthase module during its catalytic cycle

(2014) Jonathan R. Whicher et al.   NATURE

A roadmap for natural product discovery based on large-scale genomics and metabolomics

(2014) James R Doroghazi et al.   Nature Chemical Biology

Enterotoxicity of a nonribosomal peptide causes antibiotic-associated colitis

(2014) G. Schneditz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthesis and Pharmacology of Proteasome Inhibitors

(2013) Andreas Rentsch et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Drug discovery considerations in the development of covalent inhibitors

(2013) Robert Mah et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Comprehensive annotation of secondary metabolite biosynthetic genes and gene clusters of Aspergillus nidulans, A. fumigatus, A. niger and A. oryzae

(2013) Diane O Inglis et al.   BMC MICROBIOLOGY

Azaphilones: Chemistry and Biology

(2013) Jin-Ming Gao et al.   CHEMICAL REVIEWS

Two new piperidine alkaloids fromStreptomycessp. NEAU-Z4

(2013) Qian-Feng Liu et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Structure and function of mycobacterium glycopeptidolipids from comparative genomics perspective

(2013) Lei Pang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Proteomics Guided Discovery of Flavopeptins: Anti-proliferative Aldehydes Synthesized by a Reductase Domain-Containing Non-ribosomal Peptide Synthetase

(2013) Yunqiu Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The novel equisetin-like compound, TA-289, causes aberrant mitochondrial morphology which is independent of the production of reactive oxygen species in Saccharomyces cerevisiae

(2013) Natelle C. H. Quek et al.   Molecular BioSystems

Naphthyridinomycin Biosynthesis Revealing the Use of Leader Peptide to Guide Nonribosomal Peptide Assembly

(2013) Jin-Yue Pu et al.   ORGANIC LETTERS

A PKS/NRPS/FAS Hybrid Gene Cluster from Serratia plymuthica RVH1 Encoding the Biosynthesis of Three Broad Spectrum, Zeamine-Related Antibiotics

(2013) Joleen Masschelein et al.   PLoS One

Oxidative dearomatisation: the key step of sorbicillinoid biosynthesis

(2013) Ahmed al Fahad et al.   Chemical Science

Mutasynthesis of a Potent Anticancer Sibiromycin Analogue

(2012) Isaac T. Yonemoto et al.   ACS Chemical Biology

Function of Cytochrome P450 Enzymes RosC and RosD in the Biosynthesis of Rosamicin Macrolide Antibiotic Produced by Micromonospora rosaria

(2012) Yohei Iizaka et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Characterization of a Silent Azaphilone Gene Cluster from Aspergillus niger ATCC 1015 Reveals a Hydroxylation-Mediated Pyran-Ring Formation

(2012) Angelica O. Zabala et al.   CHEMISTRY & BIOLOGY

Proteasome Inhibitors: An Expanding Army Attacking a Unique Target

(2012) Alexei F. Kisselev et al.   CHEMISTRY & BIOLOGY

Nonprocessive [2 + 2]e- off-loading reductase domains from mycobacterial nonribosomal peptide synthetases

(2012) A. Chhabra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic, molecular, and biochemical basis of fungal tropolone biosynthesis

(2012) J. Davison et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and biosynthesis of the unusual polyketide alkaloid coelimycin P1, a metabolic product of the cpk gene cluster of Streptomyces coelicolor M145

(2012) Juan Pablo Gomez-Escribano et al.   Chemical Science

First Discovery of Two Polyketide Synthase Genes for Mitorubrinic Acid and Mitorubrinol Yellow Pigment Biosynthesis and Implications in Virulence of Penicillium marneffei

(2012) Patrick C. Y. Woo et al.   PLoS Neglected Tropical Diseases

A new cyclizidine analog—JBIR-102—from Saccharopolyspora sp. RL78 isolated from mangrove soil

(2011) Miho Izumikawa et al.   JOURNAL OF ANTIBIOTICS

Proteomics-Based Discovery of Koranimine, a Cyclic Imine Natural Product

(2011) Bradley S. Evans et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Identification and engineering of the cytochalasin gene cluster from Aspergillus clavatus NRRL 1

(2011) Kangjian Qiao et al.   METABOLIC ENGINEERING

Nostocyclopeptide-M1: A Potent, Nontoxic Inhibitor of the Hepatocyte Drug Transporters OATP1B3 and OATP1B1

(2011) Lars Herfindal et al.   MOLECULAR PHARMACEUTICS

A Novel Multidomain Polyketide Synthase Is Essential for Zeamine Production and the Virulence ofDickeya zeae

(2011) Jianuan Zhou et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

The sorbicillinoid family of natural products: Isolation, biosynthesis, and synthetic studies

(2011) Andrew M. Harned et al.   NATURAL PRODUCT REPORTS

Characteristics of Mycobacterium smegmatis J15cs strain lipids

(2011) Nagatoshi Fujiwara et al.   TUBERCULOSIS

Elucidation of the Structure and Intermolecular Interactions of a Reversible Cyclic-Peptide Inhibitor of the Proteasome by NMR Spectroscopy and Molecular Modeling

(2010) Benjamin Stauch et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asperfuranone from Aspergillus nidulans Inhibits Proliferation of Human Non-Small Cell Lung Cancer A549 Cells via Blocking Cell Cycle Progression and Inducing Apoptosis

(2010) Clay C. C. Wang et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

A Novel Cyanobacterial Nostocyclopeptide is a Potent Antitoxin against Microcystins

(2010) Jouni Jokela  et al.   CHEMBIOCHEM

Catalytic role of the C-terminal domains of a fungal non-reducing polyketide synthase

(2010) Katja M. Fisch et al.   CHEMICAL COMMUNICATIONS

N-Acylation during Glidobactin Biosynthesis by the Tridomain Nonribosomal Peptide Synthetase Module GlbF

(2010) Heidi J. Imker et al.   CHEMISTRY & BIOLOGY

Scytonemides A and B, Cyclic Peptides with 20S Proteasome Inhibitory Activity from the Cultured CyanobacteriumScytonema hofmanii

(2010) Aleksej Krunic et al.   JOURNAL OF NATURAL PRODUCTS

Biosynthesis, synthesis, and biological activities of pyrrolobenzodiazepines

(2010) Barbara Gerratana   MEDICINAL RESEARCH REVIEWS

A Review of Trabectedin (ET-743): A Unique Mechanism of Action

(2010) Maurizio D'Incalci et al.   MOLECULAR CANCER THERAPEUTICS

Reconstruction of the saframycin core scaffold defines dual Pictet-Spengler mechanisms

(2010) Kento Koketsu et al.   Nature Chemical Biology

New insights into the formation of fungal aromatic polyketides

(2010) Jason M. Crawford et al.   NATURE REVIEWS MICROBIOLOGY

Azaphilones: a class of fungal metabolites with diverse biological activities

(2010) Natalia Osmanova et al.   PHYTOCHEMISTRY REVIEWS

Three new sorbicillin trimers, trisorbicillinones B, C, and D, from a deep ocean sediment derived fungus, Phialocephala sp. FL30r

(2010) Dehai Li et al.   TETRAHEDRON

Molecular modeling of the reductase domain to elucidate the reaction mechanism of reduction of peptidyl thioester into its corresponding alcohol in non-ribosomal peptide synthetases

(2010) Balachandran Manavalan et al.   BMC STRUCTURAL BIOLOGY

Cloning and Characterization of the Biosynthetic Gene Cluster for Tomaymycin, an SJG-136 Monomeric Analog

(2009) W. Li et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Biosynthesis of Sibiromycin, a Potent Antitumor Antibiotic

(2009) W. Li et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Cyclopiazonic Acid Biosynthesis inAspergillussp.: Characterization of a Reductase-like R* Domain in Cyclopiazonate Synthetase That Forms and Releasescyclo-Acetoacetyl-l-tryptophan

(2009) Xinyu Liu et al.   BIOCHEMISTRY

Cytotoxic Sorbicillinoids and Bisorbicillinoids from a Marine-Derived Fungus Trichoderma sp.

(2009) Lin Du et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

13CLabeling reveals multiple amination reactions in the biosynthesis of a novel polyketide polyamine antibioticzeamine from Dickeya zeae

(2009) Jien Wu et al.   CHEMICAL COMMUNICATIONS

SylC Catalyzes Ureido-Bond Formation During Biosynthesis of the Proteasome Inhibitor Syringolin A

(2009) Heidi J. Imker et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Gene Cluster Containing Two Fungal Polyketide Synthases Encodes the Biosynthetic Pathway for a Polyketide, Asperfuranone, inAspergillus nidulans

(2009) Yi-Ming Chiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Development of Yondelis® (trabectedin, ET-743). A semisynthetic process solves the supply problem

(2009) Carmen Cuevas et al.   NATURAL PRODUCT REPORTS

PKS and NRPS release mechanisms

(2009) Liangcheng Du et al.   NATURAL PRODUCT REPORTS

Structural basis for biosynthetic programming of fungal aromatic polyketide cyclization

(2009) Jason M. Crawford et al.   NATURE

Cyclopiazonic Acid Biosynthesis of Aspergillus flavus and Aspergillus oryzae

(2009) Perng-Kuang Chang et al.   Toxins

Medium- and short-chain dehydrogenase/reductase gene and protein families

(2008) K. L. Kavanagh et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Authentic Heterologous Expression of the Tenellin Iterative Polyketide Synthase Nonribosomal Peptide Synthetase Requires Coexpression with an Enoyl Reductase

(2008) Laura M. Halo et al.   CHEMBIOCHEM

Proteasome Inhibition by Fellutamide B Induces Nerve Growth Factor Synthesis

(2008) John Hines et al.   CHEMISTRY & BIOLOGY

Characterization of the Azinomycin B Biosynthetic Gene Cluster Revealing a Different Iterative Type I Polyketide Synthase for Naphthoate Biosynthesis

(2008) Qunfei Zhao et al.   CHEMISTRY & BIOLOGY

A survey of nonribosomal peptide synthetase (NRPS) genes in Aspergillus nidulans

(2008) Hans von Döhren   FUNGAL GENETICS AND BIOLOGY

Myxochelin Biosynthesis: Direct Evidence for Two- and Four-Electron Reduction of a Carrier Protein-Bound Thioester

(2008) Yanyan Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Late Stage Oxidations during the Biosynthesis of the 2-Pyridone Tenellin in the Entomopathogenic FungusBeauveria bassiana

(2008) Laura M. Halo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Genome sequencing and analysis of the filamentous fungus Penicillium chrysogenum

(2008) Marco A van den Berg et al.   NATURE BIOTECHNOLOGY

An improved method for culturing Streptomyces sahachiroi: Biosynthetic origin of the enol fragment of azinomycin B

(2007) Gilbert T. Kelly et al.   BIOORGANIC CHEMISTRY